probenecid has been researched along with AIDS-Related Complex in 3 studies
Probenecid: The prototypical uricosuric agent. It inhibits the renal excretion of organic anions and reduces tubular reabsorption of urate. Probenecid has also been used to treat patients with renal impairment, and, because it reduces the renal tubular excretion of other drugs, has been used as an adjunct to antibacterial therapy.
probenecid : A sulfonamide in which the nitrogen of 4-sulfamoylbenzoic acid is substituted with two propyl groups.
AIDS-Related Complex: A prodromal phase of infection with the human immunodeficiency virus (HIV). Laboratory criteria separating AIDS-related complex (ARC) from AIDS include elevated or hyperactive B-cell humoral immune responses, compared to depressed or normal antibody reactivity in AIDS; follicular or mixed hyperplasia in ARC lymph nodes, leading to lymphocyte degeneration and depletion more typical of AIDS; evolving succession of histopathological lesions such as localization of Kaposi's sarcoma, signaling the transition to the full-blown AIDS.
| Excerpt | Relevance | Reference |
|---|---|---|
| " This study explores whether probenecid, which is also metabolized by glucuronidation, reduces zidovudine clearance when zidovudine is administered orally to patients with acquired immunodeficiency syndrome (AIDS) or AIDS-related complex (ARC)." | 7.67 | Alteration of zidovudine pharmacokinetics by probenecid in patients with AIDS or AIDS-related complex. ( Blum, MR; Broder, S; de Miranda, P; Good, SS; Myers, CE; Thomas, RV; Yarchoan, R, 1989) |
| " This study explores whether probenecid, which is also metabolized by glucuronidation, reduces zidovudine clearance when zidovudine is administered orally to patients with acquired immunodeficiency syndrome (AIDS) or AIDS-related complex (ARC)." | 3.67 | Alteration of zidovudine pharmacokinetics by probenecid in patients with AIDS or AIDS-related complex. ( Blum, MR; Broder, S; de Miranda, P; Good, SS; Myers, CE; Thomas, RV; Yarchoan, R, 1989) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 2 (66.67) | 18.7374 |
| 1990's | 1 (33.33) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Duckworth, AS | 1 |
| Duckworth, GW | 1 |
| Henderson, G | 1 |
| Contreras, G | 1 |
| Kornhauser, DM | 1 |
| Petty, BG | 1 |
| Hendrix, CW | 1 |
| Woods, AS | 1 |
| Nerhood, LJ | 1 |
| Bartlett, JG | 1 |
| Lietman, PS | 1 |
| de Miranda, P | 1 |
| Good, SS | 1 |
| Yarchoan, R | 1 |
| Thomas, RV | 1 |
| Blum, MR | 1 |
| Myers, CE | 1 |
| Broder, S | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Influence of Probenecid and Quinine on the Pharmacokinetics of Azidothymidine[NCT00000706] | 12 participants | Interventional | Completed | ||||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
1 trial available for probenecid and AIDS-Related Complex
| Article | Year |
|---|---|
Probenecid and zidovudine metabolism.
Topics: Acquired Immunodeficiency Syndrome; Administration, Oral; Adult; Aged; AIDS-Related Complex; Chromat | 1989 |
2 other studies available for probenecid and AIDS-Related Complex
| Article | Year |
|---|---|
Zidovudine with probenecid.
Topics: AIDS-Related Complex; Drug Eruptions; Drug Therapy, Combination; Humans; Probenecid; Zidovudine | 1990 |
Alteration of zidovudine pharmacokinetics by probenecid in patients with AIDS or AIDS-related complex.
Topics: Acquired Immunodeficiency Syndrome; Adult; AIDS-Related Complex; Drug Interactions; Drug Therapy, Co | 1989 |