proadifen has been researched along with Pregnancy in 37 studies
Proadifen: An inhibitor of drug metabolism and CYTOCHROME P-450 ENZYME SYSTEM activity.
Pregnancy: The status during which female mammals carry their developing young (EMBRYOS or FETUSES) in utero before birth, beginning from FERTILIZATION to BIRTH.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Time-mated Swiss-Webster mice were pretreated in separate experiments with phenobarbital (60 mg/kg X d sc on d 7-10 of pregnancy), SKF-525A (40 mg/kg ip on d 12 of pregnancy) or 3-methylcholanthrene (20 mg/kg X d on d 10-12 of pregnancy)." | 3.67 | Ethylenethiourea-induced hindpaw deformities in mice and effects of metabolic modifiers on their occurrence. ( Khera, KS, 1984) |
| "The possible correlations between embryotoxicity, plasma kinetics of toxic metabolites and covalent binding of metabolites to foetal tissues were studied using two drugs, albendazole and oxfendazole." | 1.27 | A correlation of toxicity of albendazole and oxfendazole with their free metabolites and bound residues. ( Benoit, E; Delatour, P; Garnier, F; Longin, C, 1984) |
| "To study the effects of SKF-525A, an inhibitor of cytochrome P-450, and of sodium phenobarbital (PB), a drug-metabolizing enzyme inducer, on the teratogenicity of thiabendazole (TBZ), pregnant mice were given ip either a single dose of 40 mg SKF-525A/kg 1 hr before oral dosing with 250 or 500 mg TBZ/kg or a dose of 75 mg PB/kg/day on three consecutive days before oral administration of a dose of 500 or 1000 mg TBZ/kg." | 1.27 | Effects of pretreatment with SKF-525A or sodium phenobarbital on thiabendazole-induced teratogenicity in ICR mice. ( Imamichi, T; Ogata, A; Sasaki, M; Suzuki, K; Yoneyama, M, 1987) |
| " MMI and ETU were dosed simultaneously, one hour after dosing with SKF." | 1.26 | Effects of pretreatment with SKF-525A, N-Methyl-2-thioimidazole, sodium phenobarbital, or methyl cholanthrene on ethylenethiourea-induced teratogenicity in rats. ( Iverson, F; Khera, KS, 1981) |
| "Diazepam was metabolized by human foetal liver microsomes to N-desmethyldiazepam and N-methyloxazepam as early as the 13th week of gestation." | 1.26 | Dizepam metabolism in human foetal and adult liver. ( Ackermann, E; Richter, K, 1977) |
| "Phenobarbital treatment antagonized THC-induced reduction of fetal body weight, but did not reduce resorption rate." | 1.26 | Alteration of delta 9-tetrahydrocannabinol-induced teratogenicity by stimulation and inhibition of its metabolism. ( Harbison, RD; Lubin, DJ; Mantilla-Plata, B, 1977) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 36 (97.30) | 18.7374 |
| 1990's | 1 (2.70) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Khera, KS | 2 |
| Kaelin, AC | 1 |
| Cummings, AJ | 1 |
| Delatour, P | 1 |
| Garnier, F | 1 |
| Benoit, E | 1 |
| Longin, C | 1 |
| Saito, H | 1 |
| Naminohira, S | 1 |
| Sakai, T | 1 |
| Ueno, K | 1 |
| Kitagawa, H | 1 |
| Iverson, F | 1 |
| Shah, NS | 3 |
| May, DA | 1 |
| Yates, JD | 1 |
| Pelkonen, O | 2 |
| Moilanen, ML | 1 |
| Allen, JR | 1 |
