probenecid has been researched along with Blood Pressure, High in 21 studies
Probenecid: The prototypical uricosuric agent. It inhibits the renal excretion of organic anions and reduces tubular reabsorption of urate. Probenecid has also been used to treat patients with renal impairment, and, because it reduces the renal tubular excretion of other drugs, has been used as an adjunct to antibacterial therapy.
probenecid : A sulfonamide in which the nitrogen of 4-sulfamoylbenzoic acid is substituted with two propyl groups.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The use of long-term allopurinol therapy in patients with gout was evaluated." | 7.67 | Evaluation of allopurinol use in patients with gout. ( Carmichael, JM; Zell, SC, 1989) |
| " These initial studies demonstrate that tienilic acid is safe and effective in the treatment of mild to moderate essential hypertension, salt and water retention states, including oedema associated with congestive cardiac failure or mild to moderate renal dysfunction, and in the management of elevated serum uric acid levels associated with gout." | 5.04 | Safety of tienilic acid. ( Beg, MA; Ragland, R, 1979) |
| "The use of long-term allopurinol therapy in patients with gout was evaluated." | 3.67 | Evaluation of allopurinol use in patients with gout. ( Carmichael, JM; Zell, SC, 1989) |
| "A total of 2,923 elderly subjects were studied to determine the relationship between obesity, hypertension, thyroid disease, renal function, alcohol consumption, selected drugs, and the serum uric acid level." | 3.66 | Selected physiologic and drug effects on serum uric acid levels in an elderly population. ( Hale, WE; Marks, RG; Stewart, RB; Yost, RL, 1981) |
| "Gout has significant impact on the quality of life with over-utilisation of health resources." | 1.56 | Burden and management of gout in a multi-ethnic Asian cohort. ( Cheung, PP; Chua, CKT; Lim, AYN; Santosa, A; Teng, GG, 2020) |
| "Gout is increasingly recognized as the most common form of inflammatory arthritis worldwide; however, no Canadian data on the disease burden of gout are available." | 1.46 | The rising prevalence and incidence of gout in British Columbia, Canada: Population-based trends from 2000 to 2012. ( Aviña-Zubieta, JA; Choi, HK; De Vera, MA; McCormick, N; Rai, SK; Sayre, EC; Shojania, K, 2017) |
| "Patients with gout have comorbidities, but the impact of these comorbidities on treatment has not been studied." | 1.37 | Prevalence of contraindications and prescription of pharmacologic therapies for gout. ( Crittenden, DB; Fisher, MC; Goldfarb, DS; Keenan, RT; Krasnokutsky, S; Lee, KH; O'Brien, WR; Oh, C; Pillinger, MH, 2011) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 15 (71.43) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 1 (4.76) | 29.6817 |
| 2010's | 4 (19.05) | 24.3611 |
| 2020's | 1 (4.76) | 2.80 |
| Authors | Studies |
|---|---|
| Chua, CKT | 1 |
| Cheung, PP | 1 |
| Santosa, A | 1 |
| Lim, AYN | 1 |
| Teng, GG | 1 |
| Kang, EH | 1 |
| Kim, SC | 1 |
| Borgi, L | 1 |
| McMullan, C | 1 |
| Wohlhueter, A | 1 |
| Curhan, GC | 1 |
| Fisher, ND | 1 |
| Forman, JP | 1 |
| Rai, SK | 1 |
| Aviña-Zubieta, JA | 1 |
| McCormick, N | 1 |
| De Vera, MA | 1 |
| Shojania, K | 1 |
| Sayre, EC | 1 |
| Choi, HK | 1 |
| Keenan, RT | 1 |
| O'Brien, WR | 1 |
| Lee, KH | 1 |
| Crittenden, DB | 1 |
| Fisher, MC | 1 |
| Goldfarb, DS | 1 |
| Krasnokutsky, S | 1 |
| Oh, C | 1 |
| Pillinger, MH | 1 |
| Sasaki, S | 1 |
| Siragy, HM | 1 |
| Gildea, JJ | 1 |
| Felder, RA | 1 |
| Carey, RM | 1 |
| Yost, RL | 1 |
| Stewart, RB | 1 |
| Hale, WE | 1 |
| Marks, RG | 1 |
| Peitzman, SJ | 1 |
| Fernandez, PC | 1 |
| Bodison, W | 1 |
| Ellis, I | 1 |
| Beg, MA | 1 |
| Ragland, R | 1 |
| Waal-Manning, HJ | 1 |
| Bolli, P | 1 |
| Wood, AJ | 1 |
| Simpson, FO | 1 |
| McMahon, FG | 2 |
| Ryan, JR | 1 |
| Jain, AK | 1 |
| Talbott, JH | 1 |
| Gottlieb, N | 1 |
| Grendelmeier, P | 1 |
| Rodriguez, E | 1 |
| Zell, SC | 1 |
| Carmichael, JM | 1 |
| Kawenoki-Minc, E | 1 |
| Kusus, T | 1 |
| Lydtin, H | 1 |
| Zöllner, N | 1 |
| Dawson, D | 1 |
| Hutchison, JC | 1 |
| Wilkinson, WH | 1 |
| Lhoda, F | 1 |
| Holländer, E | 1 |
| Schwarczmann, P | 1 |
| Brest, AN | 1 |
| Heider, C | 1 |
| Mehbod, H | 1 |
| Onesti, G | 1 |
| Freis, ED | 1 |
| Sappington, RF | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| ACTH vs Betamethasone for the Treatment of Acute Gout in Hospitalized Patients: A Randomized, Open Label, Comparative Study[NCT04306653] | 60 participants (Anticipated) | Interventional | 2018-01-05 | Recruiting | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
1 review available for probenecid and Blood Pressure, High
| Article | Year |
|---|---|
Cardiovascular Safety of Urate Lowering Therapies.
