proadifen has been researched along with Muscle Contraction in 26 studies
Proadifen: An inhibitor of drug metabolism and CYTOCHROME P-450 ENZYME SYSTEM activity.
Muscle Contraction: A process leading to shortening and/or development of tension in muscle tissue. Muscle contraction occurs by a sliding filament mechanism whereby actin filaments slide inward among the myosin filaments.
| Excerpt | Relevance | Reference |
|---|---|---|
| " Cyclooxygenase inhibition with indomethacin displaced the dose-response curve to AA to the right but did not prevent the relaxant effects of the fatty acid." | 1.27 | Arachidonic acid-induced endothelial-dependent relaxations of canine coronary arteries: contribution of a cytochrome P-450-dependent pathway. ( Abraham, NG; Mullane, KM; Pinto, A, 1987) |
| "Evidence of selective inhibition, differences in dose-response relationships, and cross-tachyphylaxis studies suggest that separate receptors and/or mechanisms may be involved in responses to angiotensin (Ang), [Sar1]Ang II, and Ang III (= des-Asp1-Ang II)." | 1.26 | Demonstration of different contractile mechanisms for angiotensin II and des-Asp1-angiotensin II in rabbit aortic strips. ( Ackerly, JA; Moore, AF; Peach, MJ, 1977) |
| " Cocaine (2 x 10(-6) M and 10(-5) M) produced 2 and 7 fold shifts to the left of the dose-response curve to (-)-noradrenaline recorded isotonically in isolated splenic capsular strips of the cat." | 1.26 | Investigation of the role of calcium in the supersensitivity produced by cocaine in cat spleen strips. ( Summers, RJ; Tillman, J, 1979) |
| " PC potentiated NA action, and its methobromide (MeBr) derivative potentiated both NA and K+ action and also, like PC, partially shifted to the left the dose-response curve to Ca2+ in NA-depolarizing Ca-free Tyrode's." | 1.26 | Calcium antagonists and contractile responses in rat vas deferens and guinea pig ileal smooth muscle. ( Swamy, VC; Triggle, CR; Triggle, DJ, 1979) |
| "Pretreatment with reserpine failed to induce supersensitivity to NE." | 1.26 | The mechanism of contraction of rat aorta to various agonists. ( Grollman, A; Krishnamurty, VS, 1976) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 22 (84.62) | 18.7374 |
| 1990's | 3 (11.54) | 18.2507 |
| 2000's | 1 (3.85) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Kamata, K | 1 |
| Hosokawa, M | 1 |
| Matsumoto, T | 1 |
| Kobayashi, T | 1 |
| Singer, HA | 1 |
| Saye, JA | 1 |
| Peach, MJ | 2 |
| Tesfamariam, B | 1 |
| Brown, ML | 1 |
| Cohen, RA | 1 |
| Van de Voorde, J | 1 |
| Vanheel, B | 1 |
| Andersson, RG | 1 |
| Djärv, L | 1 |
| Crocker, AD | 1 |
| Mayeka, IM | 1 |
| Wilson, KA | 1 |
| Fermum, R | 1 |
| Möritz, KU | 1 |
| Freer, RJ | 1 |
| Ackerly, JA | 1 |
| Moore, AF | 1 |
| Summers, RJ | 1 |
| Tillman, J | 1 |
| Triggle, CR | 1 |
| Swamy, VC | 2 |
| Triggle, DJ | 2 |
| Krishnamurty, VS | 1 |
| Grollman, A | 1 |
| Suarez-Kurtz, G | 3 |
| Weekley, LB | 1 |
| Taylor, CJ | 1 |
| Meisheri, KD | 1 |
| Choo, LK | 1 |
| Malta, E | 1 |
| Mitchelson, F | 1 |
| Pinto, A | 1 |
| Abraham, NG | 1 |
| Mullane, KM | 1 |
| Krstić, MK | 1 |
| Kalsner, S | 1 |
| Nickerson, M | 1 |
| Boyd, GN | 1 |
| Massingham, R | 1 |
| Hodgson, BJ | 1 |
| Daniel, EE | 1 |
| Thesleff, S | 1 |
| Vyskocil, F | 1 |
| Ward, MR | 1 |
| Blase, BW | 1 |
| Loomis, TA | 1 |
| Collins, JA | 1 |
| Sommer, HZ | 1 |
| Bianchi, CP | 1 |
| Paulo, LG | 1 |
26 other studies available for proadifen and Muscle Contraction
| Article | Year |
|---|---|
Altered arachidonic acid-mediated responses in the perfused kidney of the streptozotocin-induced diabetic rat.
Topics: Animals; Arachidonic Acid; Cyclooxygenase Inhibitors; Cytochrome P-450 Enzyme Inhibitors; Diabetes M | 2006 |
Effects of cytochrome P-450 inhibitors on endothelium-dependent relaxation in rabbit aorta.
Topics: Animals; Aorta; Calcium; Cytochrome P-450 Enzyme Inhibitors; Endothelium; Ionophores; Male; Methacho | 1984 |
15-Hydroxyeicosatetraenoic acid and diabetic endothelial dysfunction in rabbit aorta.
Topics: Acetylcholine; Animals; Aorta, Abdominal; Bridged Bicyclo Compounds, Heterocyclic; Cytochrome P-450 | 1995 |
Influence of cytochrome P-450 inhibitors on endothelium-dependent nitro-L-arginine-resistant relaxation and cromakalim-induced relaxation in rat mesenteric arteries.
