probenecid has been researched along with Depression in 52 studies
Probenecid: The prototypical uricosuric agent. It inhibits the renal excretion of organic anions and reduces tubular reabsorption of urate. Probenecid has also been used to treat patients with renal impairment, and, because it reduces the renal tubular excretion of other drugs, has been used as an adjunct to antibacterial therapy.
probenecid : A sulfonamide in which the nitrogen of 4-sulfamoylbenzoic acid is substituted with two propyl groups.
Depression: Depressive states usually of moderate intensity in contrast with MAJOR DEPRESSIVE DISORDER present in neurotic and psychotic disorders.
Excerpt | Relevance | Reference |
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"Cerebrospinal fluid 5-hydroxyindoleacetic acid levels were determined in 31 women with unipolar involutional depression using the probenecid technique." | 7.65 | Correlation of anxiety and related symptoms with cerebrospinal fluid 5-hydroxyindoleacetic acid in depressed women. ( Banki, CM, 1977) |
" Interestingly, throughout the last 60 years, there have been a host of apparently unrelated studies using probenecid in the clinical and basic research arena, including its potential use in the diagnosis and treatment of depression and its use to prevent fura-2 leakage in calcium transient studies." | 4.88 | The history and future of probenecid. ( Koch, SE; Robbins, N; Rubinstein, J; Tranter, M, 2012) |
"The authors report cerebrospinal fluid (CSF) concentrations of five monoamine metabolites before and after probenecid administration in normal subjects and patients with depression and schizophrenia." | 3.66 | CSF monoamine metabolites in depression and schizophrenia. ( Anderson, PJ; Barchas, JD; Berger, PA; Davis, KL; Faull, KF; Kilkowski, J; Kraemer, H, 1980) |
"Cerebrospinal fluid 5-hydroxyindoleacetic acid levels were determined in 31 women with unipolar involutional depression using the probenecid technique." | 3.65 | Correlation of anxiety and related symptoms with cerebrospinal fluid 5-hydroxyindoleacetic acid in depressed women. ( Banki, CM, 1977) |
"The probenecid technique was used in study of the central dopamine DA metabolism in patients with depressions, psychotic disorders, and Parkinson's disease." | 3.65 | Dopamine metabolism in depressions, psychoses, and Parkinson's disease: the problem of the specificity of biological variables in behaviour disorders. ( Korf, J; Praag, HM; Schut, T, 1975) |
Timeframe | Studies, this research(%) | All Research% |
---|---|---|
pre-1990 | 51 (98.08) | 18.7374 |
1990's | 0 (0.00) | 18.2507 |
2000's | 0 (0.00) | 29.6817 |
2010's | 1 (1.92) | 24.3611 |
2020's | 0 (0.00) | 2.80 |
Authors | Studies |
---|---|
Robbins, N | 1 |
Koch, SE | 1 |
Tranter, M | 1 |
Rubinstein, J | 1 |
van Praag, HM | 13 |
de Haan, S | 1 |
Goodnick, PJ | 2 |
Perel, JM | 1 |
Dunner, DL | 7 |
Fieve, RR | 4 |
Berger, PA | 1 |
Faull, KF | 1 |
Kilkowski, J | 1 |
Anderson, PJ | 1 |
Kraemer, H | 1 |
Davis, KL | 1 |
Barchas, JD | 1 |
Evans, HE | 1 |
Moussaoui, D | 1 |
Post, RM | 9 |
Cramer, H | 1 |
Goodwin, FK | 12 |
Bowers, MB | 9 |
Moore, D | 1 |
Tarsy, D | 1 |
Study, RE | 1 |
Van Scheyen, JD | 1 |
Korf, J | 10 |
Heninger, GR | 1 |
Barkai, AI | 1 |
Gross, HA | 2 |
Mayo, P | 1 |
Lake, CR | 1 |
Jimerson, DC | 2 |
Bunney, WE | 2 |
Wood, JH | 1 |
Ziegler, MG | 1 |
Lerner, P | 1 |
van Kammen, DP | 2 |
Major, LF | 1 |
Ballenger, JC | 1 |
Lovenberg, W | 1 |
Lafleur, D | 1 |
Meltzer, HL | 1 |
Banki, CM | 1 |
Smith, CC | 1 |
Tallman, JF | 1 |
Brown, GL | 1 |
Jori, A | 1 |
Dolfini, E | 1 |
Casati, C | 1 |
Argenta, G | 1 |
Mendels, J | 1 |
Frazer, A | 1 |
Praag, HM | 1 |
Schut, T | 2 |
Gordon, EK | 2 |
Oliver, J | 1 |
Véron, JP | 1 |
Mérienne, L | 1 |
Kupfer, DJ | 3 |
Foster, FG | 2 |
Bowers, M | 1 |
Weiss, BL | 1 |
Delgado, J | 1 |
Dols, LC | 1 |
Murphy, DL | 1 |
Baker, M | 1 |
Miller, H | 1 |
Kotin, J | 1 |
Sack, RL | 1 |
Molnár, G | 1 |
Fodor, A | 1 |
Karczag, I | 1 |
Szilágyi, A | 1 |
Ujvárosi, I | 1 |
Gershon, ES | 1 |
Puite, J | 1 |
Nordin, G | 1 |
Ottosson, JO | 1 |
Roos, BE | 1 |
Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
---|---|---|---|---|---|---|---|
Novel Use of Probenecid to Alleviate Symptoms of Opioid Withdrawal in People With Chronic Pain Undergoing Voluntary Opioid Tapering: a Pilot Study[NCT04939623] | Phase 2 | 40 participants (Anticipated) | Interventional | 2023-10-31 | Recruiting | ||
[information is prepared from clinicaltrials.gov, extracted Sep-2024] |
6 reviews available for probenecid and Depression
Article | Year |
---|---|
The history and future of probenecid.
