proadifen has been researched along with Abnormalities, Drug-Induced in 10 studies
Proadifen: An inhibitor of drug metabolism and CYTOCHROME P-450 ENZYME SYSTEM activity.
Abnormalities, Drug-Induced: Congenital abnormalities caused by medicinal substances or drugs of abuse given to or taken by the mother, or to which she is inadvertently exposed during the manufacture of such substances. The concept excludes abnormalities resulting from exposure to non-medicinal chemicals in the environment.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Time-mated Swiss-Webster mice were pretreated in separate experiments with phenobarbital (60 mg/kg X d sc on d 7-10 of pregnancy), SKF-525A (40 mg/kg ip on d 12 of pregnancy) or 3-methylcholanthrene (20 mg/kg X d on d 10-12 of pregnancy)." | 3.67 | Ethylenethiourea-induced hindpaw deformities in mice and effects of metabolic modifiers on their occurrence. ( Khera, KS, 1984) |
| "To study the effects of SKF-525A, an inhibitor of cytochrome P-450, and of sodium phenobarbital (PB), a drug-metabolizing enzyme inducer, on the teratogenicity of thiabendazole (TBZ), pregnant mice were given ip either a single dose of 40 mg SKF-525A/kg 1 hr before oral dosing with 250 or 500 mg TBZ/kg or a dose of 75 mg PB/kg/day on three consecutive days before oral administration of a dose of 500 or 1000 mg TBZ/kg." | 1.27 | Effects of pretreatment with SKF-525A or sodium phenobarbital on thiabendazole-induced teratogenicity in ICR mice. ( Imamichi, T; Ogata, A; Sasaki, M; Suzuki, K; Yoneyama, M, 1987) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 10 (100.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Khera, KS | 1 |
| Preache, MM | 1 |
| Gibson, JE | 3 |
| Ogata, A | 1 |
| Yoneyama, M | 1 |
| Sasaki, M | 1 |
| Suzuki, K | 1 |
| Imamichi, T | 1 |
| Posner, HS | 2 |
| Graves, A | 1 |
| King, CT | 1 |
| Wilk, A | 1 |
| Bus, JS | 1 |
| Short, RD | 1 |
| Becker, BA | 3 |
| Harbison, RD | 2 |
| Bird, CC | 1 |
| Crawford, AM | 1 |
| Currie, AR | 1 |
| Stirling, BF | 1 |
10 other studies available for proadifen and Abnormalities, Drug-Induced
| Article | Year |
|---|---|
Ethylenethiourea-induced hindpaw deformities in mice and effects of metabolic modifiers on their occurrence.
Topics: Abnormalities, Drug-Induced; Animals; Cytochrome P-450 Enzyme System; Ethylenethiourea; Female; Foot | 1984 |
Effect of food deprivation, phenobarbital, and SKF-525A on teratogenicity induced by 2-sec-butyl-4,6-dinitrophenol (dinoseb) and on disposition of [14C]dinoseb in mice.
Topics: Abnormalities, Drug-Induced; Animals; Body Water; Body Weight; Bone and Bones; Dinitrophenols; Femal | 1975 |
Effects of pretreatment with SKF-525A or sodium phenobarbital on thiabendazole-induced teratogenicity in ICR mice.
Topics: Abnormalities, Drug-Induced; Animals; Body Weight; Bone and Bones; Female; Fetal Resorption; Male; M | 1987 |
Significance of cleft palate induced by chemicals in the rat and mouse.
Topics: Abnormalities, Drug-Induced; Aminopropionitrile; Animals; Cleft Palate; Cortisone; Female; Mice; Nit | 1972 |
Experimental alteration of the metabolism of chlorcyclizine and the incidence of cleft palate in rats.
Topics: Abnormalities, Drug-Induced; Adrenal Glands; Animals; Body Weight; Brain Chemistry; Carbon Isotopes; | 1967 |
Effect of phenobarbital and SKF 525A on the toxicity, elimination and metabolism of cyclophosphamide in newborn mice.
Topics: Abnormalities, Drug-Induced; Animals; Body Weight; Carbon Isotopes; Cyclophosphamide; Drug Synergism | 1973 |
Effect of phenobarbital and SKF 525-A on the teratogenicity of cyclophosphamide in mice.
Topics: Abnormalities, Drug-Induced; Alkylation; Animals; Cyclophosphamide; Eye Abnormalities; Female; Hydro | 1968 |
Effects of phenobarbital or SKF 525A pretreatment on diphenylhydantoin disposition in pregnant mice.
Topics: Abnormalities, Drug-Induced; Adipose Tissue; Amniotic Fluid; Animals; Brain Chemistry; Carbon Isotop | 1971 |
Protection from the embryopathic effects of 7-hydroxymethyl-12-methylbenz(a)anthracene by 2-methyl-1,2-bis-(3-pyridyl)1-propanone(metopirone, Ciba) and beta-diethylaminoethyldiphenyl-n-propyl acetate (SKF 525-A).
Topics: Abnormalities, Drug-Induced; Adrenal Glands; Animals; Benz(a)Anthracenes; Embryo, Mammalian; Female; | 1970 |
Effect of phenobarbital and SKF 525A pretreatment on diphenylhydantoin teratogenicity in mice.
Topics: Abnormalities, Drug-Induced; Animals; Body Weight; Depression, Chemical; Drug Synergism; Female; Fet | 1970 |