probenecid and Depression studies

Probenecid: The prototypical uricosuric agent. It inhibits the renal excretion of organic anions and reduces tubular reabsorption of urate. Probenecid has also been used to treat patients with renal impairment, and, because it reduces the renal tubular excretion of other drugs, has been used as an adjunct to antibacterial therapy.
probenecid : A sulfonamide in which the nitrogen of 4-sulfamoylbenzoic acid is substituted with two propyl groups.

Depression: Depressive states usually of moderate intensity in contrast with MAJOR DEPRESSIVE DISORDER present in neurotic and psychotic disorders.

Research Excerpts

Excerpt	Relevance	Reference
"Cerebrospinal fluid 5-hydroxyindoleacetic acid levels were determined in 31 women with unipolar involutional depression using the probenecid technique."	7.65	Correlation of anxiety and related symptoms with cerebrospinal fluid 5-hydroxyindoleacetic acid in depressed women. ( Banki, CM, 1977)
" Interestingly, throughout the last 60 years, there have been a host of apparently unrelated studies using probenecid in the clinical and basic research arena, including its potential use in the diagnosis and treatment of depression and its use to prevent fura-2 leakage in calcium transient studies."	4.88	The history and future of probenecid. ( Koch, SE; Robbins, N; Rubinstein, J; Tranter, M, 2012)
"The authors report cerebrospinal fluid (CSF) concentrations of five monoamine metabolites before and after probenecid administration in normal subjects and patients with depression and schizophrenia."	3.66	CSF monoamine metabolites in depression and schizophrenia. ( Anderson, PJ; Barchas, JD; Berger, PA; Davis, KL; Faull, KF; Kilkowski, J; Kraemer, H, 1980)
"Cerebrospinal fluid 5-hydroxyindoleacetic acid levels were determined in 31 women with unipolar involutional depression using the probenecid technique."	3.65	Correlation of anxiety and related symptoms with cerebrospinal fluid 5-hydroxyindoleacetic acid in depressed women. ( Banki, CM, 1977)
"The probenecid technique was used in study of the central dopamine DA metabolism in patients with depressions, psychotic disorders, and Parkinson's disease."	3.65	Dopamine metabolism in depressions, psychoses, and Parkinson's disease: the problem of the specificity of biological variables in behaviour disorders. ( Korf, J; Praag, HM; Schut, T, 1975)

Timeframe	Studies, this research(%)	All Research%
pre-1990	51 (98.08)	18.7374
1990's	0 (0.00)	18.2507
2000's	0 (0.00)	29.6817
2010's	1 (1.92)	24.3611
2020's	0 (0.00)	2.80

Authors	Studies
Robbins, N	1
Koch, SE	1
Tranter, M	1
Rubinstein, J	1
van Praag, HM	13
de Haan, S	1
Goodnick, PJ	2
Perel, JM	1
Dunner, DL	7
Fieve, RR	4
Berger, PA	1
Faull, KF	1
Kilkowski, J	1
Anderson, PJ	1
Kraemer, H	1
Davis, KL	1
Barchas, JD	1
Evans, HE	1
Moussaoui, D	1
Post, RM	9
Cramer, H	1
Goodwin, FK	12
Bowers, MB	9
Moore, D	1
Tarsy, D	1
Study, RE	1
Van Scheyen, JD	1
Korf, J	10
Heninger, GR	1
Barkai, AI	1
Gross, HA	2
Mayo, P	1
Lake, CR	1
Jimerson, DC	2
Bunney, WE	2
Wood, JH	1
Ziegler, MG	1
Lerner, P	1
van Kammen, DP	2
Major, LF	1
Ballenger, JC	1
Lovenberg, W	1
Lafleur, D	1
Meltzer, HL	1
Banki, CM	1
Smith, CC	1
Tallman, JF	1
Brown, GL	1
Jori, A	1
Dolfini, E	1
Casati, C	1
Argenta, G	1
Mendels, J	1
Frazer, A	1
Praag, HM	1
Schut, T	2
Gordon, EK	2
Oliver, J	1
Véron, JP	1
Mérienne, L	1
Kupfer, DJ	3
Foster, FG	2
Bowers, M	1
Weiss, BL	1
Delgado, J	1
Dols, LC	1
Murphy, DL	1
Baker, M	1
Miller, H	1
Kotin, J	1
Sack, RL	1
Molnár, G	1
Fodor, A	1
Karczag, I	1
Szilágyi, A	1
Ujvárosi, I	1
Gershon, ES	1
Puite, J	1
Nordin, G	1
Ottosson, JO	1
Roos, BE	1

