probenecid has been researched along with Epilepsy in 14 studies
Probenecid: The prototypical uricosuric agent. It inhibits the renal excretion of organic anions and reduces tubular reabsorption of urate. Probenecid has also been used to treat patients with renal impairment, and, because it reduces the renal tubular excretion of other drugs, has been used as an adjunct to antibacterial therapy.
probenecid : A sulfonamide in which the nitrogen of 4-sulfamoylbenzoic acid is substituted with two propyl groups.
Epilepsy: A disorder characterized by recurrent episodes of paroxysmal brain dysfunction due to a sudden, disorderly, and excessive neuronal discharge. Epilepsy classification systems are generally based upon: (1) clinical features of the seizure episodes (e.g., motor seizure), (2) etiology (e.g., post-traumatic), (3) anatomic site of seizure origin (e.g., frontal lobe seizure), (4) tendency to spread to other structures in the brain, and (5) temporal patterns (e.g., nocturnal epilepsy). (From Adams et al., Principles of Neurology, 6th ed, p313)
| Excerpt | Relevance | Reference |
|---|---|---|
| "Cerebrospinal fluid (CSF) concentrations of 5-hydroxyindoleacetic acid (5-HIAA), homovanillic acid (HVA) and probenecid were examined in 14 children with epilepsy (ages 6 months to 17 years) and 17 controls (ages 14 months to 16 years)." | 7.65 | Reduced cerebrospinal fluid 5-hydroxyindoleacetic acid and homovanillic acid in children with epilepsy. ( Bowers, MB; Cohen, DJ; Shaywitz, BA, 1975) |
| "Maturation of monoamine neuronal systems was studied by measuring cerebrospinal fluid metabolites of dopamine (homovanillic acid) and serotonin (5-hydroxyindoleacetic acid) in 38 children with epilepsy and other neurological disorders, to whom probenecid had previously been administered." | 3.66 | Ontogeny of dopamine and serotonin metabolites in the cerebrospinal fluid of children with neurological disorders. ( Bowers, MB; Cohen, DJ; Leckman, JF; Shaywitz, BA; Young, JG, 1980) |
| "Cerebrospinal fluid (CSF) concentrations of 5-hydroxyindoleacetic acid (5-HIAA), homovanillic acid (HVA) and probenecid were examined in 14 children with epilepsy (ages 6 months to 17 years) and 17 controls (ages 14 months to 16 years)." | 3.65 | Reduced cerebrospinal fluid 5-hydroxyindoleacetic acid and homovanillic acid in children with epilepsy. ( Bowers, MB; Cohen, DJ; Shaywitz, BA, 1975) |
| "Transient hyperkinesia was observed in a 16-year-old epileptic and mentally retarded patient after a single intravenous perfusion of diphenylhydantoin (DPH)." | 1.26 | Transient hyperkinesia after a single intravenous perfusion of diphenylhydantoin. Report of a case associated with nontoxic plasma levels of diphenylhydantoin. ( Courjon, J; Dalery, J; de Villard, R; Mauguière, F, 1979) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 8 (57.14) | 18.7374 |
| 1990's | 1 (7.14) | 18.2507 |
| 2000's | 3 (21.43) | 29.6817 |
| 2010's | 2 (14.29) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Dossi, E | 1 |
| Blauwblomme, T | 1 |
| Moulard, J | 1 |
| Chever, O | 1 |
| Vasile, F | 1 |
| Guinard, E | 1 |
| Le Bert, M | 1 |
| Couillin, I | 1 |
| Pallud, J | 1 |
| Capelle, L | 1 |
| Huberfeld, G | 1 |
| Rouach, N | 1 |
| Kovács, R | 1 |
| Raue, C | 1 |
| Gabriel, S | 1 |
| Heinemann, U | 1 |
| RIZZUTO, VJ | 1 |
| INGLESBY, TV | 1 |
| GRACE, WJ | 1 |
| van Vliet, EA | 1 |
| Redeker, S | 1 |
| Aronica, E | 1 |
| Edelbroek, PM | 1 |
| Gorter, JA | 1 |
| Shaywitz, BA | 3 |
| Cohen, DJ | 3 |
| Leckman, JF | 1 |
| Young, JG | 1 |
| Bowers, MB | 2 |
| Scism, JL | 1 |
| Powers, KM | 1 |
| Artru, AA | 1 |
| Lewis, L | 1 |
| Shen, DD | 1 |
| Potschka, H | 1 |
| Löscher, W | 1 |
| Carrieri, P | 1 |
| Orefice, G | 1 |
| Mandarini, A | 1 |
| Rossi, V | 1 |
| Campanella, G | 1 |
| Mauguière, F | 1 |
| Dalery, J | 1 |
| de Villard, R | 1 |
| Courjon, J | 1 |
| Enna, SJ | 1 |
| Wood, JH | 1 |
| Snyder, SH | 1 |
| Abed, WT | 1 |
| Johnson, WT | 1 |
| Bowers, M | 1 |
| Molnár, G | 1 |
| Fodor, A | 1 |
| Karczag, I | 1 |
| Szilágyi, A | 1 |
| Ujvárosi, I | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| [NCT00004325] | 200 participants | Observational | 1988-12-31 | Completed | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
14 other studies available for probenecid and Epilepsy
| Article | Year |
|---|---|
Pannexin-1 channels contribute to seizure generation in human epileptic brain tissue and in a mouse model of epilepsy.
