probenecid has been researched along with AIDS Seroconversion in 5 studies
Probenecid: The prototypical uricosuric agent. It inhibits the renal excretion of organic anions and reduces tubular reabsorption of urate. Probenecid has also been used to treat patients with renal impairment, and, because it reduces the renal tubular excretion of other drugs, has been used as an adjunct to antibacterial therapy.
probenecid : A sulfonamide in which the nitrogen of 4-sulfamoylbenzoic acid is substituted with two propyl groups.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Coadministration of probenecid with zalcitabine resulted in a decrease in mean (%CV) renal clearance of zalcitabine from 310 (28%) ml/min when zalcitabine was given alone to 180 (22%) ml/min with probenecid and a prolonged half-life from 1." | 2.68 | The effect of probenecid on the pharmacokinetics of zalcitabine in HIV-positive patients. ( Massarella, JW; Min, B; Nazareno, LA; Passe, S, 1996) |
| " Terminal elimination half-life remained unchanged at 5." | 1.30 | Renal excretion and pharmacokinetics of foscarnet in HIV sero-positive patients: effect of probenecid pretreatment. ( Gazzard, BG; Higgs, CJ; Lant, AF; Noormohamed, FH; Youle, MS, 1997) |
| "Regimens accepted for the treatment of neurosyphilis appear to be adequate for the treatment of ocular syphilis in HIV-1-infected patients though further long-term follow-up will be required." | 1.28 | The ocular manifestations of syphilis in the human immunodeficiency virus type 1-infected host. ( Culbertson, WW; Holland, S; McLeish, WM; Pulido, JS; Winward, K, 1990) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 4 (80.00) | 18.2507 |
| 2000's | 1 (20.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Warwick, Z | 1 |
| Dean, G | 1 |
| Fisher, M | 1 |
| Massarella, JW | 1 |
| Nazareno, LA | 1 |
| Passe, S | 1 |
| Min, B | 1 |
| Noormohamed, FH | 1 |
| Youle, MS | 1 |
| Higgs, CJ | 1 |
| Gazzard, BG | 1 |
| Lant, AF | 1 |
| Hay, PE | 1 |
| Taylor-Robinson, D | 1 |
| Waldron, S | 1 |
| Goldmeier, D | 1 |
| McLeish, WM | 1 |
| Pulido, JS | 1 |
| Holland, S | 1 |
| Culbertson, WW | 1 |
| Winward, K | 1 |
2 trials available for probenecid and AIDS Seroconversion
| Article | Year |
|---|---|
The effect of probenecid on the pharmacokinetics of zalcitabine in HIV-positive patients.
Topics: Administration, Oral; Adult; Antiviral Agents; Cross-Over Studies; Drug Administration Schedule; Dru | 1996 |
Amoxycillin, syphilis, and HIV infection.
Topics: Amoxicillin; Clinical Trials as Topic; Double-Blind Method; Drug Evaluation; Drug Therapy, Combinati | 1990 |
3 other studies available for probenecid and AIDS Seroconversion
| Article | Year |
|---|---|
Should syphilis be treated differently in HIV-positive and HIV-negative individuals? Treatment outcomes at a university hospital, Brighton, UK.
Topics: Administration, Oral; Anti-Bacterial Agents; Drug Administration Schedule; Drug Therapy, Combination | 2009 |
Renal excretion and pharmacokinetics of foscarnet in HIV sero-positive patients: effect of probenecid pretreatment.
Topics: Adult; Antiviral Agents; Foscarnet; HIV Seropositivity; Humans; Kidney; Male; Middle Aged; Probeneci | 1997 |
The ocular manifestations of syphilis in the human immunodeficiency virus type 1-infected host.
Topics: Adult; Central Nervous System Diseases; Doxycycline; Eye Diseases; Fundus Oculi; HIV Infections; HIV | 1990 |