probenecid has been researched along with Alzheimer Disease in 5 studies
Probenecid: The prototypical uricosuric agent. It inhibits the renal excretion of organic anions and reduces tubular reabsorption of urate. Probenecid has also been used to treat patients with renal impairment, and, because it reduces the renal tubular excretion of other drugs, has been used as an adjunct to antibacterial therapy.
probenecid : A sulfonamide in which the nitrogen of 4-sulfamoylbenzoic acid is substituted with two propyl groups.
Alzheimer Disease: A degenerative disease of the BRAIN characterized by the insidious onset of DEMENTIA. Impairment of MEMORY, judgment, attention span, and problem solving skills are followed by severe APRAXIAS and a global loss of cognitive abilities. The condition primarily occurs after age 60, and is marked pathologically by severe cortical atrophy and the triad of SENILE PLAQUES; NEUROFIBRILLARY TANGLES; and NEUROPIL THREADS. (From Adams et al., Principles of Neurology, 6th ed, pp1049-57)
| Excerpt | Relevance | Reference |
|---|---|---|
| "The diagnosis of Alzheimer's disease (13 patients) and Pick's disease (4 patients) has been made on clinical and radiological grounds." | 1.26 | [Cerebral metabolism of dopamine and of serotonin during Alzheimer and Pick's diseases. Dynamic study by the test using probenecid]. ( Chazot, G; Guard, O; Renaud, B, 1976) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 3 (60.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 1 (20.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 1 (20.00) | 2.80 |
| Authors | Studies |
|---|---|
| Hanafy, AS | 1 |
| Lamprecht, A | 1 |
| Dietrich, D | 1 |
| Gellermann, GP | 1 |
| Ullrich, K | 1 |
| Unger, C | 1 |
| Fändrich, M | 1 |
| Sauter, S | 1 |
| Diekmann, S | 1 |
| Meyer, JS | 1 |
| Welch, KM | 1 |
| Deshmukh, VD | 1 |
| Perez, FI | 1 |
| Jacob, RH | 1 |
| Haufrect, DB | 1 |
| Mathew, NT | 1 |
| Morrell, RM | 1 |
| Guard, O | 1 |
| Renaud, B | 1 |
| Chazot, G | 1 |
| Gibson, CJ | 1 |
| Logue, M | 1 |
| Growdon, JH | 1 |
5 other studies available for probenecid and Alzheimer Disease
| Article | Year |
|---|---|
Local perfusion of capillaries reveals disrupted beta-amyloid homeostasis at the blood-brain barrier in Tg2576 murine Alzheimer's model.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Blood-Brain Barrier; Capillaries; Endothelial Cel | 2023 |
Identification of molecular compounds critical to Alzheimer's-like plaque formation.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Cells, Cultured; Chondroitin; Cytochalasin D; Dextran Sulf | 2007 |
Neurotransmitter precursor amino acids in the treatment of multi-infarct dementia and Alzheimer's disease.
Topics: 5-Hydroxytryptophan; Aged; Alzheimer Disease; Carbidopa; Dementia; Dopamine; Drug Combinations; Fema | 1977 |
[Cerebral metabolism of dopamine and of serotonin during Alzheimer and Pick's diseases. Dynamic study by the test using probenecid].
Topics: Aged; Alzheimer Disease; Brain Chemistry; Dementia; Dopamine; Female; Homovanillic Acid; Humans; Hyd | 1976 |
CSF monoamine metabolite levels in Alzheimer's and Parkinson's disease.
Topics: Adult; Aged; Alzheimer Disease; Female; Glycols; Homovanillic Acid; Humans; Hydroxyindoleacetic Acid | 1985 |