Page last updated: 2024-11-03

probenecid and Depression

probenecid has been researched along with Depression in 52 studies

Probenecid: The prototypical uricosuric agent. It inhibits the renal excretion of organic anions and reduces tubular reabsorption of urate. Probenecid has also been used to treat patients with renal impairment, and, because it reduces the renal tubular excretion of other drugs, has been used as an adjunct to antibacterial therapy.
probenecid : A sulfonamide in which the nitrogen of 4-sulfamoylbenzoic acid is substituted with two propyl groups.

Depression: Depressive states usually of moderate intensity in contrast with MAJOR DEPRESSIVE DISORDER present in neurotic and psychotic disorders.

Research Excerpts

ExcerptRelevanceReference
"Cerebrospinal fluid 5-hydroxyindoleacetic acid levels were determined in 31 women with unipolar involutional depression using the probenecid technique."7.65Correlation of anxiety and related symptoms with cerebrospinal fluid 5-hydroxyindoleacetic acid in depressed women. ( Banki, CM, 1977)
" Interestingly, throughout the last 60 years, there have been a host of apparently unrelated studies using probenecid in the clinical and basic research arena, including its potential use in the diagnosis and treatment of depression and its use to prevent fura-2 leakage in calcium transient studies."4.88The history and future of probenecid. ( Koch, SE; Robbins, N; Rubinstein, J; Tranter, M, 2012)
"The authors report cerebrospinal fluid (CSF) concentrations of five monoamine metabolites before and after probenecid administration in normal subjects and patients with depression and schizophrenia."3.66CSF monoamine metabolites in depression and schizophrenia. ( Anderson, PJ; Barchas, JD; Berger, PA; Davis, KL; Faull, KF; Kilkowski, J; Kraemer, H, 1980)
"Cerebrospinal fluid 5-hydroxyindoleacetic acid levels were determined in 31 women with unipolar involutional depression using the probenecid technique."3.65Correlation of anxiety and related symptoms with cerebrospinal fluid 5-hydroxyindoleacetic acid in depressed women. ( Banki, CM, 1977)
"The probenecid technique was used in study of the central dopamine DA metabolism in patients with depressions, psychotic disorders, and Parkinson's disease."3.65Dopamine metabolism in depressions, psychoses, and Parkinson's disease: the problem of the specificity of biological variables in behaviour disorders. ( Korf, J; Praag, HM; Schut, T, 1975)

Research

Studies (52)

TimeframeStudies, this research(%)All Research%
pre-199051 (98.08)18.7374
1990's0 (0.00)18.2507
2000's0 (0.00)29.6817
2010's1 (1.92)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Robbins, N1
Koch, SE1
Tranter, M1
Rubinstein, J1
van Praag, HM13
de Haan, S1
Goodnick, PJ2
Perel, JM1
Dunner, DL7
Fieve, RR4
Berger, PA1
Faull, KF1
Kilkowski, J1
Anderson, PJ1
Kraemer, H1
Davis, KL1
Barchas, JD1
Evans, HE1
Moussaoui, D1
Post, RM9
Cramer, H1
Goodwin, FK12
Bowers, MB9
Moore, D1
Tarsy, D1
Study, RE1
Van Scheyen, JD1
Korf, J10
Heninger, GR1
Barkai, AI1
Gross, HA2
Mayo, P1
Lake, CR1
Jimerson, DC2
Bunney, WE2
Wood, JH1
Ziegler, MG1
Lerner, P1
van Kammen, DP2
Major, LF1
Ballenger, JC1
Lovenberg, W1
Lafleur, D1
Meltzer, HL1
Banki, CM1
Smith, CC1
Tallman, JF1
Brown, GL1
Jori, A1
Dolfini, E1
Casati, C1
Argenta, G1
Mendels, J1
Frazer, A1
Praag, HM1
Schut, T2
Gordon, EK2
Oliver, J1
Véron, JP1
Mérienne, L1
Kupfer, DJ3
Foster, FG2
Bowers, M1
Weiss, BL1
Delgado, J1
Dols, LC1
Murphy, DL1
Baker, M1
Miller, H1
Kotin, J1
Sack, RL1
Molnár, G1
Fodor, A1
Karczag, I1
Szilágyi, A1
Ujvárosi, I1
Gershon, ES1
Puite, J1
Nordin, G1
Ottosson, JO1
Roos, BE1