Trial			Phase	Enrollment	Study Type	Start Date	Status
Novel Use of Probenecid to Alleviate Symptoms of Opioid Withdrawal in People With Chronic Pain Undergoing Voluntary Opioid Tapering: a Pilot Study[NCT04939623]			Phase 2	40 participants (Anticipated)	Interventional	2023-10-31	Recruiting
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Article	Year
The history and future of probenecid. Cardiovascular toxicology, 2012, Volume: 12, Issue:1 Topics: Animals; Anti-Bacterial Agents; Depression; Fura-2; Gout; Humans; Probenecid; TRPV Cation Channels;	2012
Central serotonin deficiency--a factor which increases depression vulnerability? Acta psychiatrica Scandinavica. Supplementum, 1980, Volume: 280 Topics: 5-Hydroxytryptophan; Adult; Biogenic Amines; Brain Chemistry; Clomipramine; Depression; Female; Huma	1980
[Biochemistry of depression. Literature analysis]. L'Encephale, 1978, Volume: 4, Issue:3 Topics: Adrenal Cortex Hormones; Animals; Antidepressive Agents, Tricyclic; Brain; Depression; Dopamine; Hum	1978
Studies of amine metabolites in affective illness and in schizophrenia: a comparative analysis. Research publications - Association for Research in Nervous and Mental Disease, 1975, Volume: 54 Topics: 3,4-Dihydroxyphenylacetic Acid; Antidepressive Agents, Tricyclic; Bipolar Disorder; Brain; Depressio	1975
Therapy-resistant depressions: biochemical and pharmacological considerations. International journal of psychiatry in medicine, 1975, Volume: 6, Issue:1-2 Topics: Adjustment Disorders; Antidepressive Agents; Brain; Depression; Drug Resistance; Homovanillic Acid;	1975
Central dopamine function in affective illness: evidence from precursors, enzyme inhibitors, and studies of central dopamine turnover. Advances in biochemical psychopharmacology, 1974, Volume: 12, Issue:0 Topics: Adult; Affective Symptoms; Anger; Bipolar Disorder; Central Nervous System; Depression; Diagnosis, D	1974

