probenecid has been researched along with Anesthesia in 5 studies
Probenecid: The prototypical uricosuric agent. It inhibits the renal excretion of organic anions and reduces tubular reabsorption of urate. Probenecid has also been used to treat patients with renal impairment, and, because it reduces the renal tubular excretion of other drugs, has been used as an adjunct to antibacterial therapy.
probenecid : A sulfonamide in which the nitrogen of 4-sulfamoylbenzoic acid is substituted with two propyl groups.
Anesthesia: A state characterized by loss of feeling or sensation. This depression of nerve function is usually the result of pharmacologic action and is induced to allow performance of surgery or other painful procedures.
| Excerpt | Relevance | Reference |
|---|---|---|
| " Manipulation of physiologic state (n=35) did not affect efflux, but sucrose efflux half time was longer with pentobarbital anesthesia (24 h) than with no anesthesia or ketamine-xylazine anesthesia (2 to 3 h)." | 3.74 | Efflux of drugs and solutes from brain: the interactive roles of diffusional transcapillary transport, bulk flow and capillary transporters. ( Allen, CV; Groothuis, DR; Hertzler, S; Itskovich, AC; Kang, EW; Lipton, HL; Schlageter, KE; Vavra, MW, 2007) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 4 (80.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 1 (20.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Groothuis, DR | 1 |
| Vavra, MW | 1 |
| Schlageter, KE | 1 |
| Kang, EW | 1 |
| Itskovich, AC | 1 |
| Hertzler, S | 1 |
| Allen, CV | 1 |
| Lipton, HL | 1 |
| Baer, JE | 1 |
| Breault, GO | 1 |
| Russo, HF | 1 |
| Wahlström, G | 1 |
| Dundee, JW | 1 |
| Halliday, NJ | 1 |
| McMurray, TJ | 1 |
| van Dyke, DH | 1 |
| Cserr, H | 1 |
| Barlow, CF | 1 |
1 trial available for probenecid and Anesthesia
| Article | Year |
|---|---|
Aspirin and probenecid pretreatment influences the potency of thiopentone and the onset of action of midazolam.
Topics: Adult; Anesthesia; Aspirin; Drug Interactions; Humans; Midazolam; Preanesthetic Medication; Probenec | 1986 |
4 other studies available for probenecid and Anesthesia
| Article | Year |
|---|---|
Efflux of drugs and solutes from brain: the interactive roles of diffusional transcapillary transport, bulk flow and capillary transporters.
Topics: Algorithms; Anesthesia; Animals; Autoradiography; Biological Transport; Blood Pressure; Blood-Brain | 2007 |
Diflunisal renal clearance in anesthetized dogs: effect of probenecid, urine flow, and urine pH.
Topics: Anesthesia; Animals; Diuresis; Dogs; Female; Glomerular Filtration Rate; Hydrogen-Ion Concentration; | 1978 |
Increased penetration of barbital through the bloodbrain barrier in the rat after pretreatment with probenecid.
Topics: Anesthesia; Animals; Barbital; Barbiturates; Biological Transport, Active; Blood-Brain Barrier; Brai | 1978 |
5-Hydroxyindoleacetic acid (5-HIAA) transport by isolated choroid plexus.
Topics: Aminohippuric Acids; Anesthesia; Animals; Biological Transport, Active; Carbon Isotopes; Choroid Ple | 1970 |