Page last updated: 2024-11-03

probenecid and Coma

probenecid has been researched along with Coma in 5 studies

Probenecid: The prototypical uricosuric agent. It inhibits the renal excretion of organic anions and reduces tubular reabsorption of urate. Probenecid has also been used to treat patients with renal impairment, and, because it reduces the renal tubular excretion of other drugs, has been used as an adjunct to antibacterial therapy.
probenecid : A sulfonamide in which the nitrogen of 4-sulfamoylbenzoic acid is substituted with two propyl groups.

Coma: A profound state of unconsciousness associated with depressed cerebral activity from which the individual cannot be aroused. Coma generally occurs when there is dysfunction or injury involving both cerebral hemispheres or the brain stem RETICULAR FORMATION.

Research Excerpts

ExcerptRelevanceReference
"Acute renal failure was induced by occlusion of bilateral renal arteries for 60 min, and the motor activity and brain monoamine turnover were examined 48 h later."1.31Uraemia suppresses central dopaminergic metabolism and impairs motor activity in rats. ( Adachi, N; Arai, T; Deshpande, G; Lei, B; Nagaro, T; Seyfried, FJ; Shimizu, I, 2001)

Research

Studies (5)

TimeframeStudies, this research(%)All Research%
pre-19904 (80.00)18.7374
1990's0 (0.00)18.2507
2000's1 (20.00)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
RIZZUTO, VJ1
INGLESBY, TV1
GRACE, WJ1
Smith, H1
Lerner, PI1
Weinstein, L1
Adachi, N1
Lei, B1
Deshpande, G1
Seyfried, FJ1
Shimizu, I1
Nagaro, T1
Arai, T1
Artru, F1
Gagnieu, MC1
Jourdan, C1
Quincy, C1
Renaud, B2
Deleuze, R1
Schott, B1
Michel, D1
Mouret, J1
Quenin, P1
Tommasi, M1

Other Studies

5 other studies available for probenecid and Coma

ArticleYear
PROBENECID (BENEMID) INTOXICATION WITH STATUS EPILEPTICUS.
    The American journal of medicine, 1965, Volume: 38

    Topics: Coma; Drug Therapy; Epilepsy; Gout; Phenobarbital; Phenytoin; Poisoning; Probenecid; Status Epilepti

1965
Neurotoxicity and "massive" intravenous therapy with penicillin. A study of possible predisposing factors.
    Archives of internal medicine, 1967, Volume: 120, Issue:1

    Topics: Adolescent; Adult; Aged; Central Nervous System; Central Nervous System Diseases; Child; Child, Pres

1967
Uraemia suppresses central dopaminergic metabolism and impairs motor activity in rats.
    Intensive care medicine, 2001, Volume: 27, Issue:10

    Topics: Acute Kidney Injury; alpha-Methyltyrosine; Animals; Brain Chemistry; Coma; Confusion; Corpus Striatu

2001
[Exploration of the metabolism of brain serotonin and dopamine in prolonged traumatic coma:prognostic value].
    Agressologie: revue internationale de physio-biologie et de pharmacologie appliquees aux effets de l'agression, 1986, Volume: 27, Issue:11

    Topics: Brain Injuries; Coma; Dopamine; Homovanillic Acid; Humans; Hydroxyindoleacetic Acid; Probenecid; Ser

1986
[Monoamines and the regulation of wakefulness. II. Lesional syndromes of the central nervous system].
    Revue neurologique, 1972, Volume: 127, Issue:1

    Topics: Attention; Brain Diseases; Catecholamines; Coma; Dihydroxyphenylalanine; Electroencephalography; Eye

1972
chemdatabank.com