primidone has been researched along with Parkinson Disease in 19 studies
Primidone: A barbiturate derivative that acts as a GABA modulator and anti-epileptic agent. It is partly metabolized to PHENOBARBITAL in the body and owes some of its actions to this metabolite.
primidone : A pyrimidone that is dihydropyrimidine-4,6(1H,5H)-dione substituted by an ethyl and a phenyl group at position 5. It is used as an anticonvulsant for treatment of various types of seizures.
Parkinson Disease: A progressive, degenerative neurologic disease characterized by a TREMOR that is maximal at rest, retropulsion (i.e. a tendency to fall backwards), rigidity, stooped posture, slowness of voluntary movements, and a masklike facial expression. Pathologic features include loss of melanin containing neurons in the substantia nigra and other pigmented nuclei of the brainstem. LEWY BODIES are present in the substantia nigra and locus coeruleus but may also be found in a related condition (LEWY BODY DISEASE, DIFFUSE) characterized by dementia in combination with varying degrees of parkinsonism. (Adams et al., Principles of Neurology, 6th ed, p1059, pp1067-75)
| Excerpt | Relevance | Reference |
|---|---|---|
| "We conducted a double-blind trial of isoniazid in 11 patients with essential tremor and four patients with other types of postural action tremor." | 9.07 | A double-blind trial of isoniazid for essential tremor and other action tremors. ( Dubinsky, RM; Gillespie, MM; Hallett, M; Moinfar, A; Ravits, J, 1991) |
| "We conducted a double-blind trial of isoniazid in 11 patients with essential tremor and four patients with other types of postural action tremor." | 5.07 | A double-blind trial of isoniazid for essential tremor and other action tremors. ( Dubinsky, RM; Gillespie, MM; Hallett, M; Moinfar, A; Ravits, J, 1991) |
| "The effect of long-acting propranolol hydrochloride (160 mg/d), primidone (250 mg at night), and clonazepam (4 mg/d) on the resting, postural, and kinetic component of tremor was investigated in ten parkinsonian patients in a double-blind crossover design." | 5.06 | Adjuvant therapy of parkinsonian tremor. ( Herbster, G; Koller, WC, 1987) |
| "Essential tremor is one of the most common movement disorders." | 2.61 | Essential Tremor. ( Reich, SG, 2019) |
| "Essential tremor is a common neurologic problem seen widely at all levels of patient care." | 2.47 | Essential tremor: choosing the right management plan for your patient. ( Abboud, H; Ahmed, A; Fernandez, HH, 2011) |
| "Tremor is one of the most frequent neurological signs." | 2.44 | [Tremor]. ( Deuschl, G; Raethjen, J, 2007) |
| "ET tremor is usually characterized by symmetric bilateral postural and kinetic tremor, which may respond to low alcohol consumption." | 2.44 | [Diagnosis and treatment of tremor in Parkinson's disease and essential tremor]. ( Benecke, R; Wolters, A, 2007) |
| "Tremor is often a disabling primary condition or secondary to another disorder." | 2.43 | Pharmacological treatment of disabling tremor. ( Charles, PD; Duffis, EI; Schadt, CR, 2005) |
| "Monosymptomatic rest tremor has recently been shown to be associated with decreased fluorodopa uptake on the positron emission tomography scan suggesting its relationship to Parkinson disease." | 2.42 | Tremor. ( Sethi, KD, 2003) |
| "Essential tremor is a common movement disorder in adults that interferes with the performance of functional and social activities." | 2.42 | Essential tremor: diagnosis and treatment. ( Chen, JJ; Swope, DM, 2003) |
| "Although Parkinson's disease (PD) and essential tremor (ET) are distinct clinical disorders, their coexistence can sometimes cause diagnostic problems." | 1.39 | Clinical and cognitive profiles of patients with both Parkinson's disease and essential tremor. ( Ankaralı, H; Gunal, DI; Mollahasanoğlu, A; Ozen Barut, B; Turkmen, C, 2013) |
| "Essential tremor is a common disorder whose aetiology is unknown." | 1.27 | Essential tremor. ( Findley, LJ, 1986) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 5 (26.32) | 18.7374 |
| 1990's | 4 (21.05) | 18.2507 |
| 2000's | 6 (31.58) | 29.6817 |
| 2010's | 4 (21.05) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Reich, SG | 1 |
| Wick, JY | 1 |
| Zanni, GR | 1 |
| Abboud, H | 1 |
| Ahmed, A | 1 |
| Fernandez, HH | 1 |
| Yaman, A | 1 |
| Akdeniz, M | 1 |
| Yaman, H | 1 |
| Ozen Barut, B | 1 |
| Gunal, DI | 1 |
| Turkmen, C | 1 |
| Mollahasanoğlu, A | 1 |
| Ankaralı, H | 1 |
| Sethi, KD | 1 |
| VIDAL, G | 1 |
| VIDAL, B | 1 |
| VALERY, B | 1 |
| Chen, JJ | 1 |
| Swope, DM | 1 |
| Schadt, CR | 1 |
| Duffis, EI | 1 |
| Charles, PD | 1 |
| Raethjen, J | 1 |
| Deuschl, G | 1 |
| Wolters, A | 1 |
| Benecke, R | 1 |
| Tárczy, M | 1 |
| Mogyorós, I | 1 |
| Takáts, A | 1 |
| Csanda, E | 1 |
| Nguyen, PB | 1 |
| Hart, LL | 1 |
| Marchand, L | 1 |
| Hallett, M | 1 |
| Ravits, J | 1 |
| Dubinsky, RM | 1 |
| Gillespie, MM | 1 |
| Moinfar, A | 1 |
| Diener, HC | 1 |
| Burton, K | 1 |
| Koller, WC | 1 |
| Herbster, G | 1 |
| Findley, LJ | 1 |
10 reviews available for primidone and Parkinson Disease
| Article | Year |
|---|---|
Essential Tremor.
