probenecid has been researched along with Arthritis, Rheumatoid in 17 studies
Probenecid: The prototypical uricosuric agent. It inhibits the renal excretion of organic anions and reduces tubular reabsorption of urate. Probenecid has also been used to treat patients with renal impairment, and, because it reduces the renal tubular excretion of other drugs, has been used as an adjunct to antibacterial therapy.
probenecid : A sulfonamide in which the nitrogen of 4-sulfamoylbenzoic acid is substituted with two propyl groups.
Arthritis, Rheumatoid: A chronic systemic disease, primarily of the joints, marked by inflammatory changes in the synovial membranes and articular structures, widespread fibrinoid degeneration of the collagen fibers in mesenchymal tissues, and by atrophy and rarefaction of bony structures. Etiology is unknown, but autoimmune mechanisms have been implicated.
| Excerpt | Relevance | Reference |
|---|---|---|
| "A patient with rheumatoid arthritis developed life-threatening pancytopenia resulting from low dose oral methotrexate (MTX) toxicity potentiated by probenecid." | 7.68 | Severe pancytopenia in a patient taking low dose methotrexate and probenecid. ( Basin, KS; Beardmore, TD; Escalante, A, 1991) |
| " Injectable gold compounds and penicillamine are not contraindicated in the elderly, because they are just as efficacious as in younger persons for the treatment of rheumatoid arthritis." | 4.76 | Problems of antiarthritic therapy in the elderly. ( Brooks, PM; Buchanan, WW; Kassam, Y; Kean, WF, 1984) |
| "A patient with rheumatoid arthritis developed life-threatening pancytopenia resulting from low dose oral methotrexate (MTX) toxicity potentiated by probenecid." | 3.68 | Severe pancytopenia in a patient taking low dose methotrexate and probenecid. ( Basin, KS; Beardmore, TD; Escalante, A, 1991) |
| "The interaction between indomethacin and probenecid has been studied in 17 patients with rheumatoid arthritis with the use of a specific gas-liquid chromatographic method for the assay of indomethacin in plasma and urine." | 3.66 | The interaction between indomethacin and probenecid. A clinical and pharmacokinetic study. ( Baber, N; Halliday, L; Littler, T; Orme, ML; Sibeon, R, 1978) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 16 (94.12) | 18.7374 |
| 1990's | 1 (5.88) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| FELHENDLER, M | 1 |
| CARCASSONNE, Y | 1 |
| CARVER, M | 1 |
| Brooks, PM | 2 |
| Kean, WF | 1 |
| Kassam, Y | 1 |
| Buchanan, WW | 1 |
| Yu, TF | 1 |
| Roboz, J | 1 |
| Johnson, S | 1 |
| Kaung, C | 1 |
| Bollet, AJ | 1 |
| Wollheim, FA | 1 |
| Stenberg, P | 1 |
| Nilsson, B | 1 |
| Mellbin, G | 1 |
| Baber, N | 1 |
| Halliday, L | 1 |
| Sibeon, R | 1 |
| Littler, T | 1 |
| Orme, ML | 1 |
| Bell, MA | 1 |
| Walker, JJ | 1 |
| Kennedy, AC | 1 |
| Sturrock, RD | 1 |
| Dick, WC | 1 |
| Basin, KS | 1 |
| Escalante, A | 1 |
| Beardmore, TD | 1 |
| Evans, WE | 1 |
| Christensen, ML | 1 |
| Jamali, F | 1 |
| Russell, AS | 1 |
| Lehmann, C | 1 |
| Berry, BW | 1 |
| McCarty, DJ | 1 |
| Ignarro, LJ | 1 |
| Bartolović, Z | 1 |
| Rothermich, NO | 1 |
4 reviews available for probenecid and Arthritis, Rheumatoid
| Article | Year |
|---|---|
Problems of antiarthritic therapy in the elderly.
Topics: Adrenal Cortex Hormones; Age Factors; Aged; Allopurinol; Anti-Inflammatory Agents; Anti-Inflammatory | 1984 |
Drug interactions with methotrexate.
Topics: Absorption; Anti-Bacterial Agents; Arthritis, Rheumatoid; Aspirin; Biological Transport; Cell Membra | 1985 |
Arthritis & other rheumatic diseases. I. Introduction.
Topics: Adrenocorticotropic Hormone; Allopurinol; Analgesics; Arthritis, Juvenile; Arthritis, Rheumatoid; Co | 1971 |
Crystal deposition joint disease.
Topics: Aged; Arthritis, Rheumatoid; Chondrocalcinosis; Colchicine; Crystallization; Diphosphates; Female; G | 1974 |
13 other studies available for probenecid and Arthritis, Rheumatoid
| Article | Year |
|---|---|
Probenecid therapy in rheumatoid arthritis.
Topics: Arthritis; Arthritis, Rheumatoid; Humans; Probenecid | 1957 |
[THE TREATMENT OF CHRONIC INFLAMMATORY RHEUMATISM IN ADULTS].
Topics: Adrenal Cortex Hormones; Antimalarials; Arthritis; Arthritis, Rheumatoid; Aspirin; Colchicine; Colla | 1964 |
ATYPICAL GOUT.
Topics: Arthritis; Arthritis, Rheumatoid; Colchicine; Diagnosis, Differential; Geriatrics; Gout; Humans; Ost | 1964 |
Studies on the metabolism of D-penicillamine and its interaction with probenecid in cystinuria and rheumatoid arthritis.
Topics: Arthritis, Rheumatoid; Cysteine; Cystinuria; Drug Therapy, Combination; Female; Humans; Male; Penici | 1984 |
Diagnostic and therapeutic aids in gout and hyperuricemia.
Topics: Acute Disease; Allopurinol; Arthritis, Rheumatoid; Colchicine; Diagnosis, Differential; Gout; Humans | 1981 |
Clinical and methodological studies on intramuscular ketoprofen in postoperative rheumatic pain.
Topics: Adult; Aged; Arthritis, Rheumatoid; Drug Evaluation; Female; Humans; Injections, Intramuscular; Keto | 1981 |
The interaction between indomethacin and probenecid. A clinical and pharmacokinetic study.
Topics: Adult; Arthritis, Rheumatoid; Blood Proteins; Drug Interactions; Drug Therapy, Combination; Female; | 1978 |
Proceedings: Ups and downs of indomethacin bioavailability.
Topics: Arthritis, Rheumatoid; Humans; Indomethacin; Probenecid | 1975 |
Severe pancytopenia in a patient taking low dose methotrexate and probenecid.
Topics: Aged; Arthritis, Rheumatoid; Blood Cell Count; Dose-Response Relationship, Drug; Drug Interactions; | 1991 |
Pharmacokinetics of tiaprofenic acid in healthy and arthritic subjects.
Topics: Adult; Aged; Anti-Inflammatory Agents; Arthritis, Rheumatoid; Creatinine; Dialysis; Female; Half-Lif | 1985 |
Release of neutral protease and beta-glucuronidase from human neutrophils in the presence of cartilage treated with various immunologic reactants.
Topics: Allopurinol; Arthritis, Rheumatoid; Aspirin; Cartilage; Chloroquine; Colchicine; Factor VIII; Glucur | 1974 |
[1st observations on the uricosuric properties of Benemid].
Topics: Arthritis, Rheumatoid; Humans; Probenecid | 1965 |
An extended study of indomethacin. II. Clinical therapy.
Topics: Adolescent; Adult; Arthritis; Arthritis, Rheumatoid; Aspirin; Child; Female; Gout; Humans; Indometha | 1966 |