primidone has been researched along with Absence Seizure in 101 studies
Primidone: A barbiturate derivative that acts as a GABA modulator and anti-epileptic agent. It is partly metabolized to PHENOBARBITAL in the body and owes some of its actions to this metabolite.
primidone : A pyrimidone that is dihydropyrimidine-4,6(1H,5H)-dione substituted by an ethyl and a phenyl group at position 5. It is used as an anticonvulsant for treatment of various types of seizures.
| Excerpt | Relevance | Reference |
|---|---|---|
| "In the present study, the new low-affinity partial BZD-receptor agonist ELB 138 [former name AWD 131-138; 1-(4-chlorophenyl)-4-morpholino-imidazolin-2-one] was evaluated in a dog seizure model and in epileptic dogs with spontaneously recurrent seizures." | 3.72 | Anticonvulsant efficacy of the low-affinity partial benzodiazepine receptor agonist ELB 138 in a dog seizure model and in epileptic dogs with spontaneously recurrent seizures. ( Löscher, W; Potschka, H; Rieck, S; Rundfeldt, C; Tipold, A, 2004) |
| " Sensitivity to phenobarbital and related anticonvulsants may induce life-threatening leukopenia, thrombocytopenia, and anemia in dogs." | 3.70 | Neutropenia and thrombocytopenia in three dogs treated with anticonvulsants. ( Calvert, C; Jacobs, G; Kaufman, A, 1998) |
| "The anticonvulsant effect of primidone was determined in gerbils, in which seizures were elicited by a blast of compressed air, over the time range of 30 min to 18 h after oral administration." | 3.67 | Anticonvulsant effect of primidone in the gerbil. Time course and significance of the active metabolites. ( Frey, HH; Löscher, W; Reiche, R; Schultz, D, 1984) |
| "We studied 21 patients with complex partial seizures during phenobarbital (PB) or primidone withdrawal." | 3.67 | Seizures during barbiturate withdrawal: relation to blood level. ( Porter, RJ; Raubertas, RF; Theodore, WH, 1987) |
| "Neurotoxicity and protection against maximal electroshock and Metrazol seizures from primidone (PRM), phenobarbital (PB), and phenylethylmalonamide (PEMA) were determined in mice for each drug separately and expressed in terms of brain concentrations." | 3.66 | Primidone, phenobarbital, and PEMA: I. Seizure protection, neurotoxicity, and therapeutic index of individual compounds in mice. ( Bourgeois, BF; Dodson, WE; Ferrendelli, JA, 1983) |
| "Neurotoxicity and protection against maximal electroshock (MES) and pentylenetrazol (Metrazol) seizures were determined in mice for various combinations of primidone (PRM), phenobarbital (PB), and phenylethylmalonamide (PEMA)." | 3.66 | Primidone, phenobarbital, and PEMA: II. Seizure protection, neurotoxicity, and therapeutic index of varying combinations in mice. ( Bourgeois, BF; Dodson, WE; Ferrendelli, JA, 1983) |
| "The therapeutics results with the use of different drugs (diazepam, nitrazepam, clonazepam, diphenylhydantoin, barbiturates--phenobarbital and primidone--, sodium dipropylacetate and ACTH) in twenty-nine patients with Lennox--Gastaut syndrome are carefully analysed." | 3.65 | [Effect of drugs on electroclinical types of epileptic seizures in Lennox-Gastaut syndrome]. ( Lison, MP; Speciali, GG, 1977) |
| "Senegalese baboons (Papio papio), with a natural syndrome of photosensitive epilepsy, consistently show generalized myoclonic jerks if stimulated stroboscopically at hourly intervals, two to eight hours after the intravenous administration of allylglycine, 200 mg/kg." | 3.65 | A primate model for testing anticonvulsant drugs. ( Horton, RW; Meldrum, BS; Toseland, PA, 1975) |
| "In two children treated for hypoglycemia and convulsions with diazoxide and diphenylhydantoin, therapeutic serum diphenylhydantoin levels were not achieved despite doses of diphenylhydantoin of 17 and 29 mg/kg/day, respectively." | 3.65 | Drug interaction: diazoxide and diphenylhydantoin. ( Blaskovics, ME; Podosin, RL; Roe, TF, 1975) |
| " To test the validity of this primate model, the effects of diphenylhydantoin (DPH), phenobarbital, and primidone on spontaneous seizures evaluated for 8 months with a Latin-Squar experimental design." | 3.65 | Efficacy of standard anticonvulsants in monkey model with spontaneous motor seizures. ( DuCharme, LL; Farquhar, JA; Huntsman, BJ; Lockard, JS; Uhlir, V, 1975) |
