primidone has been researched along with Delayed Effects, Prenatal Exposure in 6 studies
Primidone: A barbiturate derivative that acts as a GABA modulator and anti-epileptic agent. It is partly metabolized to PHENOBARBITAL in the body and owes some of its actions to this metabolite.
primidone : A pyrimidone that is dihydropyrimidine-4,6(1H,5H)-dione substituted by an ethyl and a phenyl group at position 5. It is used as an anticonvulsant for treatment of various types of seizures.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Experimental production of hemifacial microsomia by a folic acid antagonist, triaxene, is mediated via hemorrhage in the fetus." | 1.27 | Goldenhar syndrome, anterior encephalocele, and aqueductal stenosis following fetal primidone exposure. ( Chen, H; Gustavson, EE, 1985) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 3 (50.00) | 18.7374 |
| 1990's | 2 (33.33) | 18.2507 |
| 2000's | 1 (16.67) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Koch, S | 2 |
| Göpfert-Geyer, I | 1 |
| Jäger-Roman, E | 2 |
| Jakob, S | 1 |
| Huth, H | 1 |
| Hartmann, A | 1 |
| Rating, D | 2 |
| Helge, H | 2 |
| Burn, J | 1 |
| Baraitser, M | 1 |
| Lösche, G | 1 |
| Nau, H | 1 |
| Pizzi, WJ | 1 |
| Alexander, TD | 1 |
| Loftus, JT | 1 |
| Laskowska, M | 1 |
| Leszczyńska-Gorzelak, B | 1 |
| Oleszczuk, J | 1 |
| Gustavson, EE | 1 |
| Chen, H | 1 |
3 trials available for primidone and Delayed Effects, Prenatal Exposure
| Article | Year |
|---|---|
[Anti-epileptic agents during pregnancy. A prospective study on the course of pregnancy, malformations and child development].
Topics: Abnormalities, Drug-Induced; Abortion, Spontaneous; Adult; Akathisia, Drug-Induced; Anencephaly; Ant | 1983 |
Antiepileptic drug treatment in pregnancy: drug side effects in the neonate and neurological outcome.
Topics: Anticonvulsants; Child; Drug Monitoring; Epilepsy; Female; Follow-Up Studies; Humans; Nervous System | 1996 |
[Evaluation of antiepileptic therapy during pregnancy].
Topics: Adult; Anticonvulsants; Apgar Score; Drug Therapy, Combination; Epilepsy; Female; Humans; Phenobarbi | 2002 |
3 other studies available for primidone and Delayed Effects, Prenatal Exposure
| Article | Year |
|---|---|
Primidone teratogenicity or Noonan syndrome?
Topics: Abnormalities, Drug-Induced; Diagnosis, Differential; Female; Humans; Infant, Newborn; Noonan Syndro | 1982 |
Developmental and behavioral effects of prenatal primidone exposure in the rat.
Topics: Animals; Anticonvulsants; Behavior, Animal; Body Weight; Exploratory Behavior; Female; Growth; Male; | 1996 |
Goldenhar syndrome, anterior encephalocele, and aqueductal stenosis following fetal primidone exposure.
Topics: Adult; Brain Diseases; Cerebral Aqueduct; Constriction, Pathologic; Encephalocele; Epilepsy; Female; | 1985 |