primidone has been researched along with Chronic Disease in 8 studies
Primidone: A barbiturate derivative that acts as a GABA modulator and anti-epileptic agent. It is partly metabolized to PHENOBARBITAL in the body and owes some of its actions to this metabolite.
primidone : A pyrimidone that is dihydropyrimidine-4,6(1H,5H)-dione substituted by an ethyl and a phenyl group at position 5. It is used as an anticonvulsant for treatment of various types of seizures.
Chronic Disease: Diseases which have one or more of the following characteristics: they are permanent, leave residual disability, are caused by nonreversible pathological alteration, require special training of the patient for rehabilitation, or may be expected to require a long period of supervision, observation, or care (Dictionary of Health Services Management, 2d ed). For epidemiological studies chronic disease often includes HEART DISEASES; STROKE; CANCER; and diabetes (DIABETES MELLITUS, TYPE 2).
| Excerpt | Relevance | Reference |
|---|---|---|
| " In a prospective trial in dogs with newly diagnosed epilepsy, ELB 138 markedly reduced seizure frequency and severity without significant difference to standard treatments (phenobarbital or primidone) but was much better tolerated than the standard drugs." | 3.72 | Anticonvulsant efficacy of the low-affinity partial benzodiazepine receptor agonist ELB 138 in a dog seizure model and in epileptic dogs with spontaneously recurrent seizures. ( Löscher, W; Potschka, H; Rieck, S; Rundfeldt, C; Tipold, A, 2004) |
| "Both patients were found to have a fine tremor in both legs on standing only." | 1.28 | [Orthostatic tremor]. ( Deisenhammer, F; Gerstenbrand, F; Ransmayr, G; Willeit, J, 1991) |
| "Fifty-nine patients with chronic generalized tonic-clonic or partial seizures refractory to the maximally tolerated daily dosage of single-drug therapy with carbamazepine, phenytoin, phenobarbital, or primidone subsequently received single-drug therapy with another one of these primary anticonvulsant drugs." | 1.27 | Alternative single anticonvulsant drug therapy for refractory epilepsy. ( Richter, K; Schmidt, D, 1986) |
| "Phenytoin dosage was increased to study the effect on the frequency of seizures and the serum concentrations of phenytoin and phenobarbitone." | 1.26 | Therapeutic and pharmacokinetic effects of increasing phenytoin in chronic epileptics on multiple drug therapy. ( Johnson, RH; Lambie, DG; Nanda, RN; Shakir, RA, 1976) |
| " (3) Use of well-standardized, yet simplified, mental performance tests in combination with changes in the dosage of medication can help in reaching a compromise between acceptable seizure control and avoidance of excessive slowing of mental activity." | 1.25 | Effects of different dosages of anticonvulsant drugs on mental performance in patients with chronic epilepsy. ( Dekaban, AS; Lehman, EJ, 1975) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 6 (75.00) | 18.7374 |
| 1990's | 1 (12.50) | 18.2507 |
| 2000's | 1 (12.50) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Löscher, W | 1 |
| Potschka, H | 1 |
| Rieck, S | 1 |
| Tipold, A | 1 |
| Rundfeldt, C | 1 |
| Lambie, DG | 1 |
| Johnson, RH | 1 |
| Nanda, RN | 1 |
| Shakir, RA | 1 |
| Penin, H | 1 |
| Oxley, J | 1 |
| Hebdige, S | 1 |
| Richens, A | 1 |
| Dekaban, AS | 1 |
| Lehman, EJ | 1 |
| Willeit, J | 1 |
| Deisenhammer, F | 1 |
| Ransmayr, G | 1 |
| Gerstenbrand, F | 1 |
| Schmidt, D | 1 |
| Richter, K | 1 |
| Rabe, F | 1 |
1 review available for primidone and Chronic Disease
| Article | Year |
|---|---|
[Long-term anticonvulsant therapy (author's transl)].
Topics: Anticonvulsants; Carbamazepine; Chronic Disease; Clonazepam; Epilepsy; Ethosuximide; Humans; Long-Te | 1978 |
1 trial available for primidone and Chronic Disease
| Article | Year |
|---|---|
A comparison of phenobarbitone and primidone in the control of seizures in chronic epilepsy [proceedings].
Topics: Adult; Aged; Chronic Disease; Clinical Trials as Topic; Epilepsy; Humans; Middle Aged; Phenobarbital | 1979 |
6 other studies available for primidone and Chronic Disease
| Article | Year |
|---|---|
Anticonvulsant efficacy of the low-affinity partial benzodiazepine receptor agonist ELB 138 in a dog seizure model and in epileptic dogs with spontaneously recurrent seizures.
Topics: Animals; Anticonvulsants; Bromides; Chronic Disease; Disease Models, Animal; Dog Diseases; Dogs; Dru | 2004 |
Therapeutic and pharmacokinetic effects of increasing phenytoin in chronic epileptics on multiple drug therapy.
Topics: Adult; Biological Availability; Chronic Disease; Dose-Response Relationship, Drug; Drug Therapy, Com | 1976 |
Effects of different dosages of anticonvulsant drugs on mental performance in patients with chronic epilepsy.
Topics: Adolescent; Adult; Anticonvulsants; Child; Chronic Disease; Dose-Response Relationship, Drug; Epilep | 1975 |
[Orthostatic tremor].
Topics: Aged; Chronic Disease; Dose-Response Relationship, Drug; Electromyography; Humans; Male; Middle Aged | 1991 |
Alternative single anticonvulsant drug therapy for refractory epilepsy.
Topics: Adult; Anticonvulsants; Carbamazepine; Chronic Disease; Epilepsy; Humans; Phenobarbital; Phenytoin; | 1986 |
[Drug treatment of chronic epilepsy].
Topics: Anticonvulsants; Carbamazepine; Chronic Disease; Epilepsy; Ethosuximide; Humans; Hydantoins; Primido | 1970 |