| " Phenobarbital is usually given as well to prevent grand mal seizures." | 3.64 | Treatment of epilepsy. ( BAILEY, AA, 1963) |
| "Patients, aged 8-58 years, with partial epilepsy who did not become seizure free on CBZ were randomized to either VPA add-on or PRM add-on." | 2.74 | Comparison of add-on valproate and primidone in carbamazepine-unresponsive patients with partial epilepsy. ( Deckers, CL; Liu, YX; Sun, MZ; Wang, W, 2009) |
| "The most important factor determining seizure recurrence was continued therapy, which was the case for barbiturates, phenytoin and valproate." | 2.69 | Does withdrawal of different antiepileptic drugs have different effects on seizure recurrence? Further results from the MRC Antiepileptic Drug Withdrawal Study. ( Chadwick, D, 1999) |
| "The recurrence rate of febrile convulsions is assessed in 108 children who had had either prolonged or repeated initial fits or had both a positive family history and persisting neurological disorder." | 2.64 | Continuous phrophylcatic anticonvulsants in selected childrens with febrile convulsions. ( Wallace, SJ, 1975) |
| "Successful control of seizures with anticonvulsant drugs reflects a balance in achieving seizure control while minimizing undesirable drug side effects." | 2.40 | Anticonvulsant therapy in small animals. ( Boothe, DM, 1998) |
| "This seizure-like swimming pattern was alleviated by the addition of either pyridoxal-5'-phosphate (PLP) or GABA and responded quickly to the anti-convulsing activity of gabapentin and phenytoin, two commonly prescribed anti-epileptic drugs (AEDs)." | 1.38 | Zebrafish larvae exposed to ginkgotoxin exhibit seizure-like behavior that is relieved by pyridoxal-5'-phosphate, GABA and anti-epileptic drugs. ( Chang, WN; Du, HC; Fu, TF; Hsiao, TH; Kao, TT; Lee, GH; Safo, MK; Sung, SY, 2012) |
| "A high seizure frequency before tapering was related to good outcome, while seizure freedom and a history of failed withdrawal were associated with deterioration/failure." | 1.35 | Ambiguous results of an attempt to withdraw barbiturates in epilepsy patients with intellectual disability. ( Bocchicchio, M; Hauser, I; Horstmann, V; Huber, B; Jokeit, G; May, T; Meinert, T; Robertson, E; Schorlemmer, H; Schulz, L; Seidel, M; Wagner, W, 2009) |
| "There was a greater risk of recurrence among girls." | 1.28 | [Factors influencing the effectiveness of preventive treatment of febrile convulsions]. ( Armijo Simón, JA; Arteaga Manjón-Cabeza, R; Herranz Fernández, JL, 1989) |
| " The dosage of anticonvulsant drug was found to modify certain test results." | 1.27 | Compromised hepatic function in dogs treated with anticonvulsant drugs. ( Baldwin, BH; Bunch, SE; Hornbuckle, WE; Tennant, BC, 1984) |
| "Prominal reduced the severity of convulsions in pp'DDT-treated animals." | 1.26 | A possible neurochemical basis of the central stimulatory effects of pp'DDT. ( Jaffery, FN; Matin, MA; Siddiqui, RA, 1981) |
| "In a certain percentage of patients seizures are abolished or diminish in frequency only on attaining such a serum level." | 1.26 | [The serum concentration of anticonvulsants -- pharmacokinetic findings and practical therapeutic applications (author's transl)]. ( Deisenhammer, E; Sommer, R, 1979) |
| " The half-life of PB is twice that of PRM and PEMA." | 1.26 | Single-dose pharmacokinetics and anticonvulsant efficacy of primidone in mice. ( Friel, PN; Leal, KW; Rapport, RL; Wilensky, AJ, 1979) |
| "Successful treatment of partial complex seizures (and the epilepsies in general) is a process of management over time and involves several factors." | 1.25 | Management of the difficult patient with complex partial seizures. ( Booker, HE, 1975) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 89 (88.12) | 18.7374 |
| 1990's | 6 (5.94) | 18.2507 |
| 2000's | 5 (4.95) | 29.6817 |
| 2010's | 1 (0.99) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Wolfe, JF | 1 |
| Rathman, TL | 1 |
| Sleevi, MC | 1 |
| Campbell, JA | 1 |
| Greenwood, TD | 1 |
| Sun, MZ | 1 |
| Deckers, CL | 1 |
| Liu, YX | 1 |
| Wang, W | 1 |
| Huber, B | 1 |
| Bocchicchio, M | 1 |
| Hauser, I | 1 |
| Horstmann, V | 1 |
| Jokeit, G | 1 |
| May, T | 1 |
| Meinert, T | 1 |
| Robertson, E | 1 |
