Compounds > primidone
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primidone and Complications, Pregnancy

primidone has been researched along with Complications, Pregnancy in 35 studies

Primidone: A barbiturate derivative that acts as a GABA modulator and anti-epileptic agent. It is partly metabolized to PHENOBARBITAL in the body and owes some of its actions to this metabolite.
primidone : A pyrimidone that is dihydropyrimidine-4,6(1H,5H)-dione substituted by an ethyl and a phenyl group at position 5. It is used as an anticonvulsant for treatment of various types of seizures.

Research Excerpts

ExcerptRelevanceReference
"Fourteen epileptic women treated with primidone, either alone or in combination with other antiepileptic drugs, were studied prospectively during their pregnancy."7.66Teratogenic and pharmacokinetic studies of primidone during pregnancy and in the offspring of epileptic women. ( Beck-Mannagetta, G; Göpfert-Geyer, I; Helge, H; Jäger-Roman, E; Koch, S; Nau, H; Rating, D; Schmidt, D, 1982)
"An epileptic patient whose seizures were controlled with carbamazepine and primidone was followed throughout pregnancy and lactation."7.66Carbamazepine levels in pregnancy and lactation. ( Blake, DA; Freeman, JM; Luff, RD; Niebyl, JR, 1979)
" Primidone was the only anti-epileptic drug, taken during pregnancy, to have a significant effect on infant head circumference."3.66Neonatal outcome in infants of epileptic mothers. ( Heifetz, L; Neri, A; Nitke, S; Ovadia, J, 1983)
"Fourteen epileptic women treated with primidone, either alone or in combination with other antiepileptic drugs, were studied prospectively during their pregnancy."3.66Teratogenic and pharmacokinetic studies of primidone during pregnancy and in the offspring of epileptic women. ( Beck-Mannagetta, G; Göpfert-Geyer, I; Helge, H; Jäger-Roman, E; Koch, S; Nau, H; Rating, D; Schmidt, D, 1982)
"An epileptic patient whose seizures were controlled with carbamazepine and primidone was followed throughout pregnancy and lactation."3.66Carbamazepine levels in pregnancy and lactation. ( Blake, DA; Freeman, JM; Luff, RD; Niebyl, JR, 1979)
"Only when the epilepsy is uncontrolled despite high plasma concentrations which cannot be raised because of side effects, a second drug should be given."1.27[Pharmacotherapy of epilepsy--current problems and controversies]. ( Schmidt, D, 1983)
" The mechanisms responsible for these effects have not been elucidated and possibly include decreased bioavailability or compliance, increased metabolic clearance, or decreased plasma protein binding."1.27Effects of pregnancy on antiepileptic drug utilization. ( Levy, RH; Yerby, MS, 1985)

Research

Studies (35)

TimeframeStudies, this research(%)All Research%
pre-199030 (85.71)18.7374
1990's4 (11.43)18.2507
2000's1 (2.86)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
BERIC, B2
RYDER, RJ1
Koch, S5
Göpfert-Geyer, I2
Jäger-Roman, E3
Jakob, S1
Huth, H1
Hartmann, A1
Rating, D4
Helge, H4
Friis, ML2
Schmidt, D2
Mallow, DW1
Herrick, MK1
Gathman, G1
Neri, A1
Heifetz, L1
Nitke, S1
Ovadia, J1
Nau, H3
Beck-Mannagetta, G1
Bossi, L1
Assael, BM1
Avanzini, G1
Battino, D1
Caccamo, ML1
Canger, R1
Como, ML1
Pifarotti, G1
de Giambattista, M1
Franceschetti, S1
Marini, A1
Pardi, G1
Porro, MG1
Rovei, V1
Sanjuan, M1
Soffientini, ME1
Spina, S1
Spreafico, R1
Häuser, I1
Jäger, E1
Tulokas, S1
Lösche, G1
Titze, K1
Zimmermann, RB1
Schröder, M1
Lehmkuhl, U1
Rauh, H1
Laskowska, M1
Leszczyńska-Gorzelak, B1
Oleszczuk, J1
Hanson, JW1
Smith, DW1
Niebyl, JR1
Blake, DA1
Freeman, JM1
Luff, RD1
Biale, Y1
Lewenthal, H1
Aderet, NB1
Annegers, JF2
Elveback, LR2
Hauser, WA2
Kurland, LT2
Yerby, MS2
Leavitt, A1
Erickson, DM1
McCormick, KB1
Loewenson, RB1
Sells, CJ1
Benedetti, TJ1
Klepel, H1
Donat, H1
Köppe, I1
Cohen, A1
Mundel, G1
Levy, RH1
Lowe, CR1
Evans, AR1
Forrester, RM1
Discombe, C1
Waltl, H1
Mitterstieler, G1
Schwingshackl, A1
Sherwin, AL1
Loynd, JS1
Bock, GW1
Sokolowski, CD1
Zellweger, H1
Gregoriades, AD1
Martinez, G1
Snyder, RD1
Stenchever, MA1
Allen, M1
Meyer, JG1
Hill, RM1
Verniaud, WM1
Horning, MG1
McCulley, LB1
Morgan, NF1
Elshove, J1
van Eck, JH1

