Page last updated: 2024-11-03

probenecid and Epilepsy

probenecid has been researched along with Epilepsy in 14 studies

Probenecid: The prototypical uricosuric agent. It inhibits the renal excretion of organic anions and reduces tubular reabsorption of urate. Probenecid has also been used to treat patients with renal impairment, and, because it reduces the renal tubular excretion of other drugs, has been used as an adjunct to antibacterial therapy.
probenecid : A sulfonamide in which the nitrogen of 4-sulfamoylbenzoic acid is substituted with two propyl groups.

Epilepsy: A disorder characterized by recurrent episodes of paroxysmal brain dysfunction due to a sudden, disorderly, and excessive neuronal discharge. Epilepsy classification systems are generally based upon: (1) clinical features of the seizure episodes (e.g., motor seizure), (2) etiology (e.g., post-traumatic), (3) anatomic site of seizure origin (e.g., frontal lobe seizure), (4) tendency to spread to other structures in the brain, and (5) temporal patterns (e.g., nocturnal epilepsy). (From Adams et al., Principles of Neurology, 6th ed, p313)

Research Excerpts

ExcerptRelevanceReference
"Cerebrospinal fluid (CSF) concentrations of 5-hydroxyindoleacetic acid (5-HIAA), homovanillic acid (HVA) and probenecid were examined in 14 children with epilepsy (ages 6 months to 17 years) and 17 controls (ages 14 months to 16 years)."7.65Reduced cerebrospinal fluid 5-hydroxyindoleacetic acid and homovanillic acid in children with epilepsy. ( Bowers, MB; Cohen, DJ; Shaywitz, BA, 1975)
"Maturation of monoamine neuronal systems was studied by measuring cerebrospinal fluid metabolites of dopamine (homovanillic acid) and serotonin (5-hydroxyindoleacetic acid) in 38 children with epilepsy and other neurological disorders, to whom probenecid had previously been administered."3.66Ontogeny of dopamine and serotonin metabolites in the cerebrospinal fluid of children with neurological disorders. ( Bowers, MB; Cohen, DJ; Leckman, JF; Shaywitz, BA; Young, JG, 1980)
"Cerebrospinal fluid (CSF) concentrations of 5-hydroxyindoleacetic acid (5-HIAA), homovanillic acid (HVA) and probenecid were examined in 14 children with epilepsy (ages 6 months to 17 years) and 17 controls (ages 14 months to 16 years)."3.65Reduced cerebrospinal fluid 5-hydroxyindoleacetic acid and homovanillic acid in children with epilepsy. ( Bowers, MB; Cohen, DJ; Shaywitz, BA, 1975)
"Transient hyperkinesia was observed in a 16-year-old epileptic and mentally retarded patient after a single intravenous perfusion of diphenylhydantoin (DPH)."1.26Transient hyperkinesia after a single intravenous perfusion of diphenylhydantoin. Report of a case associated with nontoxic plasma levels of diphenylhydantoin. ( Courjon, J; Dalery, J; de Villard, R; Mauguière, F, 1979)

Research

Studies (14)

TimeframeStudies, this research(%)All Research%
pre-19908 (57.14)18.7374
1990's1 (7.14)18.2507
2000's3 (21.43)29.6817
2010's2 (14.29)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Dossi, E1
Blauwblomme, T1
Moulard, J1
Chever, O1
Vasile, F1
Guinard, E1
Le Bert, M1
Couillin, I1
Pallud, J1
Capelle, L1
Huberfeld, G1
Rouach, N1
Kovács, R1
Raue, C1
Gabriel, S1
Heinemann, U1
RIZZUTO, VJ1
INGLESBY, TV1
GRACE, WJ1
van Vliet, EA1
Redeker, S1
Aronica, E1
Edelbroek, PM1
Gorter, JA1
Shaywitz, BA3
Cohen, DJ3
Leckman, JF1
Young, JG1
Bowers, MB2
Scism, JL1
Powers, KM1
Artru, AA1
Lewis, L1
Shen, DD1
Potschka, H1
Löscher, W1
Carrieri, P1
Orefice, G1
Mandarini, A1
Rossi, V1
Campanella, G1
Mauguière, F1
Dalery, J1
de Villard, R1
Courjon, J1
Enna, SJ1
Wood, JH1
Snyder, SH1
Abed, WT1
Johnson, WT1
Bowers, M1
Molnár, G1
Fodor, A1
Karczag, I1
Szilágyi, A1
Ujvárosi, I1

Clinical Trials (1)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
[NCT00004325]200 participants Observational1988-12-31Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Other Studies

14 other studies available for probenecid and Epilepsy

ArticleYear
Pannexin-1 channels contribute to seizure generation in human epileptic brain tissue and in a mouse model of epilepsy.
    Science translational medicine, 2018, 05-30, Volume: 10, Issue:443

