probenecid has been researched along with Bipolar Disorder in 31 studies
Probenecid: The prototypical uricosuric agent. It inhibits the renal excretion of organic anions and reduces tubular reabsorption of urate. Probenecid has also been used to treat patients with renal impairment, and, because it reduces the renal tubular excretion of other drugs, has been used as an adjunct to antibacterial therapy.
probenecid : A sulfonamide in which the nitrogen of 4-sulfamoylbenzoic acid is substituted with two propyl groups.
Bipolar Disorder: A major affective disorder marked by severe mood swings (manic or major depressive episodes) and a tendency to remission and recurrence.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The metabolites of serotonin, dopamine, and norepinephrine, 5-hydroxyindoleacetic acid (5HIAA), homovanillic acid (HVA), and 3-methoxy-4-hydroxy-phenylethylene glycol (MHPG), respectively, were studied in cerebrospinal fluid of patients with acute schizophrenia." | 3.65 | Cerebrospinal fluid amine metabolites in acute schizophrenia. ( Carpenter, WT; Fink, E; Goodwin, FK; Post, RM, 1975) |
| "The probenecid technique was used in study of the central dopamine DA metabolism in patients with depressions, psychotic disorders, and Parkinson's disease." | 3.65 | Dopamine metabolism in depressions, psychoses, and Parkinson's disease: the problem of the specificity of biological variables in behaviour disorders. ( Korf, J; Praag, HM; Schut, T, 1975) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 31 (100.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Post, RM | 11 |
| Jimerson, DC | 4 |
| Bunney, WE | 3 |
| Goodwin, FK | 10 |
| Leckman, JF | 1 |
| Cohen, DJ | 1 |
| Shaywitz, BA | 1 |
| Caparulo, BK | 1 |
| Heninger, GR | 2 |
| Bowers, MB | 5 |
| Davis, KL | 1 |
| Hollister, LE | 1 |
| Mathé, AA | 1 |
| Davis, BM | 1 |
| Rothpearl, AB | 1 |
| Faull, KF | 1 |
| Hsieh, JY | 1 |
| Barchas, JD | 1 |
| Berger, PA | 1 |
| Korf, J | 2 |
| van den Burg, W | 1 |
| van den Hoofdakker, RH | 1 |
| Goodnick, PJ | 2 |
| Perel, JM | 1 |
| Dunner, DL | 5 |
| Fieve, RR | 4 |
| Cutler, NR | 1 |
| Evans, HE | 1 |
| Cramer, H | 1 |
| Carman, JS | 1 |
| van Kammen, DP | 3 |
| Wood, JH | 2 |
| Barkai, AI | 1 |
| Gross, HA | 2 |
| Mayo, P | 1 |
| Lake, CR | 1 |
| Ziegler, MG | 1 |
| Lerner, P | 1 |
| Major, LF | 1 |
| Ballenger, JC | 1 |
| Lovenberg, W | 1 |
| Lafleur, D | 1 |
| Meltzer, HL | 1 |
| Smith, CC | 1 |
| Tallman, JF | 1 |
| Brown, GL | 1 |
| Mendels, J | 1 |
| Frazer, A | 1 |
| Fink, E | 1 |
| Carpenter, WT | 1 |
| Praag, HM | 1 |
| Schut, T | 1 |
| Sjöström, R | 5 |
| Gordon, EK | 1 |
| Sack, RL | 1 |
| Roos, BE | 2 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| [NCT00004325] | 200 participants | Observational | 1988-12-31 | Completed | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
2 reviews available for probenecid and Bipolar Disorder
| Article | Year |
|---|---|
Studies of amine metabolites in affective illness and in schizophrenia: a comparative analysis.
Topics: 3,4-Dihydroxyphenylacetic Acid; Antidepressive Agents, Tricyclic; Bipolar Disorder; Brain; Depressio | 1975 |
Central dopamine function in affective illness: evidence from precursors, enzyme inhibitors, and studies of central dopamine turnover.
Topics: Adult; Affective Symptoms; Anger; Bipolar Disorder; Central Nervous System; Depression; Diagnosis, D | 1974 |
2 trials available for probenecid and Bipolar Disorder
| Article | Year |
|---|---|
Estimation of brain amine metabolism in affective illness: cerebrospinal fluid studies utilizing probenecid.
Topics: Bipolar Disorder; Brain; Depression; Dihydroxyphenylalanine; Fenclonine; Homovanillic Acid; Humans; | 1974 |
5-Hydroxyindole acetic acid and homovanillic acid in cerebrospinal fluid in manic-depressive psychosis and the effect of probenecid treatment.
Topics: Adult; Age Factors; Aged; Bipolar Disorder; Body Weight; Clinical Trials as Topic; Female; Half-Life | 1973 |
27 other studies available for probenecid and Bipolar Disorder
| Article | Year |
|---|---|
Dopamine and mania: behavioral and biochemical effects of the dopamine receptor blocker pimozide.
Topics: Adult; Behavior; Bipolar Disorder; Dopamine; Female; Homovanillic Acid; Humans; Hydroxyindoleacetic | 1980 |
CSF monoamine metabolites in child and adult psychiatric patients. A developmental perspective.
Topics: Adolescent; Adult; Age Factors; Aged; Autistic Disorder; Bipolar Disorder; Child; Child, Preschool; | 1980 |
Neuroendocrine and neurochemical measurements in depression.
Topics: Adult; Aged; Bipolar Disorder; Depressive Disorder; Dexamethasone; Glycols; Homovanillic Acid; Human | 1981 |
Acid metabolites and precursor amino acids of 5-hydroxytryptamine and dopamine in affective and other psychiatric disorders.
