probenecid has been researched along with Innate Inflammatory Response in 25 studies
Probenecid: The prototypical uricosuric agent. It inhibits the renal excretion of organic anions and reduces tubular reabsorption of urate. Probenecid has also been used to treat patients with renal impairment, and, because it reduces the renal tubular excretion of other drugs, has been used as an adjunct to antibacterial therapy.
probenecid : A sulfonamide in which the nitrogen of 4-sulfamoylbenzoic acid is substituted with two propyl groups.
| Excerpt | Relevance | Reference |
|---|---|---|
| "This study aimed to investigate the effect of probenecid (Pro) as an inhibitor of the pannexin-1 (Panx-1) channel-mediated release of intracellular ATP to the extracellular compartment on inflammation, cellular energy crisis, and organ injury in a rabbit sepsis model induced by Escherichia coli lipopolysaccharides (LPS)." | 7.88 | The Pannexin-1 Channel Inhibitor Probenecid Attenuates Skeletal Muscle Cellular Energy Crisis and Histopathological Injury in a Rabbit Endotoxemia Model. ( He, H; Liu, D; Long, Y; Wang, X; Yao, B, 2018) |
| "We examined the effects of ozone (O(3)) and endogenous antioxidant transport on canine peripheral airway function, central airway function, epithelial integrity, and inflammation." | 7.70 | Antioxidant transport modulates peripheral airway reactivity and inflammation during ozone exposure. ( Cueto, R; Freed, AN; Pryor, WA, 1999) |
| "Probenecid treatment resulted in lower disease scores as compared to EAE animals." | 5.43 | Probenecid Application Prevents Clinical Symptoms and Inflammation in Experimental Autoimmune Encephalomyelitis. ( Hainz, N; Meier, C; Tschernig, T; Wolf, S, 2016) |
| "Our study demonstrates that the anti-inflammatory drugs probenecid and AZ11645373, which have documented pharmacokinetics and safety profiles in humans, are effective at dampening hyperinflammation and severe influenza disease providing potentially new therapeutic strategies for treating severe or pathogenic IAV infections." | 3.91 | Repurposing drugs targeting the P2X7 receptor to limit hyperinflammation and disease during influenza virus infection. ( Drummond, GR; Kirby, FJ; Lawlor, KE; Mansell, A; Rainczuk, K; Rosli, S; Tate, MD, 2019) |
| "This study aimed to investigate the effect of probenecid (Pro) as an inhibitor of the pannexin-1 (Panx-1) channel-mediated release of intracellular ATP to the extracellular compartment on inflammation, cellular energy crisis, and organ injury in a rabbit sepsis model induced by Escherichia coli lipopolysaccharides (LPS)." | 3.88 | The Pannexin-1 Channel Inhibitor Probenecid Attenuates Skeletal Muscle Cellular Energy Crisis and Histopathological Injury in a Rabbit Endotoxemia Model. ( He, H; Liu, D; Long, Y; Wang, X; Yao, B, 2018) |
| "We examined the effects of ozone (O(3)) and endogenous antioxidant transport on canine peripheral airway function, central airway function, epithelial integrity, and inflammation." | 3.70 | Antioxidant transport modulates peripheral airway reactivity and inflammation during ozone exposure. ( Cueto, R; Freed, AN; Pryor, WA, 1999) |
