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primidone and Epilepsy, Absence

primidone has been researched along with Epilepsy, Absence in 49 studies

Primidone: A barbiturate derivative that acts as a GABA modulator and anti-epileptic agent. It is partly metabolized to PHENOBARBITAL in the body and owes some of its actions to this metabolite.
primidone : A pyrimidone that is dihydropyrimidine-4,6(1H,5H)-dione substituted by an ethyl and a phenyl group at position 5. It is used as an anticonvulsant for treatment of various types of seizures.

Epilepsy, Absence: A seizure disorder usually occurring in childhood characterized by rhythmic electrical brain discharges of generalized onset. Clinical features include a sudden cessation of ongoing activity usually without loss of postural tone. Rhythmic blinking of the eyelids or lip smacking frequently accompanies the SEIZURES. The usual duration is 5-10 seconds, and multiple episodes may occur daily. Juvenile absence epilepsy is characterized by the juvenile onset of absence seizures and an increased incidence of myoclonus and tonic-clonic seizures. (Menkes, Textbook of Child Neurology, 5th ed, p736)

Research Excerpts

Excerpt	Relevance	Reference
" Phenobarbital is usually given as well to prevent grand mal seizures."	3.64	Treatment of epilepsy. ( BAILEY, AA, 1963)
"Phenytoin continues to be a very popular drug for most types of seizures, but carbamazepine, used adjunctively until recently, is effective as monotherapy for the control of partial seizures, particularly those of the complex partial variety."	1.27	Treatment of the nonconvulsive epilepsies. ( Dreifuss, FE, 1983)
"Only when the epilepsy is uncontrolled despite high plasma concentrations which cannot be raised because of side effects, a second drug should be given."	1.27	[Pharmacotherapy of epilepsy--current problems and controversies]. ( Schmidt, D, 1983)
" Reduction in antiepileptic drug dosage should be carried out as a stepwise procedure over a period of about 2 years."	1.25	[A discussion of the curability of childhood epilepsies (author's transl)]. ( Groh, C, 1975)

Research

Studies (49)

Timeframe	Studies, this research(%)	All Research%
pre-1990	49 (100.00)	18.7374
1990's	0 (0.00)	18.2507
2000's	0 (0.00)	29.6817
2010's	0 (0.00)	24.3611
2020's	0 (0.00)	2.80

Authors

Authors	Studies
BAILEY, AA	1
DOBER, B	1
MILLICHAP, JG	2
JONES, JD	1
RUDIS, BP	1
GIBBS, FA	1
RICH, CL	1
GIBBS, EL	1
JONGMANS, JW	1
GASTAUT, H	1
Dreifuss, FE	1
Schmidt, D	1
Reynolds, EH	2
Shorvon, SD	1
Bittencourt, PR	1
Richens, A	2
Flachsbart, F	1
Wilhelms, E	1
Chadwick, D	1
Galbraith, AW	1
Hancock, KW	1
Levell, MJ	1
Rambeck, B	1
Aucamp, AK	1
Livingston, S	1
Pruce, I	1
Pauli, LL	1
Hosokawa, K	1
Kugoh, T	1
Otsuki, S	1
Singer, HS	1
Freeman, JM	1
Doose, H	2
Schwartz, I	1
Groh, C	1
Karbowski, K	1
Meienberg, O	1
Thomas, JA	1
Knotts, GR	1
Steidl, L	1
Tolde, I	1
Svomová, V	1
Coulter, DL	1
Sibley, WA	1
Parsonage, M	1
Dano, P	1
Völzke, E	1
Billinghurst, JR	1
German, GA	1
Orley, JH	1
Gold, AP	1
Huang, CY	1
McLeod, JG	1
Sampson, D	1
Hensley, WJ	1
Forman, PM	1
Saper, JR	1
Lossing, JH	1
Alberti, G	1
De Toma, M	1
Cottini, R	1
Gibberd, FB	1
Wilson, J	1
Jannasch, R	1
Ritter, G	1
Gregoriades, AD	1
Todt, H	1
Munde, B	1
Gudmundsson, G	1
Matthes, A	1
Roth, G	1
Rett, A	1
Frühmann, E	1
Haub, G	1
Booker, HE	1
Chun, RW	1
Sanguino, M	1
Auert, G	1

