probenecid has been researched along with Depressive Disorder in 12 studies
Probenecid: The prototypical uricosuric agent. It inhibits the renal excretion of organic anions and reduces tubular reabsorption of urate. Probenecid has also been used to treat patients with renal impairment, and, because it reduces the renal tubular excretion of other drugs, has been used as an adjunct to antibacterial therapy.
probenecid : A sulfonamide in which the nitrogen of 4-sulfamoylbenzoic acid is substituted with two propyl groups.
Depressive Disorder: An affective disorder manifested by either a dysphoric mood or loss of interest or pleasure in usual activities. The mood disturbance is prominent and relatively persistent.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Probenecid was administered to 7 unipolar depressed patients, 7 parkinsonians and 7 extrapyramidal patients with senile dementia matched for age and sex." | 3.66 | Biogenic amine disturbances in cerebrospinal fluid in parkinsonism and unipolar depression: use of the probenecid method. ( Mendlewicz, J; Noel, G; Vanderheyden, JE, 1981) |
| "Probenecid was administered to 7 unipolar depressed patients, 7 parkinsonians and 7 extrapyramidal patients with senile dementia matched for age and sex." | 1.26 | Serotonin and dopamine disturbances in patients with unipolar depression and Parkinsonism. ( Mendlewicz, J; Noel, G; Vanderheyden, JE, 1981) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 10 (83.33) | 18.7374 |
| 1990's | 2 (16.67) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| van Praag, HM | 1 |
| de Haan, S | 1 |
| Vanderheyden, JE | 2 |
| Noel, G | 2 |
| Mendlewicz, J | 2 |
| Davis, KL | 1 |
| Hollister, LE | 1 |
| Mathé, AA | 1 |
| Davis, BM | 1 |
| Rothpearl, AB | 1 |
| Faull, KF | 3 |
| Hsieh, JY | 1 |
| Barchas, JD | 2 |
| Berger, PA | 2 |
| Benson, KL | 1 |
| Zarcone, VP | 1 |
| Korf, J | 1 |
| van den Burg, W | 1 |
| van den Hoofdakker, RH | 1 |
| Goodwin, FK | 2 |
| Post, RM | 3 |
| Cowdry, RW | 1 |
| Ebert, MH | 1 |
| van Kammen, DP | 1 |
| Asberg, M | 1 |
| Bertilsson, L | 1 |
| Mårtensson, B | 1 |
| Reddy, PL | 1 |
| Khanna, S | 1 |
| Subhash, MN | 1 |
| Channabasavanna, SM | 1 |
| Rao, BS | 1 |
| Jibson, M | 1 |
| Csernansky, JG | 1 |
| Rubinow, DR | 1 |
| Uhde, TW | 1 |
| Ballenger, JC | 1 |
| Linnoila, M | 1 |
2 reviews available for probenecid and Depressive Disorder
| Article | Year |
|---|---|
Cerebrospinal fluid probenecid studies: a reinterpretation.
Topics: Biological Transport; Brain; Depressive Disorder; Dopamine; Homovanillic Acid; Humans; Hydroxyindole | 1983 |
CSF monoamine metabolites, depression, and suicide.
Topics: Aggression; Analysis of Variance; Biogenic Amines; Depressive Disorder; Dexamethasone; Homicide; Hom | 1984 |
10 other studies available for probenecid and Depressive Disorder
| Article | Year |
|---|---|
Chemoprophylaxis of depressions. An attempt to compare lithium with 5-hydroxytryptophan.
Topics: 5-Hydroxytryptophan; Adult; Depressive Disorder; Female; Humans; Hydroxyindoleacetic Acid; Lithium; | 1981 |
Biogenic amine disturbances in cerebrospinal fluid in parkinsonism and unipolar depression: use of the probenecid method.
Topics: Aged; Dementia; Depressive Disorder; Dopamine; Female; Homovanillic Acid; Humans; Hydroxyindoleaceti | 1981 |
Neuroendocrine and neurochemical measurements in depression.
Topics: Adult; Aged; Bipolar Disorder; Depressive Disorder; Dexamethasone; Glycols; Homovanillic Acid; Human | 1981 |
Serotonin and dopamine disturbances in patients with unipolar depression and Parkinsonism.
Topics: Brain; Depressive Disorder; Dopamine; Female; Homovanillic Acid; Humans; Hydroxyindoleacetic Acid; M | 1981 |
REM sleep eye movement activity and CSF concentrations of 5-hydroxyindoleacetic acid in psychiatric patients.
Topics: Adult; Depressive Disorder; Humans; Hydroxyindoleacetic Acid; Male; Middle Aged; Probenecid; Psychot | 1983 |
Acid metabolites and precursor amino acids of 5-hydroxytryptamine and dopamine in affective and other psychiatric disorders.
Topics: Adjustment Disorders; Adult; Aged; Amino Acids; Bipolar Disorder; Depressive Disorder; Dopamine; Fem | 1983 |
5-hydroxytryptamine and depression: a model for the interaction of normal variance with pathology.
Topics: Aggression; Animals; Autopsy; Biogenic Amines; Depressive Disorder; Humans; Hydroxyindoleacetic Acid | 1983 |
CSF amine metabolites in depression.
Topics: Adult; Chromatography, High Pressure Liquid; Depressive Disorder; Female; Homovanillic Acid; Humans; | 1992 |
Intercorrelations among monoamine metabolite concentrations in human lumbar CSF are not due to a shared acid transport system.
Topics: Acid-Base Equilibrium; Administration, Oral; Blood-Brain Barrier; Depressive Disorder; Dose-Response | 1990 |
Dopaminergic effects of carbamazepine. Relationship to clinical response in affective illness.
Topics: Adult; Animals; Carbamazepine; Depressive Disorder; Dopamine; Female; Homovanillic Acid; Humans; Mal | 1986 |