Clinical Trials (1)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Novel Use of Probenecid to Alleviate Symptoms of Opioid Withdrawal in People With Chronic Pain Undergoing Voluntary Opioid Tapering: a Pilot Study[NCT04939623]Phase 240 participants (Anticipated)Interventional2023-10-31Recruiting
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Reviews

6 reviews available for probenecid and Depression

ArticleYear
The history and future of probenecid.
    Cardiovascular toxicology, 2012, Volume: 12, Issue:1

    Topics: Animals; Anti-Bacterial Agents; Depression; Fura-2; Gout; Humans; Probenecid; TRPV Cation Channels;

2012
Central serotonin deficiency--a factor which increases depression vulnerability?
    Acta psychiatrica Scandinavica. Supplementum, 1980, Volume: 280

    Topics: 5-Hydroxytryptophan; Adult; Biogenic Amines; Brain Chemistry; Clomipramine; Depression; Female; Huma

1980
[Biochemistry of depression. Literature analysis].
    L'Encephale, 1978, Volume: 4, Issue:3

    Topics: Adrenal Cortex Hormones; Animals; Antidepressive Agents, Tricyclic; Brain; Depression; Dopamine; Hum

1978
Studies of amine metabolites in affective illness and in schizophrenia: a comparative analysis.
    Research publications - Association for Research in Nervous and Mental Disease, 1975, Volume: 54

    Topics: 3,4-Dihydroxyphenylacetic Acid; Antidepressive Agents, Tricyclic; Bipolar Disorder; Brain; Depressio

1975
Therapy-resistant depressions: biochemical and pharmacological considerations.
    International journal of psychiatry in medicine, 1975, Volume: 6, Issue:1-2

    Topics: Adjustment Disorders; Antidepressive Agents; Brain; Depression; Drug Resistance; Homovanillic Acid;

1975
Central dopamine function in affective illness: evidence from precursors, enzyme inhibitors, and studies of central dopamine turnover.
    Advances in biochemical psychopharmacology, 1974, Volume: 12, Issue:0

    Topics: Adult; Affective Symptoms; Anger; Bipolar Disorder; Central Nervous System; Depression; Diagnosis, D

1974

Trials

13 trials available for probenecid and Depression

ArticleYear
Tardive dyskinesia: a clinical test of the supersensitivity hypothesis.
    Psychopharmacology, 1979, Mar-22, Volume: 61, Issue:2

    Topics: Adult; Aged; Clinical Trials as Topic; Cyclic AMP; Depression; Dyskinesia, Drug-Induced; Female; Hom

1979
Controlled study comparing nomifensine and clomipramine in unipolar depression, using the probenecid technique.
    British journal of clinical pharmacology, 1977, Volume: 4Suppl 2

    Topics: Adult; Clinical Trials as Topic; Clomipramine; Depression; Dibenzazepines; Double-Blind Method; Fema

1977
Effect of ECT and imipramine treatment on the concentration of 5-hydroxyindoleacetic acid (5HIAA) and homovanillic acid (HVA) in the cerebrospinal fluid of depressed patients.
    Psychopharmacologia, 1975, Oct-14, Volume: 44, Issue:1

    Topics: Adult; Clinical Trials as Topic; Depression; Electroconvulsive Therapy; Female; Homovanillic Acid; H

1975
Estimation of brain amine metabolism in affective illness: cerebrospinal fluid studies utilizing probenecid.
    Psychotherapy and psychosomatics, 1974, Volume: 23, Issue:1-6

    Topics: Bipolar Disorder; Brain; Depression; Dihydroxyphenylalanine; Fenclonine; Homovanillic Acid; Humans;

1974
Effect of L-tryptophan on brain serotonin metabolism in depressed patients.
    Archives of general psychiatry, 1972, Volume: 26, Issue:4

    Topics: Brain; Brain Chemistry; Clinical Trials as Topic; Depression; Evaluation Studies as Topic; Humans; H

1972
A pilot study of the predictive value of the probenecid test in application of 5-hydroxytryptophan as antidepressant.
    Psychopharmacologia, 1972, Volume: 25, Issue:1

