primidone has been researched along with Pregnancy in 78 studies
Primidone: A barbiturate derivative that acts as a GABA modulator and anti-epileptic agent. It is partly metabolized to PHENOBARBITAL in the body and owes some of its actions to this metabolite.
primidone : A pyrimidone that is dihydropyrimidine-4,6(1H,5H)-dione substituted by an ethyl and a phenyl group at position 5. It is used as an anticonvulsant for treatment of various types of seizures.
Pregnancy: The status during which female mammals carry their developing young (EMBRYOS or FETUSES) in utero before birth, beginning from FERTILIZATION to BIRTH.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Fourteen epileptic women treated with primidone, either alone or in combination with other antiepileptic drugs, were studied prospectively during their pregnancy." | 7.66 | Teratogenic and pharmacokinetic studies of primidone during pregnancy and in the offspring of epileptic women. ( Beck-Mannagetta, G; Göpfert-Geyer, I; Helge, H; Jäger-Roman, E; Koch, S; Nau, H; Rating, D; Schmidt, D, 1982) |
| "An epileptic patient whose seizures were controlled with carbamazepine and primidone was followed throughout pregnancy and lactation." | 7.66 | Carbamazepine levels in pregnancy and lactation. ( Blake, DA; Freeman, JM; Luff, RD; Niebyl, JR, 1979) |
| " Mice were treated with a teratogenic dose of primidone (100 mg/kg) by gastric intubation at three different times during pregnancy, viz." | 7.65 | Plasma level studies of primidone and its metabolites in the mouse at various stages of pregnancy. ( McElhatton, PR; Sullivan, FM; Toseland, PA, 1977) |
| " Primidone was the only anti-epileptic drug, taken during pregnancy, to have a significant effect on infant head circumference." | 3.66 | Neonatal outcome in infants of epileptic mothers. ( Heifetz, L; Neri, A; Nitke, S; Ovadia, J, 1983) |
| "Fourteen epileptic women treated with primidone, either alone or in combination with other antiepileptic drugs, were studied prospectively during their pregnancy." | 3.66 | Teratogenic and pharmacokinetic studies of primidone during pregnancy and in the offspring of epileptic women. ( Beck-Mannagetta, G; Göpfert-Geyer, I; Helge, H; Jäger-Roman, E; Koch, S; Nau, H; Rating, D; Schmidt, D, 1982) |
| "An epileptic patient whose seizures were controlled with carbamazepine and primidone was followed throughout pregnancy and lactation." | 3.66 | Carbamazepine levels in pregnancy and lactation. ( Blake, DA; Freeman, JM; Luff, RD; Niebyl, JR, 1979) |
| " Mice were treated with a teratogenic dose of primidone (100 mg/kg) by gastric intubation at three different times during pregnancy, viz." | 3.65 | Plasma level studies of primidone and its metabolites in the mouse at various stages of pregnancy. ( McElhatton, PR; Sullivan, FM; Toseland, PA, 1977) |
| "Anticonvulsant therapy was among the first areas to benefit from clinical pharmacokinetic studies." | 2.35 | Clinical pharmacokinetics of anticonvulsants. ( Dam, M; Hvidberg, EF, 1976) |
| " Pharmacokinetic interactions between antiepileptic drugs may lead to considerable fluctuation in plasma drug concentration, and monotherapy is often preferable." | 1.27 | Pharmacokinetics of antiepileptic drugs. ( Neuvonen, PJ; Tokola, RA, 1983) |
