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primidone and Folic Acid Deficiency

primidone has been researched along with Folic Acid Deficiency in 18 studies

Primidone: A barbiturate derivative that acts as a GABA modulator and anti-epileptic agent. It is partly metabolized to PHENOBARBITAL in the body and owes some of its actions to this metabolite.
primidone : A pyrimidone that is dihydropyrimidine-4,6(1H,5H)-dione substituted by an ethyl and a phenyl group at position 5. It is used as an anticonvulsant for treatment of various types of seizures.

Folic Acid Deficiency: A nutritional condition produced by a deficiency of FOLIC ACID in the diet. Many plant and animal tissues contain folic acid, abundant in green leafy vegetables, yeast, liver, and mushrooms but destroyed by long-term cooking. Alcohol interferes with its intermediate metabolism and absorption. Folic acid deficiency may develop in long-term anticonvulsant therapy or with use of oral contraceptives. This deficiency causes anemia, macrocytic anemia, and megaloblastic anemia. It is indistinguishable from vitamin B 12 deficiency in peripheral blood and bone marrow findings, but the neurologic lesions seen in B 12 deficiency do not occur. (Merck Manual, 16th ed)

Research

Studies (18)

TimeframeStudies, this research(%)All Research%
pre-199018 (100.00)18.7374
1990's0 (0.00)18.2507
2000's0 (0.00)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
PODESTA, LD1
DEVOTO, RA1
PRECERUTTI, AS1
HAMFELT, A1
KILLANDER, A1
MALERS, E1
DEVERDIER, CH1
Botez, MI1
Peyronnard, JM1
Bérubé, L1
Labrecque, R1
Baylis, EM1
Crowley, JM1
Preece, JM1
Sylvester, PE1
Marks, V1
Reynolds, EH5
Fehling, C1
Jägerstad, M1
Lindstrand, K1
Westesson, AK1
Taguchi, H1
Gibberd, FB1
Loyning, Y1
Henriksen, O1
Chanarin, I1
Milner, G1
Matthews, DM1
Gordon, N1
Elsborg, L1
Jensen, ON1
Olesen, OV1

Reviews

1 review available for primidone and Folic Acid Deficiency

ArticleYear
Cerebrospinal folate levels in epileptics and their response to folate therapy.
    Nutrition reviews, 1974, Volume: 32, Issue:3

    Topics: Anticonvulsants; Blood-Brain Barrier; Clinical Trials as Topic; Epilepsy; Folic Acid; Folic Acid Def

1974

Trials

2 trials available for primidone and Folic Acid Deficiency

ArticleYear
Influence of folic acid on blood-phenytoin levels.
    Lancet (London, England), 1971, Jan-09, Volume: 1, Issue:7689

    Topics: Adult; Anticonvulsants; Epilepsy; Folic Acid; Folic Acid Deficiency; Humans; Male; Phenobarbital; Ph

1971
Cerebrospinal folate levels in epileptics and their response to folate therapy.
    Nutrition reviews, 1974, Volume: 32, Issue:3

    Topics: Anticonvulsants; Blood-Brain Barrier; Clinical Trials as Topic; Epilepsy; Folic Acid; Folic Acid Def

1974

Other Studies

16 other studies available for primidone and Folic Acid Deficiency

ArticleYear
[MEGALOBLASTIC ANEMIA PRODUCED BY ANTICONVULSANTS].
    Prensa medica argentina, 1963, Oct-25, Volume: 50

    Topics: Anemia; Anemia, Macrocytic; Anemia, Megaloblastic; Anticonvulsants; Argentina; Barbiturates; Blood C

1963
MEGALOBLASTIC ANAEMIA ASSOCIATED WITH ANTICONVULSANT DRUGS: STUDIES ON A CASE WITH FOUR RELAPSES.
    Acta medica Scandinavica, 1965, Volume: 177

    Topics: Anemia, Macrocytic; Anemia, Megaloblastic; Anticonvulsants; Drug Therapy; Electrophoresis; Epilepsy;

1965
Relapsing neuropathy, cerebral atrophy and folate deficiency. A close association.
    Applied neurophysiology, 1979, Volume: 42, Issue:3

