probenecid has been researched along with Encephalopathy, Traumatic in 4 studies
Probenecid: The prototypical uricosuric agent. It inhibits the renal excretion of organic anions and reduces tubular reabsorption of urate. Probenecid has also been used to treat patients with renal impairment, and, because it reduces the renal tubular excretion of other drugs, has been used as an adjunct to antibacterial therapy.
probenecid : A sulfonamide in which the nitrogen of 4-sulfamoylbenzoic acid is substituted with two propyl groups.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Probenecid is a classic ATP-binding cassette and solute carrier inhibitor that blocks transport of organic acids, including NAC." | 3.01 | N-Acetylcysteine and Probenecid Adjuvant Therapy for Traumatic Brain Injury. ( Bell, MJ; Clark, RSB; Empey, PE; Kochanek, PM, 2023) |
| " We sought to verify brain exposure of the systemically administered antioxidant N-acetylcysteine (NAC) and the synergistic adjuvant probenecid, and identify adverse effects of this drug combination after severe TBI in children." | 2.84 | Phase I randomized clinical trial of N-acetylcysteine in combination with an adjuvant probenecid for treatment of severe traumatic brain injury in children. ( Au, AK; Bayır, H; Bell, MJ; Clark, RSB; Empey, PE; Horvat, CM; Kochanek, PM; Nolin, TD; Poloyac, SM; Rosario, BL; Wisniewski, SR, 2017) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 3 (75.00) | 24.3611 |
| 2020's | 1 (25.00) | 2.80 |
| Authors | Studies |
|---|---|
| Clark, RSB | 3 |
| Empey, PE | 4 |
| Kochanek, PM | 4 |
| Bell, MJ | 3 |
| Bayır, H | 3 |
| Rosario, BL | 1 |
| Poloyac, SM | 2 |
| Nolin, TD | 1 |
| Au, AK | 1 |
| Horvat, CM | 1 |
| Wisniewski, SR | 1 |
| Hagos, FT | 1 |
| Wang, P | 1 |
| Ma, X | 1 |
| Du, L | 1 |
| Ji, J | 1 |
| Chao, H | 1 |
| Clark, RS | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Overcoming Membrane Transporters to Improve CNS Drug Delivery[NCT01322009] | Phase 1/Phase 2 | 14 participants (Actual) | Interventional | 2011-03-31 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
Antioxidant reserves in CSF and serum will be calculated in both treatment arms and compared. (NCT01322009)
Timeframe: Within 5 days of injury
| Intervention | reactive oxygen species scavenged (Mean) |
|---|---|
| Drug | 751 |
| Placebo | 735 |
"The number of patients experiencing one or more of the following adverse events:~Acute renal failure Anaphylaxis Acute respiratory distress syndrome Intracranial infection/abscess Arrhythmia, atrial Arrhythmia, ventricular Bradycardia Cardiac arrest Catheter positive culture Cerebrospinal fluid leak Decubitis Deep vein thrombosis Diabetes Insipidus Emesis Extraaxial hematoma Gastrointestinal bleed Gastritis Hematuria Hemorrhage, other Hemoperitonium Hemothorax Hepatitis Hydrocephalus Hypotension Hypoxemia Infection, other Intraparenchymal hemorrhage Intraventricular hemorrhage Meningitis/ventriculitis Multiorgan dysfunction syndrome Myocardial ischemia Pancreatitis Pericarditis Peritonitis Pneumothorax Pulmonary edema Pulmonary embolism Respiratory arrest Seizures Sepsis Syndrome of inappropriate antidiuretic hormone Transtentorial herniation Withdrawal of Life Support Other SAE causing re-hospitalization Other SAE" (NCT01322009)
Timeframe: 14 days after drug administration
| Intervention | participants (Number) |
|---|---|
| Drug | 0 |
| Placebo | 2 |
1 review available for probenecid and Encephalopathy, Traumatic
| Article | Year |
|---|---|
N-Acetylcysteine and Probenecid Adjuvant Therapy for Traumatic Brain Injury.
Topics: Acetylcysteine; Blood-Brain Barrier; Brain; Brain Injuries, Traumatic; Child; Humans; Pilot Projects | 2023 |
2 trials available for probenecid and Encephalopathy, Traumatic
| Article | Year |
|---|---|
Phase I randomized clinical trial of N-acetylcysteine in combination with an adjuvant probenecid for treatment of severe traumatic brain injury in children.
Topics: Acetylcysteine; Adjuvants, Pharmaceutic; Adolescent; Antioxidants; Biomarkers; Body Temperature; Bra | 2017 |
Exploratory Application of Neuropharmacometabolomics in Severe Childhood Traumatic Brain Injury.
Topics: Acetylcysteine; Adjuvants, Pharmaceutic; Adolescent; Brain Injuries, Traumatic; Child; Child, Presch | 2018 |
1 other study available for probenecid and Encephalopathy, Traumatic
| Article | Year |
|---|---|
Probenecid and N-Acetylcysteine Prevent Loss of Intracellular Glutathione and Inhibit Neuronal Death after Mechanical Stretch Injury In Vitro.
Topics: Acetylcysteine; Animals; Brain Injuries, Traumatic; Cell Death; Cells, Cultured; Female; Glutathione | 2016 |