Topics: Adrenergic beta-Antagonists; Aged; Deep Brain Stimulation; Diagnosis, Differential; Essential Tremor | 2019 |
Essential tremor: symptoms and treatment.
Topics: Adolescent; Adrenergic beta-Antagonists; Adult; Aged; Anticonvulsants; Essential Tremor; Humans; Mid | 2008 |
Essential tremor: choosing the right management plan for your patient.
Topics: Adrenergic beta-Antagonists; Anticonvulsants; Botulinum Toxins; Deep Brain Stimulation; Diagnosis, D | 2011 |
How best to address these common movement disorders.
Topics: Adrenergic beta-Antagonists; Adrenergic Uptake Inhibitors; Anticonvulsants; Antiparkinson Agents; Es | 2011 |
Tremor.
Topics: Acetates; Amines; Anticonvulsants; Antiparkinson Agents; Cyclohexanecarboxylic Acids; Diagnosis, Dif | 2003 |
Essential tremor: diagnosis and treatment.
Topics: Acetates; Amines; Cyclohexanecarboxylic Acids; Diagnosis, Differential; Essential Tremor; Gabapentin | 2003 |
Pharmacological treatment of disabling tremor.
Topics: Botulinum Toxins, Type A; Dystonia; Essential Tremor; Humans; Parkinson Disease; Primidone; Proprano | 2005 |
[Tremor].
Topics: Adrenergic beta-Antagonists; Anticonvulsants; Antiparkinson Agents; Botulinum Toxins; Cholinergic Ag | 2007 |
[Diagnosis and treatment of tremor in Parkinson's disease and essential tremor].
Topics: Adrenergic beta-Antagonists; Amantadine; Anticonvulsants; Antiparkinson Agents; Deep Brain Stimulati | 2007 |
Dronabinol in tremor.
Topics: Age Factors; Dronabinol; Female; Humans; Male; Parkinson Disease; Primidone; Propranolol; Tremor | 1993 |
2 trials available for primidone and Parkinson Disease
| Article | Year |
|---|---|
A double-blind trial of isoniazid for essential tremor and other action tremors.
Topics: Adrenergic beta-Antagonists; Adult; Aged; Double-Blind Method; Female; Humans; Isoniazid; Male; Midd | 1991 |
Adjuvant therapy of parkinsonian tremor.
Topics: Aged; Antiparkinson Agents; Carbidopa; Clonazepam; Double-Blind Method; Drug Therapy, Combination; H | 1987 |
7 other studies available for primidone and Parkinson Disease
| Article | Year |
|---|---|
Clinical and cognitive profiles of patients with both Parkinson's disease and essential tremor.
Topics: Aged; Aged, 80 and over; Anticonvulsants; Antiparkinson Agents; Attention; Cognition; Cognition Diso | 2013 |
[Cure of severe anxiety paroxysms in a female parkinsonian by primaclone].
Topics: Anxiety; Anxiety Disorders; Female; Humans; Parkinson Disease; Primidone | 1961 |
[Treatment of essential tremor with Sertan].
Topics: Age Factors; Aged; Basal Ganglia Diseases; Diagnosis, Differential; Humans; Male; Middle Aged; Parki | 1983 |
[Treatment of essential tremor].
Topics: Anti-Anxiety Agents; Anti-Dyskinesia Agents; Botulinum Toxins; Humans; Hypnotics and Sedatives; Meth | 1995 |
[Tremor. Possibilities and limits of drug therapy].
Topics: Humans; Parasympatholytics; Parkinson Disease; Primidone; Propranolol; Tremor | 1990 |
The treatment of tremor.
Topics: Adrenergic beta-Antagonists; Alcoholic Beverages; Cerebellar Diseases; Humans; Isoniazid; Levodopa; | 1987 |
Essential tremor.
Topics: Diagnosis, Differential; Humans; Parkinson Disease; Phenobarbital; Phenylethylmalonamide; Primidone; | 1986 |