Reviews

1 review available for primidone and Complications, Pregnancy

ArticleYear
Anticonvulsants during pregnancy: a danger to the developing fetus?
    Clinical pediatrics, 1974, Volume: 13, Issue:4

    Topics: Abnormalities, Drug-Induced; Anticonvulsants; Barbiturates; Blood Coagulation Disorders; Chromosome

1974

Trials

3 trials available for primidone and Complications, Pregnancy

ArticleYear
[Anti-epileptic agents during pregnancy. A prospective study on the course of pregnancy, malformations and child development].
    Deutsche medizinische Wochenschrift (1946), 1983, Feb-18, Volume: 108, Issue:7

    Topics: Abnormalities, Drug-Induced; Abortion, Spontaneous; Adult; Akathisia, Drug-Induced; Anencephaly; Ant

1983
Antiepileptic drug treatment in pregnancy: drug side effects in the neonate and neurological outcome.
    Acta paediatrica (Oslo, Norway : 1992), 1996, Volume: 85, Issue:6

    Topics: Anticonvulsants; Child; Drug Monitoring; Epilepsy; Female; Follow-Up Studies; Humans; Nervous System

1996
[Evaluation of antiepileptic therapy during pregnancy].
    Ginekologia polska, 2002, Volume: 73, Issue:1

    Topics: Adult; Anticonvulsants; Apgar Score; Drug Therapy, Combination; Epilepsy; Female; Humans; Phenobarbi

2002

Other Studies

31 other studies available for primidone and Complications, Pregnancy

ArticleYear
[Therapeutic effect of mysoline during pregnancy and pending delivery in epileptics].
    Concours medical, 1956, Oct-13, Volume: 78, Issue:41

    Topics: Anticonvulsants; Delivery, Obstetric; Epilepsy; Female; Humans; Labor, Obstetric; Pregnancy; Pregnan

1956
[Therapeutic effect of mysoline during pregnancy and pending delivery in epileptics].
    Concours medical, 1956, Oct-13, Volume: 78, Issue:41

    Topics: Anticonvulsants; Delivery, Obstetric; Epilepsy; Female; Humans; Labor, Obstetric; Pregnancy; Pregnan

1956
[Therapeutic effect of mysoline during pregnancy and pending delivery in epileptics].
    Concours medical, 1956, Oct-13, Volume: 78, Issue:41

    Topics: Anticonvulsants; Delivery, Obstetric; Epilepsy; Female; Humans; Labor, Obstetric; Pregnancy; Pregnan

1956
[Therapeutic effect of mysoline during pregnancy and pending delivery in epileptics].
    Concours medical, 1956, Oct-13, Volume: 78, Issue:41

    Topics: Anticonvulsants; Delivery, Obstetric; Epilepsy; Female; Humans; Labor, Obstetric; Pregnancy; Pregnan

1956
HAEMORRHAGE ASSOCIATED WITH THROMBOCYTOPENIA IN MEGALOBLASTIC ANAEMIA.
    Journal of the Irish Medical Association, 1964, Volume: 55

    Topics: Anemia; Anemia, Macrocytic; Anemia, Megaloblastic; Blood Platelet Disorders; Drug Therapy; Epilepsy;

1964
Antiepileptic drugs and teratogenesis. How should patients, doctors and health authorities be counselled?
    Acta neurologica Scandinavica. Supplementum, 1983, Volume: 94

    Topics: Abnormalities, Drug-Induced; Anticonvulsants; Carbamazepine; Epilepsy; Female; Humans; Infant, Newbo

