probenecid has been researched along with Brain Injuries in 6 studies
Probenecid: The prototypical uricosuric agent. It inhibits the renal excretion of organic anions and reduces tubular reabsorption of urate. Probenecid has also been used to treat patients with renal impairment, and, because it reduces the renal tubular excretion of other drugs, has been used as an adjunct to antibacterial therapy.
probenecid : A sulfonamide in which the nitrogen of 4-sulfamoylbenzoic acid is substituted with two propyl groups.
Brain Injuries: Acute and chronic (see also BRAIN INJURIES, CHRONIC) injuries to the brain, including the cerebral hemispheres, CEREBELLUM, and BRAIN STEM. Clinical manifestations depend on the nature of injury. Diffuse trauma to the brain is frequently associated with DIFFUSE AXONAL INJURY or COMA, POST-TRAUMATIC. Localized injuries may be associated with NEUROBEHAVIORAL MANIFESTATIONS; HEMIPARESIS, or other focal neurologic deficits.
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 2 (33.33) | 18.7374 |
| 1990's | 1 (16.67) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 3 (50.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Xiong, XX | 1 |
| Gu, LJ | 1 |
| Shen, J | 1 |
| Kang, XH | 1 |
| Zheng, YY | 1 |
| Yue, SB | 1 |
| Zhu, SM | 1 |
| Adamczak, SE | 1 |
| de Rivero Vaccari, JP | 1 |
| Dale, G | 1 |
| Brand, FJ | 1 |
| Nonner, D | 1 |
| Bullock, MR | 1 |
| Dahl, GP | 1 |
| Dietrich, WD | 1 |
| Keane, RW | 1 |
| Mori, Y | 1 |
| Tomonaga, D | 1 |
| Kalashnikova, A | 1 |
| Furuya, F | 1 |
| Akimoto, N | 1 |
| Ifuku, M | 1 |
| Okuno, Y | 1 |
| Beppu, K | 1 |
| Fujita, K | 1 |
| Katafuchi, T | 1 |
| Shimura, H | 1 |
| Churilov, LP | 1 |
| Noda, M | 1 |
| Walker, DW | 1 |
| Curtis, B | 1 |
| Lacey, B | 1 |
| Nitsos, I | 1 |
| Vecht, CJ | 1 |
| van Woerkom, CA | 1 |
| Teelken, AW | 1 |
| Minderhoud, JM | 1 |
| Artru, F | 1 |
| Gagnieu, MC | 1 |
| Jourdan, C | 1 |
| Quincy, C | 1 |
| Renaud, B | 1 |
| Deleuze, R | 1 |
6 other studies available for probenecid and Brain Injuries
| Article | Year |
|---|---|
Probenecid protects against transient focal cerebral ischemic injury by inhibiting HMGB1 release and attenuating AQP4 expression in mice.
Topics: Animals; Aquaporin 4; Astrocytes; Brain Edema; Brain Injuries; Cerebral Infarction; Down-Regulation; | 2014 |
Pyroptotic neuronal cell death mediated by the AIM2 inflammasome.
Topics: Adolescent; Adult; Aged; Animals; Apoptosis; Apoptosis Regulatory Proteins; Brain Injuries; Caspase | 2014 |
Effects of 3,3',5-triiodothyronine on microglial functions.
Topics: Adenosine Triphosphate; Adjuvants, Pharmaceutic; Animals; Brain Injuries; Cell Movement; Cells, Cult | 2015 |
Kynurenic acid in brain and cerebrospinal fluid of fetal, newborn, and adult sheep and effects of placental embolization.
Topics: Animals; Animals, Newborn; Brain; Brain Injuries; Embolism; Female; Fetal Hypoxia; Fetus; Kynurenic | 1999 |
Homovanillic acid and 5-hydroxyindoleacetic acid cerebrospinal fluid levels. A study with and without probenecid administration of their relationship to the state of consciousness after head injury.
Topics: Blood-Brain Barrier; Brain Injuries; Consciousness; Homovanillic Acid; Humans; Hydroxyindoleacetic A | 1975 |
[Exploration of the metabolism of brain serotonin and dopamine in prolonged traumatic coma:prognostic value].
Topics: Brain Injuries; Coma; Dopamine; Homovanillic Acid; Humans; Hydroxyindoleacetic Acid; Probenecid; Ser | 1986 |