primidone has been researched along with Drug Withdrawal Symptoms in 19 studies
Primidone: A barbiturate derivative that acts as a GABA modulator and anti-epileptic agent. It is partly metabolized to PHENOBARBITAL in the body and owes some of its actions to this metabolite.
primidone : A pyrimidone that is dihydropyrimidine-4,6(1H,5H)-dione substituted by an ethyl and a phenyl group at position 5. It is used as an anticonvulsant for treatment of various types of seizures.
| Excerpt | Relevance | Reference |
|---|---|---|
| " In a prospective trial in dogs with newly diagnosed epilepsy, ELB 138 markedly reduced seizure frequency and severity without significant difference to standard treatments (phenobarbital or primidone) but was much better tolerated than the standard drugs." | 3.72 | Anticonvulsant efficacy of the low-affinity partial benzodiazepine receptor agonist ELB 138 in a dog seizure model and in epileptic dogs with spontaneously recurrent seizures. ( Löscher, W; Potschka, H; Rieck, S; Rundfeldt, C; Tipold, A, 2004) |
| "We studied 21 patients with complex partial seizures during phenobarbital (PB) or primidone withdrawal." | 3.67 | Seizures during barbiturate withdrawal: relation to blood level. ( Porter, RJ; Raubertas, RF; Theodore, WH, 1987) |
| " To test the validity of this primate model, the effects of diphenylhydantoin (DPH), phenobarbital, and primidone on spontaneous seizures evaluated for 8 months with a Latin-Squar experimental design." | 3.65 | Efficacy of standard anticonvulsants in monkey model with spontaneous motor seizures. ( DuCharme, LL; Farquhar, JA; Huntsman, BJ; Lockard, JS; Uhlir, V, 1975) |
| "The most important factor determining seizure recurrence was continued therapy, which was the case for barbiturates, phenytoin and valproate." | 2.69 | Does withdrawal of different antiepileptic drugs have different effects on seizure recurrence? Further results from the MRC Antiepileptic Drug Withdrawal Study. ( Chadwick, D, 1999) |
| "If primidone treatment is discontinued too quickly, withdrawal seizures may appear, some of which may be severe." | 2.42 | [Antiepileptic primidone shortly to be withdrawn from sale: change medication now]. ( Carpay, JA; de Haan, GJ; van Donselaar, CA, 2003) |
| "Behavior problems, such as withdrawal symptoms, were observed in neonates who eliminated PMD with short half-lives, while other infants with longer PMD half-lives or slower elimination because of nursing showed no such symptoms." | 1.27 | Primidone and phenobarbital during lactation period in epileptic women: total and free drug serum levels in the nursed infants and their effects on neonatal behavior. ( Helge, H; Koch, S; Kuhnz, W; Nau, H, 1988) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 15 (78.95) | 18.7374 |
| 1990's | 2 (10.53) | 18.2507 |
| 2000's | 2 (10.53) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| CONKLIN, JW | 2 |
| de Haan, GJ | 1 |
| Carpay, JA | 1 |
| van Donselaar, CA | 1 |
| Löscher, W | 2 |
| Potschka, H | 1 |
| Rieck, S | 1 |
| Tipold, A | 1 |
| Rundfeldt, C | 1 |
| Koch, S | 2 |
| Göpfert-Geyer, I | 1 |
| Jäger-Roman, E | 1 |
| Jakob, S | 1 |
| Huth, H | 1 |
| Hartmann, A | 1 |
| Rating, D | 1 |
| Helge, H | 2 |
| Aminoff, MJ | 1 |
| Wilbur, R | 1 |
| Kulik, FA | 1 |
| Spencer, SS | 1 |
| Spencer, DD | 1 |
| Williamson, PD | 1 |
| Mattson, RH | 1 |
| Chadwick, D | 1 |
| Smith, RF | 1 |
| Ludwig, BI | 1 |
| Marsan, CA | 1 |
| Lockard, JS | 1 |
| Uhlir, V | 1 |
| DuCharme, LL | 1 |
| Farquhar, JA | 1 |
| Huntsman, BJ | 1 |
| Ramchandani, D | 1 |
| Riggio, S | 1 |
| Hönack, D | 1 |
| Coulter, DL | 1 |
| Kuhnz, W | 1 |
| Nau, H | 1 |
| Theodore, WH | 1 |
| Porter, RJ | 1 |
| Raubertas, RF | 1 |
| Norton, PR | 1 |
| Hill, RM | 1 |
| Verniaud, WM | 1 |
| Horning, MG | 1 |
| McCulley, LB | 1 |
| Morgan, NF | 1 |
2 reviews available for primidone and Drug Withdrawal Symptoms
| Article | Year |
|---|---|
[Antiepileptic primidone shortly to be withdrawn from sale: change medication now].
Topics: Anticonvulsants; Drug and Narcotic Control; Epilepsy; Humans; Phenobarbital; Primidone; Substance Wi | 2003 |
Anticonvulsant drugs in alcohol withdrawal: use of phenytoin, primidone, carbamazepine, valproic acid, and the sedative anticonvulsants.