| "Only when the epilepsy is uncontrolled despite high plasma concentrations which cannot be raised because of side effects, a second drug should be given." | 1.27 | [Pharmacotherapy of epilepsy--current problems and controversies]. ( Schmidt, D, 1983) |
| " The mechanisms responsible for these effects have not been elucidated and possibly include decreased bioavailability or compliance, increased metabolic clearance, or decreased plasma protein binding." | 1.27 | Effects of pregnancy on antiepileptic drug utilization. ( Levy, RH; Yerby, MS, 1985) |
| "Experimental production of hemifacial microsomia by a folic acid antagonist, triaxene, is mediated via hemorrhage in the fetus." | 1.27 | Goldenhar syndrome, anterior encephalocele, and aqueductal stenosis following fetal primidone exposure. ( Chen, H; Gustavson, EE, 1985) |
| " Monitoring plasma concentrations may lead to adaptations of the choice of the drug and of the dosage regimen." | 1.26 | Kinetics of drug interactions in the treatment of epilepsy. ( Guelen, P; Knop, H; Schobten, F; van der Kleijn, E; Vree, T; Westenberg, H, 1978) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 70 (89.74) | 18.7374 |
| 1990's | 7 (8.97) | 18.2507 |
| 2000's | 1 (1.28) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| BERIC, B | 2 |
| RYDER, RJ | 1 |
| Tokola, RA | 1 |
| Neuvonen, PJ | 1 |
| Koch, S | 5 |
| Göpfert-Geyer, I | 2 |
| Jäger-Roman, E | 4 |
| Jakob, S | 1 |
| Huth, H | 1 |
| Hartmann, A | 1 |
| Rating, D | 5 |
| Helge, H | 5 |
| Friis, ML | 2 |
| Schmidt, D | 2 |
| Bruni, J | 1 |
| Albright, PS | 1 |
| Nau, H | 5 |
| Kuhnz, W | 1 |
| Mallow, DW | 1 |
| Herrick, MK | 1 |
| Gathman, G | 1 |
| Neri, A | 1 |
| Heifetz, L | 1 |
| Nitke, S | 1 |
| Ovadia, J | 1 |
| Morselli, PL | 1 |
| Franco-Morselli, R | 1 |
| Aminoff, MJ | 1 |
| Burn, J | 1 |
| Baraitser, M | 1 |
| Beck-Mannagetta, G | 1 |
| Bossi, L | 1 |
| Assael, BM | 1 |
| Avanzini, G | 1 |
| Battino, D | 1 |
| Caccamo, ML | 1 |
| Canger, R | 1 |
| Como, ML | 1 |
| Pifarotti, G | 1 |
| de Giambattista, M | 1 |
| Franceschetti, S | 1 |
| Marini, A | 1 |
| Pardi, G | 1 |
| Porro, MG | 1 |
| Rovei, V | 1 |
| Sanjuan, M | 1 |
| Soffientini, ME | 1 |
| Spina, S | 1 |
| Spreafico, R | 1 |
| Myhre, SA | 1 |
| Williams, R | 1 |
| Jesdinsky, D | 1 |
| Wittfoht, W | 1 |
| Häuser, I | 1 |
| Jäger, E | 1 |
| Tulokas, S | 1 |
| Kutlay, B | 1 |
| Bayramoglu, S | 1 |
| Kutlar, AI | 1 |
| Yesildaglar, N | 1 |
| Lösche, G | 1 |
| Pizzi, WJ | 1 |
| Alexander, TD | 1 |
| Loftus, JT | 1 |
| Titze, K | 1 |
| Zimmermann, RB | 1 |
| Schröder, M | 1 |
| Lehmkuhl, U | 1 |
| Rauh, H | 1 |
| Laskowska, M | 1 |
| Leszczyńska-Gorzelak, B | 1 |
| Oleszczuk, J | 1 |
| Schweizer, K | 1 |
| Wick, H | 1 |
| Brechbühler, T | 1 |
| Hanson, JW | 1 |
| Smith, DW | 1 |
| Aucamp, AK | 1 |
| McElhatton, PR | 6 |
| Sullivan, FM | 6 |
| Conomy, JP | 1 |
| Reith, H | 1 |
| Schäfer, H | 1 |
| May, CJ | 1 |
| Greenwood, RE | 1 |
| Livingston, S | 1 |
| Windorfer, A | 1 |
| Stünkel, S | 1 |
| Rudd, NL | 1 |
| Freedom, RM | 1 |
| van der Kleijn, E | 1 |
