primidone has been researched along with Canine Diseases in 26 studies
Primidone: A barbiturate derivative that acts as a GABA modulator and anti-epileptic agent. It is partly metabolized to PHENOBARBITAL in the body and owes some of its actions to this metabolite.
primidone : A pyrimidone that is dihydropyrimidine-4,6(1H,5H)-dione substituted by an ethyl and a phenyl group at position 5. It is used as an anticonvulsant for treatment of various types of seizures.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The efficacy of phenobarbital and primidone against canine epilepsy was compared in a controlled study." | 7.67 | Therapeutic efficacy of phenobarbital and primidone in canine epilepsy: a comparison. ( Frey, HH; Löscher, W; Schwartz-Porsche, D, 1985) |
| " Serum concentrations differed even with the same dosage among individual dogs." | 5.28 | [Effectiveness of bromide in therapy resistant epilepsy of dogs]. ( Jürgens, U; Schwartz-Porsche, D, 1991) |
| " Further, for dogs given phenobarbital, there was a sixfold variation between dosage and achieved serum concentration, whereas dogs given primidone manifested even greater variability between dosage and serum concentration." | 5.27 | Serum concentrations and efficacy of phenytoin, phenobarbital, and primidone in canine epilepsy. ( Farnbach, GC, 1984) |
| "Forty-seven dogs with a history of generalized recurrent seizures were treated with primidone at a daily oral dosage of 13 to 100 mg/kg of body weight, divided into 2 to 3 doses." | 5.26 | Treatment of canine epilepsy with primidone. ( Frey, HH; Löscher, W; Schwartz-Porsche, D, 1982) |
| " In a prospective trial in dogs with newly diagnosed epilepsy, ELB 138 markedly reduced seizure frequency and severity without significant difference to standard treatments (phenobarbital or primidone) but was much better tolerated than the standard drugs." | 3.72 | Anticonvulsant efficacy of the low-affinity partial benzodiazepine receptor agonist ELB 138 in a dog seizure model and in epileptic dogs with spontaneously recurrent seizures. ( Löscher, W; Potschka, H; Rieck, S; Rundfeldt, C; Tipold, A, 2004) |
| " Sensitivity to phenobarbital and related anticonvulsants may induce life-threatening leukopenia, thrombocytopenia, and anemia in dogs." | 3.70 | Neutropenia and thrombocytopenia in three dogs treated with anticonvulsants. ( Calvert, C; Jacobs, G; Kaufman, A, 1998) |
| "The efficacy of phenobarbital and primidone against canine epilepsy was compared in a controlled study." | 3.67 | Therapeutic efficacy of phenobarbital and primidone in canine epilepsy: a comparison. ( Frey, HH; Löscher, W; Schwartz-Porsche, D, 1985) |
| "Fifteen dogs with idiopathic epilepsy were included in a 9-month clinical trial to determine the therapeutic serum concentrations of primidone and its active metabolites, phenobarbital and phenylethylmalonamide." | 3.66 | Therapeutic serum concentrations of primidone and its metabolites, phenobarbital and phenylethylmalonamide in epileptic dogs. ( Cunningham, JG; Haidukewych, D; Jensen, HA, 1983) |
| "A controlled clinical trial of the anti-epileptic efficacy and toxic side effects of diphenylsilanediol was conducted on 24 client-owned epileptic dogs." | 2.65 | Clinical evaluation of the new compound diphenylsilanediol for ani-epileptic efficacy and toxicity. ( Chandler, ML; Cunningham, JG; Ford, RB; Gifford, JA; Hulce, VD; LeVier, RR, 1981) |
| " When phenobarbital is used in combination with bromide, a reasonable therapeutic range for serum phenobarbital concentrations is 9 to 36 micrograms/ml, although in some dogs treated with bromide, phenobarbital can eventually be discontinued." | 1.30 | Therapeutic serum drug concentrations in epileptic dogs treated with potassium bromide alone or in combination with other anticonvulsants: 122 cases (1992-1996). ( Carrillo, J; Schwark, WS; Trepanier, LA; Van Schoick, A, 1998) |
