probenecid has been researched along with Brain Inflammation in 5 studies
Probenecid: The prototypical uricosuric agent. It inhibits the renal excretion of organic anions and reduces tubular reabsorption of urate. Probenecid has also been used to treat patients with renal impairment, and, because it reduces the renal tubular excretion of other drugs, has been used as an adjunct to antibacterial therapy.
probenecid : A sulfonamide in which the nitrogen of 4-sulfamoylbenzoic acid is substituted with two propyl groups.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Probenecid has been used for decades to treat gout, and recent studies have revealed it is also a specific inhibitor of the pannexin-1 channel." | 5.42 | Probenecid protects against cerebral ischemia/reperfusion injury by inhibiting lysosomal and inflammatory damage in rats. ( Du, Y; He, F; Luo, B; Peng, G; Wang, J; Wei, R; Xu, Y; Yin, B, 2015) |
| "A model of brain inflammation has recently been developed in mice using intraventricular injection of carrageenan (CAR)." | 5.27 | Effect of dexamethasone, indomethacin, ibuprofen, and probenecid on carrageenan-induced brain inflammation. ( Ellis, EF; Gamache, DA, 1986) |
| "Probenecid has been used for decades to treat gout, and recent studies have revealed it is also a specific inhibitor of the pannexin-1 channel." | 1.42 | Probenecid protects against cerebral ischemia/reperfusion injury by inhibiting lysosomal and inflammatory damage in rats. ( Du, Y; He, F; Luo, B; Peng, G; Wang, J; Wei, R; Xu, Y; Yin, B, 2015) |
| "A model of brain inflammation has recently been developed in mice using intraventricular injection of carrageenan (CAR)." | 1.27 | Effect of dexamethasone, indomethacin, ibuprofen, and probenecid on carrageenan-induced brain inflammation. ( Ellis, EF; Gamache, DA, 1986) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (20.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 4 (80.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Selvakumar, GP | 1 |
| Janakiraman, U | 1 |
| Essa, MM | 2 |
| Justin Thenmozhi, A | 1 |
| Manivasagam, T | 2 |
| Wei, R | 1 |
| Wang, J | 2 |
| Xu, Y | 1 |
| Yin, B | 1 |
| He, F | 1 |
| Du, Y | 1 |
| Peng, G | 1 |
| Luo, B | 1 |
| Jian, Z | 1 |
| Ding, S | 1 |
| Deng, H | 1 |
| Yi, W | 1 |
| Wang, L | 1 |
| Zhu, S | 1 |
| Gu, L | 1 |
| Xiong, X | 1 |
| Anandhan, A | 1 |
| Gamache, DA | 1 |
| Ellis, EF | 1 |
5 other studies available for probenecid and Brain Inflammation
| Article | Year |
|---|---|
Escin attenuates behavioral impairments, oxidative stress and inflammation in a chronic MPTP/probenecid mouse model of Parkinson's disease.
Topics: Animals; Antiparkinson Agents; Disease Models, Animal; Dopamine; Dopamine Plasma Membrane Transport | 2014 |
Probenecid protects against cerebral ischemia/reperfusion injury by inhibiting lysosomal and inflammatory damage in rats.
Topics: Animals; Brain Ischemia; CA1 Region, Hippocampal; Calcium-Binding Proteins; Calponins; Cathepsin B; | 2015 |
Probenecid protects against oxygen-glucose deprivation injury in primary astrocytes by regulating inflammasome activity.
Topics: Animals; Astrocytes; Brain Ischemia; Cell Survival; Connexins; Encephalitis; Glucose; Inflammasomes; | 2016 |
Therapeutic attenuation of neuroinflammation and apoptosis by black tea theaflavin in chronic MPTP/probenecid model of Parkinson's disease.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Animals; Antioxidants; Apoptosis; bcl-2-Associated X P | 2013 |
Effect of dexamethasone, indomethacin, ibuprofen, and probenecid on carrageenan-induced brain inflammation.
Topics: Animals; Anti-Inflammatory Agents; Brain Edema; Capillary Permeability; Carrageenan; Cerebrovascular | 1986 |