1983
[Pharmacotherapy of epilepsy--current problems and controversies].
    Fortschritte der Neurologie-Psychiatrie, 1983, Volume: 51, Issue:11

    Topics: Adolescent; Adult; Carbamazepine; Child; Child, Preschool; Epilepsies, Partial; Epilepsy; Epilepsy,

1983
Fetal exposure to anticonvulsant drugs. Detailed pathological study of a case.
    Archives of pathology & laboratory medicine, 1980, Volume: 104, Issue:4

    Topics: Abnormalities, Drug-Induced; Acetazolamide; Adult; Anticonvulsants; Brain; Cardiomegaly; Epilepsy; E

1980
Neonatal outcome in infants of epileptic mothers.
    European journal of obstetrics, gynecology, and reproductive biology, 1983, Volume: 16, Issue:4

    Topics: Analysis of Variance; Anticonvulsants; Cephalometry; Drug Therapy, Combination; Epilepsy; Female; Fe

1983
Teratogenic and pharmacokinetic studies of primidone during pregnancy and in the offspring of epileptic women.
    Acta paediatrica Scandinavica, 1982, Volume: 71, Issue:2

    Topics: Abnormalities, Drug-Induced; Child Development; Epilepsy; Female; Humans; Infant, Newborn; Kinetics;

1982
Plasma levels and clinical effects of antiepileptic drugs in pregnant epileptic patients and their newborns.
    Obstetrical & gynecological survey, 1980, Volume: 35, Issue:9

    Topics: Adult; Anticonvulsants; Clonazepam; Epilepsy; Female; Humans; Infant, Newborn; Phenobarbital; Phenyt

1980
Placental transfer and pharmacokinetics of primidone and its metabolites phenobarbital, PEMA and hydroxyphenobarbital in neonates and infants of epileptic mothers.
    European journal of clinical pharmacology, 1980, Volume: 18, Issue:1

    Topics: Adult; Aminopyrine; Cytochrome P-450 Enzyme System; Epilepsy; Female; Half-Life; Humans; Hydroxylati

1980
[The activation of lupus in pregnancy and its successful immunological treatment].
    Duodecim; laaketieteellinen aikakauskirja, 1994, Volume: 110, Issue:23-24

    Topics: Adult; Anti-Inflammatory Agents; Anticonvulsants; Azathioprine; Epilepsy; Female; Humans; Immunoglob

1994
Long-term neuropsychological consequences of maternal epilepsy and anticonvulsant treatment during pregnancy for school-age children and adolescents.
    Epilepsia, 1999, Volume: 40, Issue:9

    Topics: Adolescent; Adult; Animals; Anticonvulsants; Child; Developmental Disabilities; Drug Therapy, Combin

1999
The fetal hydantoin syndrome.
    The Journal of pediatrics, 1975, Volume: 87, Issue:2

    Topics: Abnormalities, Drug-Induced; Abnormalities, Multiple; Adolescent; Child, Preschool; Developmental Di

1975
Epilepsy among parents of children with facial clefts.
    Epilepsia, 1979, Volume: 20, Issue:1

    Topics: Anticonvulsants; Cleft Lip; Cleft Palate; Epilepsy; Female; Humans; Male; Parents; Phenobarbital; Ph

1979
Carbamazepine levels in pregnancy and lactation.
    Obstetrics and gynecology, 1979, Volume: 53, Issue:1

    Topics: Adult; Carbamazepine; Epilepsy, Temporal Lobe; Female; Fetal Blood; Fetus; Humans; Lactation; Milk,

1979
Congenital malformations due to anticonvulsive drugs.
    Obstetrics and gynecology, 1975, Volume: 45, Issue:4

    Topics: Abnormalities, Drug-Induced; Abnormalities, Multiple; Adult; Anencephaly; Anticonvulsants; Birth Ord

1975
Epilepsy anticonvulsants and malformations.
    Birth defects original article series, 1975, Volume: 11, Issue:5

    Topics: Abnormalities, Drug-Induced; Anticonvulsants; Cleft Lip; Cleft Palate; Epilepsy; Female; Heart Defec

1975
Antiepileptics and the development of congenital anomalies.
    Neurology, 1992, Volume: 42, Issue:4 Suppl 5

    Topics: Abnormalities, Drug-Induced; Anticonvulsants; Apgar Score; Birth Weight; Carbamazepine; Epilepsy; Fe