| Vree, T | 1 |
| Guelen, P | 1 |
| Schobten, F | 1 |
| Westenberg, H | 1 |
| Knop, H | 1 |
| Niebyl, JR | 1 |
| Blake, DA | 1 |
| Freeman, JM | 2 |
| Luff, RD | 1 |
| Hvidberg, EF | 1 |
| Dam, M | 1 |
| Singer, HS | 1 |
| Goodman, RM | 1 |
| Katznelson, MB | 1 |
| Hertz, M | 1 |
| Katznelson, D | 1 |
| Rotem, Y | 1 |
| Toseland, PA | 3 |
| Belaisch, J | 1 |
| Driguez, P | 1 |
| Janaud, A | 1 |
| Waziri, M | 1 |
| Ionasescu, V | 1 |
| Zellweger, H | 2 |
| Bishun, NP | 1 |
| Smith, NS | 1 |
| Williams, DC | 1 |
| Biale, Y | 1 |
| Lewenthal, H | 1 |
| Aderet, NB | 1 |
| Annegers, JF | 2 |
| Elveback, LR | 2 |
| Hauser, WA | 2 |
| Kurland, LT | 2 |
| Yerby, MS | 2 |
| Leavitt, A | 1 |
| Erickson, DM | 1 |
| McCormick, KB | 1 |
| Loewenson, RB | 1 |
| Sells, CJ | 1 |
| Benedetti, TJ | 1 |
| Knott, C | 1 |
| Reynolds, F | 1 |
| Klepel, H | 1 |
| Donat, H | 1 |
| Köppe, I | 1 |
| Shinnar, S | 1 |
| Cohen, A | 1 |
| Mundel, G | 1 |
| Levy, RH | 1 |
| Gustavson, EE | 1 |
| Chen, H | 1 |
| Lowe, CR | 1 |
| Evans, AR | 1 |
| Forrester, RM | 1 |
| Discombe, C | 1 |
| Waltl, H | 1 |
| Mitterstieler, G | 1 |
| Schwingshackl, A | 1 |
| Gibberd, FB | 1 |
| Pochedly, C | 1 |
| Ente, G | 1 |
| Reynolds, EH | 1 |
| Solomon, GE | 1 |
| Hilgartner, MW | 1 |
| Kutt, H | 1 |
| Sherwin, AL | 1 |
| Loynd, JS | 1 |
| Bock, GW | 1 |
| Sokolowski, CD | 1 |
| Jennings, PB | 1 |
| Utter, WF | 1 |
| Fariss, BL | 1 |
| Shapiro, IuL | 1 |
| Vaĭntrub, MIa | 1 |
| Grinberg, KN | 1 |
| Zhurkov, VS | 1 |
| Gregoriades, AD | 1 |
| Martinez, G | 1 |
| Snyder, RD | 1 |
| Stenchever, MA | 1 |
| Allen, M | 1 |
| Meyer, JG | 1 |
| Hill, RM | 1 |
| Verniaud, WM | 1 |
| Horning, MG | 1 |
| McCulley, LB | 1 |
| Morgan, NF | 1 |
| Roman, IC | 1 |
| Caratzali, A | 1 |
| Elshove, J | 1 |
| van Eck, JH | 1 |
| Williamson, DA | 1 |
9 reviews available for primidone and Pregnancy
| Article | Year |
|---|---|
The clinical pharmacology of antiepileptic drugs.
Topics: Adult; Anticonvulsants; Benzodiazepines; Carbamazepine; Drug Interactions; Ethosuximide; Female; Hal | 1984 |
Clinical pharmacokinetics of antiepileptic drugs in adults.
Topics: Adult; Aging; Anticonvulsants; Carbamazepine; Clonazepam; Diazepam; Disease; Ethosuximide; Female; H | 1980 |
The pharmacological treatment of epilepsy.
Topics: Anticonvulsants; Carbamazepine; Child, Preschool; Clonazepam; Drug Therapy, Combination; Epilepsies, | 1979 |
[Antiepileptics during pregnancy and lactation. Pharmacokinetic data].
Topics: Anticonvulsants; Bromides; Carbamazepine; Clonazepam; Diazepam; Ethosuximide; Female; Fetus; Humans; | 1979 |
Clinical pharmacokinetics of anticonvulsants.
Topics: Administration, Oral; Adult; Aged; Aging; Animals; Anticonvulsants; Carbamazepine; Child; Clonazepam | 1976 |
Antiepileptic drugs in adolescents.
Topics: Adaptation, Psychological; Adolescent; Adult; Anticonvulsants; Carbamazepine; Child; Clonazepam; Dru | 1987 |
Adverse hematologic effects of drugs.
Topics: Anemia, Hemolytic; Anemia, Macrocytic; Anti-Bacterial Agents; Anticonvulsants; Antidepressive Agents | 1972 |
[Teratogenic and mutagenic effects of anticonvulsive and psychotropic drugs (review of the literature)].
