probenecid has been researched along with Anemia, Sickle Cell in 6 studies
Probenecid: The prototypical uricosuric agent. It inhibits the renal excretion of organic anions and reduces tubular reabsorption of urate. Probenecid has also been used to treat patients with renal impairment, and, because it reduces the renal tubular excretion of other drugs, has been used as an adjunct to antibacterial therapy.
probenecid : A sulfonamide in which the nitrogen of 4-sulfamoylbenzoic acid is substituted with two propyl groups.
Anemia, Sickle Cell: A disease characterized by chronic hemolytic anemia, episodic painful crises, and pathologic involvement of many organs. It is the clinical expression of homozygosity for hemoglobin S.
| Excerpt | Relevance | Reference |
|---|---|---|
| " The uricosuric agent probenecid inhibits tubular excretion of antibiotics and may be used as β-lactam pharmacokinetic enhancer (BLPKE), even though few data are currently available for this purpose." | 1.72 | Probenecid, an old β-lactams pharmacokinetic enhancer for a renewed use: A retrospective study. ( Gallien, S; Habibi, A; Hulin, A; Huriez, P; Lepeule, R; Ourghanlian, C; Razazi, K; Vindrios, W, 2022) |
| "Patients with sickle cell anemia were often normouricemic despite urate overproduction." | 1.26 | The natural history of urate overproduction in sickle cell anemia. ( Diamond, HS; Holden, D; Meisel, AD, 1979) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 4 (66.67) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 2 (33.33) | 2.80 |
| Authors | Studies |
|---|---|
| Vandorpe, DH | 1 |
| Rivera, A | 1 |
| Ganter, M | 1 |
| Dankwa, S | 1 |
| Wohlgemuth, JG | 1 |
| Dlott, JS | 1 |
| Snyder, LM | 1 |
| Brugnara, C | 1 |
| Duraisingh, M | 1 |
| Alper, SL | 1 |
| Huriez, P | 1 |
| Ourghanlian, C | 1 |
| Razazi, K | 1 |
| Vindrios, W | 1 |
| Hulin, A | 1 |
| Lepeule, R | 1 |
| Habibi, A | 1 |
| Gallien, S | 1 |
| Diamond, HS | 3 |
| Meisel, AD | 2 |
| Holden, D | 2 |
| Meisel, A | 1 |
| Sharon, E | 1 |
| Cacatian, A | 1 |
| Talbott, JH | 1 |
| Gottlieb, N | 1 |
| Grendelmeier, P | 1 |
| Rodriguez, E | 1 |
6 other studies available for probenecid and Anemia, Sickle Cell
| Article | Year |
|---|---|
Purinergic signaling is essential for full Psickle activation by hypoxia and by normoxic acid pH in mature human sickle red cells and in vitro-differentiated cultured human sickle reticulocytes.
Topics: Adenosine Triphosphate; Anemia, Sickle Cell; Apyrase; Cations; Cells, Cultured; Erythrocytes; Humans | 2022 |
Probenecid, an old β-lactams pharmacokinetic enhancer for a renewed use: A retrospective study.
Topics: Anemia, Sickle Cell; Anti-Bacterial Agents; beta-Lactams; Humans; Probenecid; Retrospective Studies | 2022 |
The natural history of urate overproduction in sickle cell anemia.
Topics: Adolescent; Adult; Anemia, Sickle Cell; Creatinine; Female; Humans; Male; Middle Aged; p-Aminohippur | 1979 |
Classification of uricosuric states based upon response to pharmacologic inhibitors of urate transport.
Topics: Anemia, Sickle Cell; Aspirin; Biological Transport; Diatrizoate; Fanconi Syndrome; Glomerular Filtra | 1977 |
Hyperuricosuria and increased tubular secretion of urate in sickle cell anemia.
Topics: Adolescent; Adult; Aminohippuric Acids; Anemia, Sickle Cell; Biological Transport; Female; Glomerula | 1975 |
Gouty arthritis in the black race.
Topics: Adult; Aged; Anemia, Sickle Cell; Arthritis; Benzothiadiazines; Black People; Colchicine; Diuretics; | 1975 |