    Topics: 5-Hydroxytryptophan; Brain; Clinical Trials as Topic; Depression; Humans; Placebos; Probenecid; Sero

1972
5-Hydroxyindoleacetic acid (5HIAA) and homovanillic acid (HVA) following probenecid in acute psychotic patients treated with phenothiazines.
    Psychopharmacologia, 1973, Feb-20, Volume: 28, Issue:4

    Topics: Clinical Trials as Topic; Depression; Female; Humans; Hydroxyindoleacetic Acid; Male; Phenothiazines

1973
Amitriptyline in man: decreased formation of central 5-hydroxyindoleacetic acid.
    Clinical pharmacology and therapeutics, 1974, Volume: 15, Issue:2

    Topics: Aged; Amitriptyline; Clinical Trials as Topic; Depression; Female; Homovanillic Acid; Humans; Hydrox

1974
L-tryptophan in affective disorders: indoleamine changes and differential clinical effects.
    Psychopharmacologia, 1974, Jan-09, Volume: 34, Issue:1

    Topics: Affective Symptoms; Blood Platelets; Clinical Trials as Topic; Depression; Humans; Hydroxyindoleacet

1974
5-Hydroxytrytophan as an antidepressant. The predictive value of the probenecid test.
    The Journal of nervous and mental disease, 1974, Volume: 158, Issue:5

    Topics: 5-Hydroxytryptophan; Biological Transport; Brain; Brain Chemistry; Clinical Trials as Topic; Depress

1974
Serotonin metabolism in depression: clinical application of the probenecid test.
    International pharmacopsychiatry, 1974, Volume: 9, Issue:1

    Topics: 5-Hydroxytryptophan; Adjustment Disorders; Administration, Oral; Clinical Trials as Topic; Depressio

1974
The intravenous probenecid test: a possible aid in evaluation of the serotonin hypothesis on the pathogenesis of depressions.
    Psychopharmacologia, 1970, Aug-19, Volume: 18, Issue:1

    Topics: Brain; Clinical Trials as Topic; Depression; Humans; Hydroxyindoleacetic Acid; Injections, Intraveno

1970
The effect of L-DOPA treatment on brain serotonin metabolism in depressed patients.
    Life sciences. Pt. 1: Physiology and pharmacology, 1971, Jul-01, Volume: 10, Issue:13

    Topics: Brain; Depression; Dihydroxyphenylalanine; Humans; Hydroxyindoleacetic Acid; Phenylacetates; Placebo

1971

Other Studies

33 other studies available for probenecid and Depression

ArticleYear
CSF AMP in primary affective disorder: effects of probenecid and tryptophan.
    Biological psychiatry, 1980, Volume: 15, Issue:1

    Topics: Bipolar Disorder; Cyclic AMP; Depression; Humans; Probenecid; Tryptophan

1980
[Central serotonin metabolism in depression].
    Nederlands tijdschrift voor geneeskunde, 1980, Jun-14, Volume: 124, Issue:24

    Topics: 5-Hydroxytryptophan; Affect; Brain; Depression; Humans; Longitudinal Studies; Probenecid; Serotonin;

1980
CSF monoamine metabolites in depression and schizophrenia.
    The American journal of psychiatry, 1980, Volume: 137, Issue:2

    Topics: 3,4-Dihydroxyphenylacetic Acid; Depression; Homovanillic Acid; Humans; Hydroxyindoleacetic Acid; Mal

1980
Amino acid concentrations in cerebrospinal fluid: effects of aging, depression, and probenecid.
    Biological psychiatry, 1980, Volume: 15, Issue:4

    Topics: Adult; Aging; Amino Acids; Bipolar Disorder; Depression; Female; Humans; Male; Middle Aged; Probenec

1980
Cyclic AMP in cerebrospinal fluid of manic and depressive patients.
    Psychological medicine, 1977, Volume: 7, Issue:4

    Topics: Administration, Oral; Amitriptyline; Bipolar Disorder; Cyclic AMP; Depression; Humans; Imipramine; L

1977
Cerebrospinal fluid cyclic AMP and acid monoamine metabolites following probenecid: studies in psychiatric patients.
    Psychopharmacology, 1979, Mar-29, Volume: 62, Issue:1

    Topics: Adolescent; Adult; Aged; Biogenic Amines; Chlorpromazine; Cyclic AMP; Depression; Female; Homovanill