Article	Year
Tardive dyskinesia: a clinical test of the supersensitivity hypothesis. Psychopharmacology, 1979, Mar-22, Volume: 61, Issue:2 Topics: Adult; Aged; Clinical Trials as Topic; Cyclic AMP; Depression; Dyskinesia, Drug-Induced; Female; Hom	1979
Controlled study comparing nomifensine and clomipramine in unipolar depression, using the probenecid technique. British journal of clinical pharmacology, 1977, Volume: 4Suppl 2 Topics: Adult; Clinical Trials as Topic; Clomipramine; Depression; Dibenzazepines; Double-Blind Method; Fema	1977
Effect of ECT and imipramine treatment on the concentration of 5-hydroxyindoleacetic acid (5HIAA) and homovanillic acid (HVA) in the cerebrospinal fluid of depressed patients. Psychopharmacologia, 1975, Oct-14, Volume: 44, Issue:1 Topics: Adult; Clinical Trials as Topic; Depression; Electroconvulsive Therapy; Female; Homovanillic Acid; H	1975
Estimation of brain amine metabolism in affective illness: cerebrospinal fluid studies utilizing probenecid. Psychotherapy and psychosomatics, 1974, Volume: 23, Issue:1-6 Topics: Bipolar Disorder; Brain; Depression; Dihydroxyphenylalanine; Fenclonine; Homovanillic Acid; Humans;	1974
Effect of L-tryptophan on brain serotonin metabolism in depressed patients. Archives of general psychiatry, 1972, Volume: 26, Issue:4 Topics: Brain; Brain Chemistry; Clinical Trials as Topic; Depression; Evaluation Studies as Topic; Humans; H	1972
A pilot study of the predictive value of the probenecid test in application of 5-hydroxytryptophan as antidepressant. Psychopharmacologia, 1972, Volume: 25, Issue:1 Topics: 5-Hydroxytryptophan; Brain; Clinical Trials as Topic; Depression; Humans; Placebos; Probenecid; Sero	1972
5-Hydroxyindoleacetic acid (5HIAA) and homovanillic acid (HVA) following probenecid in acute psychotic patients treated with phenothiazines. Psychopharmacologia, 1973, Feb-20, Volume: 28, Issue:4 Topics: Clinical Trials as Topic; Depression; Female; Humans; Hydroxyindoleacetic Acid; Male; Phenothiazines	1973
Amitriptyline in man: decreased formation of central 5-hydroxyindoleacetic acid. Clinical pharmacology and therapeutics, 1974, Volume: 15, Issue:2 Topics: Aged; Amitriptyline; Clinical Trials as Topic; Depression; Female; Homovanillic Acid; Humans; Hydrox	1974
L-tryptophan in affective disorders: indoleamine changes and differential clinical effects. Psychopharmacologia, 1974, Jan-09, Volume: 34, Issue:1 Topics: Affective Symptoms; Blood Platelets; Clinical Trials as Topic; Depression; Humans; Hydroxyindoleacet	1974
5-Hydroxytrytophan as an antidepressant. The predictive value of the probenecid test. The Journal of nervous and mental disease, 1974, Volume: 158, Issue:5 Topics: 5-Hydroxytryptophan; Biological Transport; Brain; Brain Chemistry; Clinical Trials as Topic; Depress	1974
Serotonin metabolism in depression: clinical application of the probenecid test. International pharmacopsychiatry, 1974, Volume: 9, Issue:1 Topics: 5-Hydroxytryptophan; Adjustment Disorders; Administration, Oral; Clinical Trials as Topic; Depressio	1974
The intravenous probenecid test: a possible aid in evaluation of the serotonin hypothesis on the pathogenesis of depressions. Psychopharmacologia, 1970, Aug-19, Volume: 18, Issue:1 Topics: Brain; Clinical Trials as Topic; Depression; Humans; Hydroxyindoleacetic Acid; Injections, Intraveno	1970
The effect of L-DOPA treatment on brain serotonin metabolism in depressed patients. Life sciences. Pt. 1: Physiology and pharmacology, 1971, Jul-01, Volume: 10, Issue:13 Topics: Brain; Depression; Dihydroxyphenylalanine; Humans; Hydroxyindoleacetic Acid; Phenylacetates; Placebo	1971

probenecid and Depression

Research Excerpts

Research

Studies (52)

Authors

Clinical Trials (1)