Topics: Abnormalities, Drug-Induced; Abnormalities, Multiple; Animals; Anticonvulsants; Antidepressive Agent | 1972 |
Anticonvulsants during pregnancy: a danger to the developing fetus?
Topics: Abnormalities, Drug-Induced; Anticonvulsants; Barbiturates; Blood Coagulation Disorders; Chromosome | 1974 |
3 trials available for primidone and Pregnancy
| Article | Year |
|---|---|
[Anti-epileptic agents during pregnancy. A prospective study on the course of pregnancy, malformations and child development].
Topics: Abnormalities, Drug-Induced; Abortion, Spontaneous; Adult; Akathisia, Drug-Induced; Anencephaly; Ant | 1983 |
Antiepileptic drug treatment in pregnancy: drug side effects in the neonate and neurological outcome.
Topics: Anticonvulsants; Child; Drug Monitoring; Epilepsy; Female; Follow-Up Studies; Humans; Nervous System | 1996 |
[Evaluation of antiepileptic therapy during pregnancy].
Topics: Adult; Anticonvulsants; Apgar Score; Drug Therapy, Combination; Epilepsy; Female; Humans; Phenobarbi | 2002 |
66 other studies available for primidone and Pregnancy
| Article | Year |
|---|---|
[Therapeutic effect of mysoline during pregnancy and pending delivery in epileptics].
Topics: Anticonvulsants; Delivery, Obstetric; Epilepsy; Female; Humans; Labor, Obstetric; Pregnancy; Pregnan | 1956 |
[Therapeutic effect of mysoline during pregnancy and pending delivery in epileptics].
Topics: Anticonvulsants; Delivery, Obstetric; Epilepsy; Female; Humans; Labor, Obstetric; Pregnancy; Pregnan | 1956 |
[Therapeutic effect of mysoline during pregnancy and pending delivery in epileptics].
Topics: Anticonvulsants; Delivery, Obstetric; Epilepsy; Female; Humans; Labor, Obstetric; Pregnancy; Pregnan | 1956 |
[Therapeutic effect of mysoline during pregnancy and pending delivery in epileptics].
Topics: Anticonvulsants; Delivery, Obstetric; Epilepsy; Female; Humans; Labor, Obstetric; Pregnancy; Pregnan | 1956 |
HAEMORRHAGE ASSOCIATED WITH THROMBOCYTOPENIA IN MEGALOBLASTIC ANAEMIA.
Topics: Anemia; Anemia, Macrocytic; Anemia, Megaloblastic; Blood Platelet Disorders; Drug Therapy; Epilepsy; | 1964 |
Pharmacokinetics of antiepileptic drugs.
Topics: Adult; Anti-Anxiety Agents; Anticonvulsants; Benzodiazepines; Carbamazepine; Child; Child, Preschool | 1983 |
Antiepileptic drugs and teratogenesis. How should patients, doctors and health authorities be counselled?
Topics: Abnormalities, Drug-Induced; Anticonvulsants; Carbamazepine; Epilepsy; Female; Humans; Infant, Newbo | 1983 |
[Pharmacotherapy of epilepsy--current problems and controversies].
Topics: Adolescent; Adult; Carbamazepine; Child; Child, Preschool; Epilepsies, Partial; Epilepsy; Epilepsy, | 1983 |
Enzyme induction in neonates after fetal exposure to antiepileptic drugs.
Topics: Aminopyrine; Aminopyrine N-Demethylase; Anticonvulsants; Breath Tests; Carbamazepine; Carbon Radiois | 1983 |
Fetal exposure to anticonvulsant drugs. Detailed pathological study of a case.
Topics: Abnormalities, Drug-Induced; Acetazolamide; Adult; Anticonvulsants; Brain; Cardiomegaly; Epilepsy; E | 1980 |
Neonatal outcome in infants of epileptic mothers.
Topics: Analysis of Variance; Anticonvulsants; Cephalometry; Drug Therapy, Combination; Epilepsy; Female; Fe | 1983 |
Drug treatment of epilepsy.
Topics: Anticonvulsants; Carbamazepine; Clonazepam; Electroencephalography; Epilepsy; Ethosuximide; Female; | 1981 |
Primidone teratogenicity or Noonan syndrome?
