probenecid has been researched along with Hypokalemia in 3 studies
Probenecid: The prototypical uricosuric agent. It inhibits the renal excretion of organic anions and reduces tubular reabsorption of urate. Probenecid has also been used to treat patients with renal impairment, and, because it reduces the renal tubular excretion of other drugs, has been used as an adjunct to antibacterial therapy.
probenecid : A sulfonamide in which the nitrogen of 4-sulfamoylbenzoic acid is substituted with two propyl groups.
Hypokalemia: Abnormally low potassium concentration in the blood. It may result from potassium loss by renal secretion or by the gastrointestinal route, as by vomiting or diarrhea. It may be manifested clinically by neuromuscular disorders ranging from weakness to paralysis, by electrocardiographic abnormalities (depression of the T wave and elevation of the U wave), by renal disease, and by gastrointestinal disorders. (Dorland, 27th ed)
| Excerpt | Relevance | Reference |
|---|---|---|
| "Probenecid has been suggested as a prophylactic treatment of penicillin-induced hypokalemia, the proposed mechanism being that penicillin will be prevented from acting as a nonreabsorbable anion binding potassium and resulting in increased urinary losses." | 7.66 | Use of probenecid in ticarcillin-induced hypokalemia. ( Mittal, VK; Pierce, AK; Priestley, JC, 1980) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 3 (100.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Mittal, VK | 1 |
| Pierce, AK | 1 |
| Priestley, JC | 1 |
| Caranasos, GJ | 1 |
| Stewart, RB | 1 |
| Cluff, LE | 1 |
| Carroll, KF | 1 |
| Long, FL | 1 |
| Smith, RB | 1 |
1 review available for probenecid and Hypokalemia
| Article | Year |
|---|---|
Clinically desirable drug interactions.
Topics: Aminoglycosides; Amoxicillin; Ampicillin; Antacids; Anti-Bacterial Agents; Anti-Infective Agents; Ba | 1985 |
2 other studies available for probenecid and Hypokalemia
| Article | Year |
|---|---|
Use of probenecid in ticarcillin-induced hypokalemia.
Topics: Child; Humans; Hypokalemia; Male; Penicillins; Probenecid; Ticarcillin | 1980 |
Complications in a patient with subacute bacterial endocarditis with particular reference to massive penicillin therapy.
Topics: Blood Protein Electrophoresis; Calcinosis; Embolism; Endocarditis, Subacute Bacterial; Femoral Arter | 1969 |