Trial Overview

Reviews

Trials

Other Studies

Article	Year
CSF AMP in primary affective disorder: effects of probenecid and tryptophan. Biological psychiatry, 1980, Volume: 15, Issue:1 Topics: Bipolar Disorder; Cyclic AMP; Depression; Humans; Probenecid; Tryptophan	1980
[Central serotonin metabolism in depression]. Nederlands tijdschrift voor geneeskunde, 1980, Jun-14, Volume: 124, Issue:24 Topics: 5-Hydroxytryptophan; Affect; Brain; Depression; Humans; Longitudinal Studies; Probenecid; Serotonin;	1980
CSF monoamine metabolites in depression and schizophrenia. The American journal of psychiatry, 1980, Volume: 137, Issue:2 Topics: 3,4-Dihydroxyphenylacetic Acid; Depression; Homovanillic Acid; Humans; Hydroxyindoleacetic Acid; Mal	1980
Amino acid concentrations in cerebrospinal fluid: effects of aging, depression, and probenecid. Biological psychiatry, 1980, Volume: 15, Issue:4 Topics: Adult; Aging; Amino Acids; Bipolar Disorder; Depression; Female; Humans; Male; Middle Aged; Probenec	1980
Cyclic AMP in cerebrospinal fluid of manic and depressive patients. Psychological medicine, 1977, Volume: 7, Issue:4 Topics: Administration, Oral; Amitriptyline; Bipolar Disorder; Cyclic AMP; Depression; Humans; Imipramine; L	1977
Cerebrospinal fluid cyclic AMP and acid monoamine metabolites following probenecid: studies in psychiatric patients. Psychopharmacology, 1979, Mar-29, Volume: 62, Issue:1 Topics: Adolescent; Adult; Aged; Biogenic Amines; Chlorpromazine; Cyclic AMP; Depression; Female; Homovanill	1979
Lithium: clinical effects and cerebrospinal fluid acid monoamine metabolites. Communications in psychopharmacology, 1977, Volume: 1, Issue:2 Topics: Adult; Affective Symptoms; Aged; Biogenic Amines; Bipolar Disorder; Depression; Electroencephalograp	1977
Reduced myo-inositol levels in cerebrospinal fluid from patients with affective disorder. Biological psychiatry, 1978, Volume: 13, Issue:1 Topics: Bipolar Disorder; Depression; Fructose; Glucose; Humans; Inositol; Probenecid	1978
Cerebrospinal fluid norepinephrine in affective illness. The American journal of psychiatry, 1978, Volume: 135, Issue:8 Topics: Anxiety; Bipolar Disorder; Depression; Emotions; Female; Humans; Male; Motor Activity; Nervous Syste	1978
Dopamine-beta-hydroxylase in the cerebrospinal fluid of psychiatric patients. Biological psychiatry, 1978, Volume: 13, Issue:6 Topics: Adolescent; Adult; Aged; Alcoholism; Bipolar Disorder; Depression; Dopamine beta-Hydroxylase; Female	1978
Prostaglandin F in patients with primary affective disorder. Biological psychiatry, 1977, Volume: 12, Issue:3 Topics: Adult; Aged; Bipolar Disorder; Depression; Female; Humans; Male; Middle Aged; Probenecid; Prostaglan	1977
Correlation of anxiety and related symptoms with cerebrospinal fluid 5-hydroxyindoleacetic acid in depressed women. Journal of neural transmission, 1977, Volume: 41, Issue:2-3 Topics: Adult; Amitriptyline; Anxiety; Depression; Female; Humans; Hydroxyindoleacetic Acid; Middle Aged; Pr	1977
An examination of baseline and drug-induced levels of cyclic nucleotides in the cerebrospinal fluid of control and psychiatric patients. Life sciences, 1976, Jul-01, Volume: 19, Issue:1 Topics: Adolescent; Adult; Aged; Amitriptyline; Bipolar Disorder; Depression; Humans; Imipramine; Lithium; M	1976
Reduced central serotonergic activity in mania: implications for the relationship between depression and mania. The British journal of psychiatry : the journal of mental science, 1975, Volume: 126 Topics: Bipolar Disorder; Brain; Depression; Disease Models, Animal; Humans; Hydroxyindoleacetic Acid; Hypno	1975
Dopamine metabolism in depressions, psychoses, and Parkinson's disease: the problem of the specificity of biological variables in behaviour disorders. Psychological medicine, 1975, Volume: 5, Issue:2 Topics: Adjustment Disorders; Bipolar Disorder; Brain; Carboxy-Lyases; Depression; Dihydroxyphenylalanine; D	1975
Cerebrospinal fluid amine metabolites in affective illness and schizophrenia: clinical and pharmacological studies. Psychopharmacology communications, 1975, Volume: 1, Issue:6 Topics: Affective Symptoms; Amines; Depression; Homovanillic Acid; Humans; Hydroxyindoleacetic Acid; Imipram	1975