Reviews

4 reviews available for primidone and Epilepsy, Absence

Article	Year
The pharmacological treatment of epilepsy. South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde, 1979, Oct-06, Volume: 56, Issue:15 Topics: Anticonvulsants; Carbamazepine; Child, Preschool; Clonazepam; Drug Therapy, Combination; Epilepsies,	1979
The medical treatment of epilepsy: initiation of drug therapy. Pediatric annals, 1979, Volume: 8, Issue:4 Topics: Adolescent; Adrenocorticotropic Hormone; Anticonvulsants; Bromides; Carbamazepine; Child; Child, Pre	1979
Diagnosis and treatment of epilepsy: overview and general principles. Pediatrics, 1974, Volume: 53, Issue:4 Topics: Adolescent; Adult; Age Factors; Anticonvulsants; Child; Child, Preschool; Drug Therapy, Combination;	1974
[Antiepileptics. 39]. Pharmazeutische Praxis, 1969, Volume: 10 Topics: Acetazolamide; Adrenocorticotropic Hormone; Aminoglutethimide; Anticonvulsants; Barbiturates; Carbam	1969

Trials

1 trial available for primidone and Epilepsy, Absence

Article	Year
One drug (phenytoin) in the treatment of epilepsy. Lancet (London, England), 1976, May-01, Volume: 1, Issue:7966 Topics: Adolescent; Adult; Aged; Drug Evaluation; Drug Therapy, Combination; Epilepsy; Epilepsy, Absence; Ep	1976