1979
Lithium: clinical effects and cerebrospinal fluid acid monoamine metabolites.
    Communications in psychopharmacology, 1977, Volume: 1, Issue:2

    Topics: Adult; Affective Symptoms; Aged; Biogenic Amines; Bipolar Disorder; Depression; Electroencephalograp

1977
Reduced myo-inositol levels in cerebrospinal fluid from patients with affective disorder.
    Biological psychiatry, 1978, Volume: 13, Issue:1

    Topics: Bipolar Disorder; Depression; Fructose; Glucose; Humans; Inositol; Probenecid

1978
Cerebrospinal fluid norepinephrine in affective illness.
    The American journal of psychiatry, 1978, Volume: 135, Issue:8

    Topics: Anxiety; Bipolar Disorder; Depression; Emotions; Female; Humans; Male; Motor Activity; Nervous Syste

1978
Dopamine-beta-hydroxylase in the cerebrospinal fluid of psychiatric patients.
    Biological psychiatry, 1978, Volume: 13, Issue:6

    Topics: Adolescent; Adult; Aged; Alcoholism; Bipolar Disorder; Depression; Dopamine beta-Hydroxylase; Female

1978
Prostaglandin F in patients with primary affective disorder.
    Biological psychiatry, 1977, Volume: 12, Issue:3

    Topics: Adult; Aged; Bipolar Disorder; Depression; Female; Humans; Male; Middle Aged; Probenecid; Prostaglan

1977
Correlation of anxiety and related symptoms with cerebrospinal fluid 5-hydroxyindoleacetic acid in depressed women.
    Journal of neural transmission, 1977, Volume: 41, Issue:2-3

    Topics: Adult; Amitriptyline; Anxiety; Depression; Female; Humans; Hydroxyindoleacetic Acid; Middle Aged; Pr

1977
An examination of baseline and drug-induced levels of cyclic nucleotides in the cerebrospinal fluid of control and psychiatric patients.
    Life sciences, 1976, Jul-01, Volume: 19, Issue:1

    Topics: Adolescent; Adult; Aged; Amitriptyline; Bipolar Disorder; Depression; Humans; Imipramine; Lithium; M

1976
Reduced central serotonergic activity in mania: implications for the relationship between depression and mania.
    The British journal of psychiatry : the journal of mental science, 1975, Volume: 126

    Topics: Bipolar Disorder; Brain; Depression; Disease Models, Animal; Humans; Hydroxyindoleacetic Acid; Hypno

1975
Dopamine metabolism in depressions, psychoses, and Parkinson's disease: the problem of the specificity of biological variables in behaviour disorders.
    Psychological medicine, 1975, Volume: 5, Issue:2

    Topics: Adjustment Disorders; Bipolar Disorder; Brain; Carboxy-Lyases; Depression; Dihydroxyphenylalanine; D

1975
Cerebrospinal fluid amine metabolites in affective illness and schizophrenia: clinical and pharmacological studies.
    Psychopharmacology communications, 1975, Volume: 1, Issue:6

    Topics: Affective Symptoms; Amines; Depression; Homovanillic Acid; Humans; Hydroxyindoleacetic Acid; Imipram

1975
3 -Methoxy- 4 -hydroxyphenylethylene glycol in human cerebrospinal fluid.
    Clinica chimica acta; international journal of clinical chemistry, 1971, Volume: 35, Issue:1

    Topics: Chromatography, Gas; Depression; Dihydroxyphenylalanine; Down Syndrome; Ethers; Glycols; Humans; Hyd

1971
[The probenecid test. Evaluation in clinical medicine of cerebral metabolism of serotonin and dopamine].
    La Nouvelle presse medicale, 1972, Feb-19, Volume: 1, Issue:8

    Topics: Biological Transport, Active; Brain; Depression; Dopamine; Down Syndrome; Humans; Indoleacetic Acids

1972
Brain serotonin, affective illness, and antidepressant drugs: cerebrospinal fluid studies with probenecid.
    Advances in biochemical psychopharmacology, 1974, Volume: 11, Issue:0

    Topics: Affective Symptoms; Amitriptyline; Antidepressive Agents; Brain; Brain Chemistry; Depression; Fenclo