| Parke, DV | 1 |
| Ackermann, E | 1 |
| Richter, K | 1 |
| Hixson, E | 1 |
| Gulati, OD | 1 |
| Kuhn, D | 1 |
| Mathur, PP | 1 |
| Harbison, RD | 3 |
| Mantilla-Plata, B | 1 |
| Lubin, DJ | 1 |
| Donald, AG | 1 |
| Bertolatus, JA | 1 |
| Hixson, B | 1 |
| Schmid, R | 1 |
| McDonagh, AF | 1 |
| Preache, MM | 1 |
| Gibson, JE | 3 |
| Omar, HA | 1 |
| Figueroa, R | 1 |
| Omar, RA | 1 |
| Wolin, MS | 1 |
| Yoneyama, M | 2 |
| Ichikawa, H | 1 |
| Boeynaems, JM | 1 |
| Demolle, D | 1 |
| Van Coevorden, A | 1 |
| Ogata, A | 1 |
| Sasaki, M | 1 |
| Suzuki, K | 1 |
| Imamichi, T | 1 |
| Mukhtar, H | 1 |
| Athar, M | 1 |
| Bickers, DR | 1 |
| Posner, HS | 2 |
| Thompson, EA | 1 |
| Siiteri, PK | 1 |
| Graves, A | 1 |
| King, CT | 1 |
| Wilk, A | 1 |
| Gurtner, GH | 1 |
| Burns, B | 1 |
| Murthy, VV | 1 |
| Becker, BA | 5 |
| Steele, WJ | 1 |
| Fiserova-Bergerova, V | 1 |
| Sato, T | 1 |
| Moroi, K | 1 |
| Hodgson, BJ | 1 |
| Daniel, EE | 1 |
| Morin, RJ | 1 |
| Yard, AS | 1 |
| Juhasz, LP | 1 |
| Grimes, RM | 1 |
| Bird, CC | 2 |
| Crawford, AM | 2 |
| Currie, AR | 2 |
| Stirling, BF | 1 |
3 reviews available for proadifen and Pregnancy
| Article | Year |
|---|---|
Response of the nonhuman primate to polychlorinated biphenyl exposure.
Topics: Animals; Blood; Body Weight; Dose-Response Relationship, Drug; Drug Synergism; Feces; Female; Hair; | 1975 |
Induction of the drug-metabolizing enzymes.
Topics: Adrenal Cortex Hormones; Adrenal Glands; Animals; Barbiturates; Benzopyrene Hydroxylase; Benzopyrene | 1975 |
The enzymatic formation of bilirubin.
Topics: Animals; Benzopyrenes; Bile Pigments; Bilirubin; Cytochrome P-450 Enzyme System; Female; Heme; Human | 1975 |
34 other studies available for proadifen and Pregnancy
| Article | Year |
|---|---|
Ethylenethiourea-induced hindpaw deformities in mice and effects of metabolic modifiers on their occurrence.
Topics: Abnormalities, Drug-Induced; Animals; Cytochrome P-450 Enzyme System; Ethylenethiourea; Female; Foot | 1984 |
A study of monooxygenase activity in human placental homogenates: in vitro behaviour towards a number of substrates and inhibitors.
Topics: 7-Alkoxycoumarin O-Dealkylase; Cimetidine; Female; Humans; Mixed Function Oxygenases; Oxazoles; Oxyg | 1983 |
A correlation of toxicity of albendazole and oxfendazole with their free metabolites and bound residues.
Topics: Albendazole; Animals; Anthelmintics; Benzimidazoles; Embryo, Mammalian; Female; Kinetics; Microsomes | 1984 |
Drug metabolism and fetal toxicity: changes in fetal toxicity of aminopyrine by variation of drug metabolizing enzyme activity in mice.
Topics: Aminopyrine; Aminopyrine N-Demethylase; Aniline Hydroxylase; Animals; Cobalt; Female; Fetal Death; M | 1981 |
Effects of pretreatment with SKF-525A, N-Methyl-2-thioimidazole, sodium phenobarbital, or methyl cholanthrene on ethylenethiourea-induced teratogenicity in rats.
Topics: Animals; Dose-Response Relationship, Drug; Drug Therapy, Combination; Ethylenethiourea; Female; Imid | 1981 |
Disposition of levo-[3H]cocaine in pregnant and nonpregnant mice.
