Page last updated: 2024-11-03

proadifen and Seizures

proadifen has been researched along with Seizures in 11 studies

Proadifen: An inhibitor of drug metabolism and CYTOCHROME P-450 ENZYME SYSTEM activity.

Seizures: Clinical or subclinical disturbances of cortical function due to a sudden, abnormal, excessive, and disorganized discharge of brain cells. Clinical manifestations include abnormal motor, sensory and psychic phenomena. Recurrent seizures are usually referred to as EPILEPSY or seizure disorder.

Research Excerpts

ExcerptRelevanceReference
"Some of the more striking expressions of toxicity are the tremors and seizures observed approximately 100 min after exposure of rats to an acutely toxic dose of acrylonitrile (AN)."3.73Effect of cytochrome P450 inhibitors and anticonvulsants on the acute toxicity of acrylonitrile. ( Benz, FW; Nerland, DE, 2005)

Research

Studies (11)

TimeframeStudies, this research(%)All Research%
pre-199010 (90.91)18.7374
1990's0 (0.00)18.2507
2000's1 (9.09)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
VEATCH, RM1
ADLER, TK1
WAY, EL1
Benz, FW1
Nerland, DE1
Ater, SB1
Swinyard, EA1
Tolman, KG1
Madsen, JA1
Matsuo, F1
Bourgeois, BF1
Wad, N1
Turnbull, MJ1
Watkins, JW1
Baumel, I1
Carlson, GP1
Lal, H1
Goldberg, ME1
Sledge, K1
Dubinsky, B1
Robichaud, RC1
Hunt, WA1
Dar, MS1
Fakouhi, T1
Davis, WM1
Yeh, JZ1
Solymoss, B1
Toth, S1
Varga, S1
Selye, H1

Other Studies

11 other studies available for proadifen and Seizures

ArticleYear
THE IMPORTANCE OF STERIC CONFIGUA. ION IN CERTAIN MORPHINNE-MIMETIC ACTIONS OF SYNTHETIC ANALGETICS.
    The Journal of pharmacology and experimental therapeutics, 1964, Volume: 145

    Topics: Analgesics; Analgesics, Non-Narcotic; Antipyretics; Apnea; Chemical Phenomena; Chemistry; Methadone;

1964
Effect of cytochrome P450 inhibitors and anticonvulsants on the acute toxicity of acrylonitrile.
    Archives of toxicology, 2005, Volume: 79, Issue:10

    Topics: Acrylonitrile; Animals; Anticonvulsants; Carcinogens; Central Nervous System Depressants; Cyanides;

2005
Effects of SKF525A, phenobarbital, fasting, and carnitine on the anticonvulsant activity and neurotoxicity of valproate in mice.
    Epilepsia, 1984, Volume: 25, Issue:5

    Topics: Animals; Carnitine; Fasting; Male; Mice; Mice, Inbred Strains; Nervous System; Phenobarbital; Proadi

1984
Individual and combined antiepileptic and neurotoxic activity of carbamazepine and carbamazepine-10,11-epoxide in mice.
    The Journal of pharmacology and experimental therapeutics, 1984, Volume: 231, Issue:2

    Topics: Animals; Brain; Carbamazepine; Drug Synergism; Female; Mice; Mice, Inbred ICR; Nervous System; Proad

1984
Determination of halothane-induced sleeping time in the rat: effect of prior administration of centrally active drugs.
    British journal of pharmacology, 1976, Volume: 58, Issue:1

    Topics: Animals; Bemegride; Brain Chemistry; Circadian Rhythm; Drug Interactions; Female; Halothane; Injecti

1976
Role of hepatic metabolism in the convulsant action of m-fluorotyrosine.
    Brain research, 1971, May-07, Volume: 28, Issue:2

    Topics: Animals; Brain; Central Nervous System Stimulants; Fluorine; Hepatectomy; Injections; Injections, In

1971
The influence of SKF-525A on the acute pharmacological properties of chlordiazepoxide.
    Archives internationales de pharmacodynamie et de therapie, 1973, Volume: 204, Issue:1

    Topics: Aggression; Animals; Avoidance Learning; Behavior, Animal; Brain; Chlordiazepoxide; Conflict, Psycho

1973
Changes in the neuro-excitability of alcohol-dependent rats undergoing withdrawal as measured by the pentylenetetrazole seizure threshold.
    Neuropharmacology, 1973, Volume: 12, Issue:11

    Topics: Animals; Disease Susceptibility; Ethanol; Humans; Male; Pentylenetetrazole; Proadifen; Rats; Seizure

1973
Studies on some aspects of the neuropharmacology of butylurea.
    Archives internationales de pharmacodynamie et de therapie, 1974, Volume: 208, Issue:2

    Topics: Administration, Oral; Analgesics; Animals; Anticonvulsants; Barbiturates; Butanes; Central Nervous S

1974
Susceptibility to strychnine convulsions in maturing rats.
    Experientia, 1969, Dec-15, Volume: 25, Issue:12

    Topics: Age Factors; Animals; Liver; Proadifen; Rats; Seizures; Strychnine

1969
Protection by spironolactone and oxandrolone against chronic digitoxin or indomethacin intoxication.
    Toxicology and applied pharmacology, 1971, Volume: 18, Issue:3

    Topics: Animals; Digitoxin; Drug Antagonism; Female; Indomethacin; Intestinal Diseases; Jejunum; Microsomes,

1971