Topics: Acetylcholine; Animals; Benzopyrans; Biological Factors; Cromakalim; Cytochrome P-450 Enzyme Inhibit | 1997 |
Tension and cyclic GMP changes in potassium depolarized rabbit colon muscle.
Topics: Animals; Calcium; Colon; Cyclic AMP; Cyclic GMP; Glucose; Muscle Contraction; Muscle Tonus; Muscle, | 1978 |
The role of calcium and cyclic AMP in the contractile action of angiotensin II upon rat descending colon.
Topics: Angiotensin II; Animals; Bucladesine; Calcium; Colon; Cyclic AMP; Imidazoles; In Vitro Techniques; I | 1979 |
[Action mechanism of vascular spasmolytics. 5. Drug-related relaxation and adenosine-3',5'-monophosphate content of isolated coronary arteries under conditions of fluoride-induced contracture].
Topics: Adenosine; Animals; Calcium; Cattle; Coronary Vessels; Cyclic AMP; Fluorides; Isoproterenol; Muscle | 1979 |
Calcium and angiotensin tachyphylaxis in rat uterine smooth muscle.
Topics: Acetylcholine; Angiotensin II; Animals; Aorta; Calcium; Diethylstilbestrol; Dose-Response Relationsh | 1975 |
Demonstration of different contractile mechanisms for angiotensin II and des-Asp1-angiotensin II in rabbit aortic strips.
Topics: Angiotensin II; Angiotensin III; Animals; Aorta; Calcium; In Vitro Techniques; Muscle Contraction; N | 1977 |
Investigation of the role of calcium in the supersensitivity produced by cocaine in cat spleen strips.
Topics: Angiotensin II; Animals; Calcium; Cats; Chlorpheniramine; Cocaine; Desipramine; Drug Interactions; F | 1979 |
Calcium antagonists and contractile responses in rat vas deferens and guinea pig ileal smooth muscle.
Topics: Animals; Calcium; Guinea Pigs; Ileum; In Vitro Techniques; Male; Muscle Contraction; Muscle, Smooth; | 1979 |
The mechanism of contraction of rat aorta to various agonists.
Topics: Animals; Aorta, Thoracic; Calcium; In Vitro Techniques; Muscle Contraction; Muscle, Smooth; Norepine | 1976 |
A comparison of effects of SKF 525-A and procaine on excitation-contraction coupling in single crayfish muscle fibers.
Topics: Animals; Astacoidea; Caffeine; Drug Synergism; Electric Stimulation; Muscle Contraction; Potassium; | 1976 |
Rat duodenal smooth muscle contractile responses to angiotensin II are dependent on calmodulin.
Topics: Angiotensin II; Animals; Calmodulin; Duodenum; Female; Muscle Contraction; Muscle, Smooth; Proadifen | 1990 |
Inhibitory effects of a synthetic atrial peptide on contractions and 45Ca fluxes in vascular smooth muscle.
Topics: Acetylcholine; Animals; Atrial Natriuretic Factor; Calcium; Dose-Response Relationship, Drug; Endoth | 1986 |
Investigation of the antimuscarinic and other actions of proadifen in-vitro.
Topics: Acetylcholine; Adenosine Triphosphate; Animals; Guinea Pigs; Ileum; In Vitro Techniques; Muscle Cont | 1986 |
Arachidonic acid-induced endothelial-dependent relaxations of canine coronary arteries: contribution of a cytochrome P-450-dependent pathway.
Topics: Animals; Arachidonic Acid; Arachidonic Acids; Benzoflavones; beta-Naphthoflavone; Coronary Vessels; | 1987 |
The depressant action of SKF 525A on the guinea-pig ileum.
Topics: Acetylcholine; Animals; Atropine; Barium; Depression, Chemical; Dimethylphenylpiperazinium Iodide; G | 1973 |
Selective blockade of potassium-induced contractions of aortic strips by beta-diethylaminoethyl-diphenylpropylacetate (SKF 525A).
Topics: Angiotensin II; Animals; Aorta; Binding Sites; Calcium; Extracellular Space; Female; Histamine; Male | 1970 |
2-Halogenoethylamines and the role of Ca 2+ in adrenergic -receptor activation in the rat vas deferens.
Topics: Animals; Binding Sites; Bromine; Calcium; Diazoxide; Dibucaine; Drug Antagonism; Drug Interactions; | 1972 |
A study of compounds which inhibit vascular smooth muscle contraction.
Topics: Animals; Aorta, Thoracic; Barium; Blood Vessels; Dose-Response Relationship, Drug; Female; Guanidine | 1973 |
Studies concerning the source of calcium for contraction of rat myometrium.
Topics: Acetylcholine; Action Potentials; Animals; Calcium; Calcium Radioisotopes; Carbon Radioisotopes; Chl | 1973 |
The action potential in end-plate and extrajunctional regions of rat skeletal muscle.
Topics: Action Potentials; Animals; Carbachol; Depression, Chemical; Diaphragm; Male; Muscle Contraction; Mu | 1974 |
Two active structures for hemicholinium-like action.
Topics: Animals; Dose-Response Relationship, Drug; Hemicholinium 3; In Vitro Techniques; Molecular Conformat | 1974 |
Sites of action of SKF 525-A in nerve and muscle.
Topics: Action Potentials; Animals; Anura; Binding Sites; Caffeine; Calcium; Cell Membrane; Drug Antagonism; | 1970 |
Studies on the neuromuscular effects of beta-diethylaminoethyl-diphenyl propylacetate hydrochloride (SKF-525-A).
Topics: Animals; Cats; Decamethonium Compounds; Dogs; Drug Synergism; Electromyography; Hindlimb; Muscle Con | 1968 |