Compounds > proadifen
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proadifen and Acute Liver Injury, Drug-Induced

proadifen has been researched along with Acute Liver Injury, Drug-Induced in 45 studies

Proadifen: An inhibitor of drug metabolism and CYTOCHROME P-450 ENZYME SYSTEM activity.

Research Excerpts

ExcerptRelevanceReference
"Fipronil is an insecticide used to control pests in animals and plants that can causes hepatotoxicity in animals and humans, and it is hepatically metabolized to fipronil sulfone by cytochrome P-450."1.42Effect of fipronil on energy metabolism in the perfused rat liver. ( Constantin, J; de Medeiros, HC; Ishii-Iwamoto, EL; Mingatto, FE, 2015)
" These data demonstrate that UA is bio-transformed to less toxic metabolites in rat primary hepatocytes, probably mainly by CYP1A and 3A, but not 2B/2C."1.40Inhibition of cytochrome P450s enhances (+)-usnic acid cytotoxicity in primary cultured rat hepatocytes. ( Greenhaw, J; Salminen, WF; Shi, Q, 2014)
" Rats were pretreated with PB (75 mg/kg for 4 days) prior to itraconazole or fluconazole dosing (20 and 200 mg/kg for 4 days)."1.33Involvement of phenobarbital and SKF 525A in the hepatotoxicity of antifungal drugs itraconazole and fluconazole in rats. ( Ahmad Bustamam, A; Hasiah, AH; Israf, DA; Khairi, HM; Somchit, N; Sulaiman, MR; Wong, CW; Zuraini, A, 2006)
"Disulfiram treatment reduced the acute lethal and hepatotoxic effects of inhaled VDC and reduced the levels of covalent bound radioactivity in the liver and kidney after the intraperitoneal administration of 14C-VDC."1.26Effect of various treatments on toxicity of inhaled vinylidene chloride. ( Lee, CC; Minor, JL; Seifter, J; Short, RD; Winston, JM, 1977)

Research

Studies (45)

TimeframeStudies, this research(%)All Research%
pre-199036 (80.00)18.7374
1990's1 (2.22)18.2507
2000's3 (6.67)29.6817
2010's5 (11.11)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Warner, DJ1
Chen, H1
Cantin, LD1
Kenna, JG1
Stahl, S1
Walker, CL1
Noeske, T1
Shi, Q1
Greenhaw, J1
Salminen, WF1
de Medeiros, HC1
Constantin, J1
Ishii-Iwamoto, EL1
Mingatto, FE1
Li, Y1
Qi, XM1
Xue, X1
Wu, XF1
Wu, YF1
Chen, M1
Xing, GZ1
Luan, Y1
Ren, J1
Ishihara, Y1
Ishii, S1
Sakai, Y1
Yamamura, N1
Onishi, Y1
Shimamoto, N1
Lee, SK1
Kang, MJ1
Jeon, TW1
Ha, HW1
Yoo, JW1
Ko, GS1
Kang, W1
Jeong, HG1
Lyoo, WS1
Jeong, TC1
Labib, R1
Turkall, R1
Abdel-Rahman, MS1
Somchit, N1
Wong, CW1
Zuraini, A1
Ahmad Bustamam, A1
Hasiah, AH1
Khairi, HM1
Sulaiman, MR1
Israf, DA1
Blake, DA1
Rozman, RS1
Cascorbi, HF1
Krantz, JC1
Fernández, G1
Villarruel, MC1
Bernacchi, A1
de Castro, CR2
Castro, JA3
James, RC1
Goodman, DR1
Harbison, RD2
DeMaster, EG1
Sumner, HW1
Kaplan, E1
Shirota, FN1
Nagasawa, HT1
Ueno, I1
Horiuchi, T1
Enomoto, M1
Ueno, S1
Suzuki, T1
Susa, N1
Furukawa, Y1
Sugiyama, M1
Gopinath, C1
Ford, JH1
Suriyachan, D1
Thithapandha, A1
Jaeger, RJ2
Murphy, SD2
Reynolds, ES2
Szabo, S1
Moslen, MT1
Thompson, ML1
Shuster, L1
Shaw, K1
Short, RD1
Winston, JM1
Minor, JL1
Seifter, J1
Lee, CC1
Hanzlik, RP1
Vyas, KP1
Traiger, GJ1
Allen, JR1
Cartens, LA1
Abrahamson, LJ1
Marlar, RJ1
Cooke, WJ1
Berndt, WO1
Mudge, GH1
Conolly, RB1
Zimmerman, HJ1
Jacob, L1
Bassan, H1
Gillespie, J1
Lukacs, L1
Abernathy, CO1
Nhachi, CF1
Chikuni, O1
Duddy, SK1
Hsia, MT1
Lunam, CA1
Cousins, MJ1
Hall, PD1
Nayak, NC2
Chopra, P2
Ramalingaswami, V2
Rechnagel, RO1
Glende, EA2
Roy, S1
Reid, WD4
Krishna, G4
Zampaglione, N2
Jollow, DJ2
Mitchell, JR4
Stripp, B1
Hamrick, M1
Gillette, JR3
De Matteis, F1
Abbritti, G1
Gibbs, AH1
Gillette, R1
Brodie, BB3
Blinder, LV1
Gasparian, SA1
Maliugin, EF1
Kliuchnikova, ZhI1
Archakov, AI1
De Ferreyra, EC1
De Fenos, OM1
Sasame, H1
Torrielli, MV1
Ugazio, G1
Gabriel, L1
Burdino, E1
Mantilla-Plata, B1
Christie, B2
Moskowitz, J2
Seawright, AA1
Hrdlicka, J1
Mattocks, AR1
Rao, KS1
Recknagel, RO1
Cignoli, EV1

