Page last updated: 2024-11-03

primidone and Depressive Disorder, Major

primidone has been researched along with Depressive Disorder, Major in 2 studies

Primidone: A barbiturate derivative that acts as a GABA modulator and anti-epileptic agent. It is partly metabolized to PHENOBARBITAL in the body and owes some of its actions to this metabolite.
primidone : A pyrimidone that is dihydropyrimidine-4,6(1H,5H)-dione substituted by an ethyl and a phenyl group at position 5. It is used as an anticonvulsant for treatment of various types of seizures.

Depressive Disorder, Major: Disorder in which five (or more) of the following symptoms have been present during the same 2-week period and represent a change from previous functioning; at least one of the symptoms is either (1) depressed mood or (2) loss of interest or pleasure. Symptoms include: depressed mood most of the day, nearly every daily; markedly diminished interest or pleasure in activities most of the day, nearly every day; significant weight loss when not dieting or weight gain; Insomnia or hypersomnia nearly every day; psychomotor agitation or retardation nearly every day; fatigue or loss of energy nearly every day; feelings of worthlessness or excessive or inappropriate guilt; diminished ability to think or concentrate, or indecisiveness, nearly every day; or recurrent thoughts of death, recurrent suicidal ideation without a specific plan, or a suicide attempt. (DSM-5)

Research Excerpts

ExcerptRelevanceReference
"A 74 year old man presented to the Old Age Psychiatry Service with cognitive deficits while being treated for recurrent depressive episodes and essential tremor with Venlafaxine, Lithium, and Primidone."3.81Drug-induced cerebral glucose metabolism resembling Alzheimer's Disease: a case study. ( Beer, AJ; Riepe, MW; Vonend, C; Walther, B, 2015)

Research

Studies (2)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's1 (50.00)29.6817
2010's1 (50.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Riepe, MW1
Walther, B1
Vonend, C1
Beer, AJ1
Gaynes, BN1
Warden, D1
Trivedi, MH1
Wisniewski, SR1
Fava, M1
Rush, AJ1

Clinical Trials (2)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Xenon Inhalation Therapy for Major Depressive Disorder and Bipolar Disorder[NCT03748446]Early Phase 120 participants (Anticipated)Interventional2019-12-05Recruiting
Subanesthetic Sevoflurane for Treatment-Resistant Depression: A Proof-of-Concept Trial[NCT05008939]15 participants (Anticipated)Interventional2021-08-31Not yet recruiting
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Trials

1 trial available for primidone and Depressive Disorder, Major

ArticleYear
What did STAR*D teach us? Results from a large-scale, practical, clinical trial for patients with depression.
    Psychiatric services (Washington, D.C.), 2009, Volume: 60, Issue:11

    Topics: Adolescent; Adult; Aged; Bupropion; Citalopram; Cognitive Behavioral Therapy; Cyclohexanols; Depress

2009
What did STAR*D teach us? Results from a large-scale, practical, clinical trial for patients with depression.
    Psychiatric services (Washington, D.C.), 2009, Volume: 60, Issue:11

    Topics: Adolescent; Adult; Aged; Bupropion; Citalopram; Cognitive Behavioral Therapy; Cyclohexanols; Depress

2009
What did STAR*D teach us? Results from a large-scale, practical, clinical trial for patients with depression.
    Psychiatric services (Washington, D.C.), 2009, Volume: 60, Issue:11

    Topics: Adolescent; Adult; Aged; Bupropion; Citalopram; Cognitive Behavioral Therapy; Cyclohexanols; Depress

2009
What did STAR*D teach us? Results from a large-scale, practical, clinical trial for patients with depression.
    Psychiatric services (Washington, D.C.), 2009, Volume: 60, Issue:11

    Topics: Adolescent; Adult; Aged; Bupropion; Citalopram; Cognitive Behavioral Therapy; Cyclohexanols; Depress

2009

Other Studies

1 other study available for primidone and Depressive Disorder, Major

ArticleYear
Drug-induced cerebral glucose metabolism resembling Alzheimer's Disease: a case study.
    BMC psychiatry, 2015, Jul-11, Volume: 15

    Topics: Aged; Alzheimer Disease; Anticonvulsants; Antidepressive Agents; Attention; Cognition Disorders; Dep

2015