1974
Selective suppression of REM sleep by probenecid.
    Brain research, 1972, Jun-08, Volume: 41, Issue:1

    Topics: Adult; Depression; Electroencephalography; Female; Humans; Male; Middle Aged; Neurotic Disorders; Pr

1972
REM sleep and central monoamine oxidase inhibition.
    Psychopharmacologia, 1972, Volume: 27, Issue:3

    Topics: Adolescent; Adult; Blood-Brain Barrier; Brain; Depression; Electroencephalography; Female; Humans; H

1972
Cerebrospinal fluid amine metabolites in affective illness: the probenecid technique.
    The American journal of psychiatry, 1973, Volume: 130, Issue:1

    Topics: Affective Symptoms; Biological Transport, Active; Bipolar Disorder; Brain; Brain Chemistry; Depressi

1973
Psychomotor activity, sleep, and biogenic amine metabolites in depression.
    Biological psychiatry, 1974, Volume: 9, Issue:1

    Topics: Adult; Biological Transport, Active; Circadian Rhythm; Depression; Electroencephalography; Electromy

1974
Fluorometric measurement of 5-hydroxyindoleacetic acid (5HIAA) and tryptophan in human CSF: effects of high doses of probenecid.
    Biological psychiatry, 1974, Volume: 9, Issue:1

    Topics: Administration, Oral; Adolescent; Adult; Bipolar Disorder; Brain Chemistry; Depression; Female; Fluo

1974
5-Hydroxyindoleacetic acid in cerebrospinal fluid.
    Acta medica Academiae Scientiarum Hungaricae, 1973, Volume: 30, Issue:3

    Topics: Adult; Age Factors; Brain Diseases; Brain Stem; Depression; Epilepsy; Humans; Hydroxyindoleacetic Ac

1973
Lumbar CSF 5-hydroxyindoleacetic acid and homovanillic acid in affective syndromes.
    The Journal of nervous and mental disease, 1974, Volume: 158, Issue:5

    Topics: Adult; Affective Symptoms; Amitriptyline; Animals; Bipolar Disorder; Brain Chemistry; Cats; Depressi

1974
Toward a biochemical classification of depression.
    Advances in biochemical psychopharmacology, 1974, Volume: 11, Issue:0

    Topics: Antidepressive Agents; Biogenic Amines; Brain; Brain Stem; Depression; Dopamine; Homovanillic Acid;

1974
Cerebrospinal fluid 5-hydroxyindoleacetic acid (5HIAA) and homovanillic acid (HVA) following probenecid in unipolar depressives treated with amitriptyline.
    Psychopharmacologia, 1972, Volume: 23, Issue:1

    Topics: Adult; Age Factors; Amitriptyline; Depression; Female; Humans; Hydroxyindoleacetic Acid; Male; Middl

1972
A pilot study of some kinetic aspects of the metabolism of 5-hydroxytryptamine in depressive patients.
    Biological psychiatry, 1971, Volume: 3, Issue:2

    Topics: Administration, Oral; Biological Transport; Brain; Depression; Female; Humans; Hydroxyindoleacetic A

1971
5-Hydroxyindoleacetic acid levels in the cerebrospinal fluid of depressive patients treated with probenecid.
    Nature, 1970, Mar-28, Volume: 225, Issue:5239

    Topics: Brain; Depression; Humans; Hydroxyindoleacetic Acid; Probenecid; Serotonin

1970
Influence of convulsive therapy on 5-hydroxyindoleacetic acid and homovanillic acid in cerebrospinal fluid in endogenous depression.
    Psychopharmacologia, 1971, Volume: 20, Issue:4

    Topics: Amines; Depression; Electroshock; Humans; Hydroxyindoleacetic Acid; Phenylacetates; Probenecid

1971
Endogenous depressions with and without disturbances in the 5-hydroxytryptamine metabolism: A biochemical classification?
    Psychopharmacologia, 1971, Volume: 19, Issue:2

    Topics: Brain; Depression; Humans; Hydroxyindoleacetic Acid; Probenecid; Serotonin

1971
Retarded depression and the dopamine metabolism.
    Psychopharmacologia, 1971, Volume: 19, Issue:2

    Topics: Brain; Depression; Dopamine; Humans; Motor Activity; Parkinson Disease; Phenylacetates; Probenecid;

1971