probenecid has been researched along with Bilirubinemia in 6 studies
Probenecid: The prototypical uricosuric agent. It inhibits the renal excretion of organic anions and reduces tubular reabsorption of urate. Probenecid has also been used to treat patients with renal impairment, and, because it reduces the renal tubular excretion of other drugs, has been used as an adjunct to antibacterial therapy.
probenecid : A sulfonamide in which the nitrogen of 4-sulfamoylbenzoic acid is substituted with two propyl groups.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The effect of hyperbilirubinemia on the function of tissue efflux transporters such as multidrug resistance-associated proteins (Mrps) and organic anion transporting polypeptides (Oatps) was examined by measuring tissue accumulation of 2,4-dinitrophenyl-S-glutathione (DNP-SG) after intravenous administration of 1-chloro-2,4-dinitrobenzene (CDNB), a precursor of DNP-SG, in rats." | 7.76 | Modulated function of tissue efflux transporters under hyperbilirubinemia in rats. ( Mori, N; Murakami, T; Yokooji, T, 2010) |
| " In addition, characterization of the UGT1A locus and genetic studies directed at understanding the role of bilirubin glucuronidation and the biochemical basis of the clinical symptoms found in unconjugated hyperbilirubinemia have uncovered the structural gene polymorphisms associated with Crigler-Najjar's and Gilbert's syndrome." | 4.80 | Human UDP-glucuronosyltransferases: metabolism, expression, and disease. ( Strassburg, CP; Tukey, RH, 2000) |
| "Hyperbilirubinemia, which is involved under various disease states, may increase the small intestinal accumulation and toxicities of methotrexate, since high plasma concentrations of conjugated bilirubin can suppress the function of multidrug resistance-associated proteins, which facilitate the efflux of methotrexate out of cells." | 3.77 | Modulated pharmacokinetics and increased small intestinal toxicity of methotrexate in bilirubin-treated rats. ( Mori, N; Murakami, T; Yokooji, T, 2011) |
| "The effect of hyperbilirubinemia on the function of tissue efflux transporters such as multidrug resistance-associated proteins (Mrps) and organic anion transporting polypeptides (Oatps) was examined by measuring tissue accumulation of 2,4-dinitrophenyl-S-glutathione (DNP-SG) after intravenous administration of 1-chloro-2,4-dinitrobenzene (CDNB), a precursor of DNP-SG, in rats." | 3.76 | Modulated function of tissue efflux transporters under hyperbilirubinemia in rats. ( Mori, N; Murakami, T; Yokooji, T, 2010) |
| "The function of multidrug resistance-associated protein 2 (Mrp2) in the intestine and liver, as well as intestinal Mrp2 expression, was analyzed in CCl(4)-induced acute hepatic failure rats with hyperbilirubinemia." | 3.73 | Function of multidrug resistance-associated protein 2 in acute hepatic failure rats. ( Murakami, T; Nagai, J; Takano, M; Yokooji, T; Yumoto, R, 2006) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 4 (66.67) | 29.6817 |
| 2010's | 2 (33.33) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Tukey, RH | 1 |
| Strassburg, CP | 1 |
| Chen, C | 1 |
| Scott, D | 1 |
| Hanson, E | 1 |
| Franco, J | 1 |
| Berryman, E | 1 |
| Volberg, M | 1 |
| Liu, X | 1 |
| Yokooji, T | 3 |
| Mori, N | 2 |
| Murakami, T | 3 |
| Sugie, M | 1 |
| Asakura, E | 1 |
| Zhao, YL | 1 |
| Torita, S | 1 |
| Nadai, M | 1 |
| Baba, K | 1 |
| Kitaichi, K | 1 |
| Takagi, K | 2 |
| Hasegawa, T | 1 |
| Yumoto, R | 1 |
| Nagai, J | 1 |
| Takano, M | 1 |
1 review available for probenecid and Bilirubinemia
| Article | Year |
|---|---|
Human UDP-glucuronosyltransferases: metabolism, expression, and disease.
Topics: Autoimmunity; Chromosome Mapping; Glucuronides; Glucuronosyltransferase; Humans; Hyperbilirubinemia; | 2000 |
5 other studies available for probenecid and Bilirubinemia
| Article | Year |
|---|---|
Impact of Mrp2 on the biliary excretion and intestinal absorption of furosemide, probenecid, and methotrexate using Eisai hyperbilirubinemic rats.
Topics: Animals; ATP-Binding Cassette Transporters; Biliary Tract; Carrier Proteins; Furosemide; Hyperbiliru | 2003 |
Modulated function of tissue efflux transporters under hyperbilirubinemia in rats.
Topics: Animals; Bilirubin; Dinitrochlorobenzene; Gene Expression Regulation; Glutathione; Hyperbilirubinemi | 2010 |
Modulated pharmacokinetics and increased small intestinal toxicity of methotrexate in bilirubin-treated rats.
Topics: Alkaline Phosphatase; Animals; Biliary Tract; Bilirubin; Biological Transport; Drug Interactions; Hy | 2011 |
Possible involvement of the drug transporters P glycoprotein and multidrug resistance-associated protein Mrp2 in disposition of azithromycin.
Topics: Animals; Anti-Bacterial Agents; ATP Binding Cassette Transporter, Subfamily B, Member 1; Azithromyci | 2004 |
Function of multidrug resistance-associated protein 2 in acute hepatic failure rats.
Topics: Adenosine Triphosphate; Animals; Area Under Curve; ATP-Binding Cassette Transporters; Bile; Bilirubi | 2006 |