primidone has been researched along with Osteomalacia in 17 studies
Primidone: A barbiturate derivative that acts as a GABA modulator and anti-epileptic agent. It is partly metabolized to PHENOBARBITAL in the body and owes some of its actions to this metabolite.
primidone : A pyrimidone that is dihydropyrimidine-4,6(1H,5H)-dione substituted by an ethyl and a phenyl group at position 5. It is used as an anticonvulsant for treatment of various types of seizures.
Osteomalacia: Disorder caused by an interruption of the mineralization of organic bone matrix leading to bone softening, bone pain, and weakness. It is the adult form of rickets resulting from disruption of VITAMIN D; PHOSPHORUS; or CALCIUM homeostasis.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The investigation and treatment of osteomalacia are described in four patients with epilepsy treated with long-term anticonvulsant therapy." | 1.25 | Osteomalacia with long-term anticonvulsant therapy in epilepsy. ( Dent, CE; Richens, A; Rowe, DJ; Stamp, TC, 1970) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 16 (94.12) | 18.7374 |
| 1990's | 1 (5.88) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Radó, JP | 1 |
| Haris, A | 1 |
| Dymling, JF | 1 |
| Lidgren, L | 1 |
| Wallöe, A | 1 |
| Mehregan, U | 1 |
| Krause, KH | 1 |
| Prager, P | 1 |
| Maclay, E | 1 |
| Hadden, DR | 1 |
| McIlrath, EM | 1 |
| Nesbitt, GS | 1 |
| Lehmann, V | 1 |
| Aarli, J | 1 |
| Schreiner, A | 1 |
| Ashworth, B | 1 |
| Horn, DB | 1 |
| Wilczek, H | 1 |
| Pacovský, V | 1 |
| Hazuková, L | 1 |
| Kalvach, Z | 1 |
| Sisková, M | 1 |
| Lücking, T | 1 |
| Delling, G | 1 |
| Livingston, S | 1 |
| Pauli, LL | 1 |
| Bowden, AN | 1 |
| Flury, W | 1 |
| Slomic, A | 1 |
| Szöts, F | 1 |
| Christiansen, C | 1 |
| Rodbro, P | 1 |
| Lund, M | 1 |
| Borgstedt, AD | 1 |
| Bryson, MF | 1 |
| Young, LW | 1 |
| Forbes, GB | 1 |
| Genuth, SM | 1 |
| Klein, L | 1 |
| Rabinovich, S | 1 |
| King, KC | 1 |
| Linde, J | 1 |
| Molholm Hansen, J | 1 |
| Siersbaek-Nielsen, K | 1 |
| Fuglsang-Fredriksen, V | 1 |
| Dent, CE | 1 |
| Richens, A | 1 |
| Rowe, DJ | 1 |
| Stamp, TC | 1 |
1 review available for primidone and Osteomalacia
| Article | Year |
|---|---|
Osteomalacia and anticonvulsant drugs.
Topics: Alkaline Phosphatase; Anticonvulsants; Calcium; Epilepsy; Folic Acid; Humans; Liver; Osteomalacia; P | 1971 |
1 trial available for primidone and Osteomalacia
| Article | Year |
|---|---|
Incidence of anticonvulsant osteomalacia and effect of vitamin D: controlled therapeutic trial.
Topics: Adult; Aged; Alkaline Phosphatase; Anticonvulsants; Bone and Bones; Calcium; Creatinine; Epilepsy; F | 1973 |
15 other studies available for primidone and Osteomalacia
| Article | Year |
|---|---|
Metabolic bone disease (anticonvulsant osteomalacia) and renal tubular acidosis in tuberous sclerosis.
Topics: Acidosis, Renal Tubular; Adult; Back Pain; Bicarbonates; Bone and Bones; Calcitriol; Calcium; Calciu | 1993 |
Biochemical variables related to calcium metabolism in epileptics.
Topics: Aged; Alkaline Phosphatase; Anticonvulsants; Calcium; Carbamazepine; Epilepsy; Female; Humans; Male; | 1979 |
[The frequency of adult anticonvulsant osteomalacia in relation to duration of therapy and dosage of anticonvulsants (author's transl)].
Topics: Adult; Alkaline Phosphatase; Calcium; Dose-Response Relationship, Drug; Drug Therapy, Combination; E | 1979 |
Hypocalcaemia and secondary hyperparathyroidism in institutionalised mentally-retarded patients receiving anticonvulsant drugs: a survey of 292 patients.
Topics: Adolescent; Adult; Aged; Anticonvulsants; Child; Child, Preschool; Female; Humans; Hydroxycholecalci | 1978 |
[Hypocalcemia and tetany induced by antiepileptic treatment].
Topics: Adolescent; Epilepsy; Humans; Hypocalcemia; Male; Osteomalacia; Primidone; Tetany; Time Factors | 1977 |
Evidence of osteomalacia in an outpatient group of adult epileptics.
Topics: Adult; Aged; Diet; Epilepsy; Female; Humans; Male; Middle Aged; Osteomalacia; Phenobarbital; Phenyto | 1977 |
[Treatment of osteomalacia caused by anticonvulsants with a derivative of vitamin D (case report)].
Topics: Dihydrotachysterol; Female; Humans; Middle Aged; Osteomalacia; Primidone | 1986 |
[Severe rachitic osteopathy during long-term anticonvulsant treatment].
Topics: Administration, Oral; Alkaline Phosphatase; Anticonvulsants; Biopsy; Calcium; Carbamazepine; Child; | 1973 |
Letter: Anticonvulsants and vitamin D metabolism.
Topics: Child; Drug Therapy, Combination; Epilepsy; Humans; Osteomalacia; Phenobarbital; Phenytoin; Primidon | 1974 |
[Osteomalacia due to a long-term antiepileptic treatment].
Topics: Anticonvulsants; Calcium; Female; Humans; Middle Aged; Osteomalacia; Phenobarbital; Phenytoin; Primi | 1972 |
[Severe osteomalacic rickets induced by antiepileptic drugs. Literature review apropos of a case].
Topics: Child; Child, Preschool; Humans; Male; Osteomalacia; Phenobarbital; Phenytoin; Primidone; Rickets; V | 1973 |
Long-term administration of antiepileptic drugs and the development of rickets.
Topics: Alkaline Phosphatase; Anticonvulsants; Calcium; Diazepam; Ethosuximide; Female; Gluconates; Humans; | 1972 |
Osteomalacia accompanying chronic anticonvulsant therapy.
Topics: Adolescent; Alkaline Phosphatase; Biopsy; Bone and Bones; Calcium; Epilepsy; Humans; Hydroxyproline; | 1972 |
Bone density in patients receiving long-term anticonvulsant therapy.
Topics: Absorptiometry, Photon; Adult; Alkaline Phosphatase; Anticonvulsants; Calcium; Carbamazepine; Epilep | 1971 |
Osteomalacia with long-term anticonvulsant therapy in epilepsy.
Topics: Adolescent; Adult; Alkaline Phosphatase; Anticonvulsants; Biopsy; Calcium; Enzyme Induction; Epileps | 1970 |