probenecid has been researched along with Cirrhosis in 6 studies
Probenecid: The prototypical uricosuric agent. It inhibits the renal excretion of organic anions and reduces tubular reabsorption of urate. Probenecid has also been used to treat patients with renal impairment, and, because it reduces the renal tubular excretion of other drugs, has been used as an adjunct to antibacterial therapy.
probenecid : A sulfonamide in which the nitrogen of 4-sulfamoylbenzoic acid is substituted with two propyl groups.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Although the clinical implication of hyperuricemia in chronic kidney disease has been an issue of active debate, recent data suggested a causative role of uric acid (UA) in the development of renal disease." | 3.88 | Hyperuricemia and Progression of Chronic Kidney Disease: Role of Phenotype Transition of Renal Tubular and Endothelial Cells. ( Kang, DH, 2018) |
| " This has led to the hypothesis that uric acid may contribute to renal fibrosis and progressive renal disease." | 3.76 | Uric acid increases fibronectin synthesis through upregulation of lysyl oxidase expression in rat renal tubular epithelial cells. ( Junwei, Y; Lei, J; Li, F; Mingxia, X; Ping, W; Ruoyun, T; Weichun, H; Xiaohua, W; Yang, Z, 2010) |
| "CKD mice exhibited marked left ventricular hypertrophy and myocardial fibrosis, which were reversed by treatment with the CB1R antagonist." | 1.42 | CB1 cannabinoid receptor antagonist attenuates left ventricular hypertrophy and Akt-mediated cardiac fibrosis in experimental uremia. ( Chen, Y; Hsu, SC; Hsu, YJ; Huang, SM; Lee, HS; Lin, CY; Lin, SH; Shih, CC; Tsai, CS, 2015) |
| "Treatment with probenecid prevented increased plasma creatinine and tubulointerstitial injuries, and reduced both the extent and the severity of ultrastructural lesions induced by aristolochic acid, such as the loss of brush border, mitochondrial edema, and the disappearance of mitochondrial crests." | 1.38 | Probenecid prevents acute tubular necrosis in a mouse model of aristolochic acid nephropathy. ( Antoine, MH; Arlt, VM; Baudoux, TE; De Prez, EG; Goujon, JM; Nortier, JL; Pozdzik, AA; Quellard, N, 2012) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 6 (100.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Kang, DH | 1 |
| Penuela, S | 1 |
| Kelly, JJ | 1 |
| Churko, JM | 1 |
| Barr, KJ | 1 |
| Berger, AC | 1 |
| Laird, DW | 1 |
| Lin, CY | 1 |
| Hsu, YJ | 1 |
| Hsu, SC | 1 |
| Chen, Y | 1 |
| Lee, HS | 1 |
| Lin, SH | 1 |
| Huang, SM | 1 |
| Tsai, CS | 1 |
| Shih, CC | 1 |
| Yang, Z | 1 |
| Xiaohua, W | 1 |
| Lei, J | 1 |
| Ruoyun, T | 1 |
| Mingxia, X | 1 |
| Weichun, H | 1 |
| Li, F | 1 |
| Ping, W | 1 |
| Junwei, Y | 1 |
| Baudoux, TE | 1 |
| Pozdzik, AA | 1 |
| Arlt, VM | 1 |
| De Prez, EG | 1 |
| Antoine, MH | 1 |
| Quellard, N | 1 |
| Goujon, JM | 1 |
| Nortier, JL | 1 |
| Watanabe, H | 1 |
| Miyamoto, Y | 1 |
| Honda, D | 1 |
| Tanaka, H | 1 |
| Wu, Q | 1 |
| Endo, M | 1 |
| Noguchi, T | 1 |
| Kadowaki, D | 1 |
| Ishima, Y | 1 |
| Kotani, S | 1 |
| Nakajima, M | 1 |
| Kataoka, K | 1 |
| Kim-Mitsuyama, S | 1 |
| Tanaka, M | 1 |
| Fukagawa, M | 1 |
| Otagiri, M | 1 |
| Maruyama, T | 1 |
6 other studies available for probenecid and Cirrhosis
| Article | Year |
|---|---|
Hyperuricemia and Progression of Chronic Kidney Disease: Role of Phenotype Transition of Renal Tubular and Endothelial Cells.
Topics: Actins; Animals; Antioxidants; Capillaries; Disease Progression; Endothelial Cells; Epithelial-Mesen | 2018 |
Panx1 regulates cellular properties of keratinocytes and dermal fibroblasts in skin development and wound healing.
Topics: Actins; Adjuvants, Pharmaceutic; Animals; Cell Differentiation; Connexins; Dermis; Disease Models, A | 2014 |
CB1 cannabinoid receptor antagonist attenuates left ventricular hypertrophy and Akt-mediated cardiac fibrosis in experimental uremia.
Topics: Animals; Cannabinoid Receptor Antagonists; Cell Line; Collagen; Drug Evaluation, Preclinical; Fibros | 2015 |
Uric acid increases fibronectin synthesis through upregulation of lysyl oxidase expression in rat renal tubular epithelial cells.
Topics: Animals; Blotting, Western; Cell Line; Disease Models, Animal; Epithelial Cells; Extracellular Matri | 2010 |
Probenecid prevents acute tubular necrosis in a mouse model of aristolochic acid nephropathy.
Topics: Animals; Aristolochic Acids; Atrophy; Biomarkers; Cell Proliferation; Cell Survival; Creatinine; Cyt | 2012 |
p-Cresyl sulfate causes renal tubular cell damage by inducing oxidative stress by activation of NADPH oxidase.
Topics: Animals; Cell Line; Cell Survival; Collagen Type I; Collagen Type I, alpha 1 Chain; Cresols; Cytokin | 2013 |