probenecid has been researched along with Acquired Immune Deficiency Syndrome in 6 studies
Probenecid: The prototypical uricosuric agent. It inhibits the renal excretion of organic anions and reduces tubular reabsorption of urate. Probenecid has also been used to treat patients with renal impairment, and, because it reduces the renal tubular excretion of other drugs, has been used as an adjunct to antibacterial therapy.
probenecid : A sulfonamide in which the nitrogen of 4-sulfamoylbenzoic acid is substituted with two propyl groups.
| Excerpt | Relevance | Reference |
|---|---|---|
| " This study explores whether probenecid, which is also metabolized by glucuronidation, reduces zidovudine clearance when zidovudine is administered orally to patients with acquired immunodeficiency syndrome (AIDS) or AIDS-related complex (ARC)." | 7.67 | Alteration of zidovudine pharmacokinetics by probenecid in patients with AIDS or AIDS-related complex. ( Blum, MR; Broder, S; de Miranda, P; Good, SS; Myers, CE; Thomas, RV; Yarchoan, R, 1989) |
| " This study explores whether probenecid, which is also metabolized by glucuronidation, reduces zidovudine clearance when zidovudine is administered orally to patients with acquired immunodeficiency syndrome (AIDS) or AIDS-related complex (ARC)." | 3.67 | Alteration of zidovudine pharmacokinetics by probenecid in patients with AIDS or AIDS-related complex. ( Blum, MR; Broder, S; de Miranda, P; Good, SS; Myers, CE; Thomas, RV; Yarchoan, R, 1989) |
| "Eligible patients with acquired immune deficiency syndrome had active CMV retinitis in at least one eye and no evidence of extraocular CMV disease." | 2.68 | Intravitreal cidofovir (HPMPC) treatment of cytomegalovirus retinitis in patients with acquired immune deficiency syndrome. ( Arevalo, JF; Chavez de la Paz, E; de Clercq, E; Freeman, WR; Kirsch, LS; Munguia, D, 1995) |
| " A pretreatment regimen consisting of prednisone, H1 and H2 blockers was administered before the dosing of probenecid in order for the patient to continue with the antiviral therapy." | 1.30 | Probenecid hypersensitivity in AIDS: a case report. ( Engler, RJ; Katial, RK; Myers, KW, 1998) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 2 (33.33) | 18.7374 |
| 1990's | 3 (50.00) | 18.2507 |
| 2000's | 1 (16.67) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Lucia, MB | 1 |
| Savarino, A | 1 |
| Straface, E | 1 |
| Golotta, C | 1 |
| Rastrelli, E | 1 |
| Matarrese, P | 1 |
| Rutella, S | 1 |
| Malorni, W | 1 |
| Cauda, R | 1 |
| Kirsch, LS | 1 |
| Arevalo, JF | 1 |
| Chavez de la Paz, E | 1 |
| Munguia, D | 1 |
| de Clercq, E | 1 |
| Freeman, WR | 1 |
| Myers, KW | 1 |
| Katial, RK | 1 |
| Engler, RJ | 1 |
| Petty, BG | 2 |
| Kornhauser, DM | 2 |
| Lietman, PS | 2 |
| Hendrix, CW | 1 |
| Woods, AS | 1 |
| Nerhood, LJ | 1 |
| Bartlett, JG | 1 |
| de Miranda, P | 1 |
| Good, SS | 1 |
| Yarchoan, R | 1 |
| Thomas, RV | 1 |
| Blum, MR | 1 |
| Myers, CE | 1 |
| Broder, S | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Influence of Probenecid and Quinine on the Pharmacokinetics of Azidothymidine[NCT00000706] | 12 participants | Interventional | Completed | ||||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
3 trials available for probenecid and Acquired Immune Deficiency Syndrome
| Article | Year |
|---|---|
Role of lymphocyte multidrug resistance protein 1 in HIV infection: expression, function, and consequences of inhibition.
Topics: Acquired Immunodeficiency Syndrome; Adult; Anti-HIV Agents; Antiretroviral Therapy, Highly Active; C | 2005 |
Intravitreal cidofovir (HPMPC) treatment of cytomegalovirus retinitis in patients with acquired immune deficiency syndrome.
Topics: Acquired Immunodeficiency Syndrome; Adult; AIDS-Related Opportunistic Infections; Antiviral Agents; | 1995 |
Probenecid and zidovudine metabolism.
Topics: Acquired Immunodeficiency Syndrome; Administration, Oral; Adult; Aged; AIDS-Related Complex; Chromat | 1989 |
3 other studies available for probenecid and Acquired Immune Deficiency Syndrome
| Article | Year |
|---|---|
Probenecid hypersensitivity in AIDS: a case report.
Topics: Acquired Immunodeficiency Syndrome; Cidofovir; Cytosine; Drug Hypersensitivity; Herpes Simplex; Huma | 1998 |
Zidovudine with probenecid: a warning.
Topics: Acquired Immunodeficiency Syndrome; Drug Interactions; Humans; Male; Probenecid; Product Surveillanc | 1990 |
Alteration of zidovudine pharmacokinetics by probenecid in patients with AIDS or AIDS-related complex.
Topics: Acquired Immunodeficiency Syndrome; Adult; AIDS-Related Complex; Drug Interactions; Drug Therapy, Co | 1989 |