primidone and Ataxia
primidone has been researched along with Ataxia in 10 studies
Primidone: A barbiturate derivative that acts as a GABA modulator and anti-epileptic agent. It is partly metabolized to PHENOBARBITAL in the body and owes some of its actions to this metabolite.
primidone : A pyrimidone that is dihydropyrimidine-4,6(1H,5H)-dione substituted by an ethyl and a phenyl group at position 5. It is used as an anticonvulsant for treatment of various types of seizures.
Ataxia: Impairment of the ability to perform smoothly coordinated voluntary movements. This condition may affect the limbs, trunk, eyes, pharynx, larynx, and other structures. Ataxia may result from impaired sensory or motor function. Sensory ataxia may result from posterior column injury or PERIPHERAL NERVE DISEASES. Motor ataxia may be associated with CEREBELLAR DISEASES; CEREBRAL CORTEX diseases; THALAMIC DISEASES; BASAL GANGLIA DISEASES; injury to the RED NUCLEUS; and other conditions.
Research Excerpts
| Excerpt | Relevance | Reference |
|---|---|---|
| "Uncontrolled clinical studies have suggested that primidone may be effective in reducing essential tremor thus providing a valuable alternative to beta-adrenoreceptor antagonists which are currently the drugs of first choice." | 9.05 | Primidone in essential tremor of the hands and head: a double blind controlled clinical study. ( Calzetti, S; Cleeves, L; Findley, LJ, 1985) |
| "Uncontrolled clinical studies have suggested that primidone may be effective in reducing essential tremor thus providing a valuable alternative to beta-adrenoreceptor antagonists which are currently the drugs of first choice." | 5.05 | Primidone in essential tremor of the hands and head: a double blind controlled clinical study. ( Calzetti, S; Cleeves, L; Findley, LJ, 1985) |
| "Two patients with intractable epilepsy who had been treated with various combinations of anticonvulsant drugs developed phenytoin encephalopathy." | 3.65 | Choreo-athetosis and encephalopathy induced by phenytoin. ( McLellan, DL; Swash, M, 1974) |
Research
Studies (10)
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 10 (100.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
Authors
| Authors | Studies |
|---|---|
| DAVIS, MA | 1 |
| WINTHROP, SO | 1 |
| THOMAS, RA | 1 |
| HERR, F | 1 |
| CHAREST, MP | 1 |
| GAUDRY, R | 1 |
| KOKENGE, R | 1 |
| KUTT, H | 1 |
| MCDOWELL, F | 1 |
| Turner, CR | 1 |
| Shield, CF | 1 |
| Findley, LJ | 1 |
| Cleeves, L | 1 |
| Calzetti, S | 1 |
| McLellan, DL | 1 |
| Swash, M | 1 |
| Jennings, PB | 1 |
| Utter, WF | 1 |
| Fariss, BL | 1 |
| Gallagher, BB | 1 |
| Baumel, IP | 1 |
| Mattson, RH | 1 |
| Woodbury, SG | 1 |
| Viukari, NM | 1 |
| Garrettson, LK | 1 |
| Perel, JM | 1 |
| Dayton, PG | 1 |
Trials
1 trial available for primidone and Ataxia
| Article | Year |
|---|---|
Primidone in essential tremor of the hands and head: a double blind controlled clinical study.
Topics: Adolescent; Adult; Aged; Ataxia; Clinical Trials as Topic; Double-Blind Method; Female; Hand; Head; | 1985 |
Other Studies
9 other studies available for primidone and Ataxia
| Article | Year |
|---|---|
ANTICONVULSANTS. I. DIBENZO(A,D)CYCLOHEPTADIENE-5-CARBOXAMIDE AND RELATED COMPOUNDS.
Topics: Amides; Anticonvulsants; Ataxia; Chemistry, Pharmaceutical; Mice; Pentylenetetrazole; Pharmacology; | 1964 |
NEUROLOGICAL SEQUELAE FOLLOWING DILANTIN OVERDOSE IN A PATIENT AND IN EXPERIMENTAL ANIMALS.
Topics: Adolescent; Ataxia; Biomedical Research; Cats; Chlordiazepoxide; Drug Therapy; Epilepsy; Humans; Neu | 1965 |
Primidone intoxication and massive crystalluria.
Topics: Ataxia; Child; Crystallization; Female; Humans; Primidone | 1980 |
Unusual drug reaction.
Topics: Animals; Ataxia; Dog Diseases; Dogs; Female; Primidone | 1987 |
Choreo-athetosis and encephalopathy induced by phenytoin.
Topics: Adolescent; Adult; Ataxia; Athetosis; Carbamazepine; Chorea; Diplopia; Electroencephalography; Epile | 1974 |
Effects of long-term primidone therapy in a dog.
Topics: Alkaline Phosphatase; Animals; Ataxia; Dog Diseases; Dogs; Estrus; Feeding and Eating Disorders; Fem | 1974 |
Primidone, diphenylhydantoin and phenobarbital. Aspects of acute and chronic toxicity.
Topics: Ataxia; Chromatography, Gas; Drug Tolerance; Epilepsy; Humans; Nystagmus, Pathologic; Phenobarbital; | 1973 |
Intolerance to diphenylhydantoin in five cases of Vogt-Spielmeyer disease.
Topics: Ataxia; Brain; Humans; L-Lactate Dehydrogenase; Lipidoses; Phenobarbital; Phenytoin; Primidone; Seiz | 1969 |
Methylphenidate interaction with both anticonvulsants and ethyl biscoumacetate.
Topics: Adult; Anticonvulsants; Ataxia; Brain Diseases; Child, Preschool; Depression, Chemical; Ethyl Biscou | 1969 |