primidone has been researched along with Intellectual Disability in 23 studies
Primidone: A barbiturate derivative that acts as a GABA modulator and anti-epileptic agent. It is partly metabolized to PHENOBARBITAL in the body and owes some of its actions to this metabolite.
primidone : A pyrimidone that is dihydropyrimidine-4,6(1H,5H)-dione substituted by an ethyl and a phenyl group at position 5. It is used as an anticonvulsant for treatment of various types of seizures.
Intellectual Disability: Subnormal intellectual functioning which originates during the developmental period. This has multiple potential etiologies, including genetic defects and perinatal insults. Intelligence quotient (IQ) scores are commonly used to determine whether an individual has an intellectual disability. IQ scores between 70 and 79 are in the borderline range. Scores below 67 are in the disabled range. (from Joynt, Clinical Neurology, 1992, Ch55, p28)
| Excerpt | Relevance | Reference |
|---|---|---|
| " Outcome did not depend on duration of barbiturate therapy, dosage or serum concentration, co-medication, reduction rate, degree of intellectual disability, or epilepsy syndrome." | 1.35 | Ambiguous results of an attempt to withdraw barbiturates in epilepsy patients with intellectual disability. ( Bocchicchio, M; Hauser, I; Horstmann, V; Huber, B; Jokeit, G; May, T; Meinert, T; Robertson, E; Schorlemmer, H; Schulz, L; Seidel, M; Wagner, W, 2009) |
| "Most patients have quiescent seizure disorders and can manage well on monotherapy." | 1.27 | Reduction of polypharmacy for epilepsy in an institution for the retarded. ( Bennett, HS; Dunlop, T; Ziring, P, 1983) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 21 (91.30) | 18.7374 |
| 1990's | 1 (4.35) | 18.2507 |
| 2000's | 1 (4.35) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Huber, B | 1 |
| Bocchicchio, M | 1 |
| Hauser, I | 1 |
| Horstmann, V | 1 |
| Jokeit, G | 1 |
| May, T | 1 |
| Meinert, T | 1 |
| Robertson, E | 1 |
| Schorlemmer, H | 1 |
| Schulz, L | 1 |
| Wagner, W | 1 |
| Seidel, M | 1 |
| COUSTON, TA | 1 |
| SHARPE, DS | 1 |
| RETTIG, JH | 1 |
| KAHN, SB | 1 |
| LISCHNER, H | 1 |
| BAKER, L | 1 |
| WILLIAMS, WJ | 1 |
| Bennett, HS | 1 |
| Dunlop, T | 1 |
| Ziring, P | 1 |
| Branford, D | 1 |
| Collacott, RA | 1 |
| Hanson, JW | 1 |
| Smith, DW | 1 |
| Maclay, E | 1 |
| Hadden, DR | 1 |
| McIlrath, EM | 1 |
| Nesbitt, GS | 1 |
| Oettinger, B | 1 |
| Van Buren, JM | 1 |
| Ajmone-Marsan, C | 1 |
| Mutsuga, N | 1 |
| Sadowsky, D | 1 |
| Afifi, AK | 1 |
| Van Allen, MW | 1 |
| Alberti, G | 1 |
| De Toma, M | 1 |
| Cottini, R | 1 |
| Liu, MC | 1 |
| Annegers, JF | 1 |
| Elveback, LR | 1 |
| Hauser, WA | 1 |
| Kurland, LT | 1 |
| Rundle, AT | 1 |
| Clothier, B | 1 |
| Sudell, B | 1 |
| Lifshitz, F | 1 |
| Maclaren, NK | 1 |
| Schlack, HG | 1 |
| Vogt, HJ | 1 |
| Houben, PF | 1 |
| Hommes, OR | 1 |
| Knaven, PJ | 1 |
| Matti, N | 1 |
| Viukari, A | 1 |
| Tammisto, P | 2 |
| Viukari, NM | 1 |
| Reynolds, EH | 1 |
| Woody, NC | 1 |
| Snyder, CH | 1 |
| Harris, JA | 1 |
23 other studies available for primidone and Intellectual Disability
| Article | Year |
|---|---|
Ambiguous results of an attempt to withdraw barbiturates in epilepsy patients with intellectual disability.
Topics: Anticonvulsants; Barbiturates; Cognition; Drug Therapy, Combination; Epilepsy; Humans; Intellectual | 2009 |
Mysoline in the treatment of recalcitrant idiopathic major epilepsy in mentally defective children.
Topics: Anticonvulsants; Child; Epilepsy; Epilepsy, Tonic-Clonic; Humans; Intellectual Disability; Primidone | 1954 |
Primidone in mental deficiency practice.
Topics: Anticonvulsants; Epilepsy; Humans; Intellectual Disability; Primidone | 1954 |
Chlorpromazine and mysoline in the control of convulsive epilepsy in mentally deficient patients.