Topics: Alcoholism; Anticonvulsants; Carbamazepine; Humans; Hypnotics and Sedatives; Phenytoin; Primidone; S | 1981 |
2 trials available for primidone and Drug Withdrawal Symptoms
| Article | Year |
|---|---|
[Anti-epileptic agents during pregnancy. A prospective study on the course of pregnancy, malformations and child development].
Topics: Abnormalities, Drug-Induced; Abortion, Spontaneous; Adult; Akathisia, Drug-Induced; Anencephaly; Ant | 1983 |
Does withdrawal of different antiepileptic drugs have different effects on seizure recurrence? Further results from the MRC Antiepileptic Drug Withdrawal Study.
Topics: Adolescent; Adult; Anticonvulsants; Carbamazepine; Child; Drug Combinations; Epilepsy; Female; Human | 1999 |
15 other studies available for primidone and Drug Withdrawal Symptoms
| Article | Year |
|---|---|
Use of mysoline in barbiturate withdrawal.
Topics: Anticonvulsants; Barbiturates; Behavior, Addictive; Humans; Primidone; Psychoses, Substance-Induced; | 1956 |
Use of mysoline in barbiturate withdrawal.
Topics: Anticonvulsants; Barbiturates; Behavior, Addictive; Humans; Primidone; Psychoses, Substance-Induced; | 1956 |
Use of mysoline in barbiturate withdrawal.
Topics: Anticonvulsants; Barbiturates; Behavior, Addictive; Humans; Primidone; Psychoses, Substance-Induced; | 1956 |
Use of mysoline in barbiturate withdrawal.
Topics: Anticonvulsants; Barbiturates; Behavior, Addictive; Humans; Primidone; Psychoses, Substance-Induced; | 1956 |
Anticonvulsant efficacy of the low-affinity partial benzodiazepine receptor agonist ELB 138 in a dog seizure model and in epileptic dogs with spontaneously recurrent seizures.
Topics: Animals; Anticonvulsants; Bromides; Chronic Disease; Disease Models, Animal; Dog Diseases; Dogs; Dru | 2004 |
Drug treatment of epilepsy.
Topics: Anticonvulsants; Carbamazepine; Clonazepam; Electroencephalography; Epilepsy; Ethosuximide; Female; | 1981 |
Ictal effects of anticonvulsant medication withdrawal in epileptic patients.
Topics: Adolescent; Adult; Anticonvulsants; Carbamazepine; Electroencephalography; Epilepsy; Humans; Middle | 1981 |
Relative effectiveness of primidone (Mysoline) and diphenylhydantoin (Dilantin) in the management of sedative withdrawal seizures.
Topics: Antipsychotic Agents; Chlordiazepoxide; Drug Evaluation; Humans; Phenothiazines; Phenytoin; Primidon | 1976 |
EEG changes after withdrawal of medication in epileptic patients.
Topics: Adult; Anticonvulsants; Brain; Electroencephalography; Epilepsy; Humans; Phenobarbital; Phenytoin; P | 1975 |
Efficacy of standard anticonvulsants in monkey model with spontaneous motor seizures.
Topics: Aluminum; Animals; Anticonvulsants; Disease Models, Animal; Electroencephalography; Feeding Behavior | 1975 |
Periictal mania. A case report.
Topics: Adult; Anticonvulsants; Bipolar Disorder; Electroencephalography; Epilepsy; Functional Laterality; H | 1992 |
Comparison of the anticonvulsant efficacy of primidone and phenobarbital during chronic treatment of amygdala-kindled rats.
Topics: Amygdala; Animals; Anticonvulsants; Behavior, Animal; Electrodes, Implanted; Female; Kindling, Neuro | 1989 |
Withdrawal of barbiturate anticonvulsant drugs: prospective controlled study.
Topics: Adolescent; Adult; Aged; Anticonvulsants; Child; Drug Therapy, Combination; Epilepsies, Partial; Epi | 1988 |
Primidone and phenobarbital during lactation period in epileptic women: total and free drug serum levels in the nursed infants and their effects on neonatal behavior.
Topics: Behavior; Epilepsy; Female; Half-Life; Humans; Infant, Newborn; Milk, Human; Phenobarbital; Primidon | 1988 |
Seizures during barbiturate withdrawal: relation to blood level.
Topics: Humans; Phenobarbital; Primidone; Seizures; Substance Withdrawal Syndrome; Time Factors | 1987 |
The effects of drugs on barbiturate withdrawal convulsions in the rat.
Topics: Animals; Barbiturates; Chlordiazepoxide; Chlorpromazine; Ethanol; Ethosuximide; Female; Humans; Hydr | 1970 |
Anticonvulsant drugs in idiopathic epilepsy.
Topics: Acetazolamide; Anticonvulsants; Epilepsy; Epilepsy, Absence; Ethosuximide; Humans; Hydantoins; Mepho | 1970 |
Infants exposed in utero to antiepileptic drugs. A prospective study.
Topics: Abnormalities, Drug-Induced; Adolescent; Adult; Amitriptyline; Amniotic Fluid; Anticonvulsants; Chro | 1974 |