| Schorlemmer, H | 1 |
| Schulz, L | 1 |
| Wagner, W | 1 |
| Seidel, M | 1 |
| Galimberti, CA | 1 |
| Ossola, M | 1 |
| Colnaghi, S | 1 |
| Arbasino, C | 1 |
| Lee, GH | 1 |
| Sung, SY | 1 |
| Chang, WN | 1 |
| Kao, TT | 1 |
| Du, HC | 1 |
| Hsiao, TH | 1 |
| Safo, MK | 1 |
| Fu, TF | 1 |
| BONKALO, A | 1 |
| ARTHURS, RG | 1 |
| BOGUE, JY | 1 |
| CARRINGTON, HC | 1 |
| NATHAN, PW | 1 |
| SCIARRA, D | 1 |
| CARTER, S | 1 |
| VICALE, CT | 1 |
| MERRITT, HH | 1 |
| RUDOLF G DE, M | 1 |
| BAILEY, AA | 1 |
| MILLICHAP, JG | 4 |
| JONES, JD | 1 |
| RUDIS, BP | 1 |
| GIBBS, FA | 1 |
| RICH, CL | 1 |
| GIBBS, EL | 1 |
| SATOMI, M | 1 |
| WHITTY, CW | 1 |
| LISHMAN, WA | 1 |
| FITZGIBBON, JP | 1 |
| JONGMANS, JW | 1 |
| MEYER, HJ | 1 |
| MEYER-BURG, J | 1 |
| LORGE, M | 1 |
| DAVIS, MA | 1 |
| WINTHROP, SO | 1 |
| THOMAS, RA | 1 |
| HERR, F | 1 |
| CHAREST, MP | 1 |
| GAUDRY, R | 1 |
| CRAIG, WS | 1 |
| MACKINNON, JM | 1 |
| ZAKHARIIA, EA | 1 |
| ZAPADNIUK, VI | 1 |
| Pestaner, JP | 1 |
| Löscher, W | 4 |
| Potschka, H | 1 |
| Rieck, S | 1 |
| Tipold, A | 1 |
| Rundfeldt, C | 1 |
| Wilder, BJ | 1 |
| Bruni, J | 1 |
| Höller, M | 1 |
| Breuer, H | 1 |
| Fleischhauer, K | 1 |
| Smith, DB | 2 |
| Delgado Escueta, AV | 2 |
| Cramer, JA | 2 |
| Mattson, RH | 2 |
| Mancall, EL | 1 |
| Covington, TR | 1 |
| Alonso, RJ | 1 |
| Collier, HW | 1 |
| Engelking, K | 1 |
| Powell, C | 1 |
| Painter, MJ | 1 |
| Pippenger, CE | 2 |
| Bourgeois, BF | 2 |
| Dodson, WE | 2 |
| Ferrendelli, JA | 2 |
| Collins, JF | 1 |
| Bunch, SE | 2 |
| Baldwin, BH | 2 |
| Hornbuckle, WE | 2 |
| Tennant, BC | 2 |
| Frey, HH | 1 |
| Reiche, R | 1 |
| Schultz, D | 1 |
| Leppik, IE | 2 |
| Cloyd, JC | 2 |
| Miller, K | 1 |
| Aminoff, MJ | 1 |
| Lockard, JS | 2 |
| Levy, RH | 1 |
| DuCharme, LL | 2 |
| Congdon, WC | 1 |
| Holliday, TA | 1 |
| Matin, MA | 2 |
| Jaffery, FN | 1 |
| Siddiqui, RA | 1 |
| DeSilvey, DL | 1 |
| Moss, AJ | 1 |
| Miller, KW | 1 |
| Jacobs, G | 1 |
| Calvert, C | 1 |
| Kaufman, A | 1 |
| Boothe, DM | 1 |
| Chadwick, D | 1 |
| Smith, RF | 1 |
| Speciali, GG | 1 |
| Lison, MP | 1 |
| Meldrum, BS | 1 |
| Horton, RW | 1 |
| Toseland, PA | 1 |
| Oxley, J | 1 |
| Hebdige, S | 1 |
| Richens, A | 1 |
| Johnson, DD | 1 |
| Davis, HL | 1 |
| Crawford, RD | 1 |
| Deisenhammer, E | 1 |
| Sommer, R | 1 |
| May, CJ | 1 |
| Greenwood, RE | 1 |
| Leal, KW | 1 |
| Rapport, RL | 1 |
| Wilensky, AJ | 1 |
| Friel, PN | 1 |
| Tomasi, LG | 1 |
| Wallace, SJ | 1 |
| Roe, TF | 1 |
| Podosin, RL | 1 |
| Blaskovics, ME | 1 |
| Uhlir, V | 1 |
| Farquhar, JA | 1 |
| Huntsman, BJ | 1 |
| Booker, HE | 1 |
| Nolting, B | 1 |
| Fassbender, CP | 1 |
| Herranz Fernández, JL | 1 |
| Armijo Simón, JA | 1 |
| Arteaga Manjón-Cabeza, R | 1 |
| Hönack, D | 1 |
| Henricks, PM | 1 |
| Carl, GF | 1 |
| Smith, ML | 1 |
| Theodore, WH | 1 |
| Porter, RJ | 1 |
| Raubertas, RF | 1 |
| Wyllie, E | 1 |
| Rothner, AD | 1 |
| Conway, MB | 1 |
| Center, SA | 1 |
| Castleman, WL | 1 |
| Chiosa, L | 1 |
| Dumitrescu, S | 1 |
| Manolescu, A | 1 |
| Nicolescu-Catargi, A | 1 |
| Reynolds, EH | 2 |
| Kar, PP | 1 |
| Forman, PM | 1 |
| Alberti, G | 1 |
| De Toma, M | 1 |
| Cottini, R | 1 |
| Freeman, JM | 1 |
| Lietman, PS | 1 |
| Stille, G | 1 |
| Sayers, A | 1 |
| Rümke, CL | 1 |
| Saad, SF | 1 |
| Göres, E | 1 |
| Kurze, G | 1 |
| Oehme, P | 1 |
| Norton, PR | 1 |
| Kutt, H | 1 |
| Louis, S | 1 |
| Parker, WA | 1 |
| Cavazzuti, GB | 1 |
| Phan, DV | 1 |
| Bite, A | 1 |
| György, L | 1 |
| Jennings, PB | 1 |
| Utter, WF | 1 |
| Fariss, BL | 1 |
| Gregoriades, AD | 1 |
| Cooper, IS | 1 |
| Crighel, E | 1 |
| Amin, I | 1 |
| Izquierdo, I | 1 |
| Orsingher, OA | 1 |
| Berardi, AC | 1 |
| Baumel, IP | 1 |
| Gallagher, BB | 1 |
| DiMicco, J | 1 |
| Goico, H | 1 |
| Wilson, JT | 1 |
| Wilkinson, GR | 1 |
| Lifshitz, F | 1 |
| Maclaren, NK | 1 |
| Martinez, G | 1 |
| Snyder, RD | 1 |
| Medlinsky, HL | 1 |
| Borgstedt, AD | 1 |
| Bryson, MF | 1 |
| Young, LW | 1 |
| Forbes, GB | 1 |
| Chanarin, I | 1 |
| Milner, G | 1 |
| Matthews, DM | 1 |
| Viukari, NM | 1 |
| Schreiber, MM | 1 |
| McGregor, JG | 1 |
| Williamson, DA | 1 |
| Lou, HO | 1 |
| Haneke, K | 1 |
7 reviews available for primidone and Absence Seizure
| Article | Year |
|---|---|
Seizure disorders.
