probenecid and Coma
probenecid has been researched along with Coma in 5 studies
Probenecid: The prototypical uricosuric agent. It inhibits the renal excretion of organic anions and reduces tubular reabsorption of urate. Probenecid has also been used to treat patients with renal impairment, and, because it reduces the renal tubular excretion of other drugs, has been used as an adjunct to antibacterial therapy.
probenecid : A sulfonamide in which the nitrogen of 4-sulfamoylbenzoic acid is substituted with two propyl groups.
Coma: A profound state of unconsciousness associated with depressed cerebral activity from which the individual cannot be aroused. Coma generally occurs when there is dysfunction or injury involving both cerebral hemispheres or the brain stem RETICULAR FORMATION.
Research Excerpts
| Excerpt | Relevance | Reference |
|---|---|---|
| "Acute renal failure was induced by occlusion of bilateral renal arteries for 60 min, and the motor activity and brain monoamine turnover were examined 48 h later." | 1.31 | Uraemia suppresses central dopaminergic metabolism and impairs motor activity in rats. ( Adachi, N; Arai, T; Deshpande, G; Lei, B; Nagaro, T; Seyfried, FJ; Shimizu, I, 2001) |
Research
Studies (5)
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 4 (80.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 1 (20.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
Authors
| Authors | Studies |
|---|---|
| RIZZUTO, VJ | 1 |
| INGLESBY, TV | 1 |
| GRACE, WJ | 1 |
| Smith, H | 1 |
| Lerner, PI | 1 |
| Weinstein, L | 1 |
| Adachi, N | 1 |
| Lei, B | 1 |
| Deshpande, G | 1 |
| Seyfried, FJ | 1 |
| Shimizu, I | 1 |
| Nagaro, T | 1 |
| Arai, T | 1 |
| Artru, F | 1 |
| Gagnieu, MC | 1 |
| Jourdan, C | 1 |
| Quincy, C | 1 |
| Renaud, B | 2 |
| Deleuze, R | 1 |
| Schott, B | 1 |
| Michel, D | 1 |
| Mouret, J | 1 |
| Quenin, P | 1 |
| Tommasi, M | 1 |
Other Studies
5 other studies available for probenecid and Coma
| Article | Year |
|---|---|
PROBENECID (BENEMID) INTOXICATION WITH STATUS EPILEPTICUS.
Topics: Coma; Drug Therapy; Epilepsy; Gout; Phenobarbital; Phenytoin; Poisoning; Probenecid; Status Epilepti | 1965 |
Neurotoxicity and "massive" intravenous therapy with penicillin. A study of possible predisposing factors.
Topics: Adolescent; Adult; Aged; Central Nervous System; Central Nervous System Diseases; Child; Child, Pres | 1967 |
Uraemia suppresses central dopaminergic metabolism and impairs motor activity in rats.
Topics: Acute Kidney Injury; alpha-Methyltyrosine; Animals; Brain Chemistry; Coma; Confusion; Corpus Striatu | 2001 |
[Exploration of the metabolism of brain serotonin and dopamine in prolonged traumatic coma:prognostic value].
Topics: Brain Injuries; Coma; Dopamine; Homovanillic Acid; Humans; Hydroxyindoleacetic Acid; Probenecid; Ser | 1986 |
[Monoamines and the regulation of wakefulness. II. Lesional syndromes of the central nervous system].
Topics: Attention; Brain Diseases; Catecholamines; Coma; Dihydroxyphenylalanine; Electroencephalography; Eye | 1972 |