Topics: Animals; Cocaine; Female; Male; Maternal-Fetal Exchange; Mice; Pregnancy; Pregnancy, Animal; Proadif | 1980 |
The specificity and multiplicity of human placental xenobiotic-metabolizing monooxygenase system studied by potential substrates, inhibitors and gel electrophoresis.
Topics: Aldrin; Aminopyrine; Aryl Hydrocarbon Hydroxylases; Benzopyrenes; Biotransformation; Biphenyl Compou | 1979 |
Differential inhibition of aryl hydrocarbon hydroxylase in human foetal liver, adrenal gland and placenta*.
Topics: Adrenal Glands; Aminopyrine; Animals; Aryl Hydrocarbon Hydroxylases; Cytochrome P-450 Enzyme System; | 1977 |
Dizepam metabolism in human foetal and adult liver.
Topics: Aging; Carbon Monoxide; Dealkylation; Depression, Chemical; Diazepam; Female; Fetus; Gestational Age | 1977 |
Maternal-fetal distribution of methaqualone in control and SKF 525-A-pretreated pregnant mice.
Topics: Animals; Drug Interactions; Feces; Female; Fetus; Male; Maternal-Fetal Exchange; Methaqualone; Mice; | 1977 |
Alteration of delta 9-tetrahydrocannabinol-induced teratogenicity by stimulation and inhibition of its metabolism.
Topics: Amniotic Fluid; Animals; Body Weight; Cleft Palate; Dronabinol; Drug Interactions; Female; Fetal Dea | 1977 |
Tissue distribution of levo-methadone in nonpregnant and pregnant female and male mice: effect of SKF 525-A 1,2.
Topics: Animals; Dealkylation; Female; Fetus; Male; Methadone; Mice; Organ Specificity; Pregnancy; Proadifen | 1976 |
Effect of food deprivation, phenobarbital, and SKF-525A on teratogenicity induced by 2-sec-butyl-4,6-dinitrophenol (dinoseb) and on disposition of [14C]dinoseb in mice.
Topics: Abnormalities, Drug-Induced; Animals; Body Water; Body Weight; Bone and Bones; Dinitrophenols; Femal | 1975 |
Properties of an endogenous arachidonic acid--elicited relaxing mechanism in human placental vessels.
Topics: Arachidonic Acid; Arginine; Blood Vessels; Cyclic GMP; Endothelium, Vascular; Female; Humans; Nitric | 1992 |
Irreversible in vivo and in vitro binding of thiabendazole to tissue protein of pregnant mice.
Topics: Animals; DNA; Female; Fetus; In Vitro Techniques; Male; Mice; Microsomes, Liver; Phenobarbital; Preg | 1986 |
Prostacyclin-stimulating drugs: new prospects.
Topics: Animals; Aorta; Blood Platelets; Cattle; Cells, Cultured; Epoprostenol; Female; Humans; In Vitro Tec | 1986 |
Effects of pretreatment with SKF-525A or sodium phenobarbital on thiabendazole-induced teratogenicity in ICR mice.
Topics: Abnormalities, Drug-Induced; Animals; Body Weight; Bone and Bones; Female; Fetal Resorption; Male; M | 1987 |
Cytochrome P-450 dependent metabolism of testosterone in rat skin.
Topics: Animals; Aryl Hydrocarbon Hydroxylases; Cytochrome P-450 Enzyme System; Female; Metyrapone; Microsom | 1987 |
Significance of cleft palate induced by chemicals in the rat and mouse.
Topics: Abnormalities, Drug-Induced; Aminopropionitrile; Animals; Cleft Palate; Cortisone; Female; Mice; Nit | 1972 |
The involvement of human placental microsomal cytochrome P-450 in aromatization.
Topics: Aminoglutethimide; Androstenedione; Animals; Binding Sites; Binding, Competitive; Carbon Monoxide; C | 1974 |
Experimental alteration of the metabolism of chlorcyclizine and the incidence of cleft palate in rats.