1992
[Prenatal growth of children of epileptic mothers].
    Psychiatrie, Neurologie, und medizinische Psychologie, 1986, Volume: 38, Issue:2

    Topics: Anticonvulsants; Birth Weight; Cephalometry; Drug Therapy, Combination; Epilepsies, Partial; Epileps

1986
[The fetal primidone syndrome].
    Harefuah, 1988, Feb-15, Volume: 114, Issue:4

    Topics: Abnormalities, Drug-Induced; Abnormalities, Multiple; Epilepsy; Female; Fetal Diseases; Fetal Growth

1988
Effects of pregnancy on antiepileptic drug utilization.
    Epilepsia, 1985, Volume: 26 Suppl 1

    Topics: Anticonvulsants; Biological Availability; Carbamazepine; Epilepsy; Female; Humans; Kinetics; Metabol

1985
Congenital malformations among infants born to epileptic women.
    Lancet (London, England), 1973, Jan-06, Volume: 1, Issue:7793

    Topics: Abnormalities, Drug-Induced; Cleft Lip; Cleft Palate; Congenital Abnormalities; England; Epilepsy; F

1973
Neonatal haemorrhage following maternal anticonvulsant therapy.
    Lancet (London, England), 1970, Mar-07, Volume: 1, Issue:7645

    Topics: Adult; Anticonvulsants; Epilepsy; Female; Humans; Infant, Newborn; Male; Phenobarbital; Phenytoin; P

1970
[Haemorrhagic diathesis in a newborn child of a mother on anti-epileptic medication (author's transl)].
    Deutsche medizinische Wochenschrift (1946), 1974, Jun-14, Volume: 99, Issue:24

    Topics: Adult; Anticonvulsants; Drug Therapy, Combination; Epilepsy, Tonic-Clonic; Female; Hemostatics; Huma

1974
Do anticonvulsants have a teratogenic effect?
    Archives of neurology, 1974, Volume: 31, Issue:6

    Topics: Abnormalities, Drug-Induced; Anticonvulsants; Child, Preschool; Cleft Lip; Cleft Palate; Congenital

1974
Effects of age, sex, obesity, and pregnancy on plasma diphenylhydantoin levels.
    Epilepsia, 1974, Volume: 15, Issue:4

    Topics: Adolescent; Adult; Age Factors; Analysis of Variance; Chromatography, Gas; Dose-Response Relationshi

1974
A medical and social survey of 231 children with seizures.
    Epilepsia, 1972, Volume: 13, Issue:1

    Topics: Adolescent; Attitude to Health; Child; Child Behavior Disorders; Child, Preschool; Electroencephalog

1972
Transplacental passage of primidone.
    Neurology, 1973, Volume: 23, Issue:4

    Topics: Female; Fetus; Humans; Infant, Newborn; Infant, Newborn, Diseases; Labor, Obstetric; Maternal-Fetal

1973
The effect of selected antiepileptic drugs on the chromosomes of human lymphocytes in vitro.
    American journal of obstetrics and gynecology, 1973, Jul-15, Volume: 116, Issue:6

    Topics: Adult; Anticonvulsants; Chromatids; Chromosomes; Culture Techniques; Epilepsy; Female; Humans; Hydan

1973
The teratological effects of anticonvulsants and the effects on pregnancy and birth.
    European neurology, 1973, Volume: 10, Issue:3

    Topics: Abnormalities, Drug-Induced; Anticonvulsants; Carbamazepine; Child; Cleft Lip; Cleft Palate; Cyclohe

1973
Infants exposed in utero to antiepileptic drugs. A prospective study.
    American journal of diseases of children (1960), 1974, Volume: 127, Issue:5

    Topics: Abnormalities, Drug-Induced; Adolescent; Adult; Amitriptyline; Amniotic Fluid; Anticonvulsants; Chro

1974
[Congenital abnormalities, cleft lip and cleft palate in particular, in children of epileptic mothers].
    Nederlands tijdschrift voor geneeskunde, 1971, Aug-14, Volume: 115, Issue:33

    Topics: Abnormalities, Drug-Induced; Abnormalities, Multiple; Adult; Cleft Lip; Cleft Palate; Epilepsy; Fema

1971