| " Serum concentrations differed even with the same dosage among individual dogs." | 1.28 | [Effectiveness of bromide in therapy resistant epilepsy of dogs]. ( Jürgens, U; Schwartz-Porsche, D, 1991) |
| " Serum concentrations of phenobarbital were measured in all dogs before and after primidone therapy was initiated, to ensure that the primidone dosage achieved comparable or higher values when derived from primidone." | 1.27 | Efficacy of primidone in dogs with seizures unresponsive to phenobarbital. ( Farnbach, GC, 1984) |
| " The dosage of anticonvulsant drug was found to modify certain test results." | 1.27 | Compromised hepatic function in dogs treated with anticonvulsant drugs. ( Baldwin, BH; Bunch, SE; Hornbuckle, WE; Tennant, BC, 1984) |
| " Further, for dogs given phenobarbital, there was a sixfold variation between dosage and achieved serum concentration, whereas dogs given primidone manifested even greater variability between dosage and serum concentration." | 1.27 | Serum concentrations and efficacy of phenytoin, phenobarbital, and primidone in canine epilepsy. ( Farnbach, GC, 1984) |
| "Forty-seven dogs with a history of generalized recurrent seizures were treated with primidone at a daily oral dosage of 13 to 100 mg/kg of body weight, divided into 2 to 3 doses." | 1.26 | Treatment of canine epilepsy with primidone. ( Frey, HH; Löscher, W; Schwartz-Porsche, D, 1982) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 21 (80.77) | 18.7374 |
| 1990's | 4 (15.38) | 18.2507 |
| 2000's | 1 (3.85) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Löscher, W | 4 |
| Potschka, H | 1 |
| Rieck, S | 1 |
| Tipold, A | 1 |
| Rundfeldt, C | 1 |
| Farnbach, GC | 2 |
| Bunch, SE | 3 |
| Baldwin, BH | 2 |
| Hornbuckle, WE | 3 |
| Tennant, BC | 3 |
| Campbell, CL | 1 |
| Cunningham, JG | 2 |
| Haidukewych, D | 1 |
| Jensen, HA | 1 |
| Schulman, J | 1 |
| Holliday, TA | 1 |
| Ford, RB | 1 |
| Gifford, JA | 1 |
| Hulce, VD | 1 |
| Chandler, ML | 1 |
| LeVier, RR | 1 |
| Castleman, WL | 2 |
| Schwartz-Porsche, D | 4 |
| Frey, HH | 4 |
| Jacobs, G | 1 |
| Calvert, C | 1 |
| Kaufman, A | 1 |
| Trepanier, LA | 1 |
| Van Schoick, A | 1 |
| Schwark, WS | 1 |
| Carrillo, J | 1 |
| Osborne, CA | 1 |
| Lulich, JP | 1 |
| Bartges, JW | 1 |
| Ulrich, LK | 1 |
| Koehler, LA | 1 |
| Bird, KA | 1 |
| Swanson, LL | 1 |
| Austin, GW | 1 |
| Prien, EL | 1 |
| Steinam, KU | 1 |
| Higgins, G | 1 |
| Jürgens, U | 1 |
| Henricks, PM | 1 |
| Morton, DJ | 1 |
| Honhold, N | 1 |
| Shield, CF | 1 |
| Obe, G | 1 |
| Riedel, L | 1 |
| Barthel, A | 1 |
| Conway, MB | 1 |
| Center, SA | 1 |
| Poffenbarger, EM | 1 |
| Hardy, RM | 1 |
| Jennings, PB | 1 |
| Utter, WF | 1 |
| Fariss, BL | 1 |
3 reviews available for primidone and Canine Diseases
| Article | Year |
|---|---|
Seizure disorders.
Topics: Animals; Cat Diseases; Cats; Diagnosis, Differential; Diazepam; Dog Diseases; Dogs; Epilepsy; Mephob | 1980 |
Drug-induced urolithiasis.
Topics: Allopurinol; Animals; Anti-Bacterial Agents; Anti-Infective Agents; Anticonvulsants; Cat Diseases; C | 1999 |
Pharmacokinetics of anti-epileptic drugs in the dog: a review.
Topics: Animals; Anticonvulsants; Blood Proteins; Carbamazepine; Clonazepam; Diazepam; Dog Diseases; Dogs; E | 1985 |
1 trial available for primidone and Canine Diseases
| Article | Year |
|---|---|
Clinical evaluation of the new compound diphenylsilanediol for ani-epileptic efficacy and toxicity.
Topics: Animals; Anticonvulsants; Bone Marrow; Clinical Trials as Topic; Dog Diseases; Dogs; Epilepsy; Heart | 1981 |
22 other studies available for primidone and Canine Diseases
| Article | Year |
|---|---|
Anticonvulsant efficacy of the low-affinity partial benzodiazepine receptor agonist ELB 138 in a dog seizure model and in epileptic dogs with spontaneously recurrent seizures.
Topics: Animals; Anticonvulsants; Bromides; Chronic Disease; Disease Models, Animal; Dog Diseases; Dogs; Dru | 2004 |
Efficacy of primidone in dogs with seizures unresponsive to phenobarbital.