Reviews

1 review available for proadifen and Acute Liver Injury, Drug-Induced

ArticleYear
Carbon tetrachloride hepatotoxicity: an example of lethal cleavage.
    CRC critical reviews in toxicology, 1973, Volume: 2, Issue:3

    Topics: Animals; Carbon Radioisotopes; Carbon Tetrachloride; Carbon Tetrachloride Poisoning; Chemical and Dr

1973

Other Studies

44 other studies available for proadifen and Acute Liver Injury, Drug-Induced

ArticleYear
Mitigating the inhibition of human bile salt export pump by drugs: opportunities provided by physicochemical property modulation, in silico modeling, and structural modification.
    Drug metabolism and disposition: the biological fate of chemicals, 2012, Volume: 40, Issue:12

    Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters

2012
Inhibition of cytochrome P450s enhances (+)-usnic acid cytotoxicity in primary cultured rat hepatocytes.
    Journal of applied toxicology : JAT, 2014, Volume: 34, Issue:8

    Topics: Animals; Benzoflavones; Benzofurans; Cells, Cultured; Chemical and Drug Induced Liver Injury; Cytoch

2014
Effect of fipronil on energy metabolism in the perfused rat liver.
    Toxicology letters, 2015, Jul-02, Volume: 236, Issue:1

    Topics: Animals; Biotransformation; Chemical and Drug Induced Liver Injury; Chloride Channels; Cytochrome P-

2015
The relationship between diphenylamine structure and NSAIDs-induced hepatocytes injury.
    Toxicology letters, 2009, Apr-25, Volume: 186, Issue:2

    Topics: Adenosine Triphosphate; Animals; Anti-Inflammatory Agents, Non-Steroidal; Cell Survival; Cells, Cult

2009
Crucial role of cytochrome P450 in hepatotoxicity induced by 2,3-dimethoxy-1,4-naphthoquinone in rats.
    Journal of applied toxicology : JAT, 2011, Volume: 31, Issue:2

    Topics: alpha-Tocopherol; Animals; Antioxidants; Chemical and Drug Induced Liver Injury; Cimetidine; Cytochr

2011
Role of metabolism in 1-bromopropane-induced hepatotoxicity in mice.
    Journal of toxicology and environmental health. Part A, 2010, Volume: 73, Issue:21-22

    Topics: Alanine Transaminase; Animals; Aspartate Aminotransferases; Chemical and Drug Induced Liver Injury;

2010
Inhibition of cocaine oxidative metabolism attenuates endotoxin potentiation of cocaine mediated hepatotoxicity.
    Toxicology, 2002, Sep-30, Volume: 179, Issue:1-2