Topics: Abnormalities, Drug-Induced; Adrenal Glands; Animals; Body Weight; Brain Chemistry; Carbon Isotopes; | 1967 |
Possible facilitated transport of oxygen across the placenta.
Topics: Animals; Argon; Capillary Permeability; Cytochrome P-450 Enzyme Inhibitors; Deoxycholic Acid; Female | 1972 |
Effects of dosage, phenobarbital, and 2-diethylaminoethyl-2,2-diphenylvalerate on the binding of cyclophosphamide and-or its metabolites to the DNA, RNA, and protein of the embryo and liver in pregnant mice.
Topics: Animals; Cyclophosphamide; DNA; Dose-Response Relationship, Drug; Embryo, Mammalian; Female; Liver; | 1973 |
Changes of fluoride content in bone: an index of drug defluorination in vivo.
Topics: Anesthetics; Animals; Biotransformation; Body Weight; Bone and Bones; Chlorine; Drug Interactions; E | 1973 |
Species differences in induction and inhibition of liver isocarboxazid hydrolase.
Topics: Aging; Animals; Animals, Newborn; Enzyme Induction; Female; Guinea Pigs; Hydrolases; In Vitro Techni | 1973 |
Studies concerning the source of calcium for contraction of rat myometrium.
Topics: Acetylcholine; Action Potentials; Animals; Calcium; Calcium Radioisotopes; Carbon Radioisotopes; Chl | 1973 |
Inhibition of ovarian cholesterol esterification by diethylaminoethyl diphenylvalerate (SKF 525-A) and other ionic amphipathic amines.
Topics: Adenosine Triphosphate; Amines; Animals; Carbon Radioisotopes; Carnitine; Cholesterol; Coenzyme A; C | 1974 |
Studies on the antifertility effect and metabolism of a new, postcoital oral contraceptive, 2-methyl-3-ethyl-4-phenyl-delta-4-cyclohexene carboxylic acid, sodium salt (ORF-4463).
Topics: Animals; Contraceptive Agents; Contraceptives, Oral; Copulation; Cyclohexanecarboxylic Acids; Fallop | 1969 |
Effect of phenobarbital and SKF 525-A on the teratogenicity of cyclophosphamide in mice.
Topics: Abnormalities, Drug-Induced; Alkylation; Animals; Cyclophosphamide; Eye Abnormalities; Female; Hydro | 1968 |
Effects of phenobarbital or SKF 525A pretreatment on diphenylhydantoin disposition in pregnant mice.
Topics: Abnormalities, Drug-Induced; Adipose Tissue; Amniotic Fluid; Animals; Brain Chemistry; Carbon Isotop | 1971 |
Foetal adrenal necrosis induced by 7-hydroxymethyl-12-methylbenz(a)-anthracene and its prevention.
Topics: Adrenal Gland Diseases; Adrenal Glands; Animals; Benz(a)Anthracenes; Female; Fetal Diseases; Necrosi | 1970 |
Protection from the embryopathic effects of 7-hydroxymethyl-12-methylbenz(a)anthracene by 2-methyl-1,2-bis-(3-pyridyl)1-propanone(metopirone, Ciba) and beta-diethylaminoethyldiphenyl-n-propyl acetate (SKF 525-A).
Topics: Abnormalities, Drug-Induced; Adrenal Glands; Animals; Benz(a)Anthracenes; Embryo, Mammalian; Female; | 1970 |
Effect of phenobarbital and SKF 525A pretreatment on diphenylhydantoin teratogenicity in mice.
Topics: Abnormalities, Drug-Induced; Animals; Body Weight; Depression, Chemical; Drug Synergism; Female; Fet | 1970 |
Effect of phenobarbital and SKF 525A on placental transfer of cyclophosphamide in mice.
Topics: Animals; Carbon Isotopes; Chromatography, Paper; Cyclophosphamide; Embryo, Mammalian; Feces; Female; | 1971 |