Topics: Animals; Cat Diseases; Cats; Diagnosis, Differential; Diazepam; Dog Diseases; Dogs; Epilepsy; Mephob | 1980 |
Anticonvulsant therapy in small animals.
Topics: Acetates; Amines; Animals; Anticonvulsants; Bromides; Clonazepam; Clorazepate Dipotassium; Cyclohexa | 1998 |
Pharmacological and biochemical studies in epileptic fowl.
Topics: Animals; Anticonvulsants; Benzodiazepinones; Brain; Chickens; Disease Models, Animal; Ethosuximide; | 1979 |
Anticonvulsants, folic acid, and epilepsy.
Topics: Anemia, Macrocytic; Animals; Anticonvulsants; Blood-Brain Barrier; Chemical Phenomena; Chemistry; Ep | 1973 |
Relation of laboratory evaluation to clinical effectiveness of antiepileptic drugs.
Topics: Acetazolamide; Adrenocorticotropic Hormone; Animals; Anticonvulsants; Benzazepines; Clinical Trials | 1969 |
A basic approach to the understanding of seizures and the mechanism of action and metabolism of anticonvulsants.
Topics: Acetylcholine; Aminobutyrates; Anticonvulsants; Calcium; Cell Membrane Permeability; Depression, Che | 1973 |
Cerebrospinal folate levels in epileptics and their response to folate therapy.
Topics: Anticonvulsants; Blood-Brain Barrier; Clinical Trials as Topic; Epilepsy; Folic Acid; Folic Acid Def | 1974 |
9 trials available for primidone and Absence Seizure
| Article | Year |
|---|---|
Comparison of add-on valproate and primidone in carbamazepine-unresponsive patients with partial epilepsy.
Topics: Adolescent; Adult; Anticonvulsants; Carbamazepine; Child; Drug Therapy, Combination; Epilepsies, Par | 2009 |
Historical perspective on the choice of antiepileptic drugs for the treatment of seizures in adults.
Topics: Adult; Anticonvulsants; Carbamazepine; Clinical Trials as Topic; Epilepsy; History, 20th Century; Hu | 1983 |
Does withdrawal of different antiepileptic drugs have different effects on seizure recurrence? Further results from the MRC Antiepileptic Drug Withdrawal Study.
Topics: Adolescent; Adult; Anticonvulsants; Carbamazepine; Child; Drug Combinations; Epilepsy; Female; Human | 1999 |
A comparison of phenobarbitone and primidone in the control of seizures in chronic epilepsy [proceedings].
Topics: Adult; Aged; Chronic Disease; Clinical Trials as Topic; Epilepsy; Humans; Middle Aged; Phenobarbital | 1979 |
Continuous phrophylcatic anticonvulsants in selected childrens with febrile convulsions.
Topics: Child; Child, Preschool; Clinical Trials as Topic; Female; Fever; Follow-Up Studies; Humans; Infant; | 1975 |
The role of data audits in detecting scientific misconduct.
Topics: Anticonvulsants; Biomedical Research; Brain Diseases; Child; Clinical Trials as Topic; Drug Evaluati | 1990 |
Relation of laboratory evaluation to clinical effectiveness of antiepileptic drugs.
Topics: Acetazolamide; Adrenocorticotropic Hormone; Animals; Anticonvulsants; Benzazepines; Clinical Trials | 1969 |
Cerebrospinal folate levels in epileptics and their response to folate therapy.
Topics: Anticonvulsants; Blood-Brain Barrier; Clinical Trials as Topic; Epilepsy; Folic Acid; Folic Acid Def | 1974 |
Oxazepam in the treatment of psychomotor epilepsy.