3 -Methoxy- 4 -hydroxyphenylethylene glycol in human cerebrospinal fluid. Clinica chimica acta; international journal of clinical chemistry, 1971, Volume: 35, Issue:1 Topics: Chromatography, Gas; Depression; Dihydroxyphenylalanine; Down Syndrome; Ethers; Glycols; Humans; Hyd	1971
[The probenecid test. Evaluation in clinical medicine of cerebral metabolism of serotonin and dopamine]. La Nouvelle presse medicale, 1972, Feb-19, Volume: 1, Issue:8 Topics: Biological Transport, Active; Brain; Depression; Dopamine; Down Syndrome; Humans; Indoleacetic Acids	1972
Brain serotonin, affective illness, and antidepressant drugs: cerebrospinal fluid studies with probenecid. Advances in biochemical psychopharmacology, 1974, Volume: 11, Issue:0 Topics: Affective Symptoms; Amitriptyline; Antidepressive Agents; Brain; Brain Chemistry; Depression; Fenclo	1974
Selective suppression of REM sleep by probenecid. Brain research, 1972, Jun-08, Volume: 41, Issue:1 Topics: Adult; Depression; Electroencephalography; Female; Humans; Male; Middle Aged; Neurotic Disorders; Pr	1972
REM sleep and central monoamine oxidase inhibition. Psychopharmacologia, 1972, Volume: 27, Issue:3 Topics: Adolescent; Adult; Blood-Brain Barrier; Brain; Depression; Electroencephalography; Female; Humans; H	1972
Cerebrospinal fluid amine metabolites in affective illness: the probenecid technique. The American journal of psychiatry, 1973, Volume: 130, Issue:1 Topics: Affective Symptoms; Biological Transport, Active; Bipolar Disorder; Brain; Brain Chemistry; Depressi	1973
Psychomotor activity, sleep, and biogenic amine metabolites in depression. Biological psychiatry, 1974, Volume: 9, Issue:1 Topics: Adult; Biological Transport, Active; Circadian Rhythm; Depression; Electroencephalography; Electromy	1974
Fluorometric measurement of 5-hydroxyindoleacetic acid (5HIAA) and tryptophan in human CSF: effects of high doses of probenecid. Biological psychiatry, 1974, Volume: 9, Issue:1 Topics: Administration, Oral; Adolescent; Adult; Bipolar Disorder; Brain Chemistry; Depression; Female; Fluo	1974
5-Hydroxyindoleacetic acid in cerebrospinal fluid. Acta medica Academiae Scientiarum Hungaricae, 1973, Volume: 30, Issue:3 Topics: Adult; Age Factors; Brain Diseases; Brain Stem; Depression; Epilepsy; Humans; Hydroxyindoleacetic Ac	1973
Lumbar CSF 5-hydroxyindoleacetic acid and homovanillic acid in affective syndromes. The Journal of nervous and mental disease, 1974, Volume: 158, Issue:5 Topics: Adult; Affective Symptoms; Amitriptyline; Animals; Bipolar Disorder; Brain Chemistry; Cats; Depressi	1974
Toward a biochemical classification of depression. Advances in biochemical psychopharmacology, 1974, Volume: 11, Issue:0 Topics: Antidepressive Agents; Biogenic Amines; Brain; Brain Stem; Depression; Dopamine; Homovanillic Acid;	1974
Cerebrospinal fluid 5-hydroxyindoleacetic acid (5HIAA) and homovanillic acid (HVA) following probenecid in unipolar depressives treated with amitriptyline. Psychopharmacologia, 1972, Volume: 23, Issue:1 Topics: Adult; Age Factors; Amitriptyline; Depression; Female; Humans; Hydroxyindoleacetic Acid; Male; Middl	1972
A pilot study of some kinetic aspects of the metabolism of 5-hydroxytryptamine in depressive patients. Biological psychiatry, 1971, Volume: 3, Issue:2 Topics: Administration, Oral; Biological Transport; Brain; Depression; Female; Humans; Hydroxyindoleacetic A	1971
5-Hydroxyindoleacetic acid levels in the cerebrospinal fluid of depressive patients treated with probenecid. Nature, 1970, Mar-28, Volume: 225, Issue:5239 Topics: Brain; Depression; Humans; Hydroxyindoleacetic Acid; Probenecid; Serotonin	1970
Influence of convulsive therapy on 5-hydroxyindoleacetic acid and homovanillic acid in cerebrospinal fluid in endogenous depression. Psychopharmacologia, 1971, Volume: 20, Issue:4 Topics: Amines; Depression; Electroshock; Humans; Hydroxyindoleacetic Acid; Phenylacetates; Probenecid	1971
Endogenous depressions with and without disturbances in the 5-hydroxytryptamine metabolism: A biochemical classification? Psychopharmacologia, 1971, Volume: 19, Issue:2 Topics: Brain; Depression; Humans; Hydroxyindoleacetic Acid; Probenecid; Serotonin	1971
Retarded depression and the dopamine metabolism. Psychopharmacologia, 1971, Volume: 19, Issue:2 Topics: Brain; Depression; Dopamine; Humans; Motor Activity; Parkinson Disease; Phenylacetates; Probenecid;	1971