probenecid has been researched along with Allergy, Drug in 17 studies
Probenecid: The prototypical uricosuric agent. It inhibits the renal excretion of organic anions and reduces tubular reabsorption of urate. Probenecid has also been used to treat patients with renal impairment, and, because it reduces the renal tubular excretion of other drugs, has been used as an adjunct to antibacterial therapy.
probenecid : A sulfonamide in which the nitrogen of 4-sulfamoylbenzoic acid is substituted with two propyl groups.
| Excerpt | Relevance | Reference |
|---|---|---|
| "To investigate the efficacy and tolerability of allopurinol as the first-choice antihyperuricaemic treatment for gout, and compare the efficacy and tolerability of benzbromarone and probenecid as second-choice treatment." | 9.14 | Efficacy and tolerability of urate-lowering drugs in gout: a randomised controlled trial of benzbromarone versus probenecid after failure of allopurinol. ( Brouwers, JR; Delsing, J; Griep, EN; Hoekstra, M; Jansen, TL; Reinders, MK; van de Laar, MA; van Roon, EN, 2009) |
| "To investigate the efficacy and tolerability of allopurinol as the first-choice antihyperuricaemic treatment for gout, and compare the efficacy and tolerability of benzbromarone and probenecid as second-choice treatment." | 5.14 | Efficacy and tolerability of urate-lowering drugs in gout: a randomised controlled trial of benzbromarone versus probenecid after failure of allopurinol. ( Brouwers, JR; Delsing, J; Griep, EN; Hoekstra, M; Jansen, TL; Reinders, MK; van de Laar, MA; van Roon, EN, 2009) |
| "Hematuria and eosinophilia developed in two patients being treated for bacterial endocarditis with 20 or 24 gm/day of cephalexin given orally together with probenecid (Benemid)." | 3.65 | Cephalexin-related nephropathy. ( Kieff, E; Verma, S, 1975) |
| " A pretreatment regimen consisting of prednisone, H1 and H2 blockers was administered before the dosing of probenecid in order for the patient to continue with the antiviral therapy." | 1.30 | Probenecid hypersensitivity in AIDS: a case report. ( Engler, RJ; Katial, RK; Myers, KW, 1998) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 13 (76.47) | 18.7374 |
| 1990's | 1 (5.88) | 18.2507 |
| 2000's | 1 (5.88) | 29.6817 |
| 2010's | 2 (11.76) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Stamp, L | 1 |
| Dalbeth, N | 1 |
| Simon, HB | 1 |
| STROM, J | 1 |
| NIEWEG, HO | 1 |
| BOUMA, HG | 1 |
| DEVRIES, K | 1 |
| JANSZ, A | 1 |
| Reinders, MK | 1 |
| van Roon, EN | 1 |
| Jansen, TL | 1 |
| Delsing, J | 1 |
| Griep, EN | 1 |
| Hoekstra, M | 1 |
| van de Laar, MA | 1 |
| Brouwers, JR | 1 |
| Wright, AJ | 1 |
| Wilkowske, CJ | 1 |
| Myers, KW | 1 |
| Katial, RK | 1 |
| Engler, RJ | 1 |
| Ummenhofer, B | 1 |
| Djawari, D | 1 |
| Cohen, LS | 1 |
| Verma, S | 1 |
| Kieff, E | 1 |
| Niordson, AM | 1 |
| Ullman, S | 1 |
| Tattersall, MH | 1 |
| Spiers, AS | 1 |
| Darrell, JH | 1 |
| Sparling, PF | 1 |
| Wilkinson, AE | 1 |
| Knudsen, ET | 1 |
| Straus, B | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Effects of Allopurinol on Inflammatory Markers and Morphostructural Changes Evidenced by Musculoskeletal Ultrasound in Individuals With Asymptomatic Hyperuricemia. A Proof of Concept[NCT04012294] | Phase 3 | 200 participants (Anticipated) | Interventional | 2019-08-30 | Recruiting | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
2 reviews available for probenecid and Allergy, Drug
| Article | Year |
|---|---|
Urate-lowering therapy for asymptomatic hyperuricaemia: A need for caution.