    Topics: Animals; Biotransformation; Catalase; Chemical and Drug Induced Liver Injury; Cocaine; Endotoxins; E

2002
Involvement of phenobarbital and SKF 525A in the hepatotoxicity of antifungal drugs itraconazole and fluconazole in rats.
    Drug and chemical toxicology, 2006, Volume: 29, Issue:3

    Topics: Animals; Antifungal Agents; Chemical and Drug Induced Liver Injury; Cytochrome P-450 Enzyme System;

2006
Anesthesia. LXXIV. Biotransformation of fluroxene. I. Metabolism in mice and dogs in vivo.
    Biochemical pharmacology, 1967, Jul-07, Volume: 16, Issue:7

    Topics: Animals; Benzopyrenes; Biotransformation; Carbon Isotopes; Chemical and Drug Induced Liver Injury; D

1967
Effects of repeated administration of rat 2-diethylaminoethyl-2-2-diphenylvalerate-HCI (SKF 525 A) on liver.
    Toxicology, 1981, Volume: 20, Issue:2-3

    Topics: Animals; Chemical and Drug Induced Liver Injury; Endoplasmic Reticulum; Liver; Male; Microsomes, Liv

1981
Hepatic glutathione and hepatotoxicity: changes induced by selected narcotics.
    The Journal of pharmacology and experimental therapeutics, 1982, Volume: 221, Issue:3

    Topics: Acetaminophen; Alanine Transaminase; Animals; Chemical and Drug Induced Liver Injury; Cocaine; Gluta

1982
Pargyline-induced hepatotoxicity: possible mediation by the reactive metabolite, propiolaldehyde.
    Toxicology and applied pharmacology, 1982, Sep-30, Volume: 65, Issue:3

    Topics: Aldehydes; Animals; Chemical and Drug Induced Liver Injury; Glutathione; Liver; Male; Pargyline; Pro

1982
Effects of chemical agents on the hepatotoxicity and hepatic accumulation of luteoskyrin.
    Toxicology and applied pharmacology, 1980, Volume: 52, Issue:2

    Topics: Alanine Transaminase; Animals; Chemical and Drug Induced Liver Injury; Cobalt; Dibenzylchlorethamine

1980
Effect of SKF-525A on liver metabolism and hepatotoxicity of tri- and dibutyltin compounds in mice.
    Archives of toxicology, 1997, Volume: 71, Issue:8

    Topics: Animals; Biotransformation; Chemical and Drug Induced Liver Injury; Drug Synergism; Enzyme Inhibitor

1997
The role of microsomal hydroxylases in the modification of chloroform hepatotoxicity in rats.
    British journal of experimental pathology, 1975, Volume: 56, Issue:5

    Topics: Animals; Carbon Disulfide; Chemical and Drug Induced Liver Injury; Chloroform; Chlorpromazine; DDT;

1975
Modification of carbon tetrachloride hepatotoxicity by chemicals.
    Toxicology and applied pharmacology, 1977, Volume: 41, Issue:2

    Topics: Animals; Carbon Tetrachloride; Carbon Tetrachloride Poisoning; Chemical and Drug Induced Liver Injur

1977
Chemical modification of acute hepatotoxicity of vinyl chloride monomer in rats.
    Toxicology and applied pharmacology, 1977, Volume: 41, Issue:3

    Topics: Animals; Aroclors; Chemical and Drug Induced Liver Injury; Disulfiram; Ethanol; Male; Maleates; Phen

1977
Cocaine-induced hepatic necrosis in mice--the role of cocaine metabolism.
    Biochemical pharmacology, 1979, Aug-01, Volume: 28, Issue:15

    Topics: Acetaminophen; Animals; Aspartate Aminotransferases; Chemical and Drug Induced Liver Injury; Cocaine

1979
Effect of various treatments on toxicity of inhaled vinylidene chloride.
    Environmental health perspectives, 1977, Volume: 21

    Topics: Amino Acids, Sulfur; Animals; Ascorbic Acid; Chemical and Drug Induced Liver Injury; Dichloroethylen