Topics: Allopurinol; Cardiovascular Diseases; Endothelium; Febuxostat; Gout; Gout Suppressants; Heart Failur | 2019 |
7 trials available for probenecid and Blood Pressure, High
| Article | Year |
|---|---|
Effect of Uric Acid-Lowering Agents on Endothelial Function: A Randomized, Double-Blind, Placebo-Controlled Trial.
Topics: Adult; Allopurinol; Brachial Artery; Dose-Response Relationship, Drug; Double-Blind Method; Endothel | 2017 |
Ticrynafen and probenecid in hyperuricemic, hypertensive men.
Topics: Blood Pressure; Blood Urea Nitrogen; Clinical Trials as Topic; Creatinine; Diuresis; Double-Blind Me | 1979 |
Safety of tienilic acid.
Topics: Clinical Trials as Topic; Glycolates; Heart Failure; Humans; Hydrochlorothiazide; Hypertension; Kidn | 1979 |
Studies on tienilic acid in hypertensive hyperuricaemic patients in Dunedin, New Zealand.
Topics: Aged; Allopurinol; Clinical Trials as Topic; Cyclopenthiazide; Diuretics; Drug Therapy, Combination; | 1979 |
The hypouricaemic effect of tienilic acid: experience in patients with hyperuricaemia.
Topics: Adult; Aged; Blood Glucose; Clinical Trials as Topic; Diabetes Mellitus; Double-Blind Method; Drug A | 1979 |
[Saluretic treatment of hypertension and uric acid level in serum. Clinical test of a combination of hydrochlorothiazide and probenecid].
Topics: Adult; Aged; Alanine Transaminase; Blood Glucose; Blood Pressure; Blood Protein Electrophoresis; Bod | 1969 |
Long-term effect of probenecid on diuretic-induced hyperuricemia.
Topics: Adult; Aged; Blood Chemical Analysis; Blood Pressure Determination; Body Weight; Chlorthalidone; Hum | 1966 |
13 other studies available for probenecid and Blood Pressure, High
| Article | Year |
|---|---|
Burden and management of gout in a multi-ethnic Asian cohort.
Topics: Adult; Aged; Allopurinol; Comorbidity; Cross-Sectional Studies; Diabetes Mellitus; Dyslipidemias; Em | 2020 |
The rising prevalence and incidence of gout in British Columbia, Canada: Population-based trends from 2000 to 2012.
Topics: Aged; Allopurinol; Anti-Inflammatory Agents, Non-Steroidal; British Columbia; Colchicine; Comorbidit | 2017 |
Prevalence of contraindications and prescription of pharmacologic therapies for gout.
Topics: Aged; Aged, 80 and over; Allopurinol; Colchicine; Comorbidity; Contraindications; Diabetes Mellitus; | 2011 |
Production and role of extracellular guanosine cyclic 3', 5' monophosphate in sodium uptake in human proximal tubule cells.
Topics: Arginine; Biological Transport; Cells, Cultured; Cyclic GMP; Enzyme Inhibitors; Female; Humans; Hype | 2004 |
Selected physiologic and drug effects on serum uric acid levels in an elderly population.
Topics: Aged; Allopurinol; Diuretics; Female; Humans; Hypertension; Male; Obesity; Probenecid; Thyroid Disea | 1981 |
Gouty arthritis in the black race.
Topics: Adult; Aged; Anemia, Sickle Cell; Arthritis; Benzothiadiazines; Black People; Colchicine; Diuretics; | 1975 |
Evaluation of allopurinol use in patients with gout.
Topics: Allopurinol; Costs and Cost Analysis; Gout; Humans; Hypertension; Probenecid; Radiography; Risk Fact | 1989 |
[Effect of decrease in hyperuricemia levels on joint, kidney and other symptoms in patients with gout].
Topics: Adult; Aged; Allopurinol; Arthritis; Colchicine; Coronary Disease; Gout; Humans; Hypertension; Middl | 1987 |
Chlorothiazide and probenecid in the treatment of hypertension and hyperuricemia.
Topics: Chlorothiazide; Female; Glucose Tolerance Test; Humans; Hypertension; Male; Middle Aged; Probenecid; | 1968 |
Drug-induced hyperuricemia prevented by probenecid.
Topics: Adult; Aged; Female; Gout; Humans; Hydrochlorothiazide; Hypertension; Male; Middle Aged; Probenecid; | 1971 |
[Clinical aspects of gout].
Topics: Allopurinol; Cerebrovascular Disorders; Colchicine; Diagnosis, Differential; Diet Therapy; Female; G | 1970 |
[Gout in advanced age].
Topics: Age Factors; Aged; Allopurinol; Bone and Bones; Cardiovascular Diseases; Colchicine; Female; Gout; H | 1968 |
Drug control of diuretic-induced hyperuricemia.
Topics: Blood; Chlorothiazide; Humans; Hydrochlorothiazide; Hypertension; Probenecid; Sulfonamides; Uric Aci | 1966 |