Topics: Allopurinol; Asymptomatic Diseases; Drug Eruptions; Drug Hypersensitivity; Febuxostat; Gout Suppress | 2017 |
Clinical pharmacology of acetylsalicylic acid.
Topics: Absorption; Aspirin; Blood Platelets; Digestive System; Drug Combinations; Drug Hypersensitivity; He | 1976 |
2 trials available for probenecid and Allergy, Drug
| Article | Year |
|---|---|
Efficacy and tolerability of urate-lowering drugs in gout: a randomised controlled trial of benzbromarone versus probenecid after failure of allopurinol.
Topics: Aged; Allopurinol; Benzbromarone; Confidence Intervals; Dose-Response Relationship, Drug; Drug Admin | 2009 |
Treatment of gonorrhea. Penicillin.
Topics: Ampicillin; Costs and Cost Analysis; Drug Hypersensitivity; Drug Synergism; Female; Genetics, Microb | 1973 |
13 other studies available for probenecid and Allergy, Drug
| Article | Year |
|---|---|
On call. I've had gout for many years. I used to take Zyloprim without any problems, but I just had a severe allergic reaction, so my doctor switched me to Benemid. I'm doing okay, but the drug sometimes upsets my stomach. Do you have any suggestions?
Topics: Allopurinol; Drug Hypersensitivity; Gastritis; Gout; Gout Suppressants; Humans; Male; Middle Aged; P | 2010 |
Probenecid-penicillin allergy; allergic mucocutaneous reactions following treatment of hemolytic streptococci infections with penicillin preparations containing probenecid.
Topics: Child; Drug Eruptions; Drug Hypersensitivity; Humans; Hypersensitivity; Infant; Penicillins; Probene | 1957 |
HAEMATOLOGICAL SIDE-EFFECTS OF SOME ANTI-RHEUMATIC DRUGS.
Topics: Aminopyrine; Antirheumatic Agents; Aspirin; Blood Platelets; Chloroquine; Colchicine; Complement Fix | 1963 |
The penicillins.
Topics: Amoxicillin; Ampicillin; Bacterial Infections; Carbenicillin; Drug Administration Schedule; Drug Eva | 1983 |
Probenecid hypersensitivity in AIDS: a case report.
Topics: Acquired Immunodeficiency Syndrome; Cidofovir; Cytosine; Drug Hypersensitivity; Herpes Simplex; Huma | 1998 |
[Cross allergy between sulphonamide diuretics, probenecid, sulphamethoxazole and sulphonyl-urea compounds (author's transl)].
Topics: Cross Reactions; Drug Hypersensitivity; Furosemide; Glyburide; Humans; Male; Middle Aged; Probenecid | 1979 |
Cephalexin-related nephropathy.
Topics: Administration, Oral; Adult; Cephalexin; Drug Hypersensitivity; Endocarditis; Eosinophilia; Hematuri | 1975 |
Treatment of gonorrhoea with aqueous benzyl penicillin plus probenecid.
Topics: Adolescent; Adult; Drug Hypersensitivity; Female; Follow-Up Studies; Gonorrhea; Humans; Injections, | 1971 |
Initial therapy with combination of five antibiotics in febrile patients with leukaemia and neutropenia.
Topics: Administration, Oral; Agranulocytosis; Anemia, Aplastic; Anti-Bacterial Agents; Bacterial Infections | 1972 |
Problems in the treatment of venereal disease: bacterial resistance: allergy.
Topics: Drug Hypersensitivity; Gonorrhea; Humans; Kanamycin; Leucomycins; Male; Neisseria gonorrhoeae; Penic | 1972 |
[Factors, affecting penicillin therapy].
Topics: Ampicillin; Anti-Bacterial Agents; Antineoplastic Agents; Bronchitis; Carbenicillin; Cloxacillin; Do | 1971 |
Use of Probenecid in antimicrobial therapy.
Topics: Cephalosporins; Drug Hypersensitivity; Drug Synergism; Humans; Penicillins; Probenecid | 1971 |
Problems and progress in geriatrics.
Topics: Acute Disease; Aged; Aging; Calcitonin; Cardiovascular Diseases; Chronic Disease; Diabetic Coma; Dia | 1968 |