Topics: Animals; Anti-Bacterial Agents; Depression; Fura-2; Gout; Humans; Probenecid; TRPV Cation Channels; | 2012 |
Central serotonin deficiency--a factor which increases depression vulnerability?
Topics: 5-Hydroxytryptophan; Adult; Biogenic Amines; Brain Chemistry; Clomipramine; Depression; Female; Huma | 1980 |
[Biochemistry of depression. Literature analysis].
Topics: Adrenal Cortex Hormones; Animals; Antidepressive Agents, Tricyclic; Brain; Depression; Dopamine; Hum | 1978 |
Studies of amine metabolites in affective illness and in schizophrenia: a comparative analysis.
Topics: 3,4-Dihydroxyphenylacetic Acid; Antidepressive Agents, Tricyclic; Bipolar Disorder; Brain; Depressio | 1975 |
Therapy-resistant depressions: biochemical and pharmacological considerations.
Topics: Adjustment Disorders; Antidepressive Agents; Brain; Depression; Drug Resistance; Homovanillic Acid; | 1975 |
Central dopamine function in affective illness: evidence from precursors, enzyme inhibitors, and studies of central dopamine turnover.
Topics: Adult; Affective Symptoms; Anger; Bipolar Disorder; Central Nervous System; Depression; Diagnosis, D | 1974 |
13 trials available for probenecid and Depression
Article | Year |
---|---|
Tardive dyskinesia: a clinical test of the supersensitivity hypothesis.
Topics: Adult; Aged; Clinical Trials as Topic; Cyclic AMP; Depression; Dyskinesia, Drug-Induced; Female; Hom | 1979 |
Controlled study comparing nomifensine and clomipramine in unipolar depression, using the probenecid technique.
Topics: Adult; Clinical Trials as Topic; Clomipramine; Depression; Dibenzazepines; Double-Blind Method; Fema | 1977 |
Effect of ECT and imipramine treatment on the concentration of 5-hydroxyindoleacetic acid (5HIAA) and homovanillic acid (HVA) in the cerebrospinal fluid of depressed patients.
Topics: Adult; Clinical Trials as Topic; Depression; Electroconvulsive Therapy; Female; Homovanillic Acid; H | 1975 |
Estimation of brain amine metabolism in affective illness: cerebrospinal fluid studies utilizing probenecid.
Topics: Bipolar Disorder; Brain; Depression; Dihydroxyphenylalanine; Fenclonine; Homovanillic Acid; Humans; | 1974 |
Effect of L-tryptophan on brain serotonin metabolism in depressed patients.
Topics: Brain; Brain Chemistry; Clinical Trials as Topic; Depression; Evaluation Studies as Topic; Humans; H | 1972 |
A pilot study of the predictive value of the probenecid test in application of 5-hydroxytryptophan as antidepressant.
Topics: 5-Hydroxytryptophan; Brain; Clinical Trials as Topic; Depression; Humans; Placebos; Probenecid; Sero | 1972 |
5-Hydroxyindoleacetic acid (5HIAA) and homovanillic acid (HVA) following probenecid in acute psychotic patients treated with phenothiazines.
Topics: Clinical Trials as Topic; Depression; Female; Humans; Hydroxyindoleacetic Acid; Male; Phenothiazines | 1973 |
Amitriptyline in man: decreased formation of central 5-hydroxyindoleacetic acid.