Topics: Abnormalities, Drug-Induced; Diagnosis, Differential; Female; Humans; Infant, Newborn; Noonan Syndro | 1982 |
Teratogenic and pharmacokinetic studies of primidone during pregnancy and in the offspring of epileptic women.
Topics: Abnormalities, Drug-Induced; Child Development; Epilepsy; Female; Humans; Infant, Newborn; Kinetics; | 1982 |
Plasma levels and clinical effects of antiepileptic drugs in pregnant epileptic patients and their newborns.
Topics: Adult; Anticonvulsants; Clonazepam; Epilepsy; Female; Humans; Infant, Newborn; Phenobarbital; Phenyt | 1980 |
Teratogenic effects associated with maternal primidone therapy.
Topics: Abnormalities, Drug-Induced; Child; Child Development; Child, Preschool; Craniofacial Dysostosis; Ep | 1981 |
Microassay for primidone and its metabolites phenylethylmalondiamide, phenobarbital and p-hydroxyphenobarbital in human serum, saliva, breast milk and tissues by gas chromatography--mass spectrometry using selected ion monitoring.
Topics: Female; Gas Chromatography-Mass Spectrometry; Humans; Infant, Newborn; Kinetics; Malonates; Maternal | 1980 |
Placental transfer and pharmacokinetics of primidone and its metabolites phenobarbital, PEMA and hydroxyphenobarbital in neonates and infants of epileptic mothers.
Topics: Adult; Aminopyrine; Cytochrome P-450 Enzyme System; Epilepsy; Female; Half-Life; Humans; Hydroxylati | 1980 |
[The activation of lupus in pregnancy and its successful immunological treatment].
Topics: Adult; Anti-Inflammatory Agents; Anticonvulsants; Azathioprine; Epilepsy; Female; Humans; Immunoglob | 1994 |
An acardiac acephalic monster following in-utero anti-epileptic drug exposure.
Topics: Abnormalities, Multiple; Abnormalities, Severe Teratoid; Adult; Anencephaly; Anticonvulsants; Female | 1996 |
Developmental and behavioral effects of prenatal primidone exposure in the rat.
Topics: Animals; Anticonvulsants; Behavior, Animal; Body Weight; Exploratory Behavior; Female; Growth; Male; | 1996 |
Reproductive toxicology. Primaclone.
Topics: Animals; Anticonvulsants; Body Weight; Dose-Response Relationship, Drug; Female; Kidney; Liver; Male | 1997 |
Long-term neuropsychological consequences of maternal epilepsy and anticonvulsant treatment during pregnancy for school-age children and adolescents.
Topics: Adolescent; Adult; Animals; Anticonvulsants; Child; Developmental Disabilities; Drug Therapy, Combin | 1999 |
An improved method for preparation of samples for the simultaneous assay of some antiepileptic drugs by gas-liquid chromatography.
Topics: Barbiturates; Body Fluids; Chromatography, Gas; Female; Humans; Milk, Human; Phenobarbital; Phenytoi | 1978 |
The fetal hydantoin syndrome.
Topics: Abnormalities, Drug-Induced; Abnormalities, Multiple; Adolescent; Child, Preschool; Developmental Di | 1975 |
Proceedings: Teratogenic effects of primidone in mice.
Topics: Animals; Female; Folic Acid; Mice; Mice, Inbred Strains; Pregnancy; Primidone; Specific Pathogen-Fre | 1975 |
Long-term use of the major anticonvulsant drugs.
Topics: Abnormalities, Drug-Induced; Anticonvulsants; Carbamazepine; Drug Interactions; Epilepsy; Ethosuximi | 1978 |
Recurrent convulsions in a thoroughbred foal: management and treatment.
Topics: Animals; Animals, Newborn; Enteral Nutrition; Female; Horse Diseases; Horses; Male; Pregnancy; Primi | 1977 |
Medical treatment of epilepsy: Part II.
Topics: Abnormalities, Drug-Induced; Adult; Anticonvulsants; Calcium; Child; Drug Interactions; Epilepsy; Ep | 1978 |
Epilepsy among parents of children with facial clefts.
Topics: Anticonvulsants; Cleft Lip; Cleft Palate; Epilepsy; Female; Humans; Male; Parents; Phenobarbital; Ph | 1979 |
[Significance of pharmacogenic liver reactions for metabolism of endogenous and exogenous substances].