Topics: Adolescent; Adult; Age Factors; Child; Child, Preschool; Electroencephalography; Epilepsy, Temporal | 1968 |
87 other studies available for primidone and Absence Seizure
| Article | Year |
|---|---|
Synthesis and anticonvulsant activity of some new 2-substituted 3-aryl-4(3H)-quinazolinones.
Topics: Animals; Anticonvulsants; Bicuculline; Chemical Phenomena; Chemistry; Drug Evaluation, Preclinical; | 1990 |
Ambiguous results of an attempt to withdraw barbiturates in epilepsy patients with intellectual disability.
Topics: Anticonvulsants; Barbiturates; Cognition; Drug Therapy, Combination; Epilepsy; Humans; Intellectual | 2009 |
Focal epileptic seizures mimicking sleep paralysis.
Topics: Anticonvulsants; Carbamazepine; Diagnosis, Differential; Electroencephalography; Epilepsies, Partial | 2009 |
Zebrafish larvae exposed to ginkgotoxin exhibit seizure-like behavior that is relieved by pyridoxal-5'-phosphate, GABA and anti-epileptic drugs.
Topics: Animals; Anticonvulsants; Behavior, Animal; Carbon; Folic Acid; gamma-Aminobutyric Acid; Larva; Mode | 2012 |
Mysoline in treatment of epileptic and non-epileptic psychiatric patients.
Topics: Epilepsy; Humans; Mental Disorders; Primidone; Psychosurgery; Psychotherapy; Pyrimidines; Seizures | 1953 |
The evaluation of "mysoline," a new anticonvulsant drug.
Topics: Anticonvulsants; Hydantoins; Primidone; Seizures | 1953 |
Primidone in the treatment of non-idiopathic epilepsy.
Topics: Anticonvulsants; Epilepsy; Humans; Primidone; Seizures | 1954 |
Clinical evaluation of primidone (Mysoline), new anticonvulsant drug.
Topics: Anticonvulsants; Humans; Primidone; Seizures | 1954 |
Effect of primidone (mysoline) on grand mal attacks.
Topics: Animals; Anticonvulsants; Behavior, Animal; Epilepsy; Epilepsy, Tonic-Clonic; Primidone; Seizures | 1955 |
Treatment of epilepsy.
Topics: Acetazolamide; Anticonvulsants; Automatism; Child; Epilepsy; Epilepsy, Absence; Epilepsy, Tonic-Clon | 1963 |
MECHANISM OF ANTICONVULSANT ACTION OF KETOGENIC DIET. STUDIES IN ANIMALS WITH EXPERIMENTAL SEIZURES AND IN CHILDREN WITH PETIT MAL EPILEPSY.
Topics: Acetazolamide; Acid-Base Equilibrium; Acidosis; Adolescent; Anticonvulsants; Barbiturates; Biomedica | 1964 |
PSYCHOMOTOR VARIANT TYPE OF SEIZURE DISCHARGE.
Topics: Adolescent; Anticonvulsants; Child; Electroencephalography; Epilepsy; Epilepsy, Absence; Epilepsy, T | 1963 |
[CONVULSIONS IN CHILDREN (3)].
Topics: Adolescent; Adrenocorticotropic Hormone; Anticonvulsants; Barbiturates; Bromides; Child; Electroence | 1964 |
SEIZURES INDUCED BY MOVEMENT: A FORM OF REFLEX EPILEPSY.
Topics: Adolescent; Athetosis; Cerebral Angiography; Diagnosis, Differential; Electroencephalography; Epilep | 1964 |
REPORT ON THE ANTI-EPILEPTIC ACTION OF TEGRETOL.
Topics: Acetazolamide; Adolescent; Anticonvulsants; Biomedical Research; Carbamazepine; Child; Chlordiazepox | 1964 |
[INHIBITION OF ELECTROCONVULSION BY THE KAVA-PYRONES DIHYDROMETHYSTICIN AND DIHYDROKAVAIN].
Topics: Anticonvulsants; Chlorpromazine; Kava; Mice; Pharmacology; Phenobarbital; Phenytoin; Primidone; Pyro | 1964 |
[THE PROSTRATION SYNDROME. SERIOUS DANGER OF DRUG THERAPY IN EPILEPSY].
Topics: Adolescent; Anticonvulsants; Chlorpromazine; Down Syndrome; Drug Therapy; Electroencephalography; Ep | 1964 |
ANTICONVULSANTS. I. DIBENZO(A,D)CYCLOHEPTADIENE-5-CARBOXAMIDE AND RELATED COMPOUNDS.
Topics: Amides; Anticonvulsants; Ataxia; Chemistry, Pharmaceutical; Mice; Pentylenetetrazole; Pharmacology; | 1964 |
CHILD CARE IN GENERAL PRACTICE. CONVULSIONS IN INFANCY AND CHILDHOOD. II.
Topics: Acetazolamide; Anticonvulsants; Bromides; Child; Child Care; Chloral Hydrate; Diagnosis; Drug Therap | 1965 |
[THE REPRODUCTION OF AUDIOGENIC CONVULSIONS AFTER THE PRELIMINARY ADMINISTRATION OF PYRAMIDONE TO ANIMALS].