Topics: Aged; Amitriptyline; Clinical Trials as Topic; Depression; Female; Homovanillic Acid; Humans; Hydrox | 1974 |
L-tryptophan in affective disorders: indoleamine changes and differential clinical effects.
Topics: Affective Symptoms; Blood Platelets; Clinical Trials as Topic; Depression; Humans; Hydroxyindoleacet | 1974 |
5-Hydroxytrytophan as an antidepressant. The predictive value of the probenecid test.
Topics: 5-Hydroxytryptophan; Biological Transport; Brain; Brain Chemistry; Clinical Trials as Topic; Depress | 1974 |
Serotonin metabolism in depression: clinical application of the probenecid test.
Topics: 5-Hydroxytryptophan; Adjustment Disorders; Administration, Oral; Clinical Trials as Topic; Depressio | 1974 |
The intravenous probenecid test: a possible aid in evaluation of the serotonin hypothesis on the pathogenesis of depressions.
Topics: Brain; Clinical Trials as Topic; Depression; Humans; Hydroxyindoleacetic Acid; Injections, Intraveno | 1970 |
The effect of L-DOPA treatment on brain serotonin metabolism in depressed patients.
Topics: Brain; Depression; Dihydroxyphenylalanine; Humans; Hydroxyindoleacetic Acid; Phenylacetates; Placebo | 1971 |
33 other studies available for probenecid and Depression
Article | Year |
---|---|
CSF AMP in primary affective disorder: effects of probenecid and tryptophan.
Topics: Bipolar Disorder; Cyclic AMP; Depression; Humans; Probenecid; Tryptophan | 1980 |
[Central serotonin metabolism in depression].
Topics: 5-Hydroxytryptophan; Affect; Brain; Depression; Humans; Longitudinal Studies; Probenecid; Serotonin; | 1980 |
CSF monoamine metabolites in depression and schizophrenia.
Topics: 3,4-Dihydroxyphenylacetic Acid; Depression; Homovanillic Acid; Humans; Hydroxyindoleacetic Acid; Mal | 1980 |
Amino acid concentrations in cerebrospinal fluid: effects of aging, depression, and probenecid.
Topics: Adult; Aging; Amino Acids; Bipolar Disorder; Depression; Female; Humans; Male; Middle Aged; Probenec | 1980 |
Cyclic AMP in cerebrospinal fluid of manic and depressive patients.
Topics: Administration, Oral; Amitriptyline; Bipolar Disorder; Cyclic AMP; Depression; Humans; Imipramine; L | 1977 |
Cerebrospinal fluid cyclic AMP and acid monoamine metabolites following probenecid: studies in psychiatric patients.
Topics: Adolescent; Adult; Aged; Biogenic Amines; Chlorpromazine; Cyclic AMP; Depression; Female; Homovanill | 1979 |
Lithium: clinical effects and cerebrospinal fluid acid monoamine metabolites.
Topics: Adult; Affective Symptoms; Aged; Biogenic Amines; Bipolar Disorder; Depression; Electroencephalograp | 1977 |
Reduced myo-inositol levels in cerebrospinal fluid from patients with affective disorder.
Topics: Bipolar Disorder; Depression; Fructose; Glucose; Humans; Inositol; Probenecid | 1978 |
Cerebrospinal fluid norepinephrine in affective illness.
Topics: Anxiety; Bipolar Disorder; Depression; Emotions; Female; Humans; Male; Motor Activity; Nervous Syste | 1978 |
Dopamine-beta-hydroxylase in the cerebrospinal fluid of psychiatric patients.
Topics: Adolescent; Adult; Aged; Alcoholism; Bipolar Disorder; Depression; Dopamine beta-Hydroxylase; Female | 1978 |
Prostaglandin F in patients with primary affective disorder.
Topics: Adult; Aged; Bipolar Disorder; Depression; Female; Humans; Male; Middle Aged; Probenecid; Prostaglan | 1977 |
Correlation of anxiety and related symptoms with cerebrospinal fluid 5-hydroxyindoleacetic acid in depressed women.
Topics: Adult; Amitriptyline; Anxiety; Depression; Female; Humans; Hydroxyindoleacetic Acid; Middle Aged; Pr | 1977 |
An examination of baseline and drug-induced levels of cyclic nucleotides in the cerebrospinal fluid of control and psychiatric patients.
Topics: Adolescent; Adult; Aged; Amitriptyline; Bipolar Disorder; Depression; Humans; Imipramine; Lithium; M | 1976 |
Reduced central serotonergic activity in mania: implications for the relationship between depression and mania.
Topics: Bipolar Disorder; Brain; Depression; Disease Models, Animal; Humans; Hydroxyindoleacetic Acid; Hypno | 1975 |
Dopamine metabolism in depressions, psychoses, and Parkinson's disease: the problem of the specificity of biological variables in behaviour disorders.
