proadifen has been researched along with Experimental Leukemia in 3 studies
Proadifen: An inhibitor of drug metabolism and CYTOCHROME P-450 ENZYME SYSTEM activity.
| Excerpt | Relevance | Reference |
|---|---|---|
| " Dose-response curves with and without phenobarbital pretreatment showed a constant 90% (1-log) reduction in the toxicity of cyclophosphamide to leukemic colony-forming units, whereas enzyme induction had no effect on the toxicity of the drug to normal bone marrow colony-forming units." | 1.26 | The effect of phenobarbital on cyclophosphamide antitumor activity. ( Alberts, DS; van Daalen Wetters, T, 1976) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 3 (100.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Belitskiĭ, GA | 1 |
| Bukhman, VM | 1 |
| Konopleva, IA | 1 |
| Alberts, DS | 1 |
| van Daalen Wetters, T | 1 |
| Bogush, TA | 1 |
| Sitdikova, SM | 1 |
| Syrkin, AB | 1 |
3 other studies available for proadifen and Experimental Leukemia
| Article | Year |
|---|---|
[Change of toxic and antineoplastic properties of ftorafur by means of action on nonspecific microsomal oxidase].
Topics: Animals; Drug Antagonism; Drug Synergism; Enzyme Induction; Fluorouracil; Leukemia, Experimental; Me | 1979 |
The effect of phenobarbital on cyclophosphamide antitumor activity.
Topics: Animals; Bone Marrow; Bone Marrow Cells; Cyclophosphamide; Dose-Response Relationship, Drug; Drug In | 1976 |
[Effect of the induction and inhibition of liver monooxygenases on the toxic and therapeutic action of vincristine].
Topics: Animals; Benzhydryl Compounds; Dose-Response Relationship, Drug; Drug Evaluation, Preclinical; Drug | 1986 |