Topics: Acetazolamide; Aminopyrine; Anticonvulsants; Antipyrine; Epilepsy, Reflex; Mice; Pharmacology; Pheno | 1964 |
Fatal mix-up between prednisone and primidone.
Topics: Anticonvulsants; Child; Fatal Outcome; Glucocorticoids; Humans; Hyperglycemia; Male; Medication Erro | 2004 |
Anticonvulsant efficacy of the low-affinity partial benzodiazepine receptor agonist ELB 138 in a dog seizure model and in epileptic dogs with spontaneously recurrent seizures.
Topics: Animals; Anticonvulsants; Bromides; Chronic Disease; Disease Models, Animal; Dog Diseases; Dogs; Dru | 2004 |
Mechanisms of action of antiepileptic drugs.
Topics: Acetazolamide; Animals; Anti-Anxiety Agents; Anticonvulsants; Barbiturates; Benzodiazepines; Carbama | 1982 |
An improved method for perfusion of the isolated brain of the rat-influence of perfusion conditions and application of analeptic and anticonvulsant drugs.
Topics: Adenosine Triphosphate; Animals; Anticonvulsants; Brain; Central Nervous System Stimulants; Lactates | 1983 |
Pharmacologic therapy of seizures in the elderly.
Topics: Aged; Anticonvulsants; Carbamazepine; Humans; Phenobarbital; Phenytoin; Primidone; Seizures; Status | 1984 |
Todd's paralysis following an interscalene block.
Topics: Adult; Bupivacaine; Female; Hemiplegia; Humans; Nerve Block; Primidone; Seizures | 1984 |
Primidone therapy in refractory neonatal seizures.
Topics: Drug Therapy, Combination; Female; Humans; Infant; Male; Phenobarbital; Phenytoin; Primidone; Seizur | 1984 |
Primidone, phenobarbital, and PEMA: I. Seizure protection, neurotoxicity, and therapeutic index of individual compounds in mice.
Topics: Animals; Bicuculline; Brain; Brain Chemistry; Electroshock; Female; Malonates; Mice; Mice, Inbred St | 1983 |
Primidone, phenobarbital, and PEMA: II. Seizure protection, neurotoxicity, and therapeutic index of varying combinations in mice.
Topics: Animals; Brain; Brain Chemistry; Drug Synergism; Drug Therapy, Combination; Electroshock; Female; Ma | 1983 |
A design for the prospective evaluation of the efficacy and toxicity of antiepileptic drugs in adults.
Topics: Adult; Aged; Anticonvulsants; Behavior; Carbamazepine; Clinical Trials as Topic; Double-Blind Method | 1983 |
Compromised hepatic function in dogs treated with anticonvulsant drugs.
Topics: Animals; Anticonvulsants; Dog Diseases; Dogs; Dose-Response Relationship, Drug; Drug Therapy, Combin | 1984 |
Anticonvulsant effect of primidone in the gerbil. Time course and significance of the active metabolites.
Topics: Administration, Oral; Animals; Brain; Chromatography, Gas; Gerbillinae; Phenobarbital; Phenylethylma | 1984 |
Development of tolerance to the side effects of primidone.
Topics: Adult; Aged; Drug Tolerance; Humans; Middle Aged; Primidone; Seizures | 1984 |
Drug treatment of epilepsy.
Topics: Anticonvulsants; Carbamazepine; Clonazepam; Electroencephalography; Epilepsy; Ethosuximide; Female; | 1981 |
EEG quantification of drug level effects in monkey model of partial epilepsy.
Topics: Animals; Anticonvulsants; Circadian Rhythm; Clonazepam; Disease Models, Animal; Electroencephalograp | 1982 |
A possible neurochemical basis of the central stimulatory effects of pp'DDT.
Topics: Acetylcholine; Aminooxyacetic Acid; Ammonia; Animals; Central Nervous System; Corpus Striatum; DDT; | 1981 |
Primidone in the treatment of the long QT syndrome: QT shortening and ventricular arrhythmia suppression.
Topics: Adolescent; Adult; Arrhythmias, Cardiac; Death, Sudden; Electrocardiography; Female; Follow-Up Studi | 1980 |
Primidone kinetics: effects of concurrent drugs and duration of therapy.
Topics: Adolescent; Adult; Aged; Drug Therapy, Combination; Female; Humans; Kinetics; Male; Metabolic Cleara | 1981 |
Neutropenia and thrombocytopenia in three dogs treated with anticonvulsants.
Topics: Anemia; Animals; Anticonvulsants; Bacteremia; Blood Cell Count; Dog Diseases; Dogs; Female; Male; Ne | 1998 |
Relative effectiveness of primidone (Mysoline) and diphenylhydantoin (Dilantin) in the management of sedative withdrawal seizures.
Topics: Antipsychotic Agents; Chlordiazepoxide; Drug Evaluation; Humans; Phenothiazines; Phenytoin; Primidon | 1976 |
[Effect of drugs on electroclinical types of epileptic seizures in Lennox-Gastaut syndrome].
Topics: Adrenocorticotropic Hormone; Anticonvulsants; Barbiturates; Child; Child, Preschool; Clonazepam; Dia | 1977 |
A primate model for testing anticonvulsant drugs.
