probenecid has been researched along with ARC in 3 studies
Probenecid: The prototypical uricosuric agent. It inhibits the renal excretion of organic anions and reduces tubular reabsorption of urate. Probenecid has also been used to treat patients with renal impairment, and, because it reduces the renal tubular excretion of other drugs, has been used as an adjunct to antibacterial therapy.
probenecid : A sulfonamide in which the nitrogen of 4-sulfamoylbenzoic acid is substituted with two propyl groups.
| Excerpt | Relevance | Reference |
|---|---|---|
| " This study explores whether probenecid, which is also metabolized by glucuronidation, reduces zidovudine clearance when zidovudine is administered orally to patients with acquired immunodeficiency syndrome (AIDS) or AIDS-related complex (ARC)." | 7.67 | Alteration of zidovudine pharmacokinetics by probenecid in patients with AIDS or AIDS-related complex. ( Blum, MR; Broder, S; de Miranda, P; Good, SS; Myers, CE; Thomas, RV; Yarchoan, R, 1989) |
| " This study explores whether probenecid, which is also metabolized by glucuronidation, reduces zidovudine clearance when zidovudine is administered orally to patients with acquired immunodeficiency syndrome (AIDS) or AIDS-related complex (ARC)." | 3.67 | Alteration of zidovudine pharmacokinetics by probenecid in patients with AIDS or AIDS-related complex. ( Blum, MR; Broder, S; de Miranda, P; Good, SS; Myers, CE; Thomas, RV; Yarchoan, R, 1989) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 2 (66.67) | 18.7374 |
| 1990's | 1 (33.33) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Duckworth, AS | 1 |
| Duckworth, GW | 1 |
| Henderson, G | 1 |
| Contreras, G | 1 |
| Kornhauser, DM | 1 |
| Petty, BG | 1 |
| Hendrix, CW | 1 |
| Woods, AS | 1 |
| Nerhood, LJ | 1 |
| Bartlett, JG | 1 |
| Lietman, PS | 1 |
| de Miranda, P | 1 |
| Good, SS | 1 |
| Yarchoan, R | 1 |
| Thomas, RV | 1 |
| Blum, MR | 1 |
| Myers, CE | 1 |
| Broder, S | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Influence of Probenecid and Quinine on the Pharmacokinetics of Azidothymidine[NCT00000706] | 12 participants | Interventional | Completed | ||||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
1 trial available for probenecid and ARC
| Article | Year |
|---|---|
Probenecid and zidovudine metabolism.
Topics: Acquired Immunodeficiency Syndrome; Administration, Oral; Adult; Aged; AIDS-Related Complex; Chromat | 1989 |
2 other studies available for probenecid and ARC
| Article | Year |
|---|---|
Zidovudine with probenecid.
Topics: AIDS-Related Complex; Drug Eruptions; Drug Therapy, Combination; Humans; Probenecid; Zidovudine | 1990 |
Alteration of zidovudine pharmacokinetics by probenecid in patients with AIDS or AIDS-related complex.
Topics: Acquired Immunodeficiency Syndrome; Adult; AIDS-Related Complex; Drug Interactions; Drug Therapy, Co | 1989 |