| "Probenecid treatment resulted in lower disease scores as compared to EAE animals." | 1.43 | Probenecid Application Prevents Clinical Symptoms and Inflammation in Experimental Autoimmune Encephalomyelitis. ( Hainz, N; Meier, C; Tschernig, T; Wolf, S, 2016) |
| "Three common dosing regimens of the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced model of Parkinson's disease (PD) were compared in C57BL/6 mice on behavior, striatal and extra-striatal neurotransmission, and brain cytokines, to clarify the differences between regimens on these variables." | 1.35 | Behavior, neurotransmitters and inflammation in three regimens of the MPTP mouse model of Parkinson's disease. ( Luchtman, DW; Shao, D; Song, C, 2009) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 2 (8.00) | 18.7374 |
| 1990's | 1 (4.00) | 18.2507 |
| 2000's | 3 (12.00) | 29.6817 |
| 2010's | 16 (64.00) | 24.3611 |
| 2020's | 3 (12.00) | 2.80 |
| Authors | Studies |
|---|---|
| Saunders, MJ | 1 |
| Edwards, BS | 1 |
| Zhu, J | 2 |
| Sklar, LA | 1 |
| Graves, SW | 1 |
| Baldwin, AG | 1 |
| Brough, D | 1 |
| Freeman, S | 1 |
| Martínez-Reyes, CP | 1 |
| Manjarrez-Reyna, AN | 1 |
| Méndez-García, LA | 1 |
| Aguayo-Guerrero, JA | 1 |
| Aguirre-Sierra, B | 1 |
| Villalobos-Molina, R | 1 |
| López-Vidal, Y | 1 |
| Bobadilla, K | 1 |
| Escobedo, G | 1 |
| Wang, Q | 2 |
| Zhao, H | 1 |
| Gao, Y | 1 |
| Lu, J | 1 |
| Yu, W | 1 |
| He, F | 1 |
| Liu, W | 1 |
| Hisatome, I | 1 |
| Yamamoto, T | 1 |
| Wang, W | 1 |
| Cheng, J | 1 |
| Mat Nor, MN | 1 |
| Rupenthal, ID | 1 |
| Green, CR | 1 |
| Acosta, ML | 1 |
| He, H | 1 |
| Liu, D | 1 |
| Long, Y | 1 |
| Wang, X | 1 |
| Yao, B | 1 |
| Xue, X | 1 |
| Zhang, W | 1 |
| Chen, X | 1 |
| Zhou, S | 1 |
| Xu, Z | 1 |
| Hu, G | 1 |
| Su, C | 1 |
| Spray, DC | 1 |
| Iglesias, R | 1 |
| Shraer, N | 1 |
| Suadicani, SO | 1 |
| Belzer, V | 1 |
| Hanstein, R | 1 |
| Hanani, M | 1 |
| Zhang, Z | 1 |
| Lei, Y | 1 |
| Yan, C | 1 |
| Mei, X | 1 |
| Jiang, T | 1 |
| Ma, Z | 1 |
| de Marchi, FO | 1 |
| Cruz, FF | 1 |
| Menezes, FP | 1 |
| Kist, LW | 1 |
| Bogo, MR | 1 |
| Morrone, FB | 1 |
| Rosli, S | 1 |
| Kirby, FJ | 1 |
| Lawlor, KE | 1 |
| Rainczuk, K | 1 |
| Drummond, GR | 1 |
| Mansell, A | 1 |
| Tate, MD | 1 |
| Huh, Y | 1 |
| Keep, RF | 1 |
| Smith, DE | 1 |
| Wonnenberg, B | 1 |
| Tschernig, T | 2 |
| Voss, M | 1 |
| Bischoff, M | 1 |
| Meier, C | 2 |
| Schirmer, SH | 1 |
| Langer, F | 1 |
| Bals, R | 1 |
| Beisswenger, C | 1 |
| Richette, P | 1 |
| Perez-Ruiz, F | 1 |
| Doherty, M | 1 |
| Jansen, TL | 1 |
| Nuki, G | 1 |
| Pascual, E | 1 |
| Punzi, L | 1 |
| So, AK | 1 |
| Bardin, T | 1 |
| Hainz, N | 1 |
| Wolf, S | 1 |
| Heng, Y | 1 |
| Zhang, QS | 1 |
| Mu, Z | 1 |
| Hu, JF | 1 |
| Yuan, YH | 1 |
| Chen, NH | 1 |
| Luchtman, DW | 2 |
| Shao, D | 1 |
| Song, C | 2 |
| Silverman, WR | 1 |
| de Rivero Vaccari, JP | 1 |
| Locovei, S | 1 |
| Qiu, F | 1 |
| Carlsson, SK | 1 |
| Scemes, E | 1 |
| Keane, RW | 2 |
| Dahl, G | 2 |
| Cosi, C | 1 |
| Mannaioni, G | 1 |
| Cozzi, A | 1 |
| Carlà, V | 1 |