Topics: Allyl Compounds; Animals; Anticonvulsants; Carbamazepine; Chromatography, Gas; Diazepam; Disease Mod | 1975 |
[The serum concentration of anticonvulsants -- pharmacokinetic findings and practical therapeutic applications (author's transl)].
Topics: Antacids; Anticonvulsants; Biological Availability; Carbamazepine; Chromatography, Gas; Clonazepam; | 1979 |
Recurrent convulsions in a thoroughbred foal: management and treatment.
Topics: Animals; Animals, Newborn; Enteral Nutrition; Female; Horse Diseases; Horses; Male; Pregnancy; Primi | 1977 |
Single-dose pharmacokinetics and anticonvulsant efficacy of primidone in mice.
Topics: Animals; Biotransformation; Brain Chemistry; Dose-Response Relationship, Drug; Female; Mice; Phenoba | 1979 |
Seizures in childhood encephalopathy or epilepsy?
Topics: Adolescent; Child; Epilepsy; Humans; Metabolic Diseases; Neurologic Examination; Phenobarbital; Prim | 1977 |
Drug interaction: diazoxide and diphenylhydantoin.
Topics: Administration, Oral; Adolescent; Child, Preschool; Chromatography, Gas; Diazoxide; Drug Therapy, Co | 1975 |
Efficacy of standard anticonvulsants in monkey model with spontaneous motor seizures.
Topics: Aluminum; Animals; Anticonvulsants; Disease Models, Animal; Electroencephalography; Feeding Behavior | 1975 |
Management of the difficult patient with complex partial seizures.
Topics: Adult; Diagnosis, Differential; Dose-Response Relationship, Drug; Drug Therapy, Combination; Epileps | 1975 |
The role of technical, biological and pharmacological factors in the laboratory evaluation of anticonvulsant drugs. I. The influence of administration vehicles.
Topics: Absorption; Animals; Anticonvulsants; Biological Availability; Carbamazepine; Differential Threshold | 1990 |
[Factors influencing the effectiveness of preventive treatment of febrile convulsions].
Topics: Anticonvulsants; Child; Drug Evaluation; Epilepsy; Female; Fever; Humans; Male; Phenobarbital; Primi | 1989 |
Comparison of the anticonvulsant efficacy of primidone and phenobarbital during chronic treatment of amygdala-kindled rats.
Topics: Amygdala; Animals; Anticonvulsants; Behavior, Animal; Electrodes, Implanted; Female; Kindling, Neuro | 1989 |
Dermatitis associated with the use of primidone in a dog.
Topics: Animals; Dog Diseases; Dogs; Drug Eruptions; Female; Primidone; Seizures | 1987 |
Chronic primidone treatment in the rat: an animal model of primidone therapy.
Topics: Administration, Oral; Animals; Male; Models, Biological; Phenobarbital; Primidone; Rats; Rats, Inbre | 1988 |
Seizures during barbiturate withdrawal: relation to blood level.
Topics: Humans; Phenobarbital; Primidone; Seizures; Substance Withdrawal Syndrome; Time Factors | 1987 |
Increased seizure frequency with generic primidone.
Topics: Adolescent; Female; Humans; Primidone; Seizures; Therapeutic Equivalency | 1987 |
Toxic hepatopathy and intrahepatic cholestasis associated with phenytoin administration in combination with other anticonvulsant drugs in three dogs.
Topics: Animals; Anticonvulsants; Chemical and Drug Induced Liver Injury; Cholestasis, Intrahepatic; Dog Dis | 1987 |
Methylene diamines with an anticonvulsant action.
Topics: Amines; Animals; Electroshock; Methylamines; Pentylenetetrazole; Polyamines; Primidone; Rabbits; Sei | 1971 |
Effect of barbiturates and isoniazid on cerebral hemisphere gamma-aminobutyric acid content in pp' DDT treated mice.
Topics: Aminobutyrates; Animals; Anticonvulsants; Barbiturates; Behavior, Animal; Brain Chemistry; DDT; Drug | 1974 |
Therapy of seizures in children.
Topics: Child; Diazepam; Epilepsy; Epilepsy, Absence; Ethosuximide; Humans; Injections, Intramuscular; Injec | 1974 |
Drug treatment of convulsive disorders.
Topics: Acetazolamide; Adrenocorticotropic Hormone; Adult; Anticonvulsants; Barbiturates; Child; Diazepam; E | 1972 |
[Epilepsy in childhood].
Topics: Adrenocorticotropic Hormone; Child; Child, Preschool; Electroencephalography; Epilepsy; Epilepsy, Ab | 1972 |
Motor convulsions and EEG during maximal electroshock in the rat.
Topics: Animals; Anticonvulsants; Cerebral Cortex; Cornea; Electric Stimulation; Electroencephalography; Ele | 1967 |
Increased susceptibility of mice to seizures after some anticonvulsant drugs.
Topics: Animals; Anticonvulsants; Bemegride; Central Nervous System Stimulants; Drug Synergism; Electroshock | 1967 |
Drugs in management of hyperkinetic and perceptually handicapped children.