Other Studies

44 other studies available for primidone and Epilepsy, Absence

Article	Year
Treatment of epilepsy. Canadian Medical Association journal, 1963, Jun-29, Volume: 88 Topics: Acetazolamide; Anticonvulsants; Automatism; Child; Epilepsy; Epilepsy, Absence; Epilepsy, Tonic-Clon	1963
[THERAPY OF CONVULSIVE DISEASES]. Zeitschrift fur arztliche Fortbildung, 1963, Dec-15, Volume: 57 Topics: Adrenocorticotropic Hormone; Anticonvulsants; Barbiturates; Dexamethasone; Epilepsy; Epilepsy, Absen	1963
MECHANISM OF ANTICONVULSANT ACTION OF KETOGENIC DIET. STUDIES IN ANIMALS WITH EXPERIMENTAL SEIZURES AND IN CHILDREN WITH PETIT MAL EPILEPSY. American journal of diseases of children (1960), 1964, Volume: 107 Topics: Acetazolamide; Acid-Base Equilibrium; Acidosis; Adolescent; Anticonvulsants; Barbiturates; Biomedica	1964
PSYCHOMOTOR VARIANT TYPE OF SEIZURE DISCHARGE. Neurology, 1963, Volume: 13 Topics: Adolescent; Anticonvulsants; Child; Electroencephalography; Epilepsy; Epilepsy, Absence; Epilepsy, T	1963
REPORT ON THE ANTI-EPILEPTIC ACTION OF TEGRETOL. Epilepsia, 1964, Volume: 5 Topics: Acetazolamide; Adolescent; Anticonvulsants; Biomedical Research; Carbamazepine; Child; Chlordiazepox	1964
CERTAIN BASIC CONCEPTS CONCERNING THE TREATMENT OF THE EPILEPSIES. The British journal of clinical practice, 1964, Volume: 18 Topics: Amphetamine; Anticonvulsants; Barbiturates; Child; Drug Therapy; Electroencephalography; Epilepsy; E	1964
Treatment of the nonconvulsive epilepsies. Epilepsia, 1983, Volume: 24 Suppl 1 Topics: Anticonvulsants; Carbamazepine; Epilepsies, Partial; Epilepsy; Epilepsy, Absence; Humans; Phenobarbi	1983
[Pharmacotherapy of epilepsy--current problems and controversies]. Fortschritte der Neurologie-Psychiatrie, 1983, Volume: 51, Issue:11 Topics: Adolescent; Adult; Carbamazepine; Child; Child, Preschool; Epilepsies, Partial; Epilepsy; Epilepsy,	1983
Monotherapy or polytherapy for epilepsy? Epilepsia, 1981, Volume: 22, Issue:1 Topics: Adolescent; Adult; Carbamazepine; Clonazepam; Drug Combinations; Drug Interactions; Drug Therapy, Co	1981
Anticonvulsant-induced status epilepticus in Lennox-Gastaut syndrome. Epilepsia, 1981, Volume: 22, Issue:1 Topics: Adolescent; Adult; Benzodiazepinones; Carbamazepine; Child; Child, Preschool; Chlormethiazole; Clona	1981
[Generalised follicular lymphadenopathy following primidone therapy: case report (author's transl)]. Der Nervenarzt, 1982, Volume: 53, Issue:5 Topics: Adolescent; Epilepsy, Absence; Humans; Hyperplasia; Lymph Nodes; Lymphatic Diseases; Male; Primidone	1982
Primidone/dexamethasone interaction. Lancet (London, England), 1978, Jul-08, Volume: 2, Issue:8080 Topics: Adolescent; Adrenocortical Hyperfunction; Adult; Amenorrhea; Child; Child, Preschool; Dexamethasone;	1978
Pharmacological interactions of mesuximide with phenobarbital and phenytoin in hospitalized epileptic patients. Epilepsia, 1979, Volume: 20, Issue:2 Topics: Adolescent; Adult; Child; Dose-Response Relationship, Drug; Drug Interactions; Drug Therapy, Combina	1979
[Clinical study of serum level of dipropylacetic acid sodium (Depakene) by gaschromatography (author's transl)]. No to shinkei = Brain and nerve, 1977, Volume: 29, Issue:8 Topics: Adolescent; Adult; Child; Child, Preschool; Chromatography, Gas; Drug Therapy, Combination; Epilepsi	1977
Seizures in adolescents. The Medical clinics of North America, 1975, Volume: 59, Issue:6 Topics: Adolescent; Anticonvulsants; Automobile Driving; Benzodiazepines; Carbamazepine; Diagnosis, Differen	1975
Sensible prescribing. XI.--Juvenile and adult epilepsy. The Practitioner, 1975, Volume: 215, Issue:1289 Topics: Adolescent; Adult; Age Factors; Carbamazepine; Child; Clonazepam; Epilepsy; Epilepsy, Absence; Epile	1975
[Pyknoleptic petit mal and secondary grand mal]. Der Nervenarzt, 1976, Volume: 47, Issue:5 Topics: Adolescent; Adult; Age Factors; Barbiturates; Drug Therapy, Combination; Educational Status; Epileps	1976
[A discussion of the curability of childhood epilepsies (author's transl)]. Wiener klinische Wochenschrift. Supplementum, 1975, Volume: 40 Topics: Barbiturates; Benzodiazepines; Carbamazepine; Child; Drug Therapy, Combination; Epilepsies, Partial;	1975
[Epileptic seizures with psychomotor symptoms and generalized spike-wave-pattern]. Der Nervenarzt, 1976, Volume: 47, Issue:6 Topics: Adolescent; Adult; Carbamazepine; Child; Diagnosis, Differential; Drug Therapy, Combination; Electro	1976
Epilepsy and other seizure disorders in children: drug management. The Journal of school health, 1976, Volume: 46, Issue:8 Topics: Acetazolamide; Anticonvulsants; Child; Epilepsies, Partial; Epilepsy; Epilepsy, Absence; Epilepsy, T	1976
Metabolism of magnesium and zinc in patients treated with antiepileptic drugs and with magnesium lactate. Magnesium, 1987, Volume: 6, Issue:6 Topics: Adult; Anticonvulsants; Carbamazepine; Diazepam; Epilepsy, Absence; Epilepsy, Tonic-Clonic; Erythroc	1987
