probenecid has been researched along with Astrocytoma in 3 studies
Probenecid: The prototypical uricosuric agent. It inhibits the renal excretion of organic anions and reduces tubular reabsorption of urate. Probenecid has also been used to treat patients with renal impairment, and, because it reduces the renal tubular excretion of other drugs, has been used as an adjunct to antibacterial therapy.
probenecid : A sulfonamide in which the nitrogen of 4-sulfamoylbenzoic acid is substituted with two propyl groups.
Astrocytoma: Neoplasms of the brain and spinal cord derived from glial cells which vary from histologically benign forms to highly anaplastic and malignant tumors. Fibrillary astrocytomas are the most common type and may be classified in order of increasing malignancy (grades I through IV). In the first two decades of life, astrocytomas tend to originate in the cerebellar hemispheres; in adults, they most frequently arise in the cerebrum and frequently undergo malignant transformation. (From Devita et al., Cancer: Principles and Practice of Oncology, 5th ed, pp2013-7; Holland et al., Cancer Medicine, 3d ed, p1082)
Excerpt | Relevance | Reference |
---|---|---|
"1321N1 astrocytoma cells loaded with Fura-2 were found to continuously transport Fura-2 to the extracellular medium." | 3.67 | Measurement of cytoplasmic calcium concentration in cell suspensions: correction for extracellular Fura-2 through use of Mn2+ and probenecid. ( Button, DC; McDonough, PM, 1989) |
Timeframe | Studies, this research(%) | All Research% |
---|---|---|
pre-1990 | 1 (33.33) | 18.7374 |
1990's | 0 (0.00) | 18.2507 |
2000's | 1 (33.33) | 29.6817 |
2010's | 1 (33.33) | 24.3611 |
2020's | 0 (0.00) | 2.80 |
Authors | Studies |
---|---|
Blum, AE | 1 |
Walsh, BC | 1 |
Dubyak, GR | 1 |
Mehlin, C | 1 |
Crittenden, C | 1 |
Andreyka, J | 1 |
McDonough, PM | 1 |
Button, DC | 1 |
3 other studies available for probenecid and Astrocytoma
Article | Year |
---|---|
Extracellular osmolarity modulates G protein-coupled receptor-dependent ATP release from 1321N1 astrocytoma cells.
Topics: Adenosine Triphosphate; Anions; Astrocytoma; Calcium Signaling; Carbenoxolone; Cell Line, Tumor; Che | 2010 |
No-wash dyes for calcium flux measurement.
Topics: Artifacts; Astrocytoma; Calcium; Calcium Channels; Dose-Response Relationship, Drug; Fluorescent Dye | 2003 |
Measurement of cytoplasmic calcium concentration in cell suspensions: correction for extracellular Fura-2 through use of Mn2+ and probenecid.
Topics: Astrocytoma; Benzofurans; Calcium; Cells, Cultured; Fura-2; Manganese; Probenecid; Tumor Cells, Cult | 1989 |