probenecid has been researched along with Infections, Orthomyxoviridae in 2 studies
Probenecid: The prototypical uricosuric agent. It inhibits the renal excretion of organic anions and reduces tubular reabsorption of urate. Probenecid has also been used to treat patients with renal impairment, and, because it reduces the renal tubular excretion of other drugs, has been used as an adjunct to antibacterial therapy.
probenecid : A sulfonamide in which the nitrogen of 4-sulfamoylbenzoic acid is substituted with two propyl groups.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Our study demonstrates that the anti-inflammatory drugs probenecid and AZ11645373, which have documented pharmacokinetics and safety profiles in humans, are effective at dampening hyperinflammation and severe influenza disease providing potentially new therapeutic strategies for treating severe or pathogenic IAV infections." | 3.91 | Repurposing drugs targeting the P2X7 receptor to limit hyperinflammation and disease during influenza virus infection. ( Drummond, GR; Kirby, FJ; Lawlor, KE; Mansell, A; Rainczuk, K; Rosli, S; Tate, MD, 2019) |
| "Antiviral chemotherapeutics that target influenza A virus are available; however, rapid emergence of drug-resistant strains has been reported." | 1.39 | Targeting organic anion transporter 3 with probenecid as a novel anti-influenza a virus strategy. ( Brooks, P; Johnson, S; Perwitasari, O; Tompkins, SM; Tripp, RA; White, C; Yan, X, 2013) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 2 (100.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Rosli, S | 1 |
| Kirby, FJ | 1 |
| Lawlor, KE | 1 |
| Rainczuk, K | 1 |
| Drummond, GR | 1 |
| Mansell, A | 1 |
| Tate, MD | 1 |
| Perwitasari, O | 1 |
| Yan, X | 1 |
| Johnson, S | 1 |
| White, C | 1 |
| Brooks, P | 1 |
| Tompkins, SM | 1 |
| Tripp, RA | 1 |
2 other studies available for probenecid and Infections, Orthomyxoviridae
| Article | Year |
|---|---|
Repurposing drugs targeting the P2X7 receptor to limit hyperinflammation and disease during influenza virus infection.
Topics: Animals; Cells, Cultured; Drug Repositioning; Female; Inflammasomes; Inflammation; Male; Mice; Mice, | 2019 |
Targeting organic anion transporter 3 with probenecid as a novel anti-influenza a virus strategy.
Topics: Antiviral Agents; Cell Line; Drug Repositioning; Gene Expression; High-Throughput Screening Assays; | 2013 |