probenecid has been researched along with Drug-Related Side Effects and Adverse Reactions in 10 studies
Probenecid: The prototypical uricosuric agent. It inhibits the renal excretion of organic anions and reduces tubular reabsorption of urate. Probenecid has also been used to treat patients with renal impairment, and, because it reduces the renal tubular excretion of other drugs, has been used as an adjunct to antibacterial therapy.
probenecid : A sulfonamide in which the nitrogen of 4-sulfamoylbenzoic acid is substituted with two propyl groups.
Drug-Related Side Effects and Adverse Reactions: Disorders that result from the intended use of PHARMACEUTICAL PREPARATIONS. Included in this heading are a broad variety of chemically-induced adverse conditions due to toxicity, DRUG INTERACTIONS, and metabolic effects of pharmaceuticals.
| Excerpt | Relevance | Reference |
|---|---|---|
| "This is the first randomized controlled trial to demonstrate a high efficacy of amoxicillin-based regimens for treating syphilis in patients with HIV infection, and the non-inferiority of low-dose amoxicillin compared with amoxicillin plus probenecid was not seen." | 9.69 | Combination of Amoxicillin 3000 mg and Probenecid Versus 1500 mg Amoxicillin Monotherapy for Treating Syphilis in Patients With Human Immunodeficiency Virus: An Open-Label, Randomized, Controlled, Non-Inferiority Trial. ( Ando, N; Aoki, T; Gatanaga, H; Hiramoto, S; Inamura, N; Kikuchi, Y; Mizushima, D; Nemoto, T; Oka, S; Omata, K; Shiojiri, D; Takano, M; Tanuma, J; Teruya, K; Uemura, H; Watanabe, K; Yanagawa, Y, 2023) |
| "This is the first randomized controlled trial to demonstrate a high efficacy of amoxicillin-based regimens for treating syphilis in patients with HIV infection, and the non-inferiority of low-dose amoxicillin compared with amoxicillin plus probenecid was not seen." | 5.69 | Combination of Amoxicillin 3000 mg and Probenecid Versus 1500 mg Amoxicillin Monotherapy for Treating Syphilis in Patients With Human Immunodeficiency Virus: An Open-Label, Randomized, Controlled, Non-Inferiority Trial. ( Ando, N; Aoki, T; Gatanaga, H; Hiramoto, S; Inamura, N; Kikuchi, Y; Mizushima, D; Nemoto, T; Oka, S; Omata, K; Shiojiri, D; Takano, M; Tanuma, J; Teruya, K; Uemura, H; Watanabe, K; Yanagawa, Y, 2023) |
| "Nephrotoxicity is a common and often clinically relevant adverse drug reaction." | 1.37 | [Drug-drug interactions and nephrotoxicity]. ( Czock, D; Keller, F, 2011) |
| "5 million adverse drug reaction (ADR) reports for 8620 drugs/biologics that are listed for 1191 Coding Symbols for Thesaurus of Adverse Reaction (COSTAR) terms of adverse effects." | 1.32 | Assessment of the health effects of chemicals in humans: II. Construction of an adverse effects database for QSAR modeling. ( Benz, RD; Contrera, JF; Kruhlak, NL; Matthews, EJ; Weaver, JL, 2004) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 2 (20.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 2 (20.00) | 29.6817 |
| 2010's | 4 (40.00) | 24.3611 |
| 2020's | 2 (20.00) | 2.80 |
| Authors | Studies |
|---|---|
| Matthews, EJ | 1 |
| Kruhlak, NL | 1 |
| Weaver, JL | 1 |
| Benz, RD | 1 |
| Contrera, JF | 1 |
| Pedersen, JM | 1 |
| Matsson, P | 1 |
| Bergström, CA | 1 |
| Norinder, U | 1 |
| Hoogstraate, J | 1 |
| Artursson, P | 1 |