Topics: Adjustment Disorders; Adult; Aged; Amino Acids; Bipolar Disorder; Depressive Disorder; Dopamine; Fem | 1983 |
CSF AMP in primary affective disorder: effects of probenecid and tryptophan.
Topics: Bipolar Disorder; Cyclic AMP; Depression; Humans; Probenecid; Tryptophan | 1980 |
State-related cyclical dyskinesias in manic-depressive illness.
Topics: Adult; Bipolar Disorder; Dyskinesia, Drug-Induced; Female; gamma-Aminobutyric Acid; Humans; Male; Mi | 1982 |
Amino acid concentrations in cerebrospinal fluid: effects of aging, depression, and probenecid.
Topics: Adult; Aging; Amino Acids; Bipolar Disorder; Depression; Female; Humans; Male; Middle Aged; Probenec | 1980 |
Cyclic AMP in cerebrospinal fluid of manic and depressive patients.
Topics: Administration, Oral; Amitriptyline; Bipolar Disorder; Cyclic AMP; Depression; Humans; Imipramine; L | 1977 |
CSF calcium: clinical correlates in affective illness and schizophrenia.
Topics: Bipolar Disorder; Calcium; Humans; Lithium; Magnesium; Premedication; Probenecid; Schizophrenia | 1979 |
Lithium: clinical effects and cerebrospinal fluid acid monoamine metabolites.
Topics: Adult; Affective Symptoms; Aged; Biogenic Amines; Bipolar Disorder; Depression; Electroencephalograp | 1977 |
Reduced myo-inositol levels in cerebrospinal fluid from patients with affective disorder.
Topics: Bipolar Disorder; Depression; Fructose; Glucose; Humans; Inositol; Probenecid | 1978 |
Cerebrospinal fluid norepinephrine in affective illness.
Topics: Anxiety; Bipolar Disorder; Depression; Emotions; Female; Humans; Male; Motor Activity; Nervous Syste | 1978 |
Dopamine-beta-hydroxylase in the cerebrospinal fluid of psychiatric patients.
Topics: Adolescent; Adult; Aged; Alcoholism; Bipolar Disorder; Depression; Dopamine beta-Hydroxylase; Female | 1978 |
Prostaglandin F in patients with primary affective disorder.
Topics: Adult; Aged; Bipolar Disorder; Depression; Female; Humans; Male; Middle Aged; Probenecid; Prostaglan | 1977 |
An examination of baseline and drug-induced levels of cyclic nucleotides in the cerebrospinal fluid of control and psychiatric patients.
Topics: Adolescent; Adult; Aged; Amitriptyline; Bipolar Disorder; Depression; Humans; Imipramine; Lithium; M | 1976 |
CSF acid monoamine metabolities as a possible reflection of central MAO activity in chronic schizophrenia.
Topics: Acute Disease; Adolescent; Adult; Bipolar Disorder; Chronic Disease; Female; Homovanillic Acid; Huma | 1976 |
Reduced central serotonergic activity in mania: implications for the relationship between depression and mania.
Topics: Bipolar Disorder; Brain; Depression; Disease Models, Animal; Humans; Hydroxyindoleacetic Acid; Hypno | 1975 |
Cerebrospinal fluid amine metabolites in acute schizophrenia.
Topics: Acute Disease; Adolescent; Adult; Amines; Bipolar Disorder; Dopamine; Homovanillic Acid; Humans; Hyd | 1975 |
Dopamine metabolism in depressions, psychoses, and Parkinson's disease: the problem of the specificity of biological variables in behaviour disorders.
Topics: Adjustment Disorders; Bipolar Disorder; Brain; Carboxy-Lyases; Depression; Dihydroxyphenylalanine; D | 1975 |
Steady-state levels of probenecid and their relation to acid monoamine metabolites in human cerebrospinal fluid.
Topics: Adult; Aged; Benzoates; Bipolar Disorder; Blood-Brain Barrier; Female; Humans; Huntington Disease; H | 1972 |
Absence of effect of para-chlorophenylalanine on 5-hydroxyindoleacetic acid in cerebrospinal fluid in man.
Topics: Adult; Aged; Bipolar Disorder; Drug Interactions; Female; Fenclonine; Humans; Hydroxyindoleacetic Ac | 1972 |
Cerebrospinal fluid amine metabolites in affective illness: the probenecid technique.
Topics: Affective Symptoms; Biological Transport, Active; Bipolar Disorder; Brain; Brain Chemistry; Depressi | 1973 |
Fluorometric measurement of 5-hydroxyindoleacetic acid (5HIAA) and tryptophan in human CSF: effects of high doses of probenecid.
Topics: Administration, Oral; Adolescent; Adult; Bipolar Disorder; Brain Chemistry; Depression; Female; Fluo | 1974 |
5-Hydroxyindolacetic acid and homovanillic acid in cerebrospinal fluid in manic-depressive psychosis.
Topics: Adult; Aged; Antidepressive Agents; Bipolar Disorder; Butyrophenones; Female; Humans; Hydroxyindolea | 1972 |
Lumbar CSF 5-hydroxyindoleacetic acid and homovanillic acid in affective syndromes.
Topics: Adult; Affective Symptoms; Amitriptyline; Animals; Bipolar Disorder; Brain Chemistry; Cats; Depressi | 1974 |
Diagnosis of manic-depressive psychosis from cerebrospinal fluid concentration of 5-hydroxyindoleacetic acid.
Topics: Bipolar Disorder; Dose-Response Relationship, Drug; Half-Life; Homovanillic Acid; Humans; Hydroxyind | 1974 |
[Clinical pharmacology (11): diagnostic methods].
Topics: Bipolar Disorder; Diagnostic Uses of Chemicals; Humans; Hydroxyindoleacetic Acid; Parkinson Disease; | 1970 |