Withdrawal of barbiturate anticonvulsant drugs: prospective controlled study. American journal of mental retardation : AJMR, 1988, Volume: 93, Issue:3 Topics: Adolescent; Adult; Aged; Anticonvulsants; Child; Drug Therapy, Combination; Epilepsies, Partial; Epi	1988
Epilepsy. The Practitioner, 1974, Volume: 213, Issue:1276 SPEC Topics: Adrenocorticotropic Hormone; Carbamazepine; Diazepam; Drug Hypersensitivity; Drug-Related Side Effec	1974
Connective tissue disease following anti-epileptic therapy. Epilepsia, 1969, Volume: 10, Issue:4 Topics: Adult; Anticonvulsants; Child; Collagen Diseases; Electroencephalography; Epilepsy, Absence; Epileps	1969
Dipropylacetate (Dépakine, Ergenyl) in the treatment of epilepsy. Epilepsia, 1973, Volume: 14, Issue:2 Topics: Adolescent; Anticonvulsants; Barbiturates; Child; Child, Preschool; Drug Synergism; Electroencephalo	1973
The pattern of epilepsy in Uganda. Tropical and geographical medicine, 1973, Volume: 25, Issue:3 Topics: Adolescent; Adult; Age Factors; Black People; Child; Child, Preschool; Electroencephalography; Epile	1973
Psychomotor epilepsy in childhood. Pediatrics, 1974, Volume: 53, Issue:4 Topics: Bromides; Carbamazepine; Child; Child, Preschool; Diagnosis, Differential; Electroencephalography; E	1974
Clonazepam in the treatment of epilepsy. The Medical journal of Australia, 1974, Jul-06, Volume: 2, Issue:1 Topics: Adult; Anticonvulsants; Benzodiazepinones; Chlorobenzenes; Chromatography, Gas; Drug Interactions; E	1974
Therapy of seizures in children. American family physician, 1974, Volume: 10, Issue:3 Topics: Child; Diazepam; Epilepsy; Epilepsy, Absence; Ethosuximide; Humans; Injections, Intramuscular; Injec	1974
Prolonged trance-like stupor in epilepsy. Petit mal status-wave stupor, spaced-out status. Archives of internal medicine, 1974, Volume: 134, Issue:6 Topics: Adult; Behavior; Diagnosis, Differential; Diazepam; Electroencephalography; Epilepsy; Epilepsy, Abse	1974
Drug treatment of convulsive disorders. The New England journal of medicine, 1972, Mar-02, Volume: 286, Issue:9 Topics: Acetazolamide; Adrenocorticotropic Hormone; Adult; Anticonvulsants; Barbiturates; Child; Diazepam; E	1972
[Epilepsy in childhood]. Minerva medica, 1972, May-26, Volume: 63, Issue:40 Topics: Adrenocorticotropic Hormone; Child; Child, Preschool; Electroencephalography; Epilepsy; Epilepsy, Ab	1972
Epilepsy. British medical journal, 1969, Nov-01, Volume: 4, Issue:5678 Topics: Adult; Child; Epilepsies, Partial; Epilepsy; Epilepsy, Absence; Epilepsy, Temporal Lobe; Epilepsy, T	1969
Drug treatment of epilepsy in childhood. British medical journal, 1969, Nov-22, Volume: 4, Issue:5681 Topics: Anticonvulsants; Carbamazepine; Child; Child, Preschool; Diazepam; Epilepsy; Epilepsy, Absence; Epil	1969
Anticonvulsant drugs in idiopathic epilepsy. The Medical letter on drugs and therapeutics, 1970, Jun-26, Volume: 12, Issue:13 Topics: Acetazolamide; Anticonvulsants; Epilepsy; Epilepsy, Absence; Ethosuximide; Humans; Hydantoins; Mepho	1970
[Therapy of epilepsy. The causes and consequences of inadequate treatment]. Deutsche medizinische Wochenschrift (1946), 1972, Oct-13, Volume: 97, Issue:41 Topics: Acridines; Adolescent; Adult; Age Factors; Aged; Anticonvulsants; Barbiturates; Carbamazepine; Child	1972
A medical and social survey of 231 children with seizures. Epilepsia, 1972, Volume: 13, Issue:1 Topics: Adolescent; Attitude to Health; Child; Child Behavior Disorders; Child, Preschool; Electroencephalog	1972
[Epilepsy with non-pyknoleptic petit mal]. Kinderarztliche Praxis, 1972, Volume: 40, Issue:5 Topics: Adolescent; Electroencephalography; Epilepsy, Absence; Ethosuximide; Female; Humans; Male; Primidone	1972
Epilepsy in Iceland. A clinical and epidemiological investigation. Acta neurologica Scandinavica, 1966, Volume: 43 Topics: Adolescent; Adult; Aged; Anticonvulsants; Automobile Driving; Child; Child, Preschool; Epilepsy, Abs	1966
[Treatment of epilepsy in children]. Deutsche medizinische Wochenschrift (1946), 1967, Jun-09, Volume: 92, Issue:23 Topics: Anticonvulsants; Child; Child, Preschool; Epilepsy; Epilepsy, Absence; Epilepsy, Temporal Lobe; Epil	1967
[On the combination treatment of epileptic attacks]. Wiener medizinische Wochenschrift (1946), 1968, Feb-10, Volume: 118, Issue:6 Topics: Anticonvulsants; Drug Synergism; Epilepsy; Epilepsy, Absence; Epilepsy, Temporal Lobe; Epilepsy, Ton	1968
[On the therapy of centrocephalic epilepsy in childhood]. Wiener medizinische Wochenschrift (1946), 1968, May-04, Volume: 118, Issue:18 Topics: Adolescent; Age Factors; Anticonvulsants; Barbiturates; Child; Child Behavior; Epilepsy; Epilepsy, A	1968
Myasthenia gravis syndrome associated with trimethadione. JAMA, 1970, Jun-29, Volume: 212, Issue:13 Topics: Anticonvulsants; Autoimmune Diseases; Child; Drug Hypersensitivity; Epilepsy, Absence; Female; Human	1970
[Basic principles of epilepsy therapy]. Zeitschrift fur arztliche Fortbildung, 1970, Dec-15, Volume: 64, Issue:24 Topics: Anticonvulsants; Barbiturates; Benzazepines; Carbamazepine; Epilepsy; Epilepsy, Absence; Epilepsy, T	1970