proadifen has been researched along with Hypothermia in 3 studies
Proadifen: An inhibitor of drug metabolism and CYTOCHROME P-450 ENZYME SYSTEM activity.
Hypothermia: Lower than normal body temperature, especially in warm-blooded animals.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Pretreatment of mice with phenobarbital, an inducer of oxidative drug metabolism, had no effect on the early hypothermic effect of a toxic dose of acetaminophen, while pretreatment with metyrapone, SKF-525A, or piperonyl butoxide (inhibitors of mixed-function oxidase) enhanced the hypothermia." | 7.66 | Acetaminophen-induced hypothermia in mice: evidence for a central action of the parent compound. ( Massey, TE; McElligott, TF; Racz, WJ; Walker, RM, 1982) |
| "Pretreatment of mice with phenobarbital, an inducer of oxidative drug metabolism, had no effect on the early hypothermic effect of a toxic dose of acetaminophen, while pretreatment with metyrapone, SKF-525A, or piperonyl butoxide (inhibitors of mixed-function oxidase) enhanced the hypothermia." | 3.66 | Acetaminophen-induced hypothermia in mice: evidence for a central action of the parent compound. ( Massey, TE; McElligott, TF; Racz, WJ; Walker, RM, 1982) |
| " Proadifen antagonized the action of IMI when investigated in reserpine hypothermia and ptosis and in the behavioral despair test." | 3.66 | Influence of proadifen, an inhibitor of the metabolism of drugs, on the action of imipramine and desipramine in rats. ( Daniel, W; Maj, J; Rogóz, Z; Skuza, G; Sowińska, H, 1981) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 2 (66.67) | 18.7374 |
| 1990's | 1 (33.33) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Massey, TE | 1 |
| Walker, RM | 1 |
| McElligott, TF | 1 |
| Racz, WJ | 1 |
| Maj, J | 1 |
| Daniel, W | 1 |
| Rogóz, Z | 1 |
| Skuza, G | 1 |
| Sowińska, H | 1 |
| Matsuda, T | 1 |
| Nakano, Y | 1 |
| Kanda, T | 1 |
| Iwata, H | 1 |
| Baba, A | 1 |
3 other studies available for proadifen and Hypothermia
| Article | Year |
|---|---|
Acetaminophen-induced hypothermia in mice: evidence for a central action of the parent compound.
Topics: Acetaminophen; Animals; Hypothermia; Male; Mice; Phenobarbital; Piperonyl Butoxide; Proadifen; Time | 1982 |
Influence of proadifen, an inhibitor of the metabolism of drugs, on the action of imipramine and desipramine in rats.
Topics: Animals; Blepharoptosis; Desipramine; Hypothermia; Imipramine; Male; Motor Activity; Proadifen; Rats | 1981 |
Gonadal hormones affect the hypothermia induced by serotonin1A (5-HT1A) receptor activation.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Body Temperature; Castration; Dose-Response Relatio | 1991 |