1977
Substituent effects on the hepatotoxicity of thiobenzamide derivatives in the rat.
    Toxicology and applied pharmacology, 1978, Volume: 46, Issue:3

    Topics: Alanine Transaminase; Animals; Benzamides; Bilirubin; Chemical and Drug Induced Liver Injury; Dose-R

1978
Responses of rats and nonhuman primates to 2,5,2',5'-tetrachlorobiphenyl.
    Environmental research, 1975, Volume: 9, Issue:3

    Topics: Animals; Aroclors; Chemical and Drug Induced Liver Injury; Drug Antagonism; Drug Synergism; Female;

1975
Effect of biliary stasis and hepatotoxins on the excretion of iopanoate in the rat.
    The Journal of pharmacology and experimental therapeutics, 1975, Volume: 192, Issue:3

    Topics: Animals; Bile Ducts; Carbon Tetrachloride Poisoning; Chemical and Drug Induced Liver Injury; Cholest

1975
Biochemical toxicology of unsaturated halogenated monomers.
    Environmental health perspectives, 1975, Volume: 11

    Topics: Alanine Transaminase; Alcohol Oxidoreductases; Animals; Butadienes; Chemical and Drug Induced Liver

1975
Effects of H2-blocking agents on hepatocytes in vitro: correlation with potential for causing hepatic disease in patients.
    Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.), 1986, Volume: 182, Issue:4

    Topics: Animals; Aspartate Aminotransferases; Chemical and Drug Induced Liver Injury; Cimetidine; Histamine

1986
A comparative study of the hepatotoxicity of 1-fluoropentane and 1-fluorohexane.
    Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association, 1988, Volume: 26, Issue:8

    Topics: Animals; Chemical and Drug Induced Liver Injury; Drug Synergism; Hydrocarbons, Fluorinated; Liver; L

1988
Cytoprotective effects of modulators of oxidative xenobiotic metabolism in precocene II-induced hepatotoxicity.
    Fundamental and applied toxicology : official journal of the Society of Toxicology, 1987, Volume: 9, Issue:2

    Topics: Alanine Transaminase; Animals; Aspartate Aminotransferases; Benzopyrans; Cell Survival; Chemical and

1987
Guinea-pig model of halothane-associated hepatotoxicity in the absence of enzyme induction and hypoxia.
    The Journal of pharmacology and experimental therapeutics, 1985, Volume: 232, Issue:3

    Topics: Animals; Biotransformation; Blood Gas Analysis; Chemical and Drug Induced Liver Injury; Disease Mode

1985
The role of liver cell endoplasmic reticulum and microsomal enzymes in carbon tetrachloride toxicity: an in vivo study.
    Life sciences. Pt. 1: Physiology and pharmacology, 1970, Dec-15, Volume: 9, Issue:24

    Topics: Animals; Carbon Tetrachloride Poisoning; Chemical and Drug Induced Liver Injury; Dietary Proteins; E

1970
Mechanism of carbon tetrachloride hepatotoxicity. An in vivo study of its molecular basis in rats and monkeys.
    Laboratory investigation; a journal of technical methods and pathology, 1972, Volume: 26, Issue:6

    Topics: Aniline Compounds; Animals; Biopsy; Carbon Tetrachloride Poisoning; Chemical and Drug Induced Liver

1972
Centrolobular hepatic necrosis related to covalent binding of metabolites of halogenated aromatic hydrocarbons.
    Experimental and molecular pathology, 1973, Volume: 18, Issue:1

    Topics: Animals; Benzene Derivatives; Bromine; Chemical and Drug Induced Liver Injury; Enzyme Induction; Glu

1973
Role of detoxifying enzymes in bromobenzene-induced liver necrosis.
    The Journal of pharmacology and experimental therapeutics, 1973, Volume: 187, Issue:1

    Topics: Adipose Tissue; Animals; Benzene Derivatives; Carbon Radioisotopes; Chemical and Drug Induced Liver

1973
Decreased liver activity of porphyrin-metal chelatase in hepatic porphyria caused by 3,5-diethoxycarbonyl-1,4-dihydrocollidine. Studies in rats and mice.
    The Biochemical journal, 1973, Volume: 134, Issue:3