Topics: Animals; Dog Diseases; Dogs; Epilepsy; Female; Male; Phenobarbital; Primidone | 1984 |
Compromised hepatic function in dogs treated with anticonvulsant drugs.
Topics: Animals; Anticonvulsants; Dog Diseases; Dogs; Dose-Response Relationship, Drug; Drug Therapy, Combin | 1984 |
Serum concentrations and efficacy of phenytoin, phenobarbital, and primidone in canine epilepsy.
Topics: Animals; Dog Diseases; Dogs; Drug Therapy, Combination; Epilepsy; Phenobarbital; Phenytoin; Primidon | 1984 |
Primidone intoxication associated with concurrent use of chloramphenicol.
Topics: Animals; Chloramphenicol; Dog Diseases; Dogs; Drug Interactions; Male; Primidone | 1983 |
Therapeutic serum concentrations of primidone and its metabolites, phenobarbital and phenylethylmalonamide in epileptic dogs.
Topics: Animals; Dog Diseases; Dogs; Epilepsy; Malonates; Phenobarbital; Phenylethylmalonamide; Primidone | 1983 |
Epileptic seizures controlled with paramethadione/primidone.
Topics: Animals; Dog Diseases; Dogs; Drug Therapy, Combination; Epilepsy; Male; Oxazoles; Phenytoin; Primido | 1981 |
Hepatic cirrhosis associated with long-term anticonvulsant drug therapy in dogs.
Topics: Animals; Anticonvulsants; Dog Diseases; Dogs; Female; Liver; Liver Cirrhosis; Male; Microscopy, Elec | 1982 |
Treatment of canine epilepsy with primidone.
Topics: Administration, Oral; Animals; Dog Diseases; Dogs; Epilepsy; Female; Male; Primidone | 1982 |
Neutropenia and thrombocytopenia in three dogs treated with anticonvulsants.
Topics: Anemia; Animals; Anticonvulsants; Bacteremia; Blood Cell Count; Dog Diseases; Dogs; Female; Male; Ne | 1998 |
Therapeutic serum drug concentrations in epileptic dogs treated with potassium bromide alone or in combination with other anticonvulsants: 122 cases (1992-1996).
Topics: Animals; Anticonvulsants; Bromides; Dog Diseases; Dogs; Drug Therapy, Combination; Epilepsy; Follow- | 1998 |
Treatment of epilepsy in the working dog.
Topics: Animals; Dog Diseases; Dogs; Epilepsy; Female; Primidone | 1977 |
[Effectiveness of bromide in therapy resistant epilepsy of dogs].
Topics: Animals; Bromides; Dog Diseases; Dogs; Dose-Response Relationship, Drug; Drug Resistance; Epilepsy; | 1991 |
Dermatitis associated with the use of primidone in a dog.
Topics: Animals; Dog Diseases; Dogs; Drug Eruptions; Female; Primidone; Seizures | 1987 |
Use of anticonvulsants in small animals.
Topics: Animals; Anticonvulsants; Cat Diseases; Cats; Dog Diseases; Dogs; Epilepsy; Epilepsy, Tonic-Clonic; | 1986 |
Effectiveness of a therapeutic drug monitoring service as an aid to the control of canine seizures.
Topics: Animals; Dog Diseases; Dogs; Epilepsy; Female; Male; Phenobarbital; Primidone | 1988 |
Unusual drug reaction.
Topics: Animals; Ataxia; Dog Diseases; Dogs; Female; Primidone | 1987 |
[Cytogenetic analysis of lymphocytes from epileptic dogs].
Topics: Animals; Anticonvulsants; Chromosome Aberrations; Dog Diseases; Dogs; Epilepsy; Lymphocytes; Phenoba | 1987 |
Toxic hepatopathy and intrahepatic cholestasis associated with phenytoin administration in combination with other anticonvulsant drugs in three dogs.
Topics: Animals; Anticonvulsants; Chemical and Drug Induced Liver Injury; Cholestasis, Intrahepatic; Dog Dis | 1987 |
Hepatic cirrhosis associated with long-term primidone therapy in a dog.
Topics: Animals; Dog Diseases; Dogs; Female; Liver; Liver Cirrhosis; Primidone; Time Factors | 1985 |
Therapeutic efficacy of phenobarbital and primidone in canine epilepsy: a comparison.
Topics: Animals; Dog Diseases; Dogs; Epilepsy; Phenobarbital; Primidone | 1985 |
Effects of long-term primidone therapy in a dog.
Topics: Alkaline Phosphatase; Animals; Ataxia; Dog Diseases; Dogs; Estrus; Feeding and Eating Disorders; Fem | 1974 |