Topics: Adjustment Disorders; Bipolar Disorder; Brain; Carboxy-Lyases; Depression; Dihydroxyphenylalanine; D | 1975 |
Cerebrospinal fluid amine metabolites in affective illness and schizophrenia: clinical and pharmacological studies.
Topics: Affective Symptoms; Amines; Depression; Homovanillic Acid; Humans; Hydroxyindoleacetic Acid; Imipram | 1975 |
3 -Methoxy- 4 -hydroxyphenylethylene glycol in human cerebrospinal fluid.
Topics: Chromatography, Gas; Depression; Dihydroxyphenylalanine; Down Syndrome; Ethers; Glycols; Humans; Hyd | 1971 |
[The probenecid test. Evaluation in clinical medicine of cerebral metabolism of serotonin and dopamine].
Topics: Biological Transport, Active; Brain; Depression; Dopamine; Down Syndrome; Humans; Indoleacetic Acids | 1972 |
Brain serotonin, affective illness, and antidepressant drugs: cerebrospinal fluid studies with probenecid.
Topics: Affective Symptoms; Amitriptyline; Antidepressive Agents; Brain; Brain Chemistry; Depression; Fenclo | 1974 |
Selective suppression of REM sleep by probenecid.
Topics: Adult; Depression; Electroencephalography; Female; Humans; Male; Middle Aged; Neurotic Disorders; Pr | 1972 |
REM sleep and central monoamine oxidase inhibition.
Topics: Adolescent; Adult; Blood-Brain Barrier; Brain; Depression; Electroencephalography; Female; Humans; H | 1972 |
Cerebrospinal fluid amine metabolites in affective illness: the probenecid technique.
Topics: Affective Symptoms; Biological Transport, Active; Bipolar Disorder; Brain; Brain Chemistry; Depressi | 1973 |
Psychomotor activity, sleep, and biogenic amine metabolites in depression.
Topics: Adult; Biological Transport, Active; Circadian Rhythm; Depression; Electroencephalography; Electromy | 1974 |
Fluorometric measurement of 5-hydroxyindoleacetic acid (5HIAA) and tryptophan in human CSF: effects of high doses of probenecid.
Topics: Administration, Oral; Adolescent; Adult; Bipolar Disorder; Brain Chemistry; Depression; Female; Fluo | 1974 |
5-Hydroxyindoleacetic acid in cerebrospinal fluid.
Topics: Adult; Age Factors; Brain Diseases; Brain Stem; Depression; Epilepsy; Humans; Hydroxyindoleacetic Ac | 1973 |
Lumbar CSF 5-hydroxyindoleacetic acid and homovanillic acid in affective syndromes.
Topics: Adult; Affective Symptoms; Amitriptyline; Animals; Bipolar Disorder; Brain Chemistry; Cats; Depressi | 1974 |
Toward a biochemical classification of depression.
Topics: Antidepressive Agents; Biogenic Amines; Brain; Brain Stem; Depression; Dopamine; Homovanillic Acid; | 1974 |
Cerebrospinal fluid 5-hydroxyindoleacetic acid (5HIAA) and homovanillic acid (HVA) following probenecid in unipolar depressives treated with amitriptyline.
Topics: Adult; Age Factors; Amitriptyline; Depression; Female; Humans; Hydroxyindoleacetic Acid; Male; Middl | 1972 |
A pilot study of some kinetic aspects of the metabolism of 5-hydroxytryptamine in depressive patients.
Topics: Administration, Oral; Biological Transport; Brain; Depression; Female; Humans; Hydroxyindoleacetic A | 1971 |
5-Hydroxyindoleacetic acid levels in the cerebrospinal fluid of depressive patients treated with probenecid.
Topics: Brain; Depression; Humans; Hydroxyindoleacetic Acid; Probenecid; Serotonin | 1970 |
Influence of convulsive therapy on 5-hydroxyindoleacetic acid and homovanillic acid in cerebrospinal fluid in endogenous depression.
Topics: Amines; Depression; Electroshock; Humans; Hydroxyindoleacetic Acid; Phenylacetates; Probenecid | 1971 |
Endogenous depressions with and without disturbances in the 5-hydroxytryptamine metabolism: A biochemical classification?
Topics: Brain; Depression; Humans; Hydroxyindoleacetic Acid; Probenecid; Serotonin | 1971 |
Retarded depression and the dopamine metabolism.
Topics: Brain; Depression; Dopamine; Humans; Motor Activity; Parkinson Disease; Phenylacetates; Probenecid; | 1971 |