Page last updated: 2024-11-03

probenecid and Anemia, Sickle Cell

probenecid has been researched along with Anemia, Sickle Cell in 6 studies

Probenecid: The prototypical uricosuric agent. It inhibits the renal excretion of organic anions and reduces tubular reabsorption of urate. Probenecid has also been used to treat patients with renal impairment, and, because it reduces the renal tubular excretion of other drugs, has been used as an adjunct to antibacterial therapy.
probenecid : A sulfonamide in which the nitrogen of 4-sulfamoylbenzoic acid is substituted with two propyl groups.

Anemia, Sickle Cell: A disease characterized by chronic hemolytic anemia, episodic painful crises, and pathologic involvement of many organs. It is the clinical expression of homozygosity for hemoglobin S.

Research Excerpts

ExcerptRelevanceReference
" The uricosuric agent probenecid inhibits tubular excretion of antibiotics and may be used as β-lactam pharmacokinetic enhancer (BLPKE), even though few data are currently available for this purpose."1.72Probenecid, an old β-lactams pharmacokinetic enhancer for a renewed use: A retrospective study. ( Gallien, S; Habibi, A; Hulin, A; Huriez, P; Lepeule, R; Ourghanlian, C; Razazi, K; Vindrios, W, 2022)
"Patients with sickle cell anemia were often normouricemic despite urate overproduction."1.26The natural history of urate overproduction in sickle cell anemia. ( Diamond, HS; Holden, D; Meisel, AD, 1979)

Research

Studies (6)

TimeframeStudies, this research(%)All Research%
pre-19904 (66.67)18.7374
1990's0 (0.00)18.2507
2000's0 (0.00)29.6817
2010's0 (0.00)24.3611
2020's2 (33.33)2.80

Authors

AuthorsStudies
Vandorpe, DH1
Rivera, A1
Ganter, M1
Dankwa, S1
Wohlgemuth, JG1
Dlott, JS1
Snyder, LM1
Brugnara, C1
Duraisingh, M1
Alper, SL1
Huriez, P1
Ourghanlian, C1
Razazi, K1
Vindrios, W1
Hulin, A1
Lepeule, R1
Habibi, A1
Gallien, S1
Diamond, HS3
Meisel, AD2
Holden, D2
Meisel, A1
Sharon, E1
Cacatian, A1
Talbott, JH1
Gottlieb, N1
Grendelmeier, P1
Rodriguez, E1

Other Studies

6 other studies available for probenecid and Anemia, Sickle Cell

ArticleYear
Purinergic signaling is essential for full Psickle activation by hypoxia and by normoxic acid pH in mature human sickle red cells and in vitro-differentiated cultured human sickle reticulocytes.
    Pflugers Archiv : European journal of physiology, 2022, Volume: 474, Issue:5

    Topics: Adenosine Triphosphate; Anemia, Sickle Cell; Apyrase; Cations; Cells, Cultured; Erythrocytes; Humans

2022
Probenecid, an old β-lactams pharmacokinetic enhancer for a renewed use: A retrospective study.
    Infectious diseases now, 2022, Volume: 52, Issue:5

    Topics: Anemia, Sickle Cell; Anti-Bacterial Agents; beta-Lactams; Humans; Probenecid; Retrospective Studies

2022
The natural history of urate overproduction in sickle cell anemia.
    Annals of internal medicine, 1979, Volume: 90, Issue:5

    Topics: Adolescent; Adult; Anemia, Sickle Cell; Creatinine; Female; Humans; Male; Middle Aged; p-Aminohippur

1979
Classification of uricosuric states based upon response to pharmacologic inhibitors of urate transport.
    Advances in experimental medicine and biology, 1977, Volume: 76B

    Topics: Anemia, Sickle Cell; Aspirin; Biological Transport; Diatrizoate; Fanconi Syndrome; Glomerular Filtra

1977
Hyperuricosuria and increased tubular secretion of urate in sickle cell anemia.
    The American journal of medicine, 1975, Volume: 59, Issue:6

    Topics: Adolescent; Adult; Aminohippuric Acids; Anemia, Sickle Cell; Biological Transport; Female; Glomerula

1975
Gouty arthritis in the black race.
    Seminars in arthritis and rheumatism, 1975, Volume: 4, Issue:3

    Topics: Adult; Aged; Anemia, Sickle Cell; Arthritis; Benzothiadiazines; Black People; Colchicine; Diuretics;

1975