primidone has been researched along with Disease Models, Animal in 11 studies
Primidone: A barbiturate derivative that acts as a GABA modulator and anti-epileptic agent. It is partly metabolized to PHENOBARBITAL in the body and owes some of its actions to this metabolite.
primidone : A pyrimidone that is dihydropyrimidine-4,6(1H,5H)-dione substituted by an ethyl and a phenyl group at position 5. It is used as an anticonvulsant for treatment of various types of seizures.
Disease Models, Animal: Naturally-occurring or experimentally-induced animal diseases with pathological processes analogous to human diseases.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Like valproic acid, treatment with primidone reduced free-C levels in LE/LY in NPC1-null/mutant cells." | 5.62 | Beneficial effects of primidone in Niemann-Pick disease type C (NPC)-model cells and mice: Reduction of unesterified cholesterol levels in cells and extension of lifespan in mice. ( Ashikawa, H; Honda, T; Mogi, H; Murayama, T; Nakamura, H, 2021) |
| "3 to 30 mg/kg), a new anticonvulsant drug, in a model of essential tremor in comparison to the reference compounds propranolol and primidone." | 3.74 | Lacosamide, the new anticonvulsant, effectively reduces harmaline-induced tremors in rats. ( Freitag, J; Lekieffre, D; Stöhr, T, 2008) |
| " In a prospective trial in dogs with newly diagnosed epilepsy, ELB 138 markedly reduced seizure frequency and severity without significant difference to standard treatments (phenobarbital or primidone) but was much better tolerated than the standard drugs." | 3.72 | Anticonvulsant efficacy of the low-affinity partial benzodiazepine receptor agonist ELB 138 in a dog seizure model and in epileptic dogs with spontaneously recurrent seizures. ( Löscher, W; Potschka, H; Rieck, S; Rundfeldt, C; Tipold, A, 2004) |
| "Senegalese baboons (Papio papio), with a natural syndrome of photosensitive epilepsy, consistently show generalized myoclonic jerks if stimulated stroboscopically at hourly intervals, two to eight hours after the intravenous administration of allylglycine, 200 mg/kg." | 3.65 | A primate model for testing anticonvulsant drugs. ( Horton, RW; Meldrum, BS; Toseland, PA, 1975) |
| " To test the validity of this primate model, the effects of diphenylhydantoin (DPH), phenobarbital, and primidone on spontaneous seizures evaluated for 8 months with a Latin-Squar experimental design." | 3.65 | Efficacy of standard anticonvulsants in monkey model with spontaneous motor seizures. ( DuCharme, LL; Farquhar, JA; Huntsman, BJ; Lockard, JS; Uhlir, V, 1975) |
| "Like valproic acid, treatment with primidone reduced free-C levels in LE/LY in NPC1-null/mutant cells." | 1.62 | Beneficial effects of primidone in Niemann-Pick disease type C (NPC)-model cells and mice: Reduction of unesterified cholesterol levels in cells and extension of lifespan in mice. ( Ashikawa, H; Honda, T; Mogi, H; Murayama, T; Nakamura, H, 2021) |
| "Essential tremor is the most common movement disorder and has an unknown etiology." | 1.33 | Genetic essential tremor in gamma-aminobutyric acidA receptor alpha1 subunit knockout mice. ( Breese, GR; Criswell, HE; Hamre, K; Homanics, GE; Kralic, JE; Matthews, DB; Morrow, AL; O'Buckley, TK; Osterman, JL; Wilkie, ME, 2005) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 4 (36.36) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 3 (27.27) | 29.6817 |
| 2010's | 2 (18.18) | 24.3611 |
| 2020's | 2 (18.18) | 2.80 |
| Authors | Studies |
|---|---|
| Solinski, HJ | 1 |
| Dranchak, P | 1 |
| Oliphant, E | 1 |
| Gu, X | 1 |
| Earnest, TW | 1 |
| Braisted, J | 1 |
| Inglese, J | 1 |
| Hoon, MA | 1 |
