probenecid has been researched along with Glycosuria in 8 studies
Probenecid: The prototypical uricosuric agent. It inhibits the renal excretion of organic anions and reduces tubular reabsorption of urate. Probenecid has also been used to treat patients with renal impairment, and, because it reduces the renal tubular excretion of other drugs, has been used as an adjunct to antibacterial therapy.
probenecid : A sulfonamide in which the nitrogen of 4-sulfamoylbenzoic acid is substituted with two propyl groups.
Glycosuria: The appearance of an abnormally large amount of GLUCOSE in the urine, such as more than 500 mg/day in adults. It can be due to HYPERGLYCEMIA or genetic defects in renal reabsorption (RENAL GLYCOSURIA).
| Excerpt | Relevance | Reference |
|---|---|---|
| " Studies with [35S]-PAP-GSH at 40 mumol kg-1 showed selective retention of radioactivity in the kidney, relative to other organs 24 h after dosing and that some radioactivity was covalently bound to renal proteins." | 1.29 | Nephrotoxicity of 4-amino-3-S-glutathionylphenol and its modulation by metabolism or transport inhibitors. ( Foster, JR; Fowler, LM; Lock, EA, 1994) |
| "Pretreatment with probenecid (240 mg kg-1 body weight) potentiated the hyperglycaemic effect of frusemide (25 or 200 mg kg-1 body weight)." | 1.27 | Probenecid potentiates the hyperglycaemic effect but reduces the diuretic effect of frusemide in mice. ( Sandström, PE, 1986) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 6 (75.00) | 18.7374 |
| 1990's | 2 (25.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Fowler, LM | 1 |
| Foster, JR | 1 |
| Lock, EA | 1 |
| Diamond, HS | 1 |
| Meisel, AD | 1 |
| Chakrabarti, S | 1 |
| Malick, MA | 1 |
| Elfarra, AA | 2 |
| Jakobson, I | 1 |
| Anders, MW | 2 |
| Sandström, PE | 1 |
| Baggs, RB | 1 |
| Silverman, M | 1 |
| Aganon, MA | 1 |
| Chinard, FP | 1 |
| Huang, KC | 1 |
| Woosley, RL | 1 |
8 other studies available for probenecid and Glycosuria
| Article | Year |
|---|---|
Nephrotoxicity of 4-amino-3-S-glutathionylphenol and its modulation by metabolism or transport inhibitors.
Topics: Aminooxyacetic Acid; Animals; Ascorbic Acid; Blood Urea Nitrogen; gamma-Glutamyltransferase; Glutath | 1994 |
Renal tubular transport of urate in Fanconi syndrome.
Topics: Amino Acids; Biological Transport; Fanconi Syndrome; Female; Glomerular Filtration Rate; Glycosuria; | 1977 |
In vivo nephrotoxic action of an isomeric mixture of S-(1-phenyl-2-hydroxyethyl)glutathione and S-(2-phenyl-2-hydroxyethyl)glutathione in Fischer-344 rats.
Topics: Acetylglucosaminidase; Aminooxyacetic Acid; Animals; Antimetabolites; Butyrates; Dipeptides; gamma-G | 1991 |
Mechanism of S-(1,2-dichlorovinyl)glutathione-induced nephrotoxicity.
Topics: Aminooxyacetic Acid; Animals; Blood Urea Nitrogen; Carbon-Sulfur Lyases; Cysteine; gamma-Glutamyltra | 1986 |
Probenecid potentiates the hyperglycaemic effect but reduces the diuretic effect of frusemide in mice.
Topics: Animals; Blood Glucose; Body Weight; Diuretics; Drug Synergism; Female; Furosemide; Glycosuria; Hype | 1986 |
Structure-nephrotoxicity relationships of S-(2-chloroethyl)-DL-cysteine and analogs: role for an episulfonium ion.
Topics: Acute Kidney Injury; Alanine Transaminase; Animals; Blood Urea Nitrogen; Cysteine; Glycosuria; Ions; | 1985 |
D-glucose interactions with renal tubule cell surfaces.
Topics: Absorption; Animals; Azo Compounds; Biological Transport; Blood Glucose; Carbon Isotopes; Cell Membr | 1970 |
Renal tubular secretion of L-glucose.
Topics: Absorption; Animals; Biological Transport, Active; Blood Glucose; Carbon Isotopes; Dogs; Female; Glo | 1968 |