Topics: Carbamazepine; Diazepam; Drug-Related Side Effects and Adverse Reactions; Female; Fenoterol; Humans; | 1979 |
A possible primidone embryopathy.
Topics: Abnormalities, Drug-Induced; Aortic Coarctation; Face; Female; Heart Septal Defects, Ventricular; Hu | 1979 |
Kinetics of drug interactions in the treatment of epilepsy.
Topics: Animals; Anticonvulsants; Carbamazepine; Drug Interactions; Epilepsy; Ethanol; Female; Humans; Kinet | 1978 |
Carbamazepine levels in pregnancy and lactation.
Topics: Adult; Carbamazepine; Epilepsy, Temporal Lobe; Female; Fetal Blood; Fetus; Humans; Lactation; Milk, | 1979 |
Seizures in adolescents.
Topics: Adolescent; Anticonvulsants; Automobile Driving; Benzodiazepines; Carbamazepine; Diagnosis, Differen | 1975 |
Congenital malformations in four siblings of a mother taking anticonvulsant drugs.
Topics: Abnormalities, Drug-Induced; Abnormalities, Multiple; Anticonvulsants; Child; Child, Preschool; Epil | 1976 |
Teratogenic activity and metabolism of primidone in the mouse.
Topics: Animals; Cleft Palate; Dose-Response Relationship, Drug; Female; Fetus; Mice; Palate; Pregnancy; Pri | 1977 |
A comparison of the teratogenic activity of the antiepileptic drugs carbamazepine, clonazepam, ethosuximide, phenobarbital, phenytoin, and primidone in mice.
Topics: Abnormalities, Drug-Induced; Animals; Anticonvulsants; Carbamazepine; Clonazepam; Ethosuximide; Fema | 1977 |
The metabolism of primidone in non-pregnant and 14-day pregnant mice.
Topics: Animals; Female; Mice; Phenobarbital; Phenylethylmalonamide; Pregnancy; Pregnancy, Animal; Primidone | 1977 |
Plasma level studies of primidone and its metabolites in the mouse at various stages of pregnancy.
Topics: Animals; Female; Gestational Age; Malonates; Metabolic Clearance Rate; Mice; Phenobarbital; Phenylet | 1977 |
[Letter: Influence of certain drugs on the action of contraceptive pills].
Topics: Adult; Contraceptives, Oral; Drug Interactions; Female; Humans; Pregnancy; Primidone | 1976 |
Teratogenic effect of anticonvulsant drugs.
Topics: Abnormalities, Drug-Induced; Abnormalities, Multiple; Acetazolamide; Anticonvulsants; Child; Child, | 1976 |
Teratogenic activity of the antiepileptic drugs phenobarbital, phenytoin, and primidone in mice.
Topics: Animals; Cleft Palate; Drug Interactions; Female; Gestational Age; Leucovorin; Maternal-Fetal Exchan | 1975 |
Chromosomes and anticonvulsant drugs.
Topics: Abnormalities, Drug-Induced; Anticonvulsants; Cells, Cultured; Chromatids; Chromosome Aberrations; C | 1975 |
Congenital malformations due to anticonvulsive drugs.
Topics: Abnormalities, Drug-Induced; Abnormalities, Multiple; Adult; Anencephaly; Anticonvulsants; Birth Ord | 1975 |
Epilepsy anticonvulsants and malformations.
Topics: Abnormalities, Drug-Induced; Anticonvulsants; Cleft Lip; Cleft Palate; Epilepsy; Female; Heart Defec | 1975 |
Antiepileptics and the development of congenital anomalies.
Topics: Abnormalities, Drug-Induced; Anticonvulsants; Apgar Score; Birth Weight; Carbamazepine; Epilepsy; Fe | 1992 |
Value of saliva anticonvulsant monitoring in pregnancy and the newborn.
Topics: Anticonvulsants; Carbamazepine; Female; Humans; Infant, Newborn; Monitoring, Physiologic; Phenobarbi | 1989 |
[Prenatal growth of children of epileptic mothers].
Topics: Anticonvulsants; Birth Weight; Cephalometry; Drug Therapy, Combination; Epilepsies, Partial; Epileps | 1986 |
[The fetal primidone syndrome].
Topics: Abnormalities, Drug-Induced; Abnormalities, Multiple; Epilepsy; Female; Fetal Diseases; Fetal Growth | 1988 |
Effects of pregnancy on antiepileptic drug utilization.