Topics: Chlorpromazine; Epilepsy; Humans; Intellectual Disability; Primidone | 1956 |
MEGALOBLASTIC ANEMIA ASSOCIATED WITH THE INGESTION OF PHENOBARBITAL AND PRIMIDONE. REPORT OF A CASE IN A SIX-YEAR-OLD CHILD.
Topics: Anemia, Aplastic; Anemia, Macrocytic; Anemia, Megaloblastic; Anti-Bacterial Agents; Barbiturates; Ca | 1963 |
Reduction of polypharmacy for epilepsy in an institution for the retarded.
Topics: Adolescent; Adult; Anticonvulsants; Carbamazepine; Drug Therapy, Combination; Epilepsy; Female; Huma | 1983 |
Comparison of community and institutional prescription of antiepileptic drugs for individuals with learning disabilities.
Topics: Adult; Ambulatory Care; Anticonvulsants; Cognition Disorders; Day Care, Medical; Drug Therapy, Combi | 1994 |
The fetal hydantoin syndrome.
Topics: Abnormalities, Drug-Induced; Abnormalities, Multiple; Adolescent; Child, Preschool; Developmental Di | 1975 |
Hypocalcaemia and secondary hyperparathyroidism in institutionalised mentally-retarded patients receiving anticonvulsant drugs: a survey of 292 patients.
Topics: Adolescent; Adult; Aged; Anticonvulsants; Child; Child, Preschool; Female; Humans; Hydroxycholecalci | 1978 |
[Psychotropic drugs for behavior disorder treatment in oligophrenic epileptics].
Topics: Adult; Epilepsy; Humans; Intellectual Disability; Methotrimeprazine; Phenytoin; Primidone; Promazine | 1976 |
Surgery of temporal lobe epilepsy.
Topics: Adolescent; Adult; Astrocytes; Brain Neoplasms; Cerebral Cortex; Child; Child, Preschool; Electroenc | 1975 |
Cerebellar atrophy in epilepsy. Pneumographic and histological documentation of a case with psychosis.
Topics: Adult; Brain; Cerebellar Ataxia; Cerebral Ventriculography; Chlorpromazine; Diplopia; Electroconvuls | 1968 |
[Epilepsy in childhood].
Topics: Adrenocorticotropic Hormone; Child; Child, Preschool; Electroencephalography; Epilepsy; Epilepsy, Ab | 1972 |
Clinical experience with sulthiame (Ospolot).
Topics: Adolescent; Adult; Anticonvulsants; Brain Damage, Chronic; Epilepsy, Temporal Lobe; Female; Humans; | 1966 |
Do anticonvulsants have a teratogenic effect?
Topics: Abnormalities, Drug-Induced; Anticonvulsants; Child, Preschool; Cleft Lip; Cleft Palate; Congenital | 1974 |
Haptoglobin phenotype frequencies in mentally retarded persons.
Topics: Acid Phosphatase; Adenine Nucleotides; Adenosine; Alanine Transaminase; Aminohydrolases; Blood Prote | 1972 |
Vitamin D-dependent rickets in institutionalized, mentally retarded children receiving long-term anticonvulsant therapy. I. A survey of 288 patients.
Topics: Adolescent; Alkaline Phosphatase; Anticonvulsants; Calcium; Child; Child, Preschool; Female; Humans; | 1973 |
[Development inhibition in brain-damaged children due to anticonvulsants].
Topics: Anticonvulsants; Carbamazepine; Child; Child Development; Electroencephalography; Humans; Intellectu | 1973 |
Anticonvulsant drugs and folic acid in young mentally retarded epileptic patients. A study of serum folate, fit frequency and I.Q.
Topics: Adolescent; Anticonvulsants; Carbamazepine; Child; Epilepsy; Ethosuximide; Female; Folic Acid; Human | 1971 |
Central effects of diphenylhydantoin (dilantin) in epileptic oligophrenics during phenobarbital-primidone withdrawal, sodium bicarbonate, and ammonium chloride administration.
Topics: Adolescent; Adult; Ammonium Chloride; Bicarbonates; Epilepsy; Female; Humans; Hydrogen-Ion Concentra | 1969 |
Central effect of diphenylhydantoin (Dilantin) in epileptic oligophrenics during phenobarbital-primidone withdrawal, sodium bicarbonate, and ammonium chloride administration.
Topics: Adolescent; Adult; Ammonium Chloride; Bicarbonates; Epilepsy; Female; Humans; Hydrogen-Ion Concentra | 1969 |
Mental effects of anticonvulsants, and folic acid metabolism.
Topics: Age Factors; Anemia, Macrocytic; Anticonvulsants; Brain; Epilepsy; Female; Folic Acid; Folic Acid De | 1968 |
Histidinemia.
Topics: Amino Acid Metabolism, Inborn Errors; Blood Chemical Analysis; Child; Child, Preschool; Consanguinit | 1965 |