primidone has been researched along with Aging in 6 studies
Primidone: A barbiturate derivative that acts as a GABA modulator and anti-epileptic agent. It is partly metabolized to PHENOBARBITAL in the body and owes some of its actions to this metabolite.
primidone : A pyrimidone that is dihydropyrimidine-4,6(1H,5H)-dione substituted by an ethyl and a phenyl group at position 5. It is used as an anticonvulsant for treatment of various types of seizures.
Aging: The gradual irreversible changes in structure and function of an organism that occur as a result of the passage of time.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Phenobarbitone (PB) and primidone (PRM) plasma concentrations were measured in 88 patients of both sexes with different types of epilepsy and treated with PRM, alone or in association with carbamazepine (CBZ), phenytoin (PHT), ethosuximide (ESM) or valproic acid (VPA)." | 7.66 | PB:PRM ratio in patients with epilepsy treated with primidone. ( Altamura, AC; Bianchi, M; Canger, R; Cornaggia, CM; Polana, P; Pruneri, C, 1983) |
| "Phenobarbitone (PB) and primidone (PRM) plasma concentrations were measured in 88 patients of both sexes with different types of epilepsy and treated with PRM, alone or in association with carbamazepine (CBZ), phenytoin (PHT), ethosuximide (ESM) or valproic acid (VPA)." | 3.66 | PB:PRM ratio in patients with epilepsy treated with primidone. ( Altamura, AC; Bianchi, M; Canger, R; Cornaggia, CM; Polana, P; Pruneri, C, 1983) |
| "Anticonvulsant therapy was among the first areas to benefit from clinical pharmacokinetic studies." | 2.35 | Clinical pharmacokinetics of anticonvulsants. ( Dam, M; Hvidberg, EF, 1976) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 3 (50.00) | 18.7374 |
| 1990's | 2 (33.33) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 1 (16.67) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Schwindt, G | 1 |
| Rezmovitz, J | 1 |
| Cornaggia, CM | 1 |
| Altamura, AC | 1 |
| Bianchi, M | 1 |
| Canger, R | 1 |
| Polana, P | 1 |
| Pruneri, C | 1 |
| Morselli, PL | 1 |
| Franco-Morselli, R | 1 |
| Hvidberg, EF | 1 |
| Dam, M | 1 |
| Lou, JS | 1 |
| Jankovic, J | 1 |
| Martines, C | 1 |
| Gatti, G | 1 |
| Sasso, E | 1 |
| Calzetti, S | 1 |
| Perucca, E | 1 |
2 reviews available for primidone and Aging
| Article | Year |
|---|---|
Clinical pharmacokinetics of antiepileptic drugs in adults.
Topics: Adult; Aging; Anticonvulsants; Carbamazepine; Clonazepam; Diazepam; Disease; Ethosuximide; Female; H | 1980 |
Clinical pharmacokinetics of anticonvulsants.
Topics: Administration, Oral; Adult; Aged; Aging; Animals; Anticonvulsants; Carbamazepine; Child; Clonazepam | 1976 |
4 other studies available for primidone and Aging
| Article | Year |
|---|---|
Essential tremor.
Topics: Adrenergic beta-Antagonists; Aging; Essential Tremor; Humans; Primidone | 2017 |
PB:PRM ratio in patients with epilepsy treated with primidone.
Topics: Adolescent; Adult; Aging; Child; Epilepsy; Female; Humans; Male; Middle Aged; Phenobarbital; Primido | 1983 |
Essential tremor: clinical correlates in 350 patients.
Topics: Adult; Aged; Aging; Alcohol Drinking; Female; Humans; Male; Middle Aged; Movement Disorders; Primido | 1991 |
The disposition of primidone in elderly patients.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Aging; Biotransformation; Chromatography, High Pressure | 1990 |