probenecid has been researched along with Brain Ischemia in 7 studies
Probenecid: The prototypical uricosuric agent. It inhibits the renal excretion of organic anions and reduces tubular reabsorption of urate. Probenecid has also been used to treat patients with renal impairment, and, because it reduces the renal tubular excretion of other drugs, has been used as an adjunct to antibacterial therapy.
probenecid : A sulfonamide in which the nitrogen of 4-sulfamoylbenzoic acid is substituted with two propyl groups.
Brain Ischemia: Localized reduction of blood flow to brain tissue due to arterial obstruction or systemic hypoperfusion. This frequently occurs in conjunction with brain hypoxia (HYPOXIA, BRAIN). Prolonged ischemia is associated with BRAIN INFARCTION.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Probenecid has been used for decades to treat gout, and recent studies have revealed it is also a specific inhibitor of the pannexin-1 channel." | 5.42 | Probenecid protects against cerebral ischemia/reperfusion injury by inhibiting lysosomal and inflammatory damage in rats. ( Du, Y; He, F; Luo, B; Peng, G; Wang, J; Wei, R; Xu, Y; Yin, B, 2015) |
| "Probenecid has been used for decades to treat gout, and recent studies have revealed it is also a specific inhibitor of the pannexin-1 channel." | 1.42 | Probenecid protects against cerebral ischemia/reperfusion injury by inhibiting lysosomal and inflammatory damage in rats. ( Du, Y; He, F; Luo, B; Peng, G; Wang, J; Wei, R; Xu, Y; Yin, B, 2015) |
| "L-kynurenine is a metabolic precursor of kynurenic acid, which is one of the few known endogenous N-methyl-D-aspartate receptor inhibitors." | 1.35 | Neuroprotection achieved in the ischaemic rat cortex with L-kynurenine sulphate. ( Agoston, M; Gigler, G; Robotka, H; Rózsa, E; Sas, K; Szénási, G; Toldi, J; Vécsei, L, 2008) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (14.29) | 18.7374 |
| 1990's | 3 (42.86) | 18.2507 |
| 2000's | 1 (14.29) | 29.6817 |
| 2010's | 2 (28.57) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Wei, R | 1 |
| Wang, J | 2 |
| Xu, Y | 1 |
| Yin, B | 1 |
| He, F | 1 |
| Du, Y | 1 |
| Peng, G | 1 |
| Luo, B | 1 |
| Jian, Z | 1 |
| Ding, S | 1 |
| Deng, H | 1 |
| Yi, W | 1 |
| Wang, L | 1 |
| Zhu, S | 1 |
| Gu, L | 1 |
| Xiong, X | 1 |
| Robotka, H | 1 |
| Sas, K | 1 |
| Agoston, M | 1 |
| Rózsa, E | 1 |
| Szénási, G | 1 |
| Gigler, G | 1 |
| Vécsei, L | 1 |
| Toldi, J | 1 |
| Galli, C | 1 |
| Spagnuolo, C | 1 |
| Petroni, A | 1 |
| Zhang, Y | 1 |
| Liu, GQ | 1 |
| Liu, XD | 1 |
| Xiao, XQ | 1 |
| Nozaki, K | 1 |
| Beal, MF | 1 |
| Assaf, HM | 1 |
| Ricci, AJ | 1 |
| Whittingham, TS | 1 |
| LaManna, JC | 1 |
| Ratcheson, RA | 1 |
| Lust, WD | 1 |
7 other studies available for probenecid and Brain Ischemia
| Article | Year |
|---|---|
Probenecid protects against cerebral ischemia/reperfusion injury by inhibiting lysosomal and inflammatory damage in rats.
Topics: Animals; Brain Ischemia; CA1 Region, Hippocampal; Calcium-Binding Proteins; Calponins; Cathepsin B; | 2015 |
Probenecid protects against oxygen-glucose deprivation injury in primary astrocytes by regulating inflammasome activity.
Topics: Animals; Astrocytes; Brain Ischemia; Cell Survival; Connexins; Encephalitis; Glucose; Inflammasomes; | 2016 |
Neuroprotection achieved in the ischaemic rat cortex with L-kynurenine sulphate.
Topics: Animals; Brain Ischemia; Cerebral Cortex; Cerebrovascular Circulation; Fluoresceins; Kynurenine; Neu | 2008 |
Factors affecting brain prostaglandin formation.
Topics: Animals; Brain; Brain Ischemia; Cerebral Cortex; Convulsants; Fatty Acids, Essential; Gerbillinae; H | 1980 |
Efflux transport of [3H]GABA across blood-brain barrier after cerebral ischemia-reperfusion in rats.
Topics: Animals; Blood-Brain Barrier; Brain Ischemia; gamma-Aminobutyric Acid; Male; Microinjections; Proben | 1999 |
Neuroprotective effects of L-kynurenine on hypoxia-ischemia and NMDA lesions in neonatal rats.
Topics: Animals; Animals, Newborn; Brain Ischemia; Cerebral Cortex; Disease Models, Animal; Dose-Response Re | 1992 |
Lactate compartmentation in hippocampal slices: evidence for a transporter.
Topics: Adenosine Triphosphate; Animals; Biological Transport; Brain Ischemia; Cell Compartmentation; Gerbil | 1990 |