| Dawson, S | 1 |
| Stahl, S | 1 |
| Paul, N | 1 |
| Barber, J | 1 |
| Kenna, JG | 1 |
| Liu, Z | 1 |
| Shi, Q | 1 |
| Ding, D | 1 |
| Kelly, R | 1 |
| Fang, H | 1 |
| Tong, W | 1 |
| Morgan, RE | 1 |
| van Staden, CJ | 1 |
| Chen, Y | 1 |
| Kalyanaraman, N | 1 |
| Kalanzi, J | 1 |
| Dunn, RT | 1 |
| Afshari, CA | 1 |
| Hamadeh, HK | 1 |
| Kalgutkar, AS | 1 |
| Ando, N | 1 |
| Mizushima, D | 1 |
| Omata, K | 1 |
| Nemoto, T | 1 |
| Inamura, N | 1 |
| Hiramoto, S | 1 |
| Takano, M | 1 |
| Aoki, T | 1 |
| Watanabe, K | 1 |
| Uemura, H | 1 |
| Shiojiri, D | 1 |
| Yanagawa, Y | 1 |
| Tanuma, J | 1 |
| Teruya, K | 1 |
| Kikuchi, Y | 1 |
| Gatanaga, H | 1 |
| Oka, S | 1 |
| Czock, D | 1 |
| Keller, F | 1 |
| BURNS, JJ | 1 |
| CUCINELL, SA | 1 |
| KOSTER, R | 1 |
| CONNEY, AH | 1 |
| Chase, TN | 1 |
1 review available for probenecid and Drug-Related Side Effects and Adverse Reactions
| Article | Year |
|---|---|
Drug-induced extrapyramidal disorders.
Topics: Antiparkinson Agents; Apomorphine; Basal Ganglia Diseases; Benztropine; Dihydroxyphenylalanine; Dopa | 1972 |
1 trial available for probenecid and Drug-Related Side Effects and Adverse Reactions
| Article | Year |
|---|---|
Combination of Amoxicillin 3000 mg and Probenecid Versus 1500 mg Amoxicillin Monotherapy for Treating Syphilis in Patients With Human Immunodeficiency Virus: An Open-Label, Randomized, Controlled, Non-Inferiority Trial.
Topics: Amoxicillin; Anti-Bacterial Agents; Drug-Related Side Effects and Adverse Reactions; HIV; HIV Infect | 2023 |
8 other studies available for probenecid and Drug-Related Side Effects and Adverse Reactions
| Article | Year |
|---|---|
Assessment of the health effects of chemicals in humans: II. Construction of an adverse effects database for QSAR modeling.
Topics: Adverse Drug Reaction Reporting Systems; Artificial Intelligence; Computers; Databases, Factual; Dru | 2004 |
Prediction and identification of drug interactions with the human ATP-binding cassette transporter multidrug-resistance associated protein 2 (MRP2; ABCC2).
Topics: Administration, Oral; Animals; Antineoplastic Agents; Antipsychotic Agents; Antiviral Agents; ATP Bi | 2008 |
In vitro inhibition of the bile salt export pump correlates with risk of cholestatic drug-induced liver injury in humans.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters | 2012 |
Translating clinical findings into knowledge in drug safety evaluation--drug induced liver injury prediction system (DILIps).
Topics: Animals; Anti-Infective Agents; Anti-Inflammatory Agents; Chemical and Drug Induced Liver Injury; Da | 2011 |
A multifactorial approach to hepatobiliary transporter assessment enables improved therapeutic compound development.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily | 2013 |
Designing around Structural Alerts in Drug Discovery.
Topics: Drug Design; Drug Development; Drug Discovery; Drug-Related Side Effects and Adverse Reactions; Huma | 2020 |
[Drug-drug interactions and nephrotoxicity].
Topics: Aminoglycosides; Analgesics; Anti-Bacterial Agents; Anti-HIV Agents; Antineoplastic Agents; Antirheu | 2011 |
APPLICATION OF DRUG METABOLISM TO DRUG TOXICITY STUDIES.
Topics: Aspirin; Blood; Chromatography; Dicumarol; Diphenhydramine; Dogs; Drug-Related Side Effects and Adve | 1965 |