    Topics: 5-Aminolevulinate Synthetase; Allylisopropylacetamide; Animals; Chemical and Drug Induced Liver Inju

1973
Biochemical mechanism of hepatic necrosis induced by aromatic hydrocarbons.
    Pharmacology, 1973, Volume: 10, Issue:4

    Topics: Animals; Benzene Derivatives; Bromine; Carbon Radioisotopes; Chemical and Drug Induced Liver Injury;

1973
[Use of enzyme tests for diagnosing the character of toxic liver damage and for controlling the effectiveness of chemotherapy for CCl-4 poisoning].
    Biulleten' eksperimental'noi biologii i meditsiny, 1973, Volume: 75, Issue:5

    Topics: Acid Phosphatase; Alkaline Phosphatase; Animals; Carbon Tetrachloride Poisoning; Chemical and Drug I

1973
Prevention of carbon tetrachloride-induced necrosis by inhibitors of drug metabolism--further studies on their mechanism of action.
    Biochemical pharmacology, 1974, Jan-15, Volume: 23, Issue:2

    Topics: Animals; Antimetabolites; Body Temperature; Carbon Tetrachloride; Carbon Tetrachloride Poisoning; Ch

1974
Bromobenzene-induced liver necrosis. Protective role of glutathione and evidence for 3,4-bromobenzene oxide as the hepatotoxic metabolite.
    Pharmacology, 1974, Volume: 11, Issue:3

    Topics: Animals; Benzene Derivatives; Biotransformation; Carbon Radioisotopes; Chemical and Drug Induced Liv

1974
Effect of drug pretreatment on CBrCl3-induced liver injury.
    Toxicology, 1974, Volume: 2, Issue:4

    Topics: Alanine Transaminase; Animals; Aspartate Aminotransferases; Bromine; Chemical and Drug Induced Liver

1974
Effects of phenobarbital and SKF 525A pretreatment, sex, liver injury, and vehicle on delta9-tetrahydrocannabinol toxicity.
    Toxicology and applied pharmacology, 1974, Volume: 27, Issue:1

    Topics: Animals; Brain Chemistry; Cannabis; Carbon Radioisotopes; Carbon Tetrachloride Poisoning; Chemical a

1974
Bromobenzene-induced hepatic necrosis: species differences and protection by SKF 525-A.
    Research communications in chemical pathology and pharmacology, 1971, Volume: 2, Issue:6

    Topics: Age Factors; Animals; Animals, Newborn; Anura; Bufo marinus; Chemical and Drug Induced Liver Injury;

1971
The effect of prior dosing with phenobarbitone and -diethylaminoethyl diphenylpropyl acetate (SKF525A) on the toxicity and liver lesion caused by ngaione in the mouse.
    British journal of experimental pathology, 1972, Volume: 53, Issue:3

    Topics: Animals; Chemical and Drug Induced Liver Injury; Lipid Metabolism; Liver; Male; Mice; Microsomes, Li

1972
Acute hepatotoxicity and pyrrolic metabolites in rats dosed with pyrrolizidine alkaloids.
    Chemico-biological interactions, 1972, Volume: 5, Issue:4

    Topics: Animals; Chemical and Drug Induced Liver Injury; Female; Lethal Dose 50; Liver; Male; Microsomes, Li

1972
Bromobenzene metabolism and hepatic necrosis.
    Pharmacology, 1971, Volume: 6, Issue:1

    Topics: Adipose Tissue; Animals; Benzene Derivatives; Bromine; Carbon Isotopes; Chemical and Drug Induced Li

1971
Effect of drug pretreatment on carbon tetrachloride-induced lipid peroxidation in rat liver microsomal lipids.
    Experimental and molecular pathology, 1970, Volume: 12, Issue:3

    Topics: Animals; Carbon Tetrachloride Poisoning; Centrifugation; Chemical and Drug Induced Liver Injury; Lip

1970
Effect of inhibitors of drug metabolizing enzymes on carbon tetrachloride hepatotoxicity.
    Toxicology and applied pharmacology, 1971, Volume: 18, Issue:3

    Topics: Aminopyrine; Animals; Biotransformation; Carbon Tetrachloride; Carbon Tetrachloride Poisoning; Chemi

1971