Topics: Anticonvulsants; Biological Availability; Carbamazepine; Epilepsy; Female; Humans; Kinetics; Metabol | 1985 |
Goldenhar syndrome, anterior encephalocele, and aqueductal stenosis following fetal primidone exposure.
Topics: Adult; Brain Diseases; Cerebral Aqueduct; Constriction, Pathologic; Encephalocele; Epilepsy; Female; | 1985 |
Congenital malformations among infants born to epileptic women.
Topics: Abnormalities, Drug-Induced; Cleft Lip; Cleft Palate; Congenital Abnormalities; England; Epilepsy; F | 1973 |
Neonatal haemorrhage following maternal anticonvulsant therapy.
Topics: Adult; Anticonvulsants; Epilepsy; Female; Humans; Infant, Newborn; Male; Phenobarbital; Phenytoin; P | 1970 |
[Haemorrhagic diathesis in a newborn child of a mother on anti-epileptic medication (author's transl)].
Topics: Adult; Anticonvulsants; Drug Therapy, Combination; Epilepsy, Tonic-Clonic; Female; Hemostatics; Huma | 1974 |
Epilepsy.
Topics: Adult; Child; Epilepsies, Partial; Epilepsy; Epilepsy, Absence; Epilepsy, Temporal Lobe; Epilepsy, T | 1969 |
Do anticonvulsants have a teratogenic effect?
Topics: Abnormalities, Drug-Induced; Anticonvulsants; Child, Preschool; Cleft Lip; Cleft Palate; Congenital | 1974 |
Iatrogenic nutritional effects of anticonvulsants.
Topics: Adolescent; Adult; Anticonvulsants; Blood Coagulation Disorders; Bone Diseases; Child; Child, Presch | 1974 |
Phenobarbital-induced coagulation defects in cats.
Topics: Alanine Transaminase; Animals; Animals, Newborn; Blood Coagulation; Blood Coagulation Disorders; Cat | 1974 |
Effects of age, sex, obesity, and pregnancy on plasma diphenylhydantoin levels.
Topics: Adolescent; Adult; Age Factors; Analysis of Variance; Chromatography, Gas; Dose-Response Relationshi | 1974 |
Effects of long-term primidone therapy in a dog.
Topics: Alkaline Phosphatase; Animals; Ataxia; Dog Diseases; Dogs; Estrus; Feeding and Eating Disorders; Fem | 1974 |
A medical and social survey of 231 children with seizures.
Topics: Adolescent; Attitude to Health; Child; Child Behavior Disorders; Child, Preschool; Electroencephalog | 1972 |
Transplacental passage of primidone.
Topics: Female; Fetus; Humans; Infant, Newborn; Infant, Newborn, Diseases; Labor, Obstetric; Maternal-Fetal | 1973 |
The effect of selected antiepileptic drugs on the chromosomes of human lymphocytes in vitro.
Topics: Adult; Anticonvulsants; Chromatids; Chromosomes; Culture Techniques; Epilepsy; Female; Humans; Hydan | 1973 |
The teratological effects of anticonvulsants and the effects on pregnancy and birth.
Topics: Abnormalities, Drug-Induced; Anticonvulsants; Carbamazepine; Child; Cleft Lip; Cleft Palate; Cyclohe | 1973 |
Infants exposed in utero to antiepileptic drugs. A prospective study.
Topics: Abnormalities, Drug-Induced; Adolescent; Adult; Amitriptyline; Amniotic Fluid; Anticonvulsants; Chro | 1974 |
Effects of anticonvulsant drugs on chromosomes.
Topics: Animals; Bone Marrow; Bone Marrow Cells; Chromosome Aberrations; Embryo, Mammalian; Female; Fertilit | 1971 |
[Congenital abnormalities, cleft lip and cleft palate in particular, in children of epileptic mothers].
Topics: Abnormalities, Drug-Induced; Abnormalities, Multiple; Adult; Cleft Lip; Cleft Palate; Epilepsy; Fema | 1971 |
Fits in utero, followed by infantile myoclonic twitchings.
Topics: Adult; Female; Fetal Diseases; Humans; Infant, Newborn; Infant, Newborn, Diseases; Male; Myoclonus; | 1968 |