| Abrams, RPM | 1 |
| Yasgar, A | 1 |
| Teramoto, T | 1 |
| Lee, MH | 1 |
| Dorjsuren, D | 1 |
| Eastman, RT | 1 |
| Malik, N | 1 |
| Zakharov, AV | 1 |
| Li, W | 1 |
| Bachani, M | 1 |
| Brimacombe, K | 1 |
| Steiner, JP | 1 |
| Hall, MD | 1 |
| Balasubramanian, A | 1 |
| Jadhav, A | 1 |
| Padmanabhan, R | 1 |
| Simeonov, A | 1 |
| Nath, A | 1 |
| Ashikawa, H | 1 |
| Mogi, H | 1 |
| Honda, T | 1 |
| Nakamura, H | 1 |
| Murayama, T | 1 |
| Krügel, U | 1 |
| Straub, I | 1 |
| Beckmann, H | 1 |
| Schaefer, M | 1 |
| Stöhr, T | 1 |
| Lekieffre, D | 1 |
| Freitag, J | 1 |
| Löscher, W | 1 |
| Potschka, H | 1 |
| Rieck, S | 1 |
| Tipold, A | 1 |
| Rundfeldt, C | 1 |
| Kralic, JE | 1 |
| Criswell, HE | 1 |
| Osterman, JL | 1 |
| O'Buckley, TK | 1 |
| Wilkie, ME | 1 |
| Matthews, DB | 1 |
| Hamre, K | 1 |
| Breese, GR | 1 |
| Homanics, GE | 1 |
| Morrow, AL | 1 |
| Lockard, JS | 2 |
| Levy, RH | 1 |
| DuCharme, LL | 2 |
| Congdon, WC | 1 |
| Meldrum, BS | 1 |
| Horton, RW | 1 |
| Toseland, PA | 1 |
| Johnson, DD | 1 |
| Davis, HL | 1 |
| Crawford, RD | 1 |
| Uhlir, V | 1 |
| Farquhar, JA | 1 |
| Huntsman, BJ | 1 |
1 review available for primidone and Disease Models, Animal
| Article | Year |
|---|---|
Pharmacological and biochemical studies in epileptic fowl.
Topics: Animals; Anticonvulsants; Benzodiazepinones; Brain; Chickens; Disease Models, Animal; Ethosuximide; | 1979 |
10 other studies available for primidone and Disease Models, Animal
| Article | Year |
|---|---|
Inhibition of natriuretic peptide receptor 1 reduces itch in mice.
Topics: Animals; Behavior, Animal; Cell-Free System; Dermatitis, Contact; Disease Models, Animal; Ganglia, S | 2019 |
Therapeutic candidates for the Zika virus identified by a high-throughput screen for Zika protease inhibitors.
Topics: Animals; Antiviral Agents; Artificial Intelligence; Chlorocebus aethiops; Disease Models, Animal; Dr | 2020 |
Beneficial effects of primidone in Niemann-Pick disease type C (NPC)-model cells and mice: Reduction of unesterified cholesterol levels in cells and extension of lifespan in mice.
Topics: Animals; Biological Transport; CHO Cells; Cholesterol; Cricetulus; Disease Models, Animal; Endoplasm | 2021 |
Primidone inhibits TRPM3 and attenuates thermal nociception in vivo.
Topics: Adrenergic Uptake Inhibitors; Analgesics; Animals; Anti-Inflammatory Agents, Non-Steroidal; Calcium; | 2017 |
Lacosamide, the new anticonvulsant, effectively reduces harmaline-induced tremors in rats.
Topics: Acetamides; Animals; Anticonvulsants; Disease Models, Animal; Dose-Response Relationship, Drug; Esse | 2008 |
Anticonvulsant efficacy of the low-affinity partial benzodiazepine receptor agonist ELB 138 in a dog seizure model and in epileptic dogs with spontaneously recurrent seizures.
Topics: Animals; Anticonvulsants; Bromides; Chronic Disease; Disease Models, Animal; Dog Diseases; Dogs; Dru | 2004 |
Genetic essential tremor in gamma-aminobutyric acidA receptor alpha1 subunit knockout mice.
Topics: Adrenergic beta-Antagonists; Animals; Anticonvulsants; Disease Models, Animal; Dizocilpine Maleate; | 2005 |
EEG quantification of drug level effects in monkey model of partial epilepsy.
Topics: Animals; Anticonvulsants; Circadian Rhythm; Clonazepam; Disease Models, Animal; Electroencephalograp | 1982 |
A primate model for testing anticonvulsant drugs.
Topics: Allyl Compounds; Animals; Anticonvulsants; Carbamazepine; Chromatography, Gas; Diazepam; Disease Mod | 1975 |
Efficacy of standard anticonvulsants in monkey model with spontaneous motor seizures.
Topics: Aluminum; Animals; Anticonvulsants; Disease Models, Animal; Electroencephalography; Feeding Behavior | 1975 |