    Topics: Adenosine Triphosphate; Animals; Brain; Cerebral Cortex; Connexins; Disease Models, Animal; Epilepsy

2018
Functional test of multidrug transporter activity in hippocampal-neocortical brain slices from epileptic patients.
    Journal of neuroscience methods, 2011, Sep-15, Volume: 200, Issue:2

    Topics: Adjuvants, Pharmaceutic; Anticonvulsants; ATP Binding Cassette Transporter, Subfamily B, Member 1; E

2011
PROBENECID (BENEMID) INTOXICATION WITH STATUS EPILEPTICUS.
    The American journal of medicine, 1965, Volume: 38

    Topics: Coma; Drug Therapy; Epilepsy; Gout; Phenobarbital; Phenytoin; Poisoning; Probenecid; Status Epilepti

1965
Expression of multidrug transporters MRP1, MRP2, and BCRP shortly after status epilepticus, during the latent period, and in chronic epileptic rats.
    Epilepsia, 2005, Volume: 46, Issue:10

    Topics: Animals; Anticonvulsants; ATP Binding Cassette Transporter, Subfamily G, Member 2; ATP-Binding Casse

2005
Ontogeny of dopamine and serotonin metabolites in the cerebrospinal fluid of children with neurological disorders.
    Developmental medicine and child neurology, 1980, Volume: 22, Issue:6

    Topics: Adolescent; Child; Child, Preschool; Dopamine; Epilepsy; Female; Homovanillic Acid; Humans; Hydroxyi

1980
Probenecid-inhibitable efflux transport of valproic acid in the brain parenchymal cells of rabbits: a microdialysis study.
    Brain research, 2000, Nov-24, Volume: 884, Issue:1--2

    Topics: Animals; Biological Transport, Active; Blood-Brain Barrier; Brain; Carrier Proteins; Cell Membrane;

2000
Multidrug resistance-associated protein is involved in the regulation of extracellular levels of phenytoin in the brain.
    Neuroreport, 2001, Aug-08, Volume: 12, Issue:11

    Topics: Animals; Anticonvulsants; ATP-Binding Cassette Transporters; Blood-Brain Barrier; Brain; Drug Resist

2001
[Determination of HVA and 5-HIAA in epileptic syndromes in basal conditions and after treatment with probenecid].
    Acta neurologica. Quaderni, 1979, Volume: 39

    Topics: Adolescent; Adult; Anticonvulsants; Brain; Dopamine; Epilepsy; Homovanillic Acid; Humans; Hydroxyind

1979
Transient hyperkinesia after a single intravenous perfusion of diphenylhydantoin. Report of a case associated with nontoxic plasma levels of diphenylhydantoin.
    European neurology, 1979, Volume: 18, Issue:2

    Topics: Adolescent; Epilepsy; Homovanillic Acid; Humans; Hydroxyindoleacetic Acid; Hyperkinesis; Infusions,

1979
Reduced cerebrospinal fluid 5-hydroxyindoleacetic acid and homovanillic acid in children with epilepsy.
    Neurology, 1975, Volume: 25, Issue:1

    Topics: Acetazolamide; Adolescent; Age Factors; Child; Child, Preschool; Drug Therapy, Combination; Epilepsy

1975
gamma-Aminobutyric acid (GABA) in human cerebrospinal fluid: radioreceptor assay.
    Journal of neurochemistry, 1977, Volume: 28, Issue:5

    Topics: Adolescent; Adult; Aged; Aminobutyrates; Animals; Epilepsy; Female; gamma-Aminobutyric Acid; Hot Tem

1977
Anticonvulsant activity of di-n-propylacetate and brain monoamine metabolism in the rat.
    Clinical and experimental pharmacology & physiology, 1990, Volume: 17, Issue:1

    Topics: Animals; Biogenic Monoamines; Brain; Catecholamines; Epilepsy; Female; gamma-Aminobutyric Acid; Homo

1990
Biogenic amines in autistic and atypical children. Cerebrospinal fluid measures of homovanillic acid and 5-hydroxyindoleacetic acid.
    Archives of general psychiatry, 1974, Volume: 31, Issue:6

    Topics: Autistic Disorder; Brain; Child; Child, Preschool; Diagnosis, Differential; Dopamine; Electroencepha

1974
5-Hydroxyindoleacetic acid in cerebrospinal fluid.
    Acta medica Academiae Scientiarum Hungaricae, 1973, Volume: 30, Issue:3

    Topics: Adult; Age Factors; Brain Diseases; Brain Stem; Depression; Epilepsy; Humans; Hydroxyindoleacetic Ac

1973