    Topics: Atrophy; Brain Diseases; Edema; Epilepsy; Female; Folic Acid; Folic Acid Deficiency; Humans; Intesti

1979
Effects of folic acid on the mental state and fit-frequency of drug-treated epileptic patients.
    Lancet (London, England), 1967, May-20, Volume: 1, Issue:7499

    Topics: Adolescent; Adult; Epilepsy; Female; Folic Acid; Folic Acid Deficiency; Follow-Up Studies; Humans; M

1967
The effect of anticonvulsant therapy upon the absorption of folates.
    Clinical science, 1973, Volume: 44, Issue:6

    Topics: Adult; Aged; Anticonvulsants; Biological Assay; Epilepsy; Folic Acid; Folic Acid Deficiency; Humans;

1973
Clinical and experimental studies on folic acid deficiency due to anticonvulsants. 2. Investigations on patients receiving anticonvulsants and experimental study on the effect of diphenylhydantoin on the absorption of folic acid in rats.
    Acta medicinae Okayama, 1971, Volume: 25, Issue:5

    Topics: Adolescent; Adult; Animals; Anticonvulsants; Cell Nucleus; Depression, Chemical; Epithelial Cells; F

1971
Epilepsy.
    British medical journal, 1969, Nov-01, Volume: 4, Issue:5678

    Topics: Adult; Child; Epilepsies, Partial; Epilepsy; Epilepsy, Absence; Epilepsy, Temporal Lobe; Epilepsy, T

1969
Iatrogenic nutritional effects of anticonvulsants.
    The Proceedings of the Nutrition Society, 1974, Volume: 33, Issue:3

    Topics: Adolescent; Adult; Anticonvulsants; Blood Coagulation Disorders; Bone Diseases; Child; Child, Presch

1974
Clinical conference: megaloblastic anemia associated with anticonvulsant drugs.
    Journal of the Tennessee Medical Association, 1972, Volume: 65, Issue:9

    Topics: Adult; Anemia, Macrocytic; Anticonvulsants; Female; Folic Acid; Folic Acid Deficiency; Humans; Pheno

1972
[Editorial: Antiepileptic agents--folic acid].
    Tidsskrift for den Norske laegeforening : tidsskrift for praktisk medicin, ny raekke, 1973, Jun-30, Volume: 93, Issue:18

    Topics: Anemia, Macrocytic; Epilepsy; Folic Acid; Folic Acid Deficiency; Humans; Phenobarbital; Phenytoin; P

1973
Folate metabolism and anticonvulsant therapy.
    Proceedings of the Royal Society of Medicine, 1974, Volume: 67, Issue:1

    Topics: Anticonvulsants; Blood-Brain Barrier; Folic Acid Deficiency; Humans; Phenobarbital; Phenytoin; Primi

1974
Anticonvulsant therapy, folic acid and vitamin B12 metabolism and mental symptoms.
    Epilepsia, 1966, Volume: 7, Issue:4

    Topics: Adult; Anemia, Macrocytic; Female; Folic Acid Deficiency; Humans; Male; Mental Disorders; Middle Age

1966
Folic acid deficiency from anticonvulsant therapy.
    Developmental medicine and child neurology, 1968, Volume: 10, Issue:4

    Topics: Adolescent; Anticonvulsants; Child; Child, Preschool; Epilepsy; Female; Folic Acid; Folic Acid Defic

1968
Gastrointestinal dysfunction in anticonvulsant megaloblastic anaemia.
    Danish medical bulletin, 1968, Volume: 15, Issue:6

    Topics: Adult; Anemia, Macrocytic; Female; Folic Acid Deficiency; Gastrointestinal Diseases; Humans; Phenyto

1968
Mental effects of anticonvulsants, and folic acid metabolism.
    Brain : a journal of neurology, 1968, Volume: 91, Issue:2

    Topics: Age Factors; Anemia, Macrocytic; Anticonvulsants; Brain; Epilepsy; Female; Folic Acid; Folic Acid De

1968
Folic acid and anticonvulsive drugs.
    Archives of neurology, 1969, Volume: 21, Issue:2

    Topics: Adolescent; Adult; Anticonvulsants; Epilepsy; Erythrocyte Count; Female; FIGLU Test; Folic Acid; Fol

1969