Topics: Adenosine Triphosphate; Animals; Brain; Cerebral Cortex; Connexins; Disease Models, Animal; Epilepsy | 2018 |
Functional test of multidrug transporter activity in hippocampal-neocortical brain slices from epileptic patients.
Topics: Adjuvants, Pharmaceutic; Anticonvulsants; ATP Binding Cassette Transporter, Subfamily B, Member 1; E | 2011 |
PROBENECID (BENEMID) INTOXICATION WITH STATUS EPILEPTICUS.
Topics: Coma; Drug Therapy; Epilepsy; Gout; Phenobarbital; Phenytoin; Poisoning; Probenecid; Status Epilepti | 1965 |
Expression of multidrug transporters MRP1, MRP2, and BCRP shortly after status epilepticus, during the latent period, and in chronic epileptic rats.
Topics: Animals; Anticonvulsants; ATP Binding Cassette Transporter, Subfamily G, Member 2; ATP-Binding Casse | 2005 |
Ontogeny of dopamine and serotonin metabolites in the cerebrospinal fluid of children with neurological disorders.
Topics: Adolescent; Child; Child, Preschool; Dopamine; Epilepsy; Female; Homovanillic Acid; Humans; Hydroxyi | 1980 |
Probenecid-inhibitable efflux transport of valproic acid in the brain parenchymal cells of rabbits: a microdialysis study.
Topics: Animals; Biological Transport, Active; Blood-Brain Barrier; Brain; Carrier Proteins; Cell Membrane; | 2000 |
Multidrug resistance-associated protein is involved in the regulation of extracellular levels of phenytoin in the brain.
Topics: Animals; Anticonvulsants; ATP-Binding Cassette Transporters; Blood-Brain Barrier; Brain; Drug Resist | 2001 |
[Determination of HVA and 5-HIAA in epileptic syndromes in basal conditions and after treatment with probenecid].
Topics: Adolescent; Adult; Anticonvulsants; Brain; Dopamine; Epilepsy; Homovanillic Acid; Humans; Hydroxyind | 1979 |
Transient hyperkinesia after a single intravenous perfusion of diphenylhydantoin. Report of a case associated with nontoxic plasma levels of diphenylhydantoin.
Topics: Adolescent; Epilepsy; Homovanillic Acid; Humans; Hydroxyindoleacetic Acid; Hyperkinesis; Infusions, | 1979 |
Reduced cerebrospinal fluid 5-hydroxyindoleacetic acid and homovanillic acid in children with epilepsy.
Topics: Acetazolamide; Adolescent; Age Factors; Child; Child, Preschool; Drug Therapy, Combination; Epilepsy | 1975 |
gamma-Aminobutyric acid (GABA) in human cerebrospinal fluid: radioreceptor assay.
Topics: Adolescent; Adult; Aged; Aminobutyrates; Animals; Epilepsy; Female; gamma-Aminobutyric Acid; Hot Tem | 1977 |
Anticonvulsant activity of di-n-propylacetate and brain monoamine metabolism in the rat.
Topics: Animals; Biogenic Monoamines; Brain; Catecholamines; Epilepsy; Female; gamma-Aminobutyric Acid; Homo | 1990 |
Biogenic amines in autistic and atypical children. Cerebrospinal fluid measures of homovanillic acid and 5-hydroxyindoleacetic acid.
Topics: Autistic Disorder; Brain; Child; Child, Preschool; Diagnosis, Differential; Dopamine; Electroencepha | 1974 |
5-Hydroxyindoleacetic acid in cerebrospinal fluid.
Topics: Adult; Age Factors; Brain Diseases; Brain Stem; Depression; Epilepsy; Humans; Hydroxyindoleacetic Ac | 1973 |