Topics: Anticonvulsants; Central Nervous System Stimulants; Child; Child, Preschool; Chlordiazepoxide; Chlor | 1968 |
The effect of isoniazid and some anticonvulsant drugs on the gamma-aminobutyric acid content of mouse brain in insulin hypoglycaemia.
Topics: Aminobutyrates; Animals; Barbiturates; Brain; Brain Chemistry; Cerebral Cortex; Hypoglycemia; Insuli | 1970 |
[Comparative action of p-chlorbenzolsulfonamide with other anticonvulsants in audiogenic convulsions in rats].
Topics: Acetazolamide; Animals; Anticonvulsants; Hearing; Noise; Phenobarbital; Primidone; Rats; Seizures; S | 1969 |
The effects of drugs on barbiturate withdrawal convulsions in the rat.
Topics: Animals; Barbiturates; Chlordiazepoxide; Chlorpromazine; Ethanol; Ethosuximide; Female; Humans; Hydr | 1970 |
Anticonvulsant drugs. I. Patho-physiological and pharmacological aspects.
Topics: Acetates; Acetazolamide; Anticonvulsants; Carbamazepine; Diazepam; Dibenzazepines; Electroencephalog | 1972 |
Letter: Primidone thrombocytopenia.
Topics: Adult; Female; Humans; Phenobarbital; Primidone; Seizures; Thrombocytopenia | 1974 |
[Considerations and research on febrile convulsions].
Topics: Anticonvulsants; Brain Diseases; Child, Preschool; Diagnosis, Differential; Diazepam; Electroencepha | 1974 |
Effect of oxotremorine on behaviour and EEG of reserpine-pretreated rats.
Topics: Animals; Atropine; Atropine Derivatives; Brain; Electroencephalography; Female; Male; Mecamylamine; | 1974 |
Effects of long-term primidone therapy in a dog.
Topics: Alkaline Phosphatase; Animals; Ataxia; Dog Diseases; Dogs; Estrus; Feeding and Eating Disorders; Fem | 1974 |
A medical and social survey of 231 children with seizures.
Topics: Adolescent; Attitude to Health; Child; Child Behavior Disorders; Child, Preschool; Electroencephalog | 1972 |
Clinical and physiological effects of stimulation of the paleocerebellum in humans.
Topics: Adult; Cerebellum; Electric Stimulation; Electrodes, Implanted; Electroencephalography; Epilepsy; Ep | 1973 |
Effect of cannabidiol and of other cannabis sativa compounds on hippocampal seizure discharges.
Topics: Animals; Cannabis; Electric Stimulation; Electrodes, Implanted; Hippocampus; Injections, Intraperito | 1973 |
Metabolism and anticonvulsant properties of primidone in the rat.
Topics: Amides; Animals; Anticonvulsants; Brain Chemistry; Chromatography, Gas; Electroshock; Male; Malonate | 1973 |
Chronic and severe phenobarbital intoxication in a child treated with primidone and diphenylhydantoin.
Topics: Anticonvulsants; Biotransformation; Chromatography, Gas; Drug Interactions; Female; Humans; Infant; | 1973 |
Vitamin D-dependent rickets in institutionalized, mentally retarded children receiving long-term anticonvulsant therapy. I. A survey of 288 patients.
Topics: Adolescent; Alkaline Phosphatase; Anticonvulsants; Calcium; Child; Child, Preschool; Female; Humans; | 1973 |
Transplacental passage of primidone.
Topics: Female; Fetus; Humans; Infant, Newborn; Infant, Newborn, Diseases; Labor, Obstetric; Maternal-Fetal | 1973 |
Rickets associated with anticonvulsant medication.
Topics: Alkaline Phosphatase; Calcium; Child, Preschool; Female; Humans; Phenobarbital; Phenytoin; Phosphoru | 1974 |
Long-term administration of antiepileptic drugs and the development of rickets.
Topics: Alkaline Phosphatase; Anticonvulsants; Calcium; Diazepam; Ethosuximide; Female; Gluconates; Humans; | 1972 |
Anticonvulsant therapy, folic acid and vitamin B12 metabolism and mental symptoms.
Topics: Adult; Anemia, Macrocytic; Female; Folic Acid Deficiency; Humans; Male; Mental Disorders; Middle Age | 1966 |
Intolerance to diphenylhydantoin in five cases of Vogt-Spielmeyer disease.
Topics: Ataxia; Brain; Humans; L-Lactate Dehydrogenase; Lipidoses; Phenobarbital; Phenytoin; Primidone; Seiz | 1969 |
Pseudolymphoma syndrome. A sensitivity to anticonvulsant drugs.
Topics: Biopsy; Blood Cell Count; Blood Chemical Analysis; Chlordiazepoxide; Drug Hypersensitivity; Female; | 1968 |
Fits in utero, followed by infantile myoclonic twitchings.
Topics: Adult; Female; Fetal Diseases; Humans; Infant, Newborn; Infant, Newborn, Diseases; Male; Myoclonus; | 1968 |
[Experiences with mylepsinum in the treatment of cerebral seizures in childhood].
Topics: Adolescent; Child; Child, Preschool; Epilepsy; Humans; Infant; Primidone; Seizures | 1965 |