| Sili, M | 1 |
| Cavone, L | 1 |
| Maratea, D | 1 |
| Moroni, F | 1 |
| Meng, Q | 1 |
| Wein, S | 1 |
| Fauroux, M | 1 |
| Laffitte, J | 1 |
| de Nadaï, P | 1 |
| Guaïni, C | 1 |
| Pons, F | 1 |
| Coméra, C | 1 |
| Freed, AN | 1 |
| Cueto, R | 1 |
| Pryor, WA | 1 |
| Raghoebar, M | 1 |
| Huisman, JA | 1 |
| van den Berg, WB | 1 |
| van Ginneken, CA | 1 |
| Barza, M | 1 |
| Baum, J | 1 |
| Birkby, B | 1 |
| Weinstein, L | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Allopurinol in the Treatment of Patients With Diabetes Mellitus and Multivessel Coronary Artery Disease Treated by Either PCI or CABG: Pilot Study[NCT03700645] | Phase 4 | 100 participants (Anticipated) | Interventional | 2018-12-01 | Not yet recruiting | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
3 reviews available for probenecid and Innate Inflammatory Response
| Article | Year |
|---|---|
Inhibiting the Inflammasome: A Chemical Perspective.
Topics: Animals; Humans; Inflammasomes; Inflammation; Molecular Conformation; Small Molecule Libraries; Stru | 2016 |
Improving cardiovascular and renal outcomes in gout: what should we target?
Topics: Allopurinol; Cardiovascular Diseases; Colchicine; Diabetes Mellitus, Type 2; Disease Management; Gou | 2014 |
Pannexin: from discovery to bedside in 11±4 years?
Topics: Adenosine Triphosphate; Animals; Cell Death; Connexins; Gap Junctions; HIV Infections; Humans; Infla | 2012 |
22 other studies available for probenecid and Innate Inflammatory Response
| Article | Year |
|---|---|
Microsphere-based flow cytometry protease assays for use in protease activity detection and high-throughput screening.
Topics: Animals; Biotinylation; Flow Cytometry; Fluorescence Resonance Energy Transfer; Green Fluorescent Pr | 2010 |
Uric Acid Has Direct Proinflammatory Effects on Human Macrophages by Increasing Proinflammatory Mediators and Bacterial Phagocytosis Probably via URAT1.
Topics: Adolescent; Adult; Cells, Cultured; CX3C Chemokine Receptor 1; Escherichia coli; Humans; Inflammatio | 2020 |
Uric acid inhibits HMGB1-TLR4-NF-κB signaling to alleviate oxygen-glucose deprivation/reoxygenation injury of microglia.
Topics: Animals; Cell Hypoxia; Cell Line; Cell Survival; Disease Models, Animal; Glucose; HMGB1 Protein; Inf | 2021 |
Differential Action of Connexin Hemichannel and Pannexin Channel Therapeutics for Potential Treatment of Retinal Diseases.
Topics: Animals; Benzamides; Benzopyrans; Connexin 43; Connexins; Female; Inflammation; Light; Male; Nerve T | 2021 |
The Pannexin-1 Channel Inhibitor Probenecid Attenuates Skeletal Muscle Cellular Energy Crisis and Histopathological Injury in a Rabbit Endotoxemia Model.
Topics: Adenosine Triphosphate; Animals; Endotoxemia; Energy Metabolism; Inflammation; Interleukin-1beta; In | 2018 |
Aquaporin-4 deficiency reduces TGF-β1 in mouse midbrains and exacerbates pathology in experimental Parkinson's disease.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; alpha-Synuclein; Animals; Aquaporin 4; Astrocytes; Cel | 2019 |
Gap junction mediated signaling between satellite glia and neurons in trigeminal ganglia.
Topics: Animals; Boron Compounds; Carbenoxolone; Cells, Cultured; Disease Models, Animal; Female; Flufenamic | 2019 |
Probenecid Relieves Cerebral Dysfunction of Sepsis by Inhibiting Pannexin 1-Dependent ATP Release.
Topics: Adenosine Triphosphate; Adjuvants, Pharmaceutic; Animals; Cerebral Cortex; Cognition Disorders; Conn | 2019 |
P2X7R and PANX-1 channel relevance in a zebrafish larvae copper-induced inflammation model.
Topics: Acetamides; Animals; Connexins; Copper; Disease Models, Animal; Female; Gene Expression Regulation; | 2019 |
Repurposing drugs targeting the P2X7 receptor to limit hyperinflammation and disease during influenza virus infection.
Topics: Animals; Cells, Cultured; Drug Repositioning; Female; Inflammasomes; Inflammation; Male; Mice; Mice, | 2019 |
Impact of lipopolysaccharide-induced inflammation on the disposition of the aminocephalosporin cefadroxil.
Topics: Adjuvants, Pharmaceutic; Animals; Anti-Bacterial Agents; Area Under Curve; Cefadroxil; Gene Expressi | 2013 |
Probenecid reduces infection and inflammation in acute Pseudomonas aeruginosa pneumonia.
Topics: Animals; Anti-Inflammatory Agents; Cell Line; Cytokines; Disease Models, Animal; Humans; Inflammatio | 2014 |
Probenecid Application Prevents Clinical Symptoms and Inflammation in Experimental Autoimmune Encephalomyelitis.
Topics: Adjuvants, Pharmaceutic; Animals; Central Nervous System; Connexins; Disease Models, Animal; Encepha | 2016 |
Ginsenoside Rg1 attenuates motor impairment and neuroinflammation in the MPTP-probenecid-induced parkinsonism mouse model by targeting α-synuclein abnormalities in the substantia nigra.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; alpha-Synuclein; Animals; Anti-Inflammatory Agents; Di | 2016 |
Behavior, neurotransmitters and inflammation in three regimens of the MPTP mouse model of Parkinson's disease.
Topics: Animals; Behavior, Animal; Brain Chemistry; Chromatography, High Pressure Liquid; Cytokines; Inflamm | 2009 |
The pannexin 1 channel activates the inflammasome in neurons and astrocytes.
Topics: Animals; Astrocytes; Caspase 1; Cell Death; Cells, Cultured; Cerebral Cortex; Connexins; Gene Silenc | 2009 |
G-protein coupled receptor 35 (GPR35) activation and inflammatory pain: Studies on the antinociceptive effects of kynurenic acid and zaprinast.
Topics: Analgesics; Animals; Antidepressive Agents, Second-Generation; Dose-Response Relationship, Drug; Dru | 2011 |
Ethyl-eicosapentaenoate (E-EPA) attenuates motor impairments and inflammation in the MPTP-probenecid mouse model of Parkinson's disease.
Topics: Animals; Biogenic Monoamines; Brain; Cyclooxygenase 2; Cytokines; Eicosapentaenoic Acid; Exploratory | 2012 |
Mediation of annexin 1 secretion by a probenecid-sensitive ABC-transporter in rat inflamed mucosa.
Topics: Adenosine Triphosphate; Animals; Annexin A1; ATP-Binding Cassette Transporters; Biological Transport | 2004 |
Antioxidant transport modulates peripheral airway reactivity and inflammation during ozone exposure.
Topics: Airway Resistance; Aldehydes; Animals; Antioxidants; Ascorbic Acid; Biological Transport, Active; Br | 1999 |
Characteristics of the transport of ascorbic acid into leucocytes.
Topics: Adult; Ascorbic Acid; Biological Transport; Dehydroascorbic Acid; Glucose; Humans; Hydrogen-Ion Conc | 1987 |
Intraocular penetration of carbenicillin in the rabbit.
Topics: Animals; Aqueous Humor; Biological Transport; Carbenicillin